ATE160943T1 - Bicycloazamakrocyclophosphon-säure, komplexe, konjugate, kontrastmittel und herstellung - Google Patents

Bicycloazamakrocyclophosphon-säure, komplexe, konjugate, kontrastmittel und herstellung

Info

Publication number
ATE160943T1
ATE160943T1 AT93901000T AT93901000T ATE160943T1 AT E160943 T1 ATE160943 T1 AT E160943T1 AT 93901000 T AT93901000 T AT 93901000T AT 93901000 T AT93901000 T AT 93901000T AT E160943 T1 ATE160943 T1 AT E160943T1
Authority
AT
Austria
Prior art keywords
complexes
conjugates
preparation
contrast agents
bicycloazamacrocyclophosphone
Prior art date
Application number
AT93901000T
Other languages
English (en)
Inventor
Garry E Kiefer
Jaime Simon
Joseph R Garlich
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of ATE160943T1 publication Critical patent/ATE160943T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT93901000T 1991-12-10 1992-12-10 Bicycloazamakrocyclophosphon-säure, komplexe, konjugate, kontrastmittel und herstellung ATE160943T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80555191A 1991-12-10 1991-12-10

Publications (1)

Publication Number Publication Date
ATE160943T1 true ATE160943T1 (de) 1997-12-15

Family

ID=25191891

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93901000T ATE160943T1 (de) 1991-12-10 1992-12-10 Bicycloazamakrocyclophosphon-säure, komplexe, konjugate, kontrastmittel und herstellung

Country Status (17)

Country Link
EP (2) EP0735040A3 (de)
JP (1) JPH07502043A (de)
CN (1) CN1038328C (de)
AT (1) ATE160943T1 (de)
AU (1) AU3246893A (de)
CA (1) CA2103556C (de)
DE (1) DE69223504T2 (de)
DK (1) DK0570575T3 (de)
ES (1) ES2110593T3 (de)
GR (1) GR3026121T3 (de)
HU (1) HUT66220A (de)
IL (1) IL104060A (de)
MX (1) MX9207166A (de)
RU (1) RU2114115C1 (de)
SG (1) SG46598A1 (de)
WO (1) WO1993011802A1 (de)
ZA (1) ZA929576B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
NZ252554A (en) * 1993-05-06 1998-01-26 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acid compounds, complexes, conjugates, as contrast imaging agents
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
JPH10508036A (ja) 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド 窒素含有大環状化合物
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
IL126659A (en) * 1996-04-19 2003-05-29 Dow Global Technologies Inc Fluorescent chelates as visual tissue specific imaging agents
US5888476A (en) * 1996-11-13 1999-03-30 Mallinckrodt Medical, Inc. Magnetic resonance blood pool agents
US6440389B1 (en) 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
EP2759535A1 (de) * 2008-12-05 2014-07-30 Molecular Insight Pharmaceuticals, Inc. CA-IX spezifische Radiopharmazeutika zur Behandlung und bildlichen Darstellung von Krebs
NO331773B1 (no) * 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
JP7258753B2 (ja) * 2016-12-21 2023-04-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｍｒｉイメージング剤として好適なテトラアザビシクロ大員環系マンガンキレート化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds

Also Published As

Publication number Publication date
DE69223504T2 (de) 1998-04-02
EP0570575B1 (de) 1997-12-10
CN1074447A (zh) 1993-07-21
WO1993011802A1 (en) 1993-06-24
ZA929576B (en) 1994-06-10
EP0570575A1 (de) 1993-11-24
DK0570575T3 (da) 1998-08-24
JPH07502043A (ja) 1995-03-02
AU3246893A (en) 1993-07-19
GR3026121T3 (en) 1998-05-29
SG46598A1 (en) 1998-02-20
ES2110593T3 (es) 1998-02-16
CA2103556A1 (en) 1993-06-11
MX9207166A (es) 1993-07-01
IL104060A0 (en) 1993-05-13
HUT66220A (en) 1994-10-28
EP0735040A3 (de) 1997-02-26
CN1038328C (zh) 1998-05-13
HK1006654A1 (en) 1999-03-12
HU9302312D0 (en) 1993-12-28
RU2114115C1 (ru) 1998-06-27
IL104060A (en) 1998-12-06
EP0735040A2 (de) 1996-10-02
CA2103556C (en) 2002-04-16
DE69223504D1 (de) 1998-01-22

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee