ZA928170B - Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid - Google Patents

Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid

Info

Publication number: ZA928170B
Authority: ZA; South Africa
Prior art keywords: derivatives; antiviral; didehydro; deoxy; alpha
Prior art date: 1991-10-23

Application number

ZA928170A

Other languages

English (en)

Inventor

Laurence Mark Von Itzstein

Wen-Yang Wu

Tho Van Phan

Basil Danylec

Betty Jin

Original Assignee

Biota Scient Management

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-10-23

Filing date

1992-10-22

Publication date

1993-11-15

1992-10-22 Application filed by Biota Scient Management filed Critical Biota Scient Management

1993-11-15 Publication of ZA928170B publication Critical patent/ZA928170B/xx

Links

CERZMXAJYMMUDR-LSRLBZCKSA-N alpha-neuraminic acid Chemical class N[C@@H]1[C@@H](O)C[C@](O)(C(O)=O)O[C@H]1[C@H](O)[C@H](O)CO CERZMXAJYMMUDR-LSRLBZCKSA-N 0.000 title 1
230000000840 anti-viral effect Effects 0.000 title 1
239000003443 antiviral agent Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Communicable Diseases (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Pyrane Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

ZA928170A 1991-10-23 1992-10-22 Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid ZA928170B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AUPK905191		1991-10-23

Publications (1)

Publication Number	Publication Date
ZA928170B true ZA928170B (en)	1993-11-15

Family

ID=3775765

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA928170A ZA928170B (en)	1991-10-23	1992-10-22	Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid

Country Status (10)

Country	Link
EP (1)	EP0539204B1 (de)
JP (1)	JP2925863B2 (de)
AT (1)	ATE161836T1 (de)
AU (1)	AU659501B2 (de)
CA (1)	CA2081068C (de)
DE (1)	DE69223914T2 (de)
DK (1)	DK0539204T3 (de)
ES (1)	ES2113413T3 (de)
GR (1)	GR3026218T3 (de)
ZA (1)	ZA928170B (de)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9220241D0 (en) *	1992-09-25	1992-11-11	Glaxo Group Ltd	Process
GB9220327D0 (en) *	1992-09-25	1992-11-11	Glaxo Group Ltd	Process
GB9325841D0 (en) *	1993-12-17	1994-02-23	Glaxo Group Ltd	Chemical compounds
AUPM354694A0 (en) *	1994-01-27	1994-02-17	Biota Scientific Management Pty Ltd	Chemical compounds
GB9410817D0 (en) *	1994-05-28	1994-07-20	Glaxo Group Ltd	Medicaments
US5561146A (en) *	1994-06-10	1996-10-01	Bristol-Myers Squibb Company	Modified guanidino and amidino thrombin inhibitors
US5512596A (en) *	1994-09-02	1996-04-30	Gilead Sciences, Inc.	Aromatic compounds
US5866601A (en) *	1995-02-27	1999-02-02	Gilead Sciences, Inc.	Carbocyclic compounds
CN100409844C (zh) *	1995-02-27	2008-08-13	吉里德科学公司	神经氨酸苷酶抑制剂
NZ520724A (en) *	1995-02-27	2004-03-26	Gilead Sciences Inc	Tetrahydro-pyridine compounds for inhibiting neuraminidase and treating influenza neuraminidase
US5602277A (en) *	1995-03-30	1997-02-11	Biocryst Pharmaceuticals, Inc.	Substituted benzene derivatives useful as neuraminidase inhibitors
ATE206116T1 (de) *	1995-05-19	2001-10-15	Biota Scient Management	6-carboxamido-dihydropyran-derivate
GB9516276D0 (en) *	1995-08-08	1995-10-11	Biota Scient Management	Chemical compounds
US5763483A (en) *	1995-12-29	1998-06-09	Gilead Sciences, Inc.	Carbocyclic compounds
US6340702B1 (en)	1996-07-22	2002-01-22	Sankyo Company, Limited	Neuraminic acid derivatives, their preparation and their medical use
DK0823428T3 (da) *	1996-07-22	2002-02-18	Sankyo Co	Neuraminsyrederivater, deres fremstilling og deres medicinske anvendelse
US6451766B1 (en)	1996-07-22	2002-09-17	Sankyo Company, Limited	Neuraminic acid derivatives, their preparation and their medical use
ATE239006T1 (de) *	1996-08-13	2003-05-15	Sankyo Co	Verbindungen der neuraminsaeure
US6518438B2 (en)	1996-08-23	2003-02-11	Gilead Sciences, Inc.	Preparation of cyclohexene carboxylate derivatives
US5859284A (en) *	1996-08-23	1999-01-12	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
AU711845B2 (en) *	1996-09-10	1999-10-21	Daikin Industries, Ltd.	4-substituted-2,7-dideoxy-7-fluoro-2,3-didehydro-sialic acid compounds
US5994377A (en) *	1996-10-21	1999-11-30	Gilead Sciences, Inc.	Piperidine compounds
CN1238762A (zh) *	1996-10-21	1999-12-15	吉里德科学公司	哌啶化合物
KR20000068986A (ko) *	1996-11-14	2000-11-25	리차드웨드레이	신규 용도 화합물 및 그 제조방법
US5886213A (en) *	1997-08-22	1999-03-23	Gilead Sciences, Inc.	Preparation of carbocyclic compounds
TW477783B (en) *	1997-12-12	2002-03-01	Gilead Sciences Inc	Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
US6518305B1 (en)	1998-04-23	2003-02-11	Abbott Laboratories	Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
US6455571B1 (en)	1998-04-23	2002-09-24	Abbott Laboratories	Inhibitors of neuraminidases
US6608081B2 (en)	1999-08-12	2003-08-19	Ortho-Mcneil Pharmaceutical, Inc.	Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
US6593314B1 (en)	1999-10-19	2003-07-15	Abbott Laboratories	Neuraminidase inhibitors
WO2002092555A1 (en) *	2001-05-11	2002-11-21	Sankyo Company, Limited	Sialic acid derivatives
PL215419B1 (pl)	2003-02-10	2013-12-31	Nippon Catalytic Chem Ind	Srodek pochlaniajacy wode
AU2008208865B2 (en)	2007-01-23	2013-01-24	Therapicon Srl	Antiviral compounds
WO2009004899A1 (ja) *	2007-06-15	2009-01-08	National University Corporation Hokkaido University	シアリダーゼ阻害剤
EP2358695B1 (de)	2008-11-28	2014-07-02	Cipla Limited	Verfahren zur herstellung von zanamivir und zwischenprodukte zur verwendung in dem verfahren
BRPI1010981A2 (pt)	2009-05-15	2018-12-04	Redx Pharma Ltd	"derivados de fármaco redox"
IT1396620B1 (it)	2009-11-25	2012-12-14	Therapicon Srl	Analoghi chimerici
EP2678324A1 (de)	2011-02-24	2014-01-01	Cadila Healthcare Limited	Verfahren zur herstellung von zanamivir
DE102011117128A1 (de) *	2011-10-28	2013-05-02	Christian-Albrechts-Universität Zu Kiel	Verbindungen zur Therapie der Influenza

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK282950B6 (sk) *	1990-04-24	2003-01-09	Biota Scientific Management Pty Ltd	Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze
GB9220241D0 (en) *	1992-09-25	1992-11-11	Glaxo Group Ltd	Process

1992
- 1992-10-21 AU AU27242/92A patent/AU659501B2/en not_active Ceased
- 1992-10-21 CA CA002081068A patent/CA2081068C/en not_active Expired - Fee Related
- 1992-10-22 ES ES92309684T patent/ES2113413T3/es not_active Expired - Lifetime
- 1992-10-22 ZA ZA928170A patent/ZA928170B/xx unknown
- 1992-10-22 AT AT92309684T patent/ATE161836T1/de not_active IP Right Cessation
- 1992-10-22 EP EP92309684A patent/EP0539204B1/de not_active Expired - Lifetime
- 1992-10-22 DE DE69223914T patent/DE69223914T2/de not_active Expired - Lifetime
- 1992-10-22 DK DK92309684T patent/DK0539204T3/da active
- 1992-10-23 JP JP4309626A patent/JP2925863B2/ja not_active Expired - Fee Related
1998
- 1998-02-25 GR GR980400397T patent/GR3026218T3/el unknown

Also Published As

Publication number	Publication date
AU659501B2 (en)	1995-05-18
AU2724292A (en)	1993-04-29
ATE161836T1 (de)	1998-01-15
JPH0625209A (ja)	1994-02-01
DE69223914D1 (de)	1998-02-12
CA2081068C (en)	2005-11-29
JP2925863B2 (ja)	1999-07-28
EP0539204B1 (de)	1998-01-07
DK0539204T3 (da)	1998-09-07
HK1015137A1 (en)	1999-10-08
ES2113413T3 (es)	1998-05-01
CA2081068A1 (en)	1993-04-24
GR3026218T3 (en)	1998-05-29
DE69223914T2 (de)	1998-04-30
EP0539204A1 (de)	1993-04-28

Publication	Publication Date	Title
GR3026218T3 (en)	1998-05-29	Antiviral 4-substituted-2-deoxy-2,3-didehydro derivatives of alpha D-neuraminic acid
PT83647A (en)	1986-11-01	Process for the preparation of novel pharmaceutical benzimidazole derivatives and of pharmaceutical compositions containing the same
NZ244021A (en)	1995-01-27	Benzylthiazolidinedione derivatives, preparation and pharmaceutical compositions thereof
IL101883A0 (en)	1992-12-30	Antiviral combinations and pharmaceutical compositions containing them
NZ240936A (en)	1993-09-27	Alkoxy-substituted 1-phenyl-isoquinoline derivative and pharmaceutical compositions
IL109578A0 (en)	1994-08-26	Nor-bile acid derivatives, processes for their preparation and the use of these compounds as medicaments
IL114894A (en)	2003-04-10	Pyrrolidine derivatives as endothelin antagonists, pharmaceutical compositions containing them, and their use in the preparation of medicaments
CA2081356A1 (en)	1991-10-25	Derivatives and analogues of 2-deoxy-2,3-didehydro-n- acetyl neuraminic acid and their use as antiviral agents
IL94819A0 (en)	1991-04-15	11beta-aryl-4-estrene derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
HUT61004A (en)	1992-11-30	Process for producing quinoxaline derivatives and pharmaceutical compositions comprising such compounds as active ingredient
GR3006091T3 (de)	1993-06-21
GR3024686T3 (en)	1997-12-31	Novel guinolone and naphthyridone derivatives.
IT1228288B (it)	1991-06-07	Composti ad attivita' antiserotoninica
EP0321968A3 (en)	1990-10-31	Compounds active on the cardiovascular system
SE8600658D0 (sv)	1986-02-14	Novel composition of matter
GR3002679T3 (en)	1993-01-25	Dihydropyridinamides, process for their preparation and their use in medicines
DE68927055D1 (de)	1996-10-02	2',5'-oligoadenylat-derivate zur verwendung als heilmittel
GR3017599T3 (en)	1996-01-31	Thiochromane derivatives, process for their preparation and pharmaceutical compositions containing them.
DK0418990T3 (da)	1994-03-14	13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
EP0321967A3 (en)	1990-10-24	Compounds active on the cardiovascular system
IL85508A (en)	1991-11-21	2-substituted-4-(2-benzyl-aminophenyl)-1,4,5,7-tetra-hydro-5-oxofuro(3,4,-b)-pyridine-3-carboxylic acid derivatives and pharmaceutical compositions containing them