GR3025093T3 - Esters of L-carnitine and acyl L-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same - Google Patents

Esters of L-carnitine and acyl L-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same

Info

Publication number: GR3025093T3
Authority: GR; Greece
Prior art keywords: carnitine; acyl; endowed; esters; gastrointestinal tract
Prior art date: 1992-03-02

Application number

GR970402734T

Other languages

Greek (el)

English (en)

Inventor

Nazareno Scafetta

Mose Santaniello

Maria Ornella Tinti

Domenico Misiti

Maria Antonietta Stasi

Loredana Vesci

Nerina Corsico

Original Assignee

Sigma Tau Ind Farmaceuti

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-02

Filing date

1997-10-20

Publication date

1998-01-30

1997-10-20 Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti

1998-01-30 Publication of GR3025093T3 publication Critical patent/GR3025093T3/el

Links

PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title abstract 2
-1 acyl L-carnitine Chemical compound 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
210000001035 gastrointestinal tract Anatomy 0.000 title abstract 2
239000003158 myorelaxant agent Substances 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
125000004432 carbon atom Chemical group C* 0.000 abstract 2
229920006395 saturated elastomer Polymers 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 1
125000002252 acyl group Chemical group 0.000 abstract 1
230000003044 adaptive effect Effects 0.000 abstract 1
150000001450 anions Chemical class 0.000 abstract 1
206010009887 colitis Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
230000003389 potentiating effect Effects 0.000 abstract 1
208000011580 syndromic disease Diseases 0.000 abstract 1
125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

GR970402734T 1992-03-02 1997-10-20 Esters of L-carnitine and acyl L-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same GR3025093T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM920138A IT1258370B (it)	1992-03-02	1992-03-02	Esteri della l-carnitina e di acil l-carnitine dotati di attivita' miorilassante selettiva sull'apparato gastro-intestinale e composizioni farmaceutiche che li contengono.

Publications (1)

Publication Number	Publication Date
GR3025093T3 true GR3025093T3 (en)	1998-01-30

Family

ID=11400749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970402734T GR3025093T3 (en)	1992-03-02	1997-10-20	Esters of L-carnitine and acyl L-carnitine endowed with muscle relaxant activityselective on gastrointestinal tract and pharmaceutical compositions containing same

Country Status (7)

Country	Link
EP (1)	EP0559625B1 (de)
AT (1)	ATE157348T1 (de)
DE (1)	DE69313325T2 (de)
DK (1)	DK0559625T3 (de)
ES (1)	ES2106998T3 (de)
GR (1)	GR3025093T3 (de)
IT (1)	IT1258370B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5607691A (en) *	1992-06-12	1997-03-04	Affymax Technologies N.V.	Compositions and methods for enhanced drug delivery
IT1261231B (it) *	1993-04-08	1996-05-09	Sigma Tau Ind Farmaceuti	Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261828B (it)	1993-07-14	1996-06-03	Sigma Tau Ind Farmaceuti	Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
US5741816A (en) *	1994-06-20	1998-04-21	Tanabe Seiyaku Co., Ltd.	Hair-growth agent
AU718308B2 (en) *	1996-05-31	2000-04-13	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Stable, non-hygroscopic salts of L(-)carnitine and alkanoyl L(-)carnitines, a process for their preparation and solid, orally administrable compositions containing such salts
IT1284661B1 (it) *	1996-06-06	1998-05-21	Sigma Tau Ind Farmaceuti	Uso di alcanoil l-carnitine nel trattamento terapeutico di malattie infiammatorie croniche intestinali.
IT1299172B1 (it) *	1998-05-06	2000-02-29	Sigma Tau Ind Farmaceuti	Esteri perfluorurati di alcanoil l-carnitine utilizzabili quali lipidi cationici per l'immissione intracellulare di composti
IT1306129B1 (it) *	1999-04-13	2001-05-30	Sigma Tau Ind Farmaceuti	Esteri della l-carnitina o di alcanoil l-carnitine utilizzabili comelipidi cationici per l'immissione intracellulare di composti
AU2007214359B2 (en) *	1999-04-13	2009-02-12	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Esters of L-carnitine or alkanoyl L-carnitines useful as cationic lipids for the intracellular delivery of pharmacologically active compounds
US11591287B2 (en) *	2017-06-06	2023-02-28	Wayne State University	Antifouling zwitterionic polymer coating and reverse coating method
JP7305088B2 (ja) *	2019-03-06	2023-07-10	源至技術有限公司	動物用飼料添加物の調製にγ－第四級アンモニウム酪酸エステル化合物の適用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1116037B (it) *	1979-04-23	1986-02-10	Sigma Tau Ind Farmaceuti	Esteri e ammidi di acil carnitine loro procedimenti di preparazione e loro uso terapeutico
IT1147079B (it) *	1980-05-30	1986-11-19	Sigma Tau Ind Farmacuetiche Ri	Esteri di alcossi-acil derivati della carnitina procedimento per la loro preparatione e composizioni farmaceutiche che li contengono
IT1209564B (it) *	1984-06-29	1989-08-30	Magis Farmaceutici	Derivati della l-carnitina o di l-acil carnitina.
IT1254136B (it) *	1992-01-16	1995-09-08	Sigma Tau Ind Farmaceuti	Esteri di acil carnitine con alcooli alifatici a lunga catena e composizioni farmaceutiche che li contengono, ad attivita' antimicotica.

1992
- 1992-03-02 IT ITRM920138A patent/IT1258370B/it active IP Right Grant
1993
- 1993-03-01 DK DK93830083.7T patent/DK0559625T3/da active
- 1993-03-01 DE DE69313325T patent/DE69313325T2/de not_active Expired - Lifetime
- 1993-03-01 EP EP93830083A patent/EP0559625B1/de not_active Expired - Lifetime
- 1993-03-01 ES ES93830083T patent/ES2106998T3/es not_active Expired - Lifetime
- 1993-03-01 AT AT93830083T patent/ATE157348T1/de active
1997
- 1997-10-20 GR GR970402734T patent/GR3025093T3/el unknown

Also Published As

Publication number	Publication date
EP0559625B1 (de)	1997-08-27
DK0559625T3 (da)	1997-12-29
ES2106998T3 (es)	1997-11-16
ITRM920138A1 (it)	1993-09-02
EP0559625A2 (de)	1993-09-08
ATE157348T1 (de)	1997-09-15
HK1006368A1 (en)	1999-02-26
ITRM920138A0 (it)	1992-03-02
DE69313325D1 (de)	1997-10-02
EP0559625A3 (en)	1993-12-01
IT1258370B (it)	1996-02-26
DE69313325T2 (de)	1998-01-29

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