ATE160589T1 - Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid - Google Patents
Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amidInfo
- Publication number
- ATE160589T1 ATE160589T1 AT94924421T AT94924421T ATE160589T1 AT E160589 T1 ATE160589 T1 AT E160589T1 AT 94924421 T AT94924421 T AT 94924421T AT 94924421 T AT94924421 T AT 94924421T AT E160589 T1 ATE160589 T1 AT E160589T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- phenylglycine
- phenylglycine amide
- separation
- enzymatic production
- Prior art date
Links
- 150000003952 β-lactams Chemical class 0.000 title abstract 5
- KIYRSYYOVDHSPG-SSDOTTSWSA-N (2r)-2-amino-2-phenylacetamide Chemical compound NC(=O)[C@H](N)C1=CC=CC=C1 KIYRSYYOVDHSPG-SSDOTTSWSA-N 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- 230000002255 enzymatic effect Effects 0.000 title 1
- 238000000926 separation method Methods 0.000 title 1
- 102000004190 Enzymes Human genes 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 2
- 239000002262 Schiff base Substances 0.000 abstract 2
- 150000004753 Schiff bases Chemical class 0.000 abstract 2
- 238000006911 enzymatic reaction Methods 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000007787 solid Substances 0.000 abstract 2
- ZGUNAGUHMKGQNY-SSDOTTSWSA-N D-alpha-phenylglycine Chemical compound OC(=O)[C@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-SSDOTTSWSA-N 0.000 abstract 1
- ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/16—Preparation of optical isomers
- C07C231/20—Preparation of optical isomers by separation of optical isomers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE9300750A BE1007296A3 (nl) | 1993-07-19 | 1993-07-19 | Werkwijze voor de bereiding van een beta-lactamderivaat. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE160589T1 true ATE160589T1 (de) | 1997-12-15 |
Family
ID=3887201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94924421T ATE160589T1 (de) | 1993-07-19 | 1994-07-13 | Verfahren zur enzymatischen herstellung von beta- lactam derivaten und abtrennung von d- phenylglycine amid |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP0712443B1 (de) |
| KR (1) | KR960704061A (de) |
| CN (1) | CN1127531A (de) |
| AT (1) | ATE160589T1 (de) |
| BE (1) | BE1007296A3 (de) |
| DE (1) | DE69407049T2 (de) |
| ES (1) | ES2110255T3 (de) |
| WO (1) | WO1995003420A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE1009264A3 (nl) * | 1995-03-31 | 1997-01-07 | Dsm Nv | Werkwijze voor de winning van ampicilline. |
| US5916762A (en) * | 1995-03-31 | 1999-06-29 | Chemferm V.O.F. | Process for the recovery of ampicillin |
| NL1006266C2 (nl) | 1997-06-10 | 1998-12-14 | Chemferm Vof | Werkwijze voor de bereiding van ampicilline. |
| NL1007077C2 (nl) * | 1997-09-19 | 1999-03-22 | Dsm Nv | Werkwijze voor de winning van een ß-lactam antibioticum. |
| NL1007076C2 (nl) * | 1997-09-19 | 1999-03-22 | Dsm Nv | Werkwijze voor de winning van een ß-lactam antibioticum. |
| KR100423442B1 (ko) * | 1999-12-28 | 2004-03-19 | 주식회사 포스코 | 편류를 방지할 수 있는 연속주조용 슬라이딩 게이트장치 |
| CN102851332A (zh) * | 2012-09-07 | 2013-01-02 | 石药集团中诺药业（石家庄）有限公司 | 一种酶法氨苄西林母液中d（-）苯甘氨酸的回收方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL187110C (nl) * | 1976-11-10 | 1991-06-03 | Stamicarbon | Werkwijze voor het scheiden van een mengsel van een optisch aktief fenylglycine-amide en een optisch aktief fenylglycine. |
| NL9000386A (nl) * | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor de bereiding van optisch aktief aminozuuramide. |
| NL9000387A (nl) * | 1990-02-16 | 1991-09-16 | Stamicarbon | Werkwijze voor het racemiseren van een optisch aktief aminozuuramide. |
| EP0537255B1 (de) * | 1990-07-04 | 2006-02-15 | DSM IP Assets B.V. | Verfahren zur herstellung von beta-lactamen |
| CZ148593A3 (en) * | 1991-01-25 | 1994-01-19 | Novo Nordisk As | Process of separating a non-dissolved catalyst from one or a plurality of other non-dissolved components comprised in the same reaction mixture |
-
1993
- 1993-07-19 BE BE9300750A patent/BE1007296A3/nl not_active IP Right Cessation
-
1994
- 1994-07-13 CN CN94192818A patent/CN1127531A/zh active Pending
- 1994-07-13 DE DE69407049T patent/DE69407049T2/de not_active Expired - Fee Related
- 1994-07-13 AT AT94924421T patent/ATE160589T1/de active
- 1994-07-13 EP EP94924421A patent/EP0712443B1/de not_active Expired - Lifetime
- 1994-07-13 WO PCT/NL1994/000161 patent/WO1995003420A1/en not_active Ceased
- 1994-07-13 ES ES94924421T patent/ES2110255T3/es not_active Expired - Lifetime
- 1994-07-13 KR KR1019960700360A patent/KR960704061A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO1995003420A1 (en) | 1995-02-02 |
| ES2110255T3 (es) | 1998-02-01 |
| KR960704061A (ko) | 1996-08-31 |
| CN1127531A (zh) | 1996-07-24 |
| DE69407049T2 (de) | 1998-07-09 |
| EP0712443B1 (de) | 1997-11-26 |
| EP0712443A1 (de) | 1996-05-22 |
| DE69407049D1 (de) | 1998-01-08 |
| BE1007296A3 (nl) | 1995-05-09 |
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