ATE157872T1 - Ketanserin enthaltende augentropfen zur behandlung von intraokularem druck - Google Patents

Ketanserin enthaltende augentropfen zur behandlung von intraokularem druck

Info

Publication number: ATE157872T1
Authority: AT; Austria
Prior art keywords: optionally; treatment; inhibitors; combinations; group
Prior art date: 1991-07-12

Application number

AT91830581T

Other languages

English (en)

Inventor

Ciro Costagliola

Original Assignee

Ciro Costagliola

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-07-12

Filing date

1991-12-20

Publication date

1997-09-15

1991-12-20 Application filed by Ciro Costagliola filed Critical Ciro Costagliola

1997-09-15 Application granted granted Critical

1997-09-15 Publication of ATE157872T1 publication Critical patent/ATE157872T1/de

Links

FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 title abstract 3
239000003889 eye drop Substances 0.000 title abstract 2
229940012356 eye drops Drugs 0.000 title 1
230000004410 intraocular pressure Effects 0.000 title 1
239000003112 inhibitor Substances 0.000 abstract 2
229960005417 ketanserin Drugs 0.000 abstract 2
239000000243 solution Substances 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 2
QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 abstract 1
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 abstract 1
UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
102000003846 Carbonic anhydrases Human genes 0.000 abstract 1
108090000209 Carbonic anhydrases Proteins 0.000 abstract 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
206010030043 Ocular hypertension Diseases 0.000 abstract 1
102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
QCHFTSOMWOSFHM-UHFFFAOYSA-N SJ000285536 Natural products C1OC(=O)C(CC)C1CC1=CN=CN1C QCHFTSOMWOSFHM-UHFFFAOYSA-N 0.000 abstract 1
229920002125 Sokalan® Polymers 0.000 abstract 1
239000002160 alpha blocker Substances 0.000 abstract 1
229940124308 alpha-adrenoreceptor antagonist Drugs 0.000 abstract 1
229940089206 anhydrous dextrose Drugs 0.000 abstract 1
229960000686 benzalkonium chloride Drugs 0.000 abstract 1
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
239000002876 beta blocker Substances 0.000 abstract 1
229940097320 beta blocking agent Drugs 0.000 abstract 1
239000007853 buffer solution Substances 0.000 abstract 1
239000003283 colorimetric indicator Substances 0.000 abstract 1
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 abstract 1
229910000397 disodium phosphate Inorganic materials 0.000 abstract 1
235000019800 disodium phosphate Nutrition 0.000 abstract 1
239000012530 fluid Substances 0.000 abstract 1
229940031574 hydroxymethyl cellulose Drugs 0.000 abstract 1
229920003063 hydroxymethyl cellulose Polymers 0.000 abstract 1
229910000402 monopotassium phosphate Inorganic materials 0.000 abstract 1
235000019796 monopotassium phosphate Nutrition 0.000 abstract 1
230000003204 osmotic effect Effects 0.000 abstract 1
229960001416 pilocarpine Drugs 0.000 abstract 1
239000004584 polyacrylic acid Substances 0.000 abstract 1
GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 abstract 1
LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 1
239000003755 preservative agent Substances 0.000 abstract 1
230000002335 preservative effect Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000001488 sodium phosphate Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Ophthalmology & Optometry (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Devices For Medical Bathing And Washing (AREA)

AT91830581T 1991-07-12 1991-12-20 Ketanserin enthaltende augentropfen zur behandlung von intraokularem druck ATE157872T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
ITRM910519A IT1249678B (it)	1991-07-12	1991-07-12	Collirio per il trattamento della ipertensione oculare

Publications (1)

Publication Number	Publication Date
ATE157872T1 true ATE157872T1 (de)	1997-09-15

Family

ID=11400263

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91830581T ATE157872T1 (de)	1991-07-12	1991-12-20	Ketanserin enthaltende augentropfen zur behandlung von intraokularem druck

Country Status (5)

Country	Link
EP (1)	EP0522226B1 (de)
JP (1)	JPH0525047A (de)
AT (1)	ATE157872T1 (de)
DE (1)	DE69127619D1 (de)
IT (1)	IT1249678B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE69710258T2 (de) *	1996-06-17	2002-08-22	Mitsubishi Chemical Corp., Tokio/Tokyo	Mittel zur Beschleunigung des Tränenflusses enthaltend einen Serotonin-Liganden, insbesondere Aminoalkoxybibenzyle
US6960579B1 (en)	1998-05-19	2005-11-01	Alcon Manufacturing, Ltd.	Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
DE69928542T2 (de)	1998-09-18	2006-03-30	Alcon Manufacturing Ltd., Fort Worth	5HT2-Agonisten zur Behandlung des Glaukoms
US7005448B2 (en)	2001-12-14	2006-02-28	Alcon, Inc.	Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
AU2003243101B2 (en)	2002-07-19	2010-05-13	Biovitrum Ab (Publ)	Novel piperazinyl-pyrazinone derivatives for the treatment of 5-HT2A receptor-related disorders
US9421175B2 (en)	2004-03-17	2016-08-23	Lars Michael Larsen	Prevention of retinopathy by inhibition of the visual cycle
IT201600072000A1 (it) *	2016-07-11	2018-01-11	Luigi Ambrosone	Collirio a base di liposomi e suo uso per la valutazione in vivo dell'efficacia farmacologica della terapia medica e chirurgica anti-glaucoma
SE2250051A1 (en) *	2022-01-20	2023-07-21	Amidea Sweden Ab	New pharmaceutical composition and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3751974T2 (de) *	1986-09-22	1997-04-10	Janssen Pharmaceutica Nv	Serotonin-Antagonisten zur Behandlung von Wunden
WO1991002527A1 (en) *	1989-08-21	1991-03-07	Beth Israel Hospital Association	Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists

1991
- 1991-07-12 IT ITRM910519A patent/IT1249678B/it active IP Right Grant
- 1991-12-20 DE DE69127619T patent/DE69127619D1/de not_active Expired - Lifetime
- 1991-12-20 AT AT91830581T patent/ATE157872T1/de not_active IP Right Cessation
- 1991-12-20 EP EP91830581A patent/EP0522226B1/de not_active Expired - Lifetime
- 1991-12-27 JP JP3361478A patent/JPH0525047A/ja active Pending

Also Published As

Publication number	Publication date
DE69127619D1 (de)	1997-10-16
ITRM910519A0 (it)	1991-07-12
EP0522226A1 (de)	1993-01-13
ITRM910519A1 (it)	1993-01-12
JPH0525047A (ja)	1993-02-02
IT1249678B (it)	1995-03-09
EP0522226B1 (de)	1997-09-10

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Legal Events

Date	Code	Title	Description
1998-03-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties