ATE234934T1 - Verfahren zur herstellung von einem beta-laktam antibiotikum - Google Patents

Verfahren zur herstellung von einem beta-laktam antibiotikum

Info

Publication number
ATE234934T1
ATE234934T1 AT98949243T AT98949243T ATE234934T1 AT E234934 T1 ATE234934 T1 AT E234934T1 AT 98949243 T AT98949243 T AT 98949243T AT 98949243 T AT98949243 T AT 98949243T AT E234934 T1 ATE234934 T1 AT E234934T1
Authority
AT
Austria
Prior art keywords
beta
acylation
reaction
lactam nucleus
lactam
Prior art date
Application number
AT98949243T
Other languages
English (en)
Inventor
Dooren Theodorus Johannes Van
Harold Monro Moody
Johanna Christina Maria Smeets
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of ATE234934T1 publication Critical patent/ATE234934T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C12P35/04—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by acylation of the substituent in the 7 position

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Cephalosporin Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT98949243T 1997-10-17 1998-10-01 Verfahren zur herstellung von einem beta-laktam antibiotikum ATE234934T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL1007302A NL1007302C2 (nl) 1997-10-17 1997-10-17 Werkwijze voor de bereiding van een ß-lactam antibioticum.
PCT/NL1998/000570 WO1999020786A1 (en) 1997-10-17 1998-10-01 PROCESS FOR THE PREPARATION OF A β-LACTAM ANTIBIOTIC

Publications (1)

Publication Number Publication Date
ATE234934T1 true ATE234934T1 (de) 2003-04-15

Family

ID=19765855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98949243T ATE234934T1 (de) 1997-10-17 1998-10-01 Verfahren zur herstellung von einem beta-laktam antibiotikum

Country Status (13)

Country Link
US (1) US6287799B1 (de)
EP (1) EP1023454B1 (de)
KR (1) KR100516271B1 (de)
CN (1) CN1165626C (de)
AT (1) ATE234934T1 (de)
AU (1) AU9560198A (de)
BR (1) BR9813079A (de)
EG (1) EG21235A (de)
ES (1) ES2195400T3 (de)
IN (1) IN188152B (de)
NL (1) NL1007302C2 (de)
TR (1) TR200000991T2 (de)
WO (1) WO1999020786A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL1006266C2 (nl) 1997-06-10 1998-12-14 Chemferm Vof Werkwijze voor de bereiding van ampicilline.
EP1394262A1 (de) * 2002-08-30 2004-03-03 Bioferma Murcia, S.A. Enzymatischer Prozess zur Herstellung von beta-Lactamverbindungen
KR101203287B1 (ko) * 2004-12-27 2012-11-20 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파클로르의 합성 방법
KR101420451B1 (ko) 2006-05-19 2014-07-16 디에스엠 시노켐 파마슈티칼스 네덜란드 비.브이. 세파드록실의 결정화 방법
CN101525603B (zh) * 2008-03-04 2013-12-25 中国医药集团总公司四川抗菌素工业研究所 固定化α-氨基酸酯水解酶及其制备与应用
EP2723882B1 (de) 2011-06-23 2019-05-01 Centrient Pharmaceuticals Netherlands B.V. Verfahren zur herstellung von 3 '-thiosubstituierten cephalosporinen unter verwendung einer penicillin-g-acylase
WO2012175587A2 (en) 2011-06-23 2012-12-27 Dsm Sinochem Pharmaceuticals Netherlands B.V. Novel crystalline cefoperazone intermediate
CN103467493B (zh) * 2013-10-16 2016-01-20 华北制药集团先泰药业有限公司 无水氨苄西林的制备方法
CN103757085B (zh) * 2013-11-28 2016-06-15 湖南福来格生物技术有限公司 头孢克洛及其合成方法
CN103937692B (zh) * 2014-04-30 2016-03-23 江南大学 一株丝枝霉菌株及其生产β-葡萄糖苷酶的方法
US20170101660A1 (en) 2015-10-07 2017-04-13 Gwangju Institute Of Science And Technology Enzyme-immobilized porous membrane and preparation method of antibiotics using the same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0537255B1 (de) * 1990-07-04 2006-02-15 DSM IP Assets B.V. Verfahren zur herstellung von beta-lactamen
ES2139923T3 (es) * 1994-07-18 2000-02-16 Dsm Nv Procedimiento para preparar beta-lactamas a concentraciones de reaccionantes constantemente altas.
BE1009071A3 (nl) 1995-02-02 1996-11-05 Dsm Nv Werkwijze voor de bereiding van een beta-lactam antibioticum.
US5770272A (en) * 1995-04-28 1998-06-23 Massachusetts Institute Of Technology Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
WO1997022610A1 (en) * 1995-12-08 1997-06-26 Gist-Brocades B.V. Process for the preparation of an antibiotic

Also Published As

Publication number Publication date
KR100516271B1 (ko) 2005-09-20
ES2195400T3 (es) 2003-12-01
EP1023454A1 (de) 2000-08-02
AU9560198A (en) 1999-05-10
TR200000991T2 (tr) 2000-07-21
KR20010024519A (ko) 2001-03-26
EG21235A (en) 2001-03-31
IN188152B (de) 2002-08-24
CN1165626C (zh) 2004-09-08
CN1282377A (zh) 2001-01-31
US6287799B1 (en) 2001-09-11
EP1023454B1 (de) 2003-03-19
BR9813079A (pt) 2000-08-15
WO1999020786A1 (en) 1999-04-29
NL1007302C2 (nl) 1999-04-20

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