ATE155473T1 - Benzimidazol phosphono-aminosäure - Google Patents

Benzimidazol phosphono-aminosäure

Info

Publication number: ATE155473T1
Authority: AT; Austria
Prior art keywords: hydrogen; compounds; amino acid; lower alkyl; phosphono
Prior art date: 1991-10-11

Application number

AT92309160T

Other languages

English (en)

Inventor

Reinhardt Bernhard Baudy

III Horace FLETCHER

John Patrick Yardley

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-11

Filing date

1992-10-08

Publication date

1997-08-15

1992-10-08 Application filed by American Home Prod filed Critical American Home Prod

1997-08-15 Application granted granted Critical

1997-08-15 Publication of ATE155473T1 publication Critical patent/ATE155473T1/de

Links

-1 BENZIMIDAZOLE PHOSPHONO-AMINO Chemical class 0.000 title abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Insulating Materials (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Saccharide Compounds (AREA)

AT92309160T 1991-10-11 1992-10-08 Benzimidazol phosphono-aminosäure ATE155473T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/776,528 US5124319A (en)	1991-10-11	1991-10-11	Benzimidazole phosphono-amino acids

Publications (1)

Publication Number	Publication Date
ATE155473T1 true ATE155473T1 (de)	1997-08-15

Family

ID=25107643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92309160T ATE155473T1 (de)	1991-10-11	1992-10-08	Benzimidazol phosphono-aminosäure

Country Status (22)

Country	Link
US (1)	US5124319A (de)
EP (1)	EP0539057B1 (de)
JP (1)	JPH05222077A (de)
KR (1)	KR930007961A (de)
AT (1)	ATE155473T1 (de)
AU (1)	AU656811B2 (de)
CA (1)	CA2080253A1 (de)
CZ (1)	CZ308392A3 (de)
DE (1)	DE69220879T2 (de)
DK (1)	DK0539057T3 (de)
ES (1)	ES2104841T3 (de)
FI (1)	FI924570A7 (de)
GR (1)	GR3024767T3 (de)
HU (2)	HUT62196A (de)
IL (1)	IL103330A (de)
MX (1)	MX9205816A (de)
NO (1)	NO300690B1 (de)
NZ (1)	NZ244587A (de)
RU (1)	RU2073004C1 (de)
SG (1)	SG47768A1 (de)
SK (1)	SK279381B6 (de)
ZA (1)	ZA927535B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5334618A (en) *	1991-04-04	1994-08-02	The Children's Medical Center Corporation	Method of preventing NMDA receptor-mediated neuronal damage
US5124319A (en) *	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids
USRE39300E1 (en)	1993-01-28	2006-09-19	Virginia Commonwealth University Medical College Of Virginia	Inhibiting the development of tolerance to and/or dependence on an addictive substance
US5321012A (en) *	1993-01-28	1994-06-14	Virginia Commonwealth University Medical College	Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
IS4233A (is) *	1993-12-22	1995-06-23	Astra Aktiebolag	Misleit hringtengd efnasambönd
US5864040A (en) *	1996-01-11	1999-01-26	American Home Products Corporation	Benzimidazole phosphono-amino acids
US6284748B1 (en)	1997-03-07	2001-09-04	Metabasis Therapeutics, Inc.	Purine inhibitors of fructose 1,6-bisphosphatase
DE69819311T2 (de)	1997-03-07	2004-07-29	Metabasis Therapeutics Inc., San Diego	Neue benzimidazol inhibitoren der fructose-1,6-bisphosphatase
GB9917822D0 (en) *	1999-07-29	1999-09-29	Imperial College	Nmda antagonist
US6316474B1 (en) *	1999-10-29	2001-11-13	Merck & Co., Inc.	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US7375136B2 (en) *	2001-03-08	2008-05-20	Emory University	pH-dependent NMDA receptor antagonists
UA78529C2 (en) *	2001-10-10	2007-04-10	Wyeth Corp	Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) *	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
ATE481103T1 (de) *	2003-04-09	2010-10-15	Wyeth Llc	Derivate von 2-(8,9-dioxo-2,6- diazabicyclo(5.2.0)non-1(7)-en-2- yl)alkylphosphonsäure und deren verwendung als n- methyl-d-aspartat- (nmda-) rezeptorantagonisten
CA2521394A1 (en) *	2003-04-09	2004-10-28	Wyeth	Pharmaceutical compositions for intranasal administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.o]non-1 (7)-en-2-yl)alkyl] phosphonic acid and derivatives and methods of use thereof
US20050142192A1 (en) *	2003-10-15	2005-06-30	Wyeth	Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
TW200514775A (en) *	2003-10-22	2005-05-01	Wyeth Corp	Methods for the preparation of {2-[(8,9)-dioxo-2,6-diaza-bicyclo[5.2.0]-non-1(7)-en-2-yl]ethyl} phosphonic acid and esters thereof
EA201070077A1 (ru) *	2007-06-29	2010-08-30	Эмори Юниверсити	Антагонисты nmda-рецепторов с нейропротективным действием
US20090061024A1 (en) *	2007-08-27	2009-03-05	Wyeth	Compositions and methods employing nmda antagonists for achieving an anesthetic-sparing effect

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU959724A1 (ru) *	1981-05-06	1982-09-23	Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт	Способ регулировани роста растений огурца
PH23848A (en) *	1985-05-24	1989-11-23	Ciba Geigy Ag	Certain phosphonic acids and derivatives
US4746653A (en) *	1986-02-28	1988-05-24	Ciba-Geigy Corporation	Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
EP0400835A1 (de) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituierte Benzimidazole als Angiotensin II-Hemmer
US5124319A (en) *	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids

1991
- 1991-10-11 US US07/776,528 patent/US5124319A/en not_active Expired - Lifetime
1992
- 1992-09-30 ZA ZA927535A patent/ZA927535B/xx unknown
- 1992-10-01 NZ NZ244587A patent/NZ244587A/xx unknown
- 1992-10-02 IL IL10333092A patent/IL103330A/en not_active IP Right Cessation
- 1992-10-08 AT AT92309160T patent/ATE155473T1/de not_active IP Right Cessation
- 1992-10-08 EP EP92309160A patent/EP0539057B1/de not_active Expired - Lifetime
- 1992-10-08 AU AU26269/92A patent/AU656811B2/en not_active Ceased
- 1992-10-08 ES ES92309160T patent/ES2104841T3/es not_active Expired - Lifetime
- 1992-10-08 DE DE69220879T patent/DE69220879T2/de not_active Expired - Fee Related
- 1992-10-08 SG SG1996004290A patent/SG47768A1/en unknown
- 1992-10-08 DK DK92309160.7T patent/DK0539057T3/da active
- 1992-10-09 RU SU925053101A patent/RU2073004C1/ru active
- 1992-10-09 NO NO923940A patent/NO300690B1/no unknown
- 1992-10-09 MX MX9205816A patent/MX9205816A/es not_active IP Right Cessation
- 1992-10-09 SK SK3083-92A patent/SK279381B6/sk unknown
- 1992-10-09 JP JP4271403A patent/JPH05222077A/ja active Pending
- 1992-10-09 CZ CS923083A patent/CZ308392A3/cs unknown
- 1992-10-09 FI FI924570A patent/FI924570A7/fi unknown
- 1992-10-09 HU HU9203203A patent/HUT62196A/hu unknown
- 1992-10-09 CA CA002080253A patent/CA2080253A1/en not_active Abandoned
- 1992-10-10 KR KR1019920018638A patent/KR930007961A/ko not_active Withdrawn
1995
- 1995-06-21 HU HU95P/P00314P patent/HU211942A9/hu unknown
1997
- 1997-09-17 GR GR970402423T patent/GR3024767T3/el unknown

Also Published As

Publication number	Publication date
RU2073004C1 (ru)	1997-02-10
GR3024767T3 (en)	1997-12-31
SG47768A1 (en)	1998-04-17
HU9203203D0 (en)	1992-12-28
IL103330A0 (en)	1993-03-15
ES2104841T3 (es)	1997-10-16
AU2626992A (en)	1993-04-22
SK279381B6 (sk)	1998-10-07
HUT62196A (en)	1993-04-28
HU211942A9 (en)	1996-01-29
ZA927535B (en)	1994-03-30
FI924570L (fi)	1993-04-12
CA2080253A1 (en)	1993-04-12
KR930007961A (ko)	1993-05-20
NO923940D0 (no)	1992-10-09
SK308392A3 (en)	1995-02-08
FI924570A7 (fi)	1993-04-12
MX9205816A (es)	1993-07-01
CZ308392A3 (en)	1993-08-11
IL103330A (en)	1996-10-31
JPH05222077A (ja)	1993-08-31
US5124319A (en)	1992-06-23
DE69220879T2 (de)	1997-11-20
DK0539057T3 (da)	1998-02-09
NO923940L (no)	1993-04-13
NZ244587A (en)	1994-04-27
EP0539057B1 (de)	1997-07-16
FI924570A0 (fi)	1992-10-09
DE69220879D1 (de)	1997-08-21
NO300690B1 (no)	1997-07-07
EP0539057A1 (de)	1993-04-28
AU656811B2 (en)	1995-02-16

Legal Events

Date	Code	Title	Description
1998-02-15	UEP	Publication of translation of european patent specification
2000-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69220879D1 (de)	1997-08-21	Benzimidazol Phosphono-Aminosäure
MA21896A1 (fr)	1991-04-01	Procede de prepatration d'acides imidazolyl - alcenoiques .
ATE272398T1 (de)	2004-08-15	Verwendung von ep4 rezeptorliganden zur behandlung von neuropathischen schmerz
DK0455510T3 (da)	1997-04-28	Anvendelse af 5HT1A-receptoragonist til inhibering af mavesyresekretion
DE3880396D1 (de)	1993-05-27	Zur behandlung von neurodegenerativen erkrankungen verwendbare kynurensaeurederivate.
MA22096A1 (fr)	1991-12-31	Procede de preparation d'un derive substitue de n - (imidazolyl alkyl) alanine .
DK0648744T3 (da)	1998-09-21	Phenylalkanolaminderivater som antagonister for NMDA-receptoren
PT1234818E (pt)	2005-01-31	Sais de calcio de derivados de 1,5-benzodiazepina, processo para producao dos sais e drogas que os contem
HUT60710A (en)	1992-10-28	Process for producing new substituted amine compounds
FI935799A0 (fi)	1993-12-22	Arylsubstituerade heterocykliska foereningar
MXPA04000952A (es)	2004-04-20	Sales de derivados de acido 1,2,3-4-tetrahidro-isoquinolin-2-carboxilico.
DE69622868D1 (de)	2002-09-12	Inhibitoren der blutplättchen-aggregation, die c-terminale aminosäurereste mit aminergen seitenketten enthalten
FI933652A0 (fi)	1993-08-19	Foerfarande foer framstaellning av 1-osubstituerade 3-aminopyrroler