ATE159014T1 - Alkylamino-ethynyl-alanine-aminodiolverbindunge mit morpholino/thiomorpholinoendgruppen als renin inhibitoren - Google Patents

Alkylamino-ethynyl-alanine-aminodiolverbindunge mit morpholino/thiomorpholinoendgruppen als renin inhibitoren

Info

Publication number: ATE159014T1
Authority: AT; Austria
Prior art keywords: renin inhibitors; alkylamino; ethynyl; thiomorpholino; morpholino
Prior art date: 1992-08-14

Application number

AT94908055T

Other languages

English (en)

Inventor

Gunnar J Hanson

Robert E Manning

Original Assignee

Searle & Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-14

Filing date

1993-08-13

Publication date

1997-10-15

1993-08-13 Application filed by Searle & Co filed Critical Searle & Co

1997-10-15 Application granted granted Critical

1997-10-15 Publication of ATE159014T1 publication Critical patent/ATE159014T1/de

Links

-1 MORPHOLINO/THIOMORPHOLINO END GROUPS Chemical group 0.000 title abstract 3
239000002461 renin inhibitor Substances 0.000 title abstract 2
229940086526 renin-inhibitors Drugs 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001145 hydrido group Chemical group *[H] 0.000 abstract 2
206010020772 Hypertension Diseases 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
- C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94908055T 1992-08-14 1993-08-13 Alkylamino-ethynyl-alanine-aminodiolverbindunge mit morpholino/thiomorpholinoendgruppen als renin inhibitoren ATE159014T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/930,069 US5422349A (en)	1992-08-14	1992-08-14	Morpholino-oxazinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension

Publications (1)

Publication Number	Publication Date
ATE159014T1 true ATE159014T1 (de)	1997-10-15

Family

ID=25458882

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94908055T ATE159014T1 (de)	1992-08-14	1993-08-13	Alkylamino-ethynyl-alanine-aminodiolverbindunge mit morpholino/thiomorpholinoendgruppen als renin inhibitoren

Country Status (11)

Country	Link
US (15)	US5422349A (de)
EP (1)	EP0655062B1 (de)
JP (1)	JPH08500119A (de)
AT (1)	ATE159014T1 (de)
AU (1)	AU687753B2 (de)
CA (1)	CA2136842A1 (de)
DE (1)	DE69314497T2 (de)
DK (1)	DK0655062T3 (de)
ES (1)	ES2107192T3 (de)
GR (1)	GR3025521T3 (de)
WO (1)	WO1994004518A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES8800986A1 (es) *	1985-07-27	1987-12-01	Pfizer	Un procedimiento para la produccion de un nuevo derivado de avermectina
US5508466A (en) *	1994-04-13	1996-04-16	G.D. Searle & Co.	Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent
EP0702004A2 (de) *	1994-09-15	1996-03-20	Ciba-Geigy Ag	2,9-Diamino- und 2-amino-8-carbamoyl-4-hydroxy-alkansäureamid-derivative
US5725460A (en) *	1996-07-15	1998-03-10	Marsh; John P.	Adjustable weight lifter's bench
US5912006A (en) *	1996-08-28	1999-06-15	Eboc, Inc.	Compositions and methods for alleviating discomforting menstrual pain
FR2774752B1 (fr) *	1998-02-06	2000-06-16	Air Liquide	Installation de distillation d'air et boite froide correspondante
US7332550B2 (en) *	2000-10-06	2008-02-19	Carnegie Mellon University	Stabilization of transition metal complexes for catalysis in diverse environments
BR0214297A (pt) *	2001-11-19	2004-11-09	Upjohn Co	Métodos de tratar ou prevenir mal de alzheimer em um indivìduo e uma doença distinguida por depósitos de beta-amilóide sobre ou no cérebro, de tratar mal de alzheimer um indivìduo que apresenta, ou de prevenir que um indivìduo adquira, uma doença ou condição, de inibir atividade de beta-secretase, clivagem de um isótipo de protéina precursora amilóide e produção de peptìdeo beta amilóide e de placa beta-amilóide em um animal e de produzir um complexo de beta-secretase e uso de um composto, e, composição
US6875438B2 (en) *	2002-04-27	2005-04-05	Aventis Pharma Deutschland Gmbh	Preparations for topical administration of substances having antiandrogenic activity
US8475832B2 (en) *	2009-08-07	2013-07-02	Rb Pharmaceuticals Limited	Sublingual and buccal film compositions
MX2021013299A (es) *	2019-04-30	2022-01-31	Sitryx Therapeutics Ltd	Derivados de acido itaconico y usos de estos en el tratamiento de una enfermedad inflamatoria asociada con una respuesta inmunitaria indeseable.

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59227851A (ja) *	1983-06-09	1984-12-21	Sankyo Co Ltd	レニン阻害作用を有するペプチド類
EP0181110A3 (de) *	1984-10-22	1988-05-11	Kissei Pharmaceutical Co. Ltd.	Histidinderivate als Renininhibitoren
SU1676454A3 (ru) *	1984-11-30	1991-09-07	Санкио Компани Лимитед (Фирма)	Способ получени пептидов или их фармацевтически приемлемых солей
DK34086A (da) *	1985-01-23	1986-07-24	Abbott Lab	Peptidylaminodioler
JPS61236770A (ja) *	1985-04-15	1986-10-22	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体
JPS6256458A (ja) *	1985-09-04	1987-03-12	Kissei Pharmaceut Co Ltd	新規なアミノ酸誘導体
EP0258289A4 (en) *	1986-01-16	1991-01-02	Joseph Dellaria	Peptide analogs
IL81234A (en) *	1986-01-16	1992-09-06	Abbott Lab	Peptidylaminodiols,process for their preparation and pharmaceutical compositions comprising them
US5032577A (en) *	1986-12-31	1991-07-16	Abbott Laboratories	Peptidylaminodiols
US4921855A (en) *	1987-06-22	1990-05-01	Fujisawa Pharmaceutical Co., Ltd.	New Histidyl amino acid derivatives, and pharmaceutical composition comprising the same
IL87614A0 (en) *	1987-09-16	1989-01-31	Abbott Lab	Peptidylheterocycles
DK523288A (da) *	1987-10-06	1989-04-07	Hoffmann La Roche	Aminosyrederivater
US4902706A (en) *	1988-07-01	1990-02-20	G. D. Searle & Co.	Aminoalkylaminocarbonyl aminodiol amino acid derivatives as antihypertensive agents
IE902446A1 (en) *	1989-07-26	1991-02-13	Abbott Lab	Peptidyl aminodiol renin inhibitors
IL95380A0 (en) *	1989-09-05	1991-06-30	Abbott Lab	Peptidyl difluorodiol renin inhibitors
EP0427939A3 (en) *	1989-10-11	1991-11-06	American Cyanamid Company	Renin inhibitors
DE3937640A1 (de) *	1989-11-11	1991-05-16	Huels Chemische Werke Ag	Zirkondioxidpulver, verfahren zu seiner herstellung, seine verwendung und aus ihm hergestellte sinterkoerper
US4978421A (en) *	1989-11-13	1990-12-18	International Business Machines Corporation	Monolithic silicon membrane device fabrication process
TW209870B (de) *	1990-01-18	1993-07-21	Pfizer
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
US5258362A (en) *	1991-06-11	1993-11-02	Abbott Laboratories	Renin inhibiting compounds
US5212185A (en) *	1992-08-14	1993-05-18	G. D. Searle & Co.	Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension

1992
- 1992-08-14 US US07/930,069 patent/US5422349A/en not_active Expired - Fee Related
1993
- 1993-08-13 DK DK94908055.0T patent/DK0655062T3/da active
- 1993-08-13 CA CA002136842A patent/CA2136842A1/en not_active Abandoned
- 1993-08-13 WO PCT/US1993/007512 patent/WO1994004518A1/en not_active Ceased
- 1993-08-13 AU AU50038/93A patent/AU687753B2/en not_active Ceased
- 1993-08-13 DE DE69314497T patent/DE69314497T2/de not_active Expired - Fee Related
- 1993-08-13 AT AT94908055T patent/ATE159014T1/de not_active IP Right Cessation
- 1993-08-13 JP JP6506362A patent/JPH08500119A/ja active Pending
- 1993-08-13 EP EP94908055A patent/EP0655062B1/de not_active Expired - Lifetime
- 1993-08-13 ES ES94908055T patent/ES2107192T3/es not_active Expired - Lifetime
- 1993-12-16 US US08/168,561 patent/US5411953A/en not_active Expired - Fee Related
- 1993-12-16 US US08/168,747 patent/US5409922A/en not_active Expired - Fee Related
- 1993-12-16 US US08/168,750 patent/US5411959A/en not_active Expired - Fee Related
1994
- 1994-01-25 US US08/186,355 patent/US5409921A/en not_active Expired - Fee Related
- 1994-01-25 US US08/186,728 patent/US5409925A/en not_active Expired - Fee Related
- 1994-01-25 US US08/186,211 patent/US5411975A/en not_active Expired - Fee Related
- 1994-01-25 US US08/186,748 patent/US5409913A/en not_active Expired - Fee Related
- 1994-01-25 US US08/186,353 patent/US5411961A/en not_active Expired - Fee Related
- 1994-02-22 US US08/199,410 patent/US5411954A/en not_active Expired - Fee Related
- 1994-02-22 US US08/198,419 patent/US5409924A/en not_active Expired - Fee Related
- 1994-02-22 US US08/198,414 patent/US5413998A/en not_active Expired - Fee Related
- 1994-02-22 US US08/198,424 patent/US5411950A/en not_active Expired - Fee Related
- 1994-02-22 US US08/198,425 patent/US5409945A/en not_active Expired - Fee Related
- 1994-02-22 US US08/198,412 patent/US5416084A/en not_active Expired - Fee Related
1997
- 1997-11-26 GR GR970403170T patent/GR3025521T3/el unknown

Also Published As

Publication number	Publication date
US5413998A (en)	1995-05-09
US5409921A (en)	1995-04-25
EP0655062A1 (de)	1995-05-31
CA2136842A1 (en)	1994-03-03
US5409924A (en)	1995-04-25
US5409925A (en)	1995-04-25
ES2107192T3 (es)	1997-11-16
US5422349A (en)	1995-06-06
US5411950A (en)	1995-05-02
US5411975A (en)	1995-05-02
US5409922A (en)	1995-04-25
GR3025521T3 (en)	1998-02-27
US5416084A (en)	1995-05-16
EP0655062B1 (de)	1997-10-08
AU5003893A (en)	1994-03-15
WO1994004518A1 (en)	1994-03-03
AU687753B2 (en)	1998-03-05
US5411953A (en)	1995-05-02
DK0655062T3 (da)	1998-05-18
DE69314497T2 (de)	1998-03-05
US5411954A (en)	1995-05-02
US5411961A (en)	1995-05-02
US5409913A (en)	1995-04-25
US5411959A (en)	1995-05-02
JPH08500119A (ja)	1996-01-09
US5409945A (en)	1995-04-25
DE69314497D1 (de)	1997-11-13

Legal Events

Date	Code	Title	Description
1998-03-15	UEP	Publication of translation of european patent specification
2006-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE159014T1 (de)	1997-10-15	Alkylamino-ethynyl-alanine-aminodiolverbindunge mit morpholino/thiomorpholinoendgruppen als renin inhibitoren
DE69315079D1 (de)	1997-12-11	Beta-aminoalkyl und beta-n-peptidylaminoalkylborsäure
NO970512L (no)	1997-08-07	Nye heteroaryl-oksazolidinoner
DK0527922T3 (da)	1995-05-22	Alkoxysubstituerede dihydrobenzopyran-2-carboxylsyrer og derivater deraf
DK0655056T3 (da)	2000-04-17	N-(Dihydroxyalkyl) -ethynylalanin-amider med azacyclyl-endegruppe til behandling af hypertension
SE7606440L (sv)	1976-12-10	Nya n-substituerade bensensulfonamider och sett att framstella desamma
DK0655059T3 (da)	1997-01-06	Imidazolyl/benzimidazolyl-terminerede alkylaminoethynylalaninaminodiol-forbindelser til behandling af hypertension
DK0655058T3 (da)	1999-09-27	Pyridinyl/quinolinyl-terminerede alkylamino-ethynyl-alanin-aminodiol-forbindelser til behandling af hypertension
DK0431520T3 (da)	1995-04-10	Heterocycliske acylaminodiol-beta-aminosyrederivater
DK0655063T3 (da)	1999-12-20	Ethynyl-alanin-aminodiolforbindelser med piperazinyl-endegruppe eller piperazinylamino-endegruppe til behandling af hyperte
IE42154L (en)	1976-02-20	Substituted phenyl ketones
ATE83244T1 (de)	1992-12-15	Synthese von peptid-aminoalkylamiden und peptid- hydraziden mittels festphasenmethode.
FI93457B (fi)	1994-12-30	Menetelmä metyleeni-pristinamysiini-IA- tai metyleeni-virginiamysiinijohdannaisten valmistamiseksi
DE69414117D1 (de)	1998-11-26	1,5-benzodiazepin-derivate verwendbar als cck oder gastrin antagonisten
ES8107249A1 (es)	1981-10-01	Un procedimiento para la preparacion de derivados de 2-epi- fortimicina.
SE8802162D0 (sv)	1988-06-09	Nya aminoacylater av glycerolacetal
Ma	1996	Search for anticancer and other biologically active agents