ATE157988T1 - Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämme - Google Patents
Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämmeInfo
- Publication number
- ATE157988T1 ATE157988T1 AT92912434T AT92912434T ATE157988T1 AT E157988 T1 ATE157988 T1 AT E157988T1 AT 92912434 T AT92912434 T AT 92912434T AT 92912434 T AT92912434 T AT 92912434T AT E157988 T1 ATE157988 T1 AT E157988T1
- Authority
- AT
- Austria
- Prior art keywords
- sna
- prolyl endopeptidase
- preparation
- strains used
- endopeptidase inhibitors
- Prior art date
Links
- 239000003649 prolyl endopeptidase inhibitor Substances 0.000 title abstract 3
- 208000030507 AIDS Diseases 0.000 abstract 2
- 241000894006 Bacteria Species 0.000 abstract 2
- 229940122210 Prolyl endopeptidase inhibitor Drugs 0.000 abstract 2
- ORZXYSPOAVJYRU-UHFFFAOYSA-N benzyl 2-(2-formylpyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate Chemical compound O=CC1CCCN1C(=O)C1N(C(=O)OCC=2C=CC=CC=2)CCC1 ORZXYSPOAVJYRU-UHFFFAOYSA-N 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 208000000044 Amnesia Diseases 0.000 abstract 1
- 208000031091 Amnestic disease Diseases 0.000 abstract 1
- 208000031886 HIV Infections Diseases 0.000 abstract 1
- 241000906785 Microbispora sp. Species 0.000 abstract 1
- 102000056251 Prolyl Oligopeptidases Human genes 0.000 abstract 1
- 101710178372 Prolyl endopeptidase Proteins 0.000 abstract 1
- 102000004142 Trypsin Human genes 0.000 abstract 1
- 108090000631 Trypsin Proteins 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000006986 amnesia Effects 0.000 abstract 1
- 238000012258 culturing Methods 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012588 trypsin Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17622891 | 1991-06-20 | ||
| JP04078262A JP3092877B2 (ja) | 1991-06-20 | 1992-02-28 | 新規ペプチドｓｎａ−１１５及びｓｎａ−１１５ｔ、その製造法及び新規ペプチド産生菌株 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE157988T1 true ATE157988T1 (de) | 1997-09-15 |
Family
ID=26419344
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT92912434T ATE157988T1 (de) | 1991-06-20 | 1992-06-19 | Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämme |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5449750A (de) |
| EP (1) | EP0553357B1 (de) |
| AT (1) | ATE157988T1 (de) |
| CA (1) | CA2089890A1 (de) |
| DE (1) | DE69222142T2 (de) |
| WO (1) | WO1993000361A1 (de) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5888992A (en) | 1992-03-11 | 1999-03-30 | Narhex Limited | Polar substituted hydrocarbons |
| US6071895A (en) | 1992-03-11 | 2000-06-06 | Narhex Limited | Polar-substituted hydrocarbons |
| JPH07504654A (ja) | 1992-03-11 | 1995-05-25 | ナルヘックス リミテッド | オキソ及びヒドロキシ置換炭化水素のアミン誘導体 |
| US5451660A (en) * | 1993-12-13 | 1995-09-19 | Genentech, Inc. | Method for purifying polypeptides |
| WO2004098591A2 (en) | 2003-05-05 | 2004-11-18 | Probiodrug Ag | Inhibitors of glutaminyl cyclase and their use in the treatment of neurological diseases |
| AU2004290499C1 (en) | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| CA2554809C (en) | 2004-02-05 | 2014-04-29 | Probiodrug Ag | Novel n-alkyl thiourea- and thioamide-substituted imidazolyl inhibitors of glutaminyl cyclase |
| US8278345B2 (en) | 2006-11-09 | 2012-10-02 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| ATE554085T1 (de) | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| JP5930573B2 (ja) | 2007-03-01 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤の新規使用 |
| EP2142514B1 (de) | 2007-04-18 | 2014-12-24 | Probiodrug AG | Thioharnstoffderivate als glutaminylcyclaseinhibitoren |
| US8524654B2 (en) | 2007-05-21 | 2013-09-03 | The Uab Research Foundation | Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation |
| JP5934645B2 (ja) | 2009-09-11 | 2016-06-15 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体 |
| JP6026284B2 (ja) | 2010-03-03 | 2016-11-16 | プロビオドルグ エージー | グルタミニルシクラーゼの阻害剤 |
| NZ602312A (en) | 2010-03-10 | 2014-02-28 | Probiodrug Ag | Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5) |
| WO2011131748A2 (en) | 2010-04-21 | 2011-10-27 | Probiodrug Ag | Novel inhibitors |
| EP2686313B1 (de) | 2011-03-16 | 2016-02-03 | Probiodrug AG | Benzimidazolderivate als glutaminylcyclase-hemmer |
| ES2812698T3 (es) | 2017-09-29 | 2021-03-18 | Probiodrug Ag | Inhibidores de glutaminil ciclasa |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1335079C (en) * | 1988-07-25 | 1995-04-04 | Kiyoshi Takatsuki | Preventive and curative agents for acquired immune deficiency syndrome (aids) |
| US4999349A (en) * | 1990-03-22 | 1991-03-12 | Bristol-Myers Squibb Co. | BU-4164E - A and B, prolyl endopeptidase inhibitors |
-
1992
- 1992-06-19 US US07/977,444 patent/US5449750A/en not_active Expired - Fee Related
- 1992-06-19 WO PCT/JP1992/000784 patent/WO1993000361A1/ja not_active Ceased
- 1992-06-19 DE DE69222142T patent/DE69222142T2/de not_active Expired - Fee Related
- 1992-06-19 CA CA002089890A patent/CA2089890A1/en not_active Abandoned
- 1992-06-19 AT AT92912434T patent/ATE157988T1/de not_active IP Right Cessation
- 1992-06-19 EP EP92912434A patent/EP0553357B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE69222142T2 (de) | 1998-04-09 |
| EP0553357B1 (de) | 1997-09-10 |
| EP0553357A4 (en) | 1994-09-21 |
| EP0553357A1 (de) | 1993-08-04 |
| DE69222142D1 (de) | 1997-10-16 |
| CA2089890A1 (en) | 1992-12-21 |
| US5449750A (en) | 1995-09-12 |
| WO1993000361A1 (en) | 1993-01-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE157988T1 (de) | Neuartige prolyl-endopeptidase-inhibitoren sna- 115 und sna-115t, ihre herstellung, und hierbei verwendete stämme | |
| MD1507G2 (ro) | Inhibitori, compoziţie farmaceutică pe baza lor şi procedeu de inhibare a HIV proteazei | |
| DK1142887T3 (da) | 5,6-Dihydropyronderivater som proteaseinhibitorer og antivirale midler | |
| ATE392895T1 (de) | Verwendung von ritonavir (abt-538) zur verbesserung der pharmakokinetik von arzneimitteln, die durch cytochrom p450 metabolisiert werden, im rahmen einer behandlung von aids | |
| AU9125191A (en) | Retroviral protease inhibitors | |
| ATE213733T1 (de) | Zwischenprodukte zur herstellung retroviraler proteasehemmenden verbindungen | |
| CA2081970A1 (en) | Hiv protease inhibitors useful for the treatment of aids | |
| MX9403380A (es) | Inhibidores de proteasa de vih utiles para el tratamiento de sida. | |
| DE69019533D1 (de) | Behandlung von hiv-infizierungen und nützliche verbindungen dafür. | |
| ES2101252T3 (es) | Inhibidores de la proteasa del hiv utiles para el tratamiento del sida. | |
| NO962018D0 (no) | 5,6-Dihydropyron-derivater som protease-inhibitorer og antivirus-midler | |
| MY113863A (en) | Method for preparing n, n' - disubstituted cyclic ureas | |
| DE68923169D1 (de) | Verwendung von fluor enthaltenden Pyridoncarbonsäure-Derivaten zur Herstellung eines Arzneimittels zur Behandlung von HIV infektionen. | |
| ATE179164T1 (de) | Hiv-proteaseinhibitoren | |
| NO975679L (no) | Fremgangsmåte for fremstilling av N-monosubstituerte og N,N'-disubstituerte, usymmetriske, cykliske ureaer | |
| ATE83480T1 (de) | Cyclisches peptid, seine herstellung und seine verwendung zur behandlung von cardiovasculaeren stoerungen. | |
| UA41338C2 (uk) | Спосіб інгібування ретровірусної інфекції, яка викликана вірусом імунодефіциту людини (віл), спосіб інгібування вірусу імунодефіциту людини (віл) | |
| DE68919301D1 (de) | Verwendung eines Prolylendopeptidase-Inhibitors zur Behandlung von AIDS. | |
| EP0316907A3 (en) | Enzyme inhibitor and method of producing the same |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |