DK0570575T3 - Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf - Google Patents

Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf

Info

Publication number
DK0570575T3
DK0570575T3 DK93901000T DK93901000T DK0570575T3 DK 0570575 T3 DK0570575 T3 DK 0570575T3 DK 93901000 T DK93901000 T DK 93901000T DK 93901000 T DK93901000 T DK 93901000T DK 0570575 T3 DK0570575 T3 DK 0570575T3
Authority
DK
Denmark
Prior art keywords
complexes
conjugates
preparation
contrast agents
bicycloazamacrocyclophosphonic
Prior art date
Application number
DK93901000T
Other languages
English (en)
Inventor
Jaime Simon
Garry E Kiefer
Joseph R Garlich
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Application granted granted Critical
Publication of DK0570575T3 publication Critical patent/DK0570575T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6524—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having four or more nitrogen atoms as the only ring hetero atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK93901000T 1991-12-10 1992-12-10 Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf DK0570575T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80555191A 1991-12-10 1991-12-10
PCT/US1992/010668 WO1993011802A1 (en) 1991-12-10 1992-12-10 Bicycloazamacrocyclophosphonic acid, conjugates, contrast agents and preparation

Publications (1)

Publication Number Publication Date
DK0570575T3 true DK0570575T3 (da) 1998-08-24

Family

ID=25191891

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93901000T DK0570575T3 (da) 1991-12-10 1992-12-10 Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf

Country Status (17)

Country Link
EP (2) EP0570575B1 (da)
JP (1) JPH07502043A (da)
CN (1) CN1038328C (da)
AT (1) ATE160943T1 (da)
AU (1) AU3246893A (da)
CA (1) CA2103556C (da)
DE (1) DE69223504T2 (da)
DK (1) DK0570575T3 (da)
ES (1) ES2110593T3 (da)
GR (1) GR3026121T3 (da)
HU (1) HUT66220A (da)
IL (1) IL104060A (da)
MX (1) MX9207166A (da)
RU (1) RU2114115C1 (da)
SG (1) SG46598A1 (da)
WO (1) WO1993011802A1 (da)
ZA (1) ZA929576B (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994026754A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
US5385893A (en) * 1993-05-06 1995-01-31 The Dow Chemical Company Tricyclopolyazamacrocyclophosphonic acids, complexes and derivatives thereof, for use as contrast agents
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
JPH10508036A (ja) 1995-03-27 1998-08-04 アイシス・ファーマシューティカルス・インコーポレーテッド 窒素含有大環状化合物
US5834456A (en) * 1996-02-23 1998-11-10 The Dow Chemical Company Polyazamacrocyclofluoromonoalkylphosphonic acids, and their complexes, for use as contrast agents
CA2251924C (en) * 1996-04-19 2006-05-30 The Dow Chemical Company Fluorescent chelates as visual tissue specific imaging agents
US5888476A (en) * 1996-11-13 1999-03-30 Mallinckrodt Medical, Inc. Magnetic resonance blood pool agents
US6440389B1 (en) 2000-07-19 2002-08-27 The General Hospital Corporation Fluorescent agents for real-time measurement of organ function
JP2012511024A (ja) * 2008-12-05 2012-05-17 モレキュラ インサイト ファーマシューティカルズ インコーポレイテッド 癌の治療及び撮像用のｃａ−ｉｘ特異性放射性医薬品
NO331773B1 (no) * 2009-12-18 2012-03-26 Ge Healthcare As Mangankelater, sammensetninger omfattende slike og anvendelse av disse som kontrastmidler for magnettomografi (MR)
GB201610738D0 (en) 2016-06-20 2016-08-03 Ge Healthcare As Chelate compounds
JP7258753B2 (ja) * 2016-12-21 2023-04-17 ジーイー・ヘルスケア・アクスイェ・セルスカプ Ｍｒｉイメージング剤として好適なテトラアザビシクロ大員環系マンガンキレート化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4001655A1 (de) * 1990-01-18 1991-07-25 Schering Ag 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag, 13353 Berlin 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
GB9001245D0 (en) * 1990-01-19 1990-03-21 Salutar Inc Compounds
JP3131219B2 (ja) * 1990-01-19 2001-01-31 ニユコメド・イメージング・アクシエセルカペト キレート化合物

Also Published As

Publication number Publication date
MX9207166A (es) 1993-07-01
EP0735040A3 (en) 1997-02-26
GR3026121T3 (en) 1998-05-29
EP0735040A2 (en) 1996-10-02
SG46598A1 (en) 1998-02-20
CA2103556A1 (en) 1993-06-11
EP0570575B1 (en) 1997-12-10
IL104060A (en) 1998-12-06
DE69223504T2 (de) 1998-04-02
WO1993011802A1 (en) 1993-06-24
ZA929576B (en) 1994-06-10
JPH07502043A (ja) 1995-03-02
ES2110593T3 (es) 1998-02-16
RU2114115C1 (ru) 1998-06-27
CN1038328C (zh) 1998-05-13
IL104060A0 (en) 1993-05-13
EP0570575A1 (en) 1993-11-24
CN1074447A (zh) 1993-07-21
AU3246893A (en) 1993-07-19
HK1006654A1 (en) 1999-03-12
HU9302312D0 (en) 1993-12-28
ATE160943T1 (de) 1997-12-15
HUT66220A (en) 1994-10-28
DE69223504D1 (de) 1998-01-22
CA2103556C (en) 2002-04-16

Similar Documents

Publication Publication Date Title
FI955319A0 (fi) 2-pyridyylimetyleenipolyatsamakrosyklofosfonihappoja, niiden komplekseja ja johdannaisia käytettäväksi vasta-aineina
BG100194A (bg) Трициклополиазамакроциклофосфонови киселини,техни производни и комплекси и използването им като контрастни средства
DE3766157D1 (de) Kupplungsmittel zum radiomarkieren von proteinen.
EP0579802A4 (en) Bicycle-polyazamacrocyclocarboxylic acid complexes, conjugates, preparation and use as contrast agents
DK0570575T3 (da) Bicykloazamakrocyklophosphonsyre, komplekser, konjugater, kontrastmidler og fremstilling heraf
HUT51594A (en) Process for production of celates and their complexes containing ortolizating functional groups, compositions containing such active substances and process for production of conjugates consisting of one complex and linked to it antibody or fragment of antibody
RU93053767A (ru) Бициклополиазамакроциклофосфоновые кислоты, их комплексы и конъюгаты для применения в качестве контрастных агентов и способы их получения
NO954442L (no) Bicyklopolyazamakrocyklofosfonsyrer, deres komplekser og konjugater, for anvendelse som kontrastmidler, og fremgangsmåter for deres fremstilling
FI933506L (fi) Bisyklopolyatsamakrosyklokarboksyylihappokomplekseja, niiden konjugaatteja, menetelmä niiden valmistamiseksi ja käyttö varjoaineina
MY141501A (en) Bicyclopolyazamacrocyclophosphonic acids, their complexes and conjugates, for use as contrast agents and processes for their preparation
RU93053897A (ru) Комплексы бициклополиазамакроциклокарбоновых кислот, их конъюгаты, фармацевтическая композиция, способ диагностики, набор и способ получения
MY109649A (en) Bicyclopol yazamacrocyclocarboxylic acid complexes, and conjugates, processes for their prepration, and use as contrast agents