ATE160356T1 - Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz - Google Patents

Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Info

Publication number: ATE160356T1
Authority: AT; Austria
Prior art keywords: hirudin; sequence; thrombin; thrombin inhibitors; bulky hydrophobic
Prior art date: 1990-06-15

Application number

AT91910717T

Other languages

English (en)

Inventor

John Dimaio

Feng Ni

Yasuo Konishi

Original Assignee

Ca Nat Research Council

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-15

Filing date

1991-06-14

Publication date

1997-12-15

1991-06-14 Application filed by Ca Nat Research Council filed Critical Ca Nat Research Council

1997-12-15 Application granted granted Critical

1997-12-15 Publication of ATE160356T1 publication Critical patent/ATE160356T1/de

Links

229940122388 Thrombin inhibitor Drugs 0.000 title abstract 2
239000003868 thrombin inhibitor Substances 0.000 title abstract 2
230000002209 hydrophobic effect Effects 0.000 abstract 3
150000001413 amino acids Chemical class 0.000 abstract 2
230000003197 catalytic effect Effects 0.000 abstract 2
102000007625 Hirudins Human genes 0.000 abstract 1
108010007267 Hirudins Proteins 0.000 abstract 1
101000712605 Theromyzon tessulatum Theromin Proteins 0.000 abstract 1
108090000190 Thrombin Proteins 0.000 abstract 1
208000007536 Thrombosis Diseases 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
210000004899 c-terminal region Anatomy 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 abstract 1
229940006607 hirudin Drugs 0.000 abstract 1
125000005647 linker group Chemical group 0.000 abstract 1
230000017854 proteolysis Effects 0.000 abstract 1
229960004072 thrombin Drugs 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/815—Protease inhibitors from leeches, e.g. hirudin, eglin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Hematology (AREA)
Chemical Kinetics & Catalysis (AREA)
Tropical Medicine & Parasitology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT91910717T 1990-06-15 1991-06-14 Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz ATE160356T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US53832290A	1990-06-15	1990-06-15

Publications (1)

Publication Number	Publication Date
ATE160356T1 true ATE160356T1 (de)	1997-12-15

Family

ID=24146434

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91910717T ATE160356T1 (de)	1990-06-15	1991-06-14	Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz

Country Status (14)

Country	Link
EP (1)	EP0536177B1 (de)
JP (1)	JP2669510B2 (de)
KR (1)	KR100212162B1 (de)
AT (1)	ATE160356T1 (de)
AU (1)	AU654820B2 (de)
CA (1)	CA2085465C (de)
DE (1)	DE69128247T2 (de)
DK (1)	DK0536177T3 (de)
ES (1)	ES2111567T3 (de)
FI (1)	FI925696A7 (de)
GR (1)	GR3026150T3 (de)
HU (1)	HUT63440A (de)
NO (1)	NO309040B1 (de)
WO (1)	WO1991019734A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5240913A (en) *	1989-08-18	1993-08-31	Biogen, Inc.	Inhibitors of thrombin
US5196404B1 (en) *	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin
US6060451A (en) *	1990-06-15	2000-05-09	The National Research Council Of Canada	Thrombin inhibitors based on the amino acid sequence of hirudin
FI930265A0 (fi) *	1990-07-24	1993-01-22	Merrell Dow Pharma	Antikoagulantpeptider
US5242810A (en) *	1990-12-07	1993-09-07	Biogen, Inc.	Bifunctional inhibitors of thrombin and platelet activation
US5656600A (en) *	1993-03-25	1997-08-12	Corvas International, Inc.	α-ketoamide derivatives as inhibitors of thrombosis
IT1265023B1 (it) *	1993-04-16	1996-10-28	Dev Biotechnological Processes	Inibitori della trombina, loro preparazione ed uso per applicazioni terapeutiche, profilattiche e diagnostiche
KR100330465B1 (ko) *	1993-06-11	2002-11-23	메렐 파마슈티칼스 인크.	삼관능성항트롬빈및항혈소판펩티드
CA2175388A1 (en) *	1993-10-25	1995-05-04	Yasuo Konishi	Bivalent thrombin inhibitors
GB9506212D0 (en) *	1995-03-27	1995-05-17	Iaf Biochem Int	Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
CA2726789A1 (en)	2000-02-05	2001-11-08	Theravance, Inc.	Cyclodextrin containing glycopeptide antibiotic compositions
WO2025262265A1 (en)	2024-06-21	2025-12-26	Etablissement Francais Du Sang	Chimeric molecules comprising an anti-fibrin antibody and an antithrombotic molecule

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB8305985D0 (en) *	1983-03-04	1983-04-07	Szelke M	Enzyme inhibition
JPS606647A (ja) *	1983-06-17	1985-01-14	Microbial Chem Res Found	アルフアメニン及びその関連化合物と合成法
US5196404B1 (en)	1989-08-18	1996-09-10	Biogen Inc	Inhibitors of thrombin

1991
- 1991-06-14 AT AT91910717T patent/ATE160356T1/de not_active IP Right Cessation
- 1991-06-14 DE DE69128247T patent/DE69128247T2/de not_active Expired - Fee Related
- 1991-06-14 HU HU923968A patent/HUT63440A/hu unknown
- 1991-06-14 CA CA002085465A patent/CA2085465C/en not_active Expired - Fee Related
- 1991-06-14 AU AU80855/91A patent/AU654820B2/en not_active Ceased
- 1991-06-14 EP EP91910717A patent/EP0536177B1/de not_active Expired - Lifetime
- 1991-06-14 ES ES91910717T patent/ES2111567T3/es not_active Expired - Lifetime
- 1991-06-14 FI FI925696A patent/FI925696A7/fi unknown
- 1991-06-14 DK DK91910717T patent/DK0536177T3/da active
- 1991-06-14 WO PCT/CA1991/000213 patent/WO1991019734A2/en not_active Ceased
- 1991-06-14 JP JP3510319A patent/JP2669510B2/ja not_active Expired - Fee Related
- 1991-06-14 KR KR1019920703243A patent/KR100212162B1/ko not_active Expired - Fee Related
1992
- 1992-12-14 NO NO924834A patent/NO309040B1/no unknown
1998
- 1998-02-16 GR GR980400324T patent/GR3026150T3/el unknown

Also Published As

Publication number	Publication date
WO1991019734A3 (en)	1992-02-20
DE69128247D1 (de)	1998-01-02
CA2085465C (en)	2001-07-24
DE69128247T2 (de)	1998-03-19
EP0536177A1 (de)	1993-04-14
KR100212162B1 (ko)	1999-08-02
FI925696A0 (fi)	1992-12-15
JPH06500073A (ja)	1994-01-06
HUT63440A (en)	1993-08-30
FI925696L (fi)	1992-12-15
JP2669510B2 (ja)	1997-10-29
NO924834D0 (no)	1992-12-14
AU8085591A (en)	1992-01-07
HU9203968D0 (en)	1993-03-29
ES2111567T3 (es)	1998-03-16
GR3026150T3 (en)	1998-05-29
AU654820B2 (en)	1994-11-24
NO924834L (no)	1992-12-15
FI925696A7 (fi)	1992-12-15
DK0536177T3 (da)	1998-07-27
NO309040B1 (no)	2000-12-04
EP0536177B1 (de)	1997-11-19
CA2085465A1 (en)	1991-12-16
WO1991019734A2 (en)	1991-12-26

Legal Events

Date	Code	Title	Description
1999-12-15	UEP	Publication of translation of european patent specification
2004-03-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE208401T1 (de)	2001-11-15	Thrombin inhibitore mit einer hirudin-ähnlichen sequenz
IS4166A (is)	1994-12-04	Aðferð til að framleiða nýjar peptíðafleiður sem eru þrombíntálmar
DE69128247D1 (de)	1998-01-02	Thrombin-inhibitoren mit einer hirudin-ähnlichen sequenz
ATE124997T1 (de)	1995-07-15	Enzymatische entfernung einer aminoterminalen proteinsequenz.
PT81990B (pt)	1988-03-03	Processo para a preparacao de derivados peptidicos inibidores da renina e das proteases acidas
ATE135044T1 (de)	1996-03-15	Faktor x-laci-hybridprotein
ATE24917T1 (de)	1987-01-15	Peptide-derivate, deren herstellung und verwendung als elastasehemmende mittel.
ES2058771T3 (es)	1994-11-01	Preparado combinado con efecto antitrombotico.
ATE228847T1 (de)	2002-12-15	Inhibitoren von katalytischen antikörpern
DE3852105D1 (de)	1994-12-15	Verfahren zur herstellung von aprotinin und aprotinin-homologen in hefe.
DK213589A (da)	1989-11-11	Antistoffer mod fibrin og immunogen til brug ved fremstilling deraf
PT878195E (pt)	2002-09-30	Utilizacao de um composto 2-aroil-3-arilbenzo(b)tiofeno para a reducao de fibrinogenio
SE8002602L (sv)	1980-12-09	Diagnostiskt forfarande
ES2008017A6 (es)	1989-07-01	Procedimiento para la fabricacion de un complejo conservante de sales de acidos grasos de bajo peso molecular y silicatos aluminico-calcico-sodico hidratos.
SE8700761L (sv)	1988-06-23	Tillempningar av en polypeptid