ES2107030T3 - 1,1,2-trifenilbutenos sustituidos y su uso en el tratamiento y diagnosis del cancer. - Google Patents

1,1,2-trifenilbutenos sustituidos y su uso en el tratamiento y diagnosis del cancer.

Info

Publication number
ES2107030T3
ES2107030T3 ES93911884T ES93911884T ES2107030T3 ES 2107030 T3 ES2107030 T3 ES 2107030T3 ES 93911884 T ES93911884 T ES 93911884T ES 93911884 T ES93911884 T ES 93911884T ES 2107030 T3 ES2107030 T3 ES 2107030T3
Authority
ES
Spain
Prior art keywords
compounds
represent
canceres
atom
trifenilbutenos
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93911884T
Other languages
English (en)
Inventor
Karen Jennifer Edwards
Michael Jarman
Charles Anthony Victo Laughton
Stephen Neidle
Ian Robert Reading Hardcastle
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929209509A external-priority patent/GB9209509D0/en
Priority claimed from GB939303982A external-priority patent/GB9303982D0/en
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of ES2107030T3 publication Critical patent/ES2107030T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
    • C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/18—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

COMPUESTOS DE FORMULA GENERAL (2) EN DONDE N ES UN ENTERO DE DESDE 3 A 10, EL YODO SUSTITUYENTE ESTA EN LA 3ION Y R1 Y R2, LOS CUALES PUEDEN SER EL MISMO O DIFERENTE, REPRESENTAN ALQUILO C1-3 ESPECIALMENTE METILO O ETILO, GRUPOS O R1 REPRESENTAN UN ATOMO DE HIDROGENO Y R2 UN GRUPO ALQUILO C1-3 O R1 Y R2 JUNTOS CON EL ATOMO DE NITROGENO AL CUAL ESTAN UNIDOS REPRESENTAN UN GRUPO HETEROCICLICO SATURADO, ESPECIALMENTE UN GRUPO PIRROLIDINO, EN LA FORMA DE SUS BASES LIBRES O SALES DE ADICION ACIDA FARMACEUTICAMENTE ACEPTABLES, SON POTENTES COMPUESTOS ANTI DEPENDIENTES DE ESTROGENO, ESPECIALMENTE CANCERES DE PECHO. COMPUESTOS DONDE EL ATOMO DE YODO ES RADIOISOTOPICO SE USAN EN REPRESENTACION DE IMAGENES POR RAYOS GAMMA O RADIOTERAPIA DE ESTOS CANCERES.
ES93911884T 1992-05-01 1993-04-29 1,1,2-trifenilbutenos sustituidos y su uso en el tratamiento y diagnosis del cancer. Expired - Lifetime ES2107030T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929209509A GB9209509D0 (en) 1992-05-01 1992-05-01 Substituted 1,1,2-triphenylbutenes
GB939303982A GB9303982D0 (en) 1993-02-26 1993-02-26 Substituted 1,1,2 triphenylbutenes

Publications (1)

Publication Number Publication Date
ES2107030T3 true ES2107030T3 (es) 1997-11-16

Family

ID=26300810

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93911884T Expired - Lifetime ES2107030T3 (es) 1992-05-01 1993-04-29 1,1,2-trifenilbutenos sustituidos y su uso en el tratamiento y diagnosis del cancer.

Country Status (9)

Country Link
US (1) US5589500A (es)
EP (1) EP0638064B1 (es)
JP (1) JP3153554B2 (es)
AT (1) ATE156803T1 (es)
AU (1) AU674146B2 (es)
CA (1) CA2134772A1 (es)
DE (1) DE69313106T2 (es)
ES (1) ES2107030T3 (es)
WO (1) WO1993022275A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2262798A (en) * 1991-12-24 1993-06-30 British Aerospace An aircraft cargo container
DE4311870C2 (de) * 1993-04-10 1998-07-30 Altramed Holdings Ltd Verwendung eines Anti-Östrigens zur Therapie und Prophylaxe von Demenz-Erkrankungen
US6084117A (en) * 1999-11-22 2000-07-04 Albemarle Corporation Production of silated haloarenes by selective silylation of polyhaloarenes
US6599921B2 (en) 2001-02-22 2003-07-29 Nanodesign, Inc. Non-steroidal estrogen receptor ligands
US7196119B2 (en) 2003-10-21 2007-03-27 The Regents Of The University Of California Development of new selective estrogen receptor modulators
EP3116488A4 (en) * 2014-03-11 2018-04-25 Repros Therapeutics Inc. Clomiphene synthesis using a single solvent

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2196003A (en) * 1986-09-11 1988-04-20 Nat Res Dev Iodo-and bromo-tamoxifen derivatives
DE69409502T2 (de) * 1993-10-25 1998-11-12 Taiho Pharmaceutical Co Ltd Verfahren zur herstellung von säure-additions-salzen des z-isomers von triphenylethylen-derivaten

Also Published As

Publication number Publication date
JP3153554B2 (ja) 2001-04-09
WO1993022275A1 (en) 1993-11-11
EP0638064A1 (en) 1995-02-15
EP0638064B1 (en) 1997-08-13
US5589500A (en) 1996-12-31
DE69313106D1 (de) 1997-09-18
DE69313106T2 (de) 1998-01-22
CA2134772A1 (en) 1993-11-11
AU4267393A (en) 1993-11-29
ATE156803T1 (de) 1997-08-15
JPH07506357A (ja) 1995-07-13
AU674146B2 (en) 1996-12-12

Similar Documents

Publication Publication Date Title
ATE222244T1 (de) Mono -und multimere verbindungen mit erhöhter relaxation
ES2188584T3 (es) Derivados heterociclicos de amina.
ES2266459T3 (es) Uso de compuestos de azetidinona sustituidos para el tratamiento de sitosterolemia.
YU231790A (sh) Spirocikli koji sadrže azot
WO1996014878A3 (en) Calixarene conjugates useful as MRI and CT diagnostic imaging agents
ES2128629T3 (es) Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.
ES2063036T3 (es) Compuestos (aralquil-sustituido) heterociclicos.
ES2091299T3 (es) Compuestos azaesteroides para el tratamiento de la hipertrofia prostatica, su preparacion y uso.
MX9304698A (es) Heterociclos que contienen nitrogeno substituido.
KR920003968A (ko) 염증성 장 질환의 치료방법
ES2148120T3 (es) Metodo para la preparacion de citalopram.
ES2118992T3 (es) Derivados ciclicos, medicamentos que contienen estos compuestos y procedimiento para su preparacion.
ES8305678A1 (es) "un procedimiento para prepara derivados de fenilciclobutano".
GB8817137D0 (en) Compositions
ATE216581T1 (de) Phthalocyaninderivate enthaltender photosensibilisator in der photodynamischen therapie von tumoren
EA199801000A1 (ru) Производные алкиламинобензотиазола и -бензоксазола
DK0406119T3 (da) Hidtil ukendte peptidderivater, fremgangsmåde til fremstilling heraf og farmaceutiske midler indeholdende dem
ES2084015T3 (es) Derivados de 2-aminopirimidina-4-carboxamida, su preparacion y su aplicacion en terapeutica.
ES2101073T3 (es) Nuevos aza-androstano-derivados 17-beta-substituidos.
IT1106280B (it) Procedimento per produrre poli-idrossicomposti di basso peso molecolare
MX9303961A (es) Fenilbenzamidas fungicidas y procedimientos para prepararlas.
ES2059626T3 (es) Nuevos esteres de estramustina.
ES2116612T3 (es) Nuevas bis-naftalimidas para el tratamiento del cancer.
ES2012524A6 (es) Procedimiento para la produccion de colorantes complejos de cromo 1:2.
ES2156293T3 (es) Metodo para producir vasodilatacion con derivados de (1,5-inter)arilprostaglandina.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 638064

Country of ref document: ES