BRPI1010981A2 - "derivados de fármaco redox" - Google Patents
"derivados de fármaco redox"Info
- Publication number
- BRPI1010981A2 BRPI1010981A2 BRPI1010981A BRPI1010981A BRPI1010981A2 BR PI1010981 A2 BRPI1010981 A2 BR PI1010981A2 BR PI1010981 A BRPI1010981 A BR PI1010981A BR PI1010981 A BRPI1010981 A BR PI1010981A BR PI1010981 A2 BRPI1010981 A2 BR PI1010981A2
- Authority
- BR
- Brazil
- Prior art keywords
- drug derivatives
- redox
- redox drug
- derivatives
- drug
- Prior art date
Links
- 239000003118 drug derivative Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0908338A GB0908338D0 (en) | 2009-05-15 | 2009-05-15 | Redox drug derivatives |
| GBGB1006112.5A GB201006112D0 (en) | 2010-04-13 | 2010-04-13 | Redox drug derivatives |
| PCT/GB2010/050797 WO2010131054A1 (en) | 2009-05-15 | 2010-05-17 | Redox drug derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1010981A2 true BRPI1010981A2 (pt) | 2018-12-04 |
Family
ID=42304532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1010981A BRPI1010981A2 (pt) | 2009-05-15 | 2010-05-17 | "derivados de fármaco redox" |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8877945B2 (pt) |
| EP (1) | EP2429991B1 (pt) |
| JP (1) | JP2012526793A (pt) |
| KR (1) | KR20120025519A (pt) |
| CN (1) | CN102459169B (pt) |
| AU (1) | AU2010247141A1 (pt) |
| BR (1) | BRPI1010981A2 (pt) |
| CA (1) | CA2762022A1 (pt) |
| EA (1) | EA201101564A1 (pt) |
| IL (1) | IL216214A (pt) |
| MX (1) | MX2011012134A (pt) |
| NZ (2) | NZ610978A (pt) |
| SG (1) | SG176056A1 (pt) |
| WO (1) | WO2010131054A1 (pt) |
| ZA (1) | ZA201108276B (pt) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2496972A (en) * | 2011-11-18 | 2013-05-29 | Redx Pharma Ltd | Oxime and hydrazone derivatives of fluoroquinolone antibacterial drugs |
| GB2498080A (en) * | 2011-12-21 | 2013-07-03 | Redx Pharma Ltd | Derivatives of oseltamivir |
| CN102827187B (zh) * | 2012-07-18 | 2014-05-14 | 河南大学 | 氟喹诺酮醛缩异烟腙及其制备方法和应用 |
| AU2014265483B2 (en) | 2013-05-14 | 2018-08-02 | Biocryst Pharmaceuticals, Inc. | Anti-influenza compositions and methods |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1175836A (en) | 1977-09-20 | 1984-10-09 | Marcel Pesson | Production of 1,4-dihydroquinoline-3-carboxylic acid derivatives |
| SE444566B (sv) | 1977-09-20 | 1986-04-21 | Bellon Labor Sa Roger | 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav |
| JPS5746986A (en) | 1980-09-02 | 1982-03-17 | Dai Ichi Seiyaku Co Ltd | Pyrido(1,2,3-de)(1,4)benzoxazine derivative |
| DE3333719A1 (de) | 1983-09-17 | 1985-04-04 | Bayer Ag | Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren |
| JPH0635458B2 (ja) | 1985-02-15 | 1994-05-11 | 大日本製薬株式会社 | ピリドンカルボン酸誘導体、そのエステルおよびその塩 |
| DK170473B1 (da) | 1985-06-20 | 1995-09-11 | Daiichi Seiyaku Co | S(-)-pyridobenzoxazinforbindelser |
| EP0286802B1 (en) | 1987-02-26 | 1993-06-23 | Rohto Pharmaceutical Co., Ltd. | Use of ofloxacin in treating or preventing locally periodontal disease |
| JPH07113026B2 (ja) * | 1988-06-01 | 1995-12-06 | ダイセル化学工業株式会社 | オフロキサシンのエステル類の光学分割方法 |
| DE3906365A1 (de) | 1988-07-15 | 1990-01-18 | Bayer Ag | 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe |
| JP2777661B2 (ja) | 1988-10-20 | 1998-07-23 | 大塚製薬株式会社 | ベンゾヘテロ環化合物 |
| GB8906166D0 (en) | 1989-03-17 | 1989-05-04 | Pfizer Ltd | Therapeutic agents |
| SK282950B6 (sk) | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
| US6197819B1 (en) | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
| NO179912C (no) | 1990-11-28 | 1997-01-08 | Daiichi Seiyaku Co | Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat |
| AU659501B2 (en) | 1991-10-23 | 1995-05-18 | Biota Scientific Management Pty Ltd | Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid |
| DE4200414A1 (de) | 1992-01-10 | 1993-07-15 | Bayer Ag | Chinolon- und naphthyridon-carbonsaeure-derivate |
| NO304832B1 (no) | 1992-05-27 | 1999-02-22 | Ube Industries | Aminokinolonderivater samt middel mot HIV |
| AU673824B2 (en) | 1992-05-29 | 1996-11-28 | Bayer Aktiengesellschaft | Cyclopentane- and -pentene-beta-amino acids |
| US5235054A (en) | 1992-07-15 | 1993-08-10 | Pfizer Inc. | 3-carboxaldehyde substituted quinolines and naphthyridines |
| DE4234078A1 (de) | 1992-10-09 | 1994-04-14 | Bayer Ag | Chinoloncarbonsäuren |
| CA2112165C (en) | 1992-12-25 | 2003-04-08 | Makoto Takemura | Bicyclic amine derivatives |
| US5527910A (en) | 1992-12-30 | 1996-06-18 | Cheil Foods & Chemicals, Inc. | Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria |
| KR0148277B1 (ko) * | 1993-01-18 | 1998-11-02 | 채영복 | 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법 |
| DE4301246A1 (de) | 1993-01-19 | 1994-07-21 | Bayer Ag | Chinolon- und Naphthyridoncarbonsäurederivate |
| TW301607B (pt) | 1993-03-09 | 1997-04-01 | Takeda Pharm Industry Co Ltd | |
| US5665754A (en) | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| CN100409844C (zh) | 1995-02-27 | 2008-08-13 | 吉里德科学公司 | 神经氨酸苷酶抑制剂 |
| DE19546249A1 (de) | 1995-12-12 | 1997-06-19 | Bayer Ag | Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| US5763483A (en) | 1995-12-29 | 1998-06-09 | Gilead Sciences, Inc. | Carbocyclic compounds |
| PL186737B1 (pl) | 1996-02-23 | 2004-02-27 | Bayer Ag | Kwasy 8-cyjano-1-cyklopropylo-7-/2, 8-diazabicyklo [ 4.3.0 ] nonan-8-ylo/-6-fluoro-1,4-dihydro-4-okso-3-chinolinokarboksylowe i ich pochodne, sposób ich wytwarzania, środki medyczne je zawierające i ich zastosowanie do wytwarzania środków medycznychi antybakteryjnych |
| US6340702B1 (en) | 1996-07-22 | 2002-01-22 | Sankyo Company, Limited | Neuraminic acid derivatives, their preparation and their medical use |
| DK0823428T3 (da) | 1996-07-22 | 2002-02-18 | Sankyo Co | Neuraminsyrederivater, deres fremstilling og deres medicinske anvendelse |
| EP0934061B3 (en) | 1996-07-24 | 2015-01-21 | Warner-Lambert Company LLC | Isobutylgaba and its derivatives for the treatment of pain |
| KR20000068986A (ko) | 1996-11-14 | 2000-11-25 | 리차드웨드레이 | 신규 용도 화합물 및 그 제조방법 |
| US6127418A (en) | 1997-08-20 | 2000-10-03 | Warner-Lambert Company | GABA analogs to prevent and treat gastrointestinal damage |
| TW477783B (en) | 1997-12-12 | 2002-03-01 | Gilead Sciences Inc | Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same |
| PT1040094E (pt) | 1997-12-17 | 2009-06-03 | Biocryst Pharm Inc | Compostos de ciclopentano e de ciclopenteno substituídos úteis como inibidores da neuraminidase |
| HN1999000174A (es) | 1998-10-30 | 1999-10-13 | Bayer Ag | Formulacion medicamentosa acuisa para administracion oral. |
| DE19941217A1 (de) | 1999-08-30 | 2001-03-15 | Asta Medica Ag | Behandlung der Migräne durch Verabreichung von alpha-Liponsäure oder Derivaten derselben |
| AU3223801A (en) | 2000-02-09 | 2001-08-20 | Daiichi Seiyaku Co | Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient |
| JP2004099494A (ja) | 2002-09-09 | 2004-04-02 | Shiono Chemical Co Ltd | 光学活性三環式化合物の製造方法 |
| WO2005033108A1 (en) | 2003-09-22 | 2005-04-14 | Janssen Pharmaceutica, N.V. | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones |
| DE602005009195D1 (de) | 2004-06-23 | 2008-10-02 | Robert F Hofmann | Verwendung einer gezielten oxidativen therapeutischen formulierung bei der behandlung von verbrennungen |
| EP1986636B1 (en) | 2006-02-22 | 2013-04-24 | Edison Pharmaceuticals, Inc. | Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases |
| EP2017273A1 (en) | 2007-07-18 | 2009-01-21 | Laboratorios del Dr. Esteve S.A. | Process for the enantioselective preparation of pregabalin |
| CN101883569B (zh) | 2007-08-31 | 2013-08-21 | 梁启铭 | 具有抗流感活性之含奥司他伟膦酸酯同系物的合成 |
| EP2053040A1 (en) | 2007-10-26 | 2009-04-29 | Chemo Ibérica, S.A. | Pregabalin intermediates and process for preparing them and Pregabalin |
-
2010
- 2010-05-17 BR BRPI1010981A patent/BRPI1010981A2/pt not_active IP Right Cessation
- 2010-05-17 CA CA2762022A patent/CA2762022A1/en not_active Abandoned
- 2010-05-17 NZ NZ610978A patent/NZ610978A/en not_active IP Right Cessation
- 2010-05-17 AU AU2010247141A patent/AU2010247141A1/en not_active Abandoned
- 2010-05-17 KR KR1020117029829A patent/KR20120025519A/ko not_active Ceased
- 2010-05-17 CN CN201080026597.7A patent/CN102459169B/zh not_active Expired - Fee Related
- 2010-05-17 EP EP10721845.5A patent/EP2429991B1/en not_active Not-in-force
- 2010-05-17 JP JP2012510375A patent/JP2012526793A/ja active Pending
- 2010-05-17 MX MX2011012134A patent/MX2011012134A/es active IP Right Grant
- 2010-05-17 US US13/319,377 patent/US8877945B2/en not_active Expired - Fee Related
- 2010-05-17 WO PCT/GB2010/050797 patent/WO2010131054A1/en not_active Ceased
- 2010-05-17 NZ NZ596492A patent/NZ596492A/xx not_active IP Right Cessation
- 2010-05-17 EA EA201101564A patent/EA201101564A1/ru unknown
- 2010-05-17 SG SG2011083797A patent/SG176056A1/en unknown
-
2011
- 2011-11-08 IL IL216214A patent/IL216214A/en not_active IP Right Cessation
- 2011-11-10 ZA ZA2011/08276A patent/ZA201108276B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2429991B1 (en) | 2014-09-10 |
| CN102459169B (zh) | 2014-12-31 |
| WO2010131054A1 (en) | 2010-11-18 |
| ZA201108276B (en) | 2015-08-26 |
| IL216214A0 (en) | 2012-01-31 |
| CN102459169A (zh) | 2012-05-16 |
| KR20120025519A (ko) | 2012-03-15 |
| NZ610978A (en) | 2014-11-28 |
| CA2762022A1 (en) | 2010-11-18 |
| WO2010131054A9 (en) | 2011-05-12 |
| AU2010247141A1 (en) | 2011-12-15 |
| EP2429991A1 (en) | 2012-03-21 |
| US20120077974A1 (en) | 2012-03-29 |
| SG176056A1 (en) | 2011-12-29 |
| MX2011012134A (es) | 2012-02-08 |
| IL216214A (en) | 2015-01-29 |
| JP2012526793A (ja) | 2012-11-01 |
| US8877945B2 (en) | 2014-11-04 |
| NZ596492A (en) | 2013-08-30 |
| EA201101564A1 (ru) | 2012-07-30 |
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