ATE157348T1 - Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen - Google Patents

Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen

Info

Publication number: ATE157348T1
Authority: AT; Austria
Prior art keywords: carnitine; acyl; esters; gastrointestinal tract; selective
Prior art date: 1992-03-02

Application number

AT93830083T

Other languages

English (en)

Inventor

Nazareno Scafetta

Mose Santaniello

Maria Ornella Tinti

Domenico Misiti

Maria Antonietta Stasi

Loredana Vesci

Nerina Corsico

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-02

Filing date

1993-03-01

Publication date

1997-09-15

1993-03-01 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1997-09-15 Application granted granted Critical

1997-09-15 Publication of ATE157348T1 publication Critical patent/ATE157348T1/de

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
210000001035 gastrointestinal tract Anatomy 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
230000002040 relaxant effect Effects 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
-1 acyl L-carnitine Chemical compound 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000003044 adaptive effect Effects 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
206010009887 colitis Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
239000003158 myorelaxant agent Substances 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93830083T 1992-03-02 1993-03-01 Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen ATE157348T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM920138A IT1258370B (it)	1992-03-02	1992-03-02	Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number	Publication Date
ATE157348T1 true ATE157348T1 (de)	1997-09-15

Family

ID=11400749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93830083T ATE157348T1 (de)	1992-03-02	1993-03-01	Ester von l-carnitin und acyl-l-carnitin, mit entspannender wirkung, selektiv auf den gastrointestinaltrakt und sie enthaltende pharmazeutische zusammensetzungen

Country Status (7)

Country	Link
EP (1)	EP0559625B1 (de)
AT (1)	ATE157348T1 (de)
DE (1)	DE69313325T2 (de)
DK (1)	DK0559625T3 (de)
ES (1)	ES2106998T3 (de)
GR (1)	GR3025093T3 (de)
IT (1)	IT1258370B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5607691A (en) *	1992-06-12	1997-03-04	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
IT1261231B (it) *	1993-04-08	1996-05-09	Sigma Tau Ind Farmaceuti	Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261828B (it)	1993-07-14	1996-06-03	Sigma Tau Ind Farmaceuti	Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) *	1994-06-20	1998-04-21	Tanabe Seiyaku Co., Ltd.	Hair-growth agent
PT914315E (pt) *	1996-05-31	2001-07-31	Sigma Tau Ind Farmaceuti	Sais nao higroscopicos estaveis de l(-)carnitina e alcanoil l(-)carnitinas processo para a sua preparacao e composicoes solidas administraveis oralmente contendo tais sais
IT1284661B1 (it) *	1996-06-06	1998-05-21	Sigma Tau Ind Farmaceuti	Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.
IT1299172B1 (it) *	1998-05-06	2000-02-29	Sigma Tau Ind Farmaceuti	Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
IT1306129B1 (it) *	1999-04-13	2001-05-30	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
AU2007214359B2 (en) *	1999-04-13	2009-02-12	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
US11103588B2 (en) *	2017-06-06	2021-08-31	Wayne State University	Methods and compositions relating to carnitine-derived materials
JP7305088B2 (ja) *	2019-03-06	2023-07-10	源至技術有限公司	動物用飼料添加物の調製にγ－第四級アンモニウム酪酸エステル化合物の適用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1147079B (it) *	1980-05-30	1986-11-19	Sigma Tau Ind Farmacuetiche Ri	Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1209564B (it) *	1984-06-29	1989-08-30	Magis Farmaceutici	Derivati della l-carnitina o di l-acil carnitina.
IT1254136B (it) *	1992-01-16	1995-09-08	Sigma Tau Ind Farmaceuti	Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.

1992
- 1992-03-02 IT ITRM920138A patent/IT1258370B/it active IP Right Grant
1993
- 1993-03-01 DK DK93830083.7T patent/DK0559625T3/da active
- 1993-03-01 EP EP93830083A patent/EP0559625B1/de not_active Expired - Lifetime
- 1993-03-01 AT AT93830083T patent/ATE157348T1/de active
- 1993-03-01 DE DE69313325T patent/DE69313325T2/de not_active Expired - Lifetime
- 1993-03-01 ES ES93830083T patent/ES2106998T3/es not_active Expired - Lifetime
1997
- 1997-10-20 GR GR970402734T patent/GR3025093T3/el unknown

Also Published As

Publication number	Publication date
EP0559625A2 (de)	1993-09-08
HK1006368A1 (en)	1999-02-26
DE69313325T2 (de)	1998-01-29
DE69313325D1 (de)	1997-10-02
EP0559625A3 (en)	1993-12-01
ITRM920138A0 (it)	1992-03-02
IT1258370B (it)	1996-02-26
EP0559625B1 (de)	1997-08-27
DK0559625T3 (da)	1997-12-29
GR3025093T3 (en)	1998-01-30
ITRM920138A1 (it)	1993-09-02
ES2106998T3 (es)	1997-11-16

Legal Events

Date	Code	Title	Description
1998-02-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
NO159017C (no)	1988-11-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,2,3,4-tetrahydroisokinolin-3-karboksylsyre-derivater.
LU91519I2 (fr)	2009-03-23	"Doripenem et ses dérivés pharmaceutiquement acceptables - DORIBAXr"
ZA944739B (en)	1995-10-10	Amide and urea derivatives having anti-hypercholesteremic activity their preparation and their therapeutic uses
DE69313325D1 (de)	1997-10-02	Ester von L-Carnitin und Acyl-L-Carnitin, mit entspannender Wirkung, selektiv auf den Gastrointestinaltrakt und sie enthaltende pharmazeutische Zusammensetzungen
DK0552137T3 (da)	1996-11-18	Estere af acylcarnitiner med langkædede alifatiske alkoholer og farmaceutiske præparater indeholdende sådanne med antibakteriel aktivitet
TW206970B (de)	1993-06-01
IL111581A (en)	1999-07-14	Cyclic amino acid derivatives pharmaceutical compositions containing them and process for their preparation
HUT63615A (en)	1993-09-28	Process for producing new imidazole derivatives and pharmaceutical compositions comprising same as active ingredient
ITRM910327A1 (it)	1992-11-15	Uso di esteri di acil l-carnitine con l'acido gamma-idrossibutirrico per produrre composizioni farmaceutiche per il trattamento di epatopatie
EP0103320A3 (en)	1984-09-05	Acetylsalicylic acid thioesters, a process for their preparation and pharmaceutical compositions containing them
CS302790A3 (en)	1992-03-18	Functional derivatives of 4-(2,4-difluorobiphenylyl)-2-methyl -4- oxobutanoic acid
ES531480A0 (es)	1985-07-16	Derivados del acido d-2-(6-metoxi-2-naftil)-propionico
ATE92461T1 (de)	1993-08-15	Gegen die zerebrale insuffizienz wirksame verbindungen.
IT1248558B (it)	1995-01-19	Derivati della fisovenina utili per il trattamento delle malattie associate a disordini colinergici, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.