IT1249678B - Collirio per il trattamento della ipertensione oculare - Google Patents
Collirio per il trattamento della ipertensione oculareInfo
- Publication number
- IT1249678B IT1249678B ITRM910519A ITRM910519A IT1249678B IT 1249678 B IT1249678 B IT 1249678B IT RM910519 A ITRM910519 A IT RM910519A IT RM910519 A ITRM910519 A IT RM910519A IT 1249678 B IT1249678 B IT 1249678B
- Authority
- IT
- Italy
- Prior art keywords
- possibly
- ketanserine
- blockers
- combinations
- group
- Prior art date
Links
- 206010020772 Hypertension Diseases 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- UUUHXMGGBIUAPW-UHFFFAOYSA-N 1-[1-[2-[[5-amino-2-[[1-[5-(diaminomethylideneamino)-2-[[1-[3-(1h-indol-3-yl)-2-[(5-oxopyrrolidine-2-carbonyl)amino]propanoyl]pyrrolidine-2-carbonyl]amino]pentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbon Chemical compound C1CCC(C(=O)N2C(CCC2)C(O)=O)N1C(=O)C(C(C)CC)NC(=O)C(CCC(N)=O)NC(=O)C1CCCN1C(=O)C(CCCN=C(N)N)NC(=O)C1CCCN1C(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C1CCC(=O)N1 UUUHXMGGBIUAPW-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 206010030043 Ocular hypertension Diseases 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- 102000004270 Peptidyl-Dipeptidase A Human genes 0.000 abstract 1
- 108090000882 Peptidyl-Dipeptidase A Proteins 0.000 abstract 1
- YYHGQOLZRYICRS-UHFFFAOYSA-N Polycarpin Natural products C1=2C=C(OC)C(OC)=CC=2CCN(C=O)C1=CC1=CC=C(OC)C(OC)=C1O YYHGQOLZRYICRS-UHFFFAOYSA-N 0.000 abstract 1
- YYHGQOLZRYICRS-SXGWCWSVSA-N Polycarpine Polymers C1=2C=C(OC)C(OC)=CC=2CCN(C=O)\C1=C/C1=CC=C(OC)C(OC)=C1O YYHGQOLZRYICRS-SXGWCWSVSA-N 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 229940089206 anhydrous dextrose Drugs 0.000 abstract 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 abstract 1
- 229960000686 benzalkonium chloride Drugs 0.000 abstract 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 abstract 1
- 239000007853 buffer solution Substances 0.000 abstract 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 abstract 1
- 230000000295 complement effect Effects 0.000 abstract 1
- 239000003889 eye drop Substances 0.000 abstract 1
- 229940012356 eye drops Drugs 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229940031574 hydroxymethyl cellulose Drugs 0.000 abstract 1
- 229920003063 hydroxymethyl cellulose Polymers 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000644 isotonic solution Substances 0.000 abstract 1
- FPCCSQOGAWCVBH-UHFFFAOYSA-N ketanserin Chemical compound C1=CC(F)=CC=C1C(=O)C1CCN(CCN2C(C3=CC=CC=C3NC2=O)=O)CC1 FPCCSQOGAWCVBH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 abstract 1
- 235000019796 monopotassium phosphate Nutrition 0.000 abstract 1
- 230000003204 osmotic effect Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 239000004584 polyacrylic acid Substances 0.000 abstract 1
- GBYNZTPAERUJGY-UHFFFAOYSA-N polycarpine dihydrochloride Natural products C1=CC(OC)=CC=C1C1=C(SSC=2N(C(N)=NC=2C=2C=CC(OC)=CC=2)C)N(C)C(N)=N1 GBYNZTPAERUJGY-UHFFFAOYSA-N 0.000 abstract 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 abstract 1
- LWIHDJKSTIGBAC-UHFFFAOYSA-K potassium phosphate Substances [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000000087 stabilizing effect Effects 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Devices For Medical Bathing And Washing (AREA)
Abstract
Collirio per il trattamento dell'ipertensione oculare, caratterizzato dal fatto di comprendere essenzialmente la combinazione dei seguenti componenti espressi in percentuale in peso:- da 0,01 a 2, 0% di un sale idrosolubile di ketanserina, ad esempio ketanserina-tartrato;- da 0,01 a 10%, eventualmente, di una sostanza stabilizzante del film lacrimale, scelta preferibilmente dal gruppo comprendente idrossimetilcellulosa, acido poliacrilico, propilenglicole, destrosio anidro e loro combinazioni;- da 0,001 a 0,01%, eventualmente, di un conservante, ad esempio cloruro di benzalconio;- eventualmente, un sistema tampone per mantenere il pH nell'intervallo 4,5 - 6,0, ad esempio 0,1 - 1,0% di fosfato monopotassico e 0,1 - 1,5% di fosfato bisodico;- eventualmente, un indicatore colorimetrico, biocompatibile e farmaceuticamente accettabile, per evidenziare scostamenti del pH dall'intervallo 4,5 - 6,0;- eventualmente, una soluzione isotonica con la pressione osmotica del liquido lacrimale;- eventualmente, almeno una sostanza scelta dal gruppo comprendente ?- bloccanti, policarpina, ?-bloccanti, inibitori dell'anidrasi carbonica, inibitori "dell'angiotensin converting enzyme" e loro combinazioni, essendo acqua il complemento a 100% della composizione.
Priority Applications (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910519A IT1249678B (it) | 1991-07-12 | 1991-07-12 | Collirio per il trattamento della ipertensione oculare |
| DE69127619T DE69127619D1 (de) | 1991-07-12 | 1991-12-20 | Ketanserin enthaltende Augentropfen zur Behandlung von intraokularem Druck |
| EP91830581A EP0522226B1 (en) | 1991-07-12 | 1991-12-20 | Eyedrop solution for the treatment of ocular hypertension containing ketauserin |
| AT91830581T ATE157872T1 (de) | 1991-07-12 | 1991-12-20 | Ketanserin enthaltende augentropfen zur behandlung von intraokularem druck |
| JP3361478A JPH0525047A (ja) | 1991-07-12 | 1991-12-27 | 高眼圧の治療用の点眼溶液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM910519A IT1249678B (it) | 1991-07-12 | 1991-07-12 | Collirio per il trattamento della ipertensione oculare |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM910519A0 ITRM910519A0 (it) | 1991-07-12 |
| ITRM910519A1 ITRM910519A1 (it) | 1993-01-12 |
| IT1249678B true IT1249678B (it) | 1995-03-09 |
Family
ID=11400263
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM910519A IT1249678B (it) | 1991-07-12 | 1991-07-12 | Collirio per il trattamento della ipertensione oculare |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP0522226B1 (it) |
| JP (1) | JPH0525047A (it) |
| AT (1) | ATE157872T1 (it) |
| DE (1) | DE69127619D1 (it) |
| IT (1) | IT1249678B (it) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69710258T2 (de) * | 1996-06-17 | 2002-08-22 | Mitsubishi Chemical Corp., Tokio/Tokyo | Mittel zur Beschleunigung des Tränenflusses enthaltend einen Serotonin-Liganden, insbesondere Aminoalkoxybibenzyle |
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| DK1112106T3 (da) | 1998-09-18 | 2005-12-12 | Alcon Mfg Ltd | Serotonerge 5HT2-agonister til behandling af glaukom |
| US7005448B2 (en) | 2001-12-14 | 2006-02-28 | Alcon, Inc. | Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma |
| MXPA05000784A (es) | 2002-07-19 | 2005-06-17 | Biovitrum Ab | Derivados de piperazinil-pirazinona novedosos para el tratamiento de los trastornos relacionados con el receptor 5-ht2a. |
| US9421175B2 (en) | 2004-03-17 | 2016-08-23 | Lars Michael Larsen | Prevention of retinopathy by inhibition of the visual cycle |
| IT201600072000A1 (it) * | 2016-07-11 | 2018-01-11 | Luigi Ambrosone | Collirio a base di liposomi e suo uso per la valutazione in vivo dell'efficacia farmacologica della terapia medica e chirurgica anti-glaucoma |
| SE2250051A1 (en) * | 2022-01-20 | 2023-07-21 | Amidea Sweden Ab | New pharmaceutical composition and uses thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2094718T3 (es) * | 1986-09-22 | 1997-02-01 | Janssen Pharmaceutica Nv | Antagonistas de la serotonine para el tratamiento de heridas. |
| WO1991002527A1 (en) * | 1989-08-21 | 1991-03-07 | Beth Israel Hospital Association | Method and composition for the treatment of cutaneous, ocular, and mucosal hypersensitivity, inflammation, and hyperproliferative conditions using topical preparations of serotonin antagonists |
-
1991
- 1991-07-12 IT ITRM910519A patent/IT1249678B/it active IP Right Grant
- 1991-12-20 EP EP91830581A patent/EP0522226B1/en not_active Expired - Lifetime
- 1991-12-20 AT AT91830581T patent/ATE157872T1/de not_active IP Right Cessation
- 1991-12-20 DE DE69127619T patent/DE69127619D1/de not_active Expired - Lifetime
- 1991-12-27 JP JP3361478A patent/JPH0525047A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| DE69127619D1 (de) | 1997-10-16 |
| EP0522226B1 (en) | 1997-09-10 |
| EP0522226A1 (en) | 1993-01-13 |
| ITRM910519A1 (it) | 1993-01-12 |
| ITRM910519A0 (it) | 1991-07-12 |
| JPH0525047A (ja) | 1993-02-02 |
| ATE157872T1 (de) | 1997-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted | ||
| TA | Fee payment date (situation as of event date), data collected since 19931001 |
Effective date: 19971031 |