SG47768A1 - Benzimidazole phosphono-amino acids - Google Patents

Benzimidazole phosphono-amino acids

Info

Publication number: SG47768A1
Authority: SG; Singapore
Prior art keywords: amino acids; hydrogen; compounds; lower alkyl; phosphono
Prior art date: 1991-10-11

Application number

SG1996004290A

Other languages

English (en)

Inventor

Reinhardt Bernhard Baudy

Horace Fletcher Iii

John Patrick Yardley

Original Assignee

American Home Prod

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-11

Filing date

1992-10-08

Publication date

1998-04-17

1992-10-08 Application filed by American Home Prod filed Critical American Home Prod

1998-04-17 Publication of SG47768A1 publication Critical patent/SG47768A1/en

Links

-1 pivaloyloxymethyl Chemical group 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
210000003169 central nervous system Anatomy 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
230000001575 pathological effect Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
- C07F9/6503—Five-membered rings
- C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
- C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Cardiology (AREA)
Urology & Nephrology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Insulating Materials (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Saccharide Compounds (AREA)

SG1996004290A 1991-10-11 1992-10-08 Benzimidazole phosphono-amino acids SG47768A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/776,528 US5124319A (en)	1991-10-11	1991-10-11	Benzimidazole phosphono-amino acids

Publications (1)

Publication Number	Publication Date
SG47768A1 true SG47768A1 (en)	1998-04-17

Family

ID=25107643

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996004290A SG47768A1 (en)	1991-10-11	1992-10-08	Benzimidazole phosphono-amino acids

Country Status (22)

Country	Link
US (1)	US5124319A (de)
EP (1)	EP0539057B1 (de)
JP (1)	JPH05222077A (de)
KR (1)	KR930007961A (de)
AT (1)	ATE155473T1 (de)
AU (1)	AU656811B2 (de)
CA (1)	CA2080253A1 (de)
CZ (1)	CZ308392A3 (de)
DE (1)	DE69220879T2 (de)
DK (1)	DK0539057T3 (de)
ES (1)	ES2104841T3 (de)
FI (1)	FI924570A7 (de)
GR (1)	GR3024767T3 (de)
HU (2)	HUT62196A (de)
IL (1)	IL103330A (de)
MX (1)	MX9205816A (de)
NO (1)	NO300690B1 (de)
NZ (1)	NZ244587A (de)
RU (1)	RU2073004C1 (de)
SG (1)	SG47768A1 (de)
SK (1)	SK279381B6 (de)
ZA (1)	ZA927535B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5334618A (en) *	1991-04-04	1994-08-02	The Children's Medical Center Corporation	Method of preventing NMDA receptor-mediated neuronal damage
US5124319A (en) *	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids
US5321012A (en) *	1993-01-28	1994-06-14	Virginia Commonwealth University Medical College	Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
USRE39300E1 (en)	1993-01-28	2006-09-19	Virginia Commonwealth University Medical College Of Virginia	Inhibiting the development of tolerance to and/or dependence on an addictive substance
IS4233A (is) *	1993-12-22	1995-06-23	Astra Aktiebolag	Misleit hringtengd efnasambönd
US5864040A (en) *	1996-01-11	1999-01-26	American Home Products Corporation	Benzimidazole phosphono-amino acids
ZA981936B (en)	1997-03-07	1999-09-06	Metabasis Therapeutics Inc	Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
WO1998039344A1 (en) *	1997-03-07	1998-09-11	Metabasis Therapeutics, Inc.	Novel purine inhibitors of fructose-1,6-bisphosphatase
GB9917822D0 (en) *	1999-07-29	1999-09-29	Imperial College	Nmda antagonist
US6316474B1 (en) *	1999-10-29	2001-11-13	Merck & Co., Inc.	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
WO2002072542A2 (en) *	2001-03-08	2002-09-19	Emory University	Ph-dependent nmda receptor antagonists
UA78529C2 (en) *	2001-10-10	2007-04-10	Wyeth Corp	Derivatives of [[2-(amino-3,4-dioxo-1-cyclobutene-1-yl)amino]alkyl] acid for treating pain
US20040082543A1 (en) *	2002-10-29	2004-04-29	Pharmacia Corporation	Compositions of cyclooxygenase-2 selective inhibitors and NMDA receptor antagonists for the treatment or prevention of neuropathic pain
BRPI0409088A (pt) *	2003-04-09	2006-04-11	Wyeth Corp	composições farmacêuticas para administração intranasal de ácido [2-(8,9-dioxo-2,6-diazabiciclo [5.2.0]non-1(7)-en-2-il)alquil]-fosfÈnico e derivados e métodos de uso dos mesmos
PT1611144E (pt) *	2003-04-09	2010-11-12	Wyeth Llc	Derivados do ácido 2-(8,9-dioxo-2,6-diazabiciclo(5.2.0)- non-1(7)-eno-2-il)-alquil-fosfónico e sua utilização como antagonistas do receptor n-metil-d-aspartato (nmda)
US20050142192A1 (en) *	2003-10-15	2005-06-30	Wyeth	Oral administration of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)alkyl] phosphonic acid and derivatives
GT200400213A (es) *	2003-10-22	2007-09-05		Metodos para la preparacion del acido {2-[(8,9)-dioxo-2,6-diaza-biciclo[5.2.0]-non-1(7)-en-2-il]etil} fosfonico y esteres del mismo
CN103058957A (zh)	2007-06-29	2013-04-24	埃莫里大学	用于神经保护的nmda受体拮抗剂
MX2010002191A (es) *	2007-08-27	2010-03-17	Wyeth Llc	Composiciones y metodos que emplean antagonistas nmda para lograr un efecto anestesico limitado.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SU959724A1 (ru) *	1981-05-06	1982-09-23	Ленинградский Ордена Трудового Красного Знамени Сельскохозяйственный Институт	Способ регулировани роста растений огурца
PH23848A (en) *	1985-05-24	1989-11-23	Ciba Geigy Ag	Certain phosphonic acids and derivatives
US4746653A (en) *	1986-02-28	1988-05-24	Ciba-Geigy Corporation	Certain hetero phosphonic acid derivatives of 2-piperidine or 2-tetrahydropyridinecarboxylates and esters thereof which are useful for the treatment of disorders responsive to blockade of the NMDA receptor in mammals
EP0400835A1 (de) *	1989-05-15	1990-12-05	Merck & Co. Inc.	Substituierte Benzimidazole als Angiotensin II-Hemmer
US5124319A (en) *	1991-10-11	1992-06-23	American Home Products Corporation	Benzimidazole phosphono-amino acids

1991
- 1991-10-11 US US07/776,528 patent/US5124319A/en not_active Expired - Lifetime
1992
- 1992-09-30 ZA ZA927535A patent/ZA927535B/xx unknown
- 1992-10-01 NZ NZ244587A patent/NZ244587A/xx unknown
- 1992-10-02 IL IL10333092A patent/IL103330A/en not_active IP Right Cessation
- 1992-10-08 AU AU26269/92A patent/AU656811B2/en not_active Ceased
- 1992-10-08 EP EP92309160A patent/EP0539057B1/de not_active Expired - Lifetime
- 1992-10-08 DK DK92309160.7T patent/DK0539057T3/da active
- 1992-10-08 SG SG1996004290A patent/SG47768A1/en unknown
- 1992-10-08 DE DE69220879T patent/DE69220879T2/de not_active Expired - Fee Related
- 1992-10-08 AT AT92309160T patent/ATE155473T1/de not_active IP Right Cessation
- 1992-10-08 ES ES92309160T patent/ES2104841T3/es not_active Expired - Lifetime
- 1992-10-09 FI FI924570A patent/FI924570A7/fi unknown
- 1992-10-09 JP JP4271403A patent/JPH05222077A/ja active Pending
- 1992-10-09 CA CA002080253A patent/CA2080253A1/en not_active Abandoned
- 1992-10-09 HU HU9203203A patent/HUT62196A/hu unknown
- 1992-10-09 MX MX9205816A patent/MX9205816A/es not_active IP Right Cessation
- 1992-10-09 SK SK3083-92A patent/SK279381B6/sk unknown
- 1992-10-09 RU SU925053101A patent/RU2073004C1/ru active
- 1992-10-09 NO NO923940A patent/NO300690B1/no unknown
- 1992-10-09 CZ CS923083A patent/CZ308392A3/cs unknown
- 1992-10-10 KR KR1019920018638A patent/KR930007961A/ko not_active Withdrawn
1995
- 1995-06-21 HU HU95P/P00314P patent/HU211942A9/hu unknown
1997
- 1997-09-17 GR GR970402423T patent/GR3024767T3/el unknown

Also Published As

Publication number	Publication date
HUT62196A (en)	1993-04-28
IL103330A0 (en)	1993-03-15
JPH05222077A (ja)	1993-08-31
US5124319A (en)	1992-06-23
NO923940D0 (no)	1992-10-09
AU656811B2 (en)	1995-02-16
DE69220879D1 (de)	1997-08-21
MX9205816A (es)	1993-07-01
FI924570A0 (fi)	1992-10-09
NZ244587A (en)	1994-04-27
CZ308392A3 (en)	1993-08-11
FI924570L (fi)	1993-04-12
SK308392A3 (en)	1995-02-08
ATE155473T1 (de)	1997-08-15
EP0539057B1 (de)	1997-07-16
ZA927535B (en)	1994-03-30
NO300690B1 (no)	1997-07-07
NO923940L (no)	1993-04-13
HU9203203D0 (en)	1992-12-28
DK0539057T3 (da)	1998-02-09
HU211942A9 (en)	1996-01-29
RU2073004C1 (ru)	1997-02-10
DE69220879T2 (de)	1997-11-20
ES2104841T3 (es)	1997-10-16
GR3024767T3 (en)	1997-12-31
CA2080253A1 (en)	1993-04-12
EP0539057A1 (de)	1993-04-28
SK279381B6 (sk)	1998-10-07
AU2626992A (en)	1993-04-22
IL103330A (en)	1996-10-31
FI924570A7 (fi)	1993-04-12
KR930007961A (ko)	1993-05-20

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ZA927535B (en)	1994-03-30	Benzimidazole phosphono-amino acids
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PL285591A1 (en)	1991-03-25	Method for manufacturing new imidazolilalkenecrbxylic acids
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