ATE161836T1 - 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate - Google Patents

4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate

Info

Publication number
ATE161836T1
ATE161836T1 AT92309684T AT92309684T ATE161836T1 AT E161836 T1 ATE161836 T1 AT E161836T1 AT 92309684 T AT92309684 T AT 92309684T AT 92309684 T AT92309684 T AT 92309684T AT E161836 T1 ATE161836 T1 AT E161836T1
Authority
AT
Austria
Prior art keywords
didehydro
deoxy
alpha
substituted
neuramic acid
Prior art date
Application number
AT92309684T
Other languages
English (en)
Inventor
Itzstein Von
Wen-Yang Wu
Tho Van Phan
Betty Jin
Original Assignee
Biota Scient Management
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biota Scient Management filed Critical Biota Scient Management
Application granted granted Critical
Publication of ATE161836T1 publication Critical patent/ATE161836T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT92309684T 1991-10-23 1992-10-22 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate ATE161836T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AUPK905191 1991-10-23

Publications (1)

Publication Number Publication Date
ATE161836T1 true ATE161836T1 (de) 1998-01-15

Family

ID=3775765

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92309684T ATE161836T1 (de) 1991-10-23 1992-10-22 4-substituierte-2-deoxy-2,3-didehydro alpha-d- neuraminsäure antivirale derivate

Country Status (10)

Country Link
EP (1) EP0539204B1 (de)
JP (1) JP2925863B2 (de)
AT (1) ATE161836T1 (de)
AU (1) AU659501B2 (de)
CA (1) CA2081068C (de)
DE (1) DE69223914T2 (de)
DK (1) DK0539204T3 (de)
ES (1) ES2113413T3 (de)
GR (1) GR3026218T3 (de)
ZA (1) ZA928170B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9220327D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process
GB9325841D0 (en) * 1993-12-17 1994-02-23 Glaxo Group Ltd Chemical compounds
AUPM354694A0 (en) * 1994-01-27 1994-02-17 Biota Scientific Management Pty Ltd Chemical compounds
GB9410817D0 (en) * 1994-05-28 1994-07-20 Glaxo Group Ltd Medicaments
US5561146A (en) * 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
US5512596A (en) * 1994-09-02 1996-04-30 Gilead Sciences, Inc. Aromatic compounds
CA2188835C (en) * 1995-02-27 2006-08-08 Norbert W. Bischofberger Novel compounds and methods for synthesis and therapy
US5952375A (en) 1995-02-27 1999-09-14 Gilead Sciences, Inc. Compounds and methods for synthesis and therapy
US5866601A (en) * 1995-02-27 1999-02-02 Gilead Sciences, Inc. Carbocyclic compounds
US5602277A (en) * 1995-03-30 1997-02-11 Biocryst Pharmaceuticals, Inc. Substituted benzene derivatives useful as neuraminidase inhibitors
CN1184473A (zh) * 1995-05-19 1998-06-10 比奥塔科学管理有限公司 6－羟基酰胺－二氢吡喃衍生物
GB9516276D0 (en) * 1995-08-08 1995-10-11 Biota Scient Management Chemical compounds
US5763483A (en) * 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
ATE211468T1 (de) * 1996-07-22 2002-01-15 Sankyo Co Neuraminsäuredervate, ihre herstellung und medizinische verwendung
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
US6451766B1 (en) 1996-07-22 2002-09-17 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
NZ334101A (en) * 1996-08-13 2001-07-27 Sankyo Co Neuraminic acid derivatives and use in treating viral infections
US5859284A (en) * 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
AU711845B2 (en) * 1996-09-10 1999-10-21 Daikin Industries, Ltd. 4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
CN1238762A (zh) * 1996-10-21 1999-12-15 吉里德科学公司 哌啶化合物
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
AU732916C (en) * 1996-11-14 2002-06-06 Biota Scientific Management Pty Ltd Method and novel compounds for use therein
US5886213A (en) * 1997-08-22 1999-03-23 Gilead Sciences, Inc. Preparation of carbocyclic compounds
TW477783B (en) * 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
WO2002092555A1 (en) * 2001-05-11 2002-11-21 Sankyo Company, Limited Sialic acid derivatives
KR100697944B1 (ko) 2003-02-10 2007-03-20 니폰 쇼쿠바이 컴파니 리미티드 수분-흡수제
AU2008208865B2 (en) 2007-01-23 2013-01-24 Therapicon Srl Antiviral compounds
JPWO2009004899A1 (ja) * 2007-06-15 2010-08-26 国立大学法人北海道大学 シアリダーゼ阻害剤
EP2476675A1 (de) 2008-11-28 2012-07-18 Cipla Limited Verfahren zur Herstellung von Zanamivir und Zwischenprodukte zur Verwendung in dem Verfahren
CA2762022A1 (en) 2009-05-15 2010-11-18 Redx Pharma Limited Redox drug derivatives
IT1396620B1 (it) 2009-11-25 2012-12-14 Therapicon Srl Analoghi chimerici
EP2678324A1 (de) 2011-02-24 2014-01-01 Cadila Healthcare Limited Verfahren zur herstellung von zanamivir
DE102011117128A1 (de) * 2011-10-28 2013-05-02 Christian-Albrechts-Universität Zu Kiel Verbindungen zur Therapie der Influenza

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ288492B6 (en) * 1990-04-24 2001-06-13 Biota Scient Management Derivatives of alpha-D-neuraminic acid, process of their preparation, their use and pharmaceutical preparations based thereon
GB9220241D0 (en) * 1992-09-25 1992-11-11 Glaxo Group Ltd Process

Also Published As

Publication number Publication date
ES2113413T3 (es) 1998-05-01
DE69223914D1 (de) 1998-02-12
HK1015137A1 (en) 1999-10-08
DK0539204T3 (da) 1998-09-07
AU659501B2 (en) 1995-05-18
JP2925863B2 (ja) 1999-07-28
EP0539204B1 (de) 1998-01-07
GR3026218T3 (en) 1998-05-29
CA2081068A1 (en) 1993-04-24
AU2724292A (en) 1993-04-29
DE69223914T2 (de) 1998-04-30
EP0539204A1 (de) 1993-04-28
JPH0625209A (ja) 1994-02-01
ZA928170B (en) 1993-11-15
CA2081068C (en) 2005-11-29

Similar Documents

Publication Publication Date Title
DE69223914D1 (de) 4-substituierte-2-Deoxy-2,3-Didehydro Alpha-D-Neuraminsäure antivirale Derivate
FI872864A0 (fi) Menetelmä farmaseuttisesti aktiivisten bentsimidatsolijohdannaisten valmistamiseksi
ES2095432T3 (es) Derivados de 2,4-tiazolidin-diona, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
DE69206876D1 (de) Nukleosidanalogen enthaltende Antiviren-Zubereitungen
DE68911742D1 (de) Substituierte flavonoide Verbindungen, ihre Salze, ihre Herstellung und die enthaltende Arnzeizusammensetzungen.
DE68917485D1 (de) Pyridazinon-Derivate und diese enthaltende pharmazeutische Zubereitungen.
MX9203417A (es) Compuestos de diarilo antiateroescleroticos.
SE8404065D0 (sv) Novel biologically active compounds
IT1224405B (it) Composti attivi sul sistema cardiovascolare
SE8600658D0 (sv) Novel composition of matter
FI902901A0 (fi) Dibenzol/1,5/dioxocin-5-one-derivat, deras anvaendning i laekemedel och foerfarande foer deras framstaellning.
DE3880304D1 (de) 2-hydroxy-3-aryloxy-propylaminderivate mit kardiovaskulaerer wirkung.
ATE123497T1 (de) Substituierte pyridin-verbindungen, ihre herstellung und sie enthaltende pharmazeutische zusammensetzungen.
ATE153032T1 (de) Zyklische angiopeptin derivate, deren herstellung und pharmazeutische zusammensetzungen
ES2076054T3 (es) Nuevas amino-alquil-cromonas, su procedimiento de preparacion y composiciones farmaceuticas que las contienen.
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
ITMI911845A1 (it) Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
DE3882677D1 (de) Kardiovaskulaer aktive verbindungen.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee