ATE156803T1 - Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs - Google Patents
Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebsInfo
- Publication number
- ATE156803T1 ATE156803T1 AT93911884T AT93911884T ATE156803T1 AT E156803 T1 ATE156803 T1 AT E156803T1 AT 93911884 T AT93911884 T AT 93911884T AT 93911884 T AT93911884 T AT 93911884T AT E156803 T1 ATE156803 T1 AT E156803T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- cancers
- treatment
- sec
- date
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title 1
- 238000003745 diagnosis Methods 0.000 title 1
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical group [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- 206010006187 Breast cancer Diseases 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000001833 anti-estrogenic effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000000262 estrogen Substances 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000005251 gamma ray Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000002346 iodo group Chemical group I* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 238000001959 radiotherapy Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929209509A GB9209509D0 (en) | 1992-05-01 | 1992-05-01 | Substituted 1,1,2-triphenylbutenes |
| GB939303982A GB9303982D0 (en) | 1993-02-26 | 1993-02-26 | Substituted 1,1,2 triphenylbutenes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE156803T1 true ATE156803T1 (de) | 1997-08-15 |
Family
ID=26300810
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93911884T ATE156803T1 (de) | 1992-05-01 | 1993-04-29 | Substituierte 1,1,2,-triphenylbutene und ihre verwendung zur behandlung und diagnose von krebs |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5589500A (de) |
| EP (1) | EP0638064B1 (de) |
| JP (1) | JP3153554B2 (de) |
| AT (1) | ATE156803T1 (de) |
| AU (1) | AU674146B2 (de) |
| CA (1) | CA2134772A1 (de) |
| DE (1) | DE69313106T2 (de) |
| ES (1) | ES2107030T3 (de) |
| WO (1) | WO1993022275A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2262798A (en) * | 1991-12-24 | 1993-06-30 | British Aerospace | An aircraft cargo container |
| DE4311870C2 (de) * | 1993-04-10 | 1998-07-30 | Altramed Holdings Ltd | Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen |
| US6084117A (en) * | 1999-11-22 | 2000-07-04 | Albemarle Corporation | Production of silated haloarenes by selective silylation of polyhaloarenes |
| US6599921B2 (en) | 2001-02-22 | 2003-07-29 | Nanodesign, Inc. | Non-steroidal estrogen receptor ligands |
| US7196119B2 (en) | 2003-10-21 | 2007-03-27 | The Regents Of The University Of California | Development of new selective estrogen receptor modulators |
| MX2016011567A (es) * | 2014-03-11 | 2016-12-07 | Repros Therapeutics Inc | Sintesis de clomifeno usando un solvente unico. |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3762617D1 (de) * | 1986-09-11 | 1990-06-13 | Nat Res Dev | Tamoxifenderivate. |
| WO1995011879A1 (en) * | 1993-10-25 | 1995-05-04 | Taiho Pharmaceutical Co., Ltd. | Process for producing acid-addition salt of z-isomer of triphenylethylene compound |
-
1993
- 1993-04-29 CA CA002134772A patent/CA2134772A1/en not_active Abandoned
- 1993-04-29 DE DE69313106T patent/DE69313106T2/de not_active Expired - Fee Related
- 1993-04-29 AT AT93911884T patent/ATE156803T1/de not_active IP Right Cessation
- 1993-04-29 ES ES93911884T patent/ES2107030T3/es not_active Expired - Lifetime
- 1993-04-29 WO PCT/GB1993/000889 patent/WO1993022275A1/en not_active Ceased
- 1993-04-29 EP EP93911884A patent/EP0638064B1/de not_active Expired - Lifetime
- 1993-04-29 AU AU42673/93A patent/AU674146B2/en not_active Ceased
- 1993-04-29 JP JP51907293A patent/JP3153554B2/ja not_active Expired - Fee Related
- 1993-04-29 US US08/331,582 patent/US5589500A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0638064B1 (de) | 1997-08-13 |
| JPH07506357A (ja) | 1995-07-13 |
| AU4267393A (en) | 1993-11-29 |
| AU674146B2 (en) | 1996-12-12 |
| DE69313106T2 (de) | 1998-01-22 |
| ES2107030T3 (es) | 1997-11-16 |
| EP0638064A1 (de) | 1995-02-15 |
| US5589500A (en) | 1996-12-31 |
| JP3153554B2 (ja) | 2001-04-09 |
| WO1993022275A1 (en) | 1993-11-11 |
| CA2134772A1 (en) | 1993-11-11 |
| DE69313106D1 (de) | 1997-09-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |