ATE162200T1 - Bisaminierte zyklohexapeptide - Google Patents

Bisaminierte zyklohexapeptide

Info

Publication number
ATE162200T1
ATE162200T1 AT92308985T AT92308985T ATE162200T1 AT E162200 T1 ATE162200 T1 AT E162200T1 AT 92308985 T AT92308985 T AT 92308985T AT 92308985 T AT92308985 T AT 92308985T AT E162200 T1 ATE162200 T1 AT E162200T1
Authority
AT
Austria
Prior art keywords
bisaminated
cyclohexapeptides
cyclohexapeptidyl
nucleus
found
Prior art date
Application number
AT92308985T
Other languages
English (en)
Inventor
Robert A Zambias
Frances Aileen Bouffard
James F Dropinski
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE162200T1 publication Critical patent/ATE162200T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT92308985T 1991-10-01 1992-10-01 Bisaminierte zyklohexapeptide ATE162200T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77102791A 1991-10-01 1991-10-01
US07/936,558 US6030944A (en) 1991-10-01 1992-09-03 Cyclohexapeptidyl bisamine compounds

Publications (1)

Publication Number Publication Date
ATE162200T1 true ATE162200T1 (de) 1998-01-15

Family

ID=27118389

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92308985T ATE162200T1 (de) 1991-10-01 1992-10-01 Bisaminierte zyklohexapeptide

Country Status (9)

Country Link
US (1) US6030944A (de)
EP (1) EP0535967B1 (de)
JP (1) JPH0794470B2 (de)
AT (1) ATE162200T1 (de)
CA (1) CA2079187C (de)
DE (1) DE69224027T2 (de)
DK (1) DK0535967T3 (de)
ES (1) ES2111616T3 (de)
GR (1) GR3025914T3 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6268338B1 (en) * 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
ATE206054T1 (de) * 1995-01-26 2001-10-15 Merck & Co Inc Neue fungizide cyclohexapeptide
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
EP1785432A1 (de) 2005-11-15 2007-05-16 Sandoz AG Verfahren und Zwischenprodukte zur Synthese des Caspofungins
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
WO2010008493A2 (en) * 2008-06-25 2010-01-21 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
EP2680873B1 (de) 2011-03-03 2017-08-09 Cidara Therapeutics, Inc. Antifungale mittel und anwendungen davon
HRP20231151T1 (hr) 2012-03-19 2024-01-05 Cidara Therapeutics, Inc. Režimi za doziranje spojeva iz klase ehinokandina
WO2016201283A1 (en) * 2015-06-12 2016-12-15 Cidara Therapeutics, Inc. Antifungal agents
WO2017120471A1 (en) 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
CN109154603A (zh) 2016-03-16 2019-01-04 奇达拉治疗公司 用于治疗真菌感染的给药方案
CA3069423C (en) 2017-07-12 2025-04-15 Napp Pharmaceutical Group Limited Formulations for the treatment of fungal infections
EP3620462A1 (de) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Verfahren zur herstellung von caspofungin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4173629A (en) * 1975-07-08 1979-11-06 Sandoz Ltd. Antibiotic S 31794/F-1
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4320054A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912H nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4968608A (en) * 1987-10-07 1990-11-06 Merck & Co., Inc. Process for antifungal fermentation product
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5021403A (en) * 1990-03-19 1991-06-04 Merck & Co., Inc. Antibiotic agents
EP0486011A3 (en) * 1990-11-16 1992-07-15 Fujisawa Pharmaceutical Co., Ltd. Pharmaceutical composition against pneumocystis carinii

Also Published As

Publication number Publication date
CA2079187C (en) 2000-09-19
DK0535967T3 (da) 1998-02-09
GR3025914T3 (en) 1998-04-30
EP0535967B1 (de) 1998-01-14
EP0535967A2 (de) 1993-04-07
DE69224027T2 (de) 1998-08-13
EP0535967A3 (de) 1994-04-06
US6030944A (en) 2000-02-29
DE69224027D1 (de) 1998-02-19
CA2079187A1 (en) 1993-04-02
ES2111616T3 (es) 1998-03-16
JPH0794470B2 (ja) 1995-10-11
JPH05239094A (ja) 1993-09-17

Similar Documents

Publication Publication Date Title
DE69224027D1 (de) Bisaminierte Zyklohexapeptide
SE8804036L (sv) Ny anvaendning av 11,28-dioxa-4-azatricklo (22.3.1.04.9)-oktakos-18-en-derivat och farmaceutiska kompositioner innehaallande desamma
HU9202720D0 (en) Preparatives and methods qpplicables for treatment of infections caused by organismm being sensible to beta-lactame antibiotics
DK0535959T3 (da) Cyclohexapeptidylpropanolaminforbindelser
FR2669029B1 (fr) Nouveaux derives de la n-benzoyl proline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
BG47034A3 (bg) Метод за получаване на 7-//мета-заместени/-пеницилини/- -1-карба-1-детиацефалоспорини
DK0531413T3 (da) Et antiviralt præparat indeholdende prostratin
DK0406745T3 (da) Antibiotiske GE 2270 faktorer A1, A2, A3 og H
DK0451486T3 (da) Antibiotikum GE 2270 faktorer B1, B2, C1, C2, D1, D2, E og T
GR3002679T3 (en) Dihydropyridinamides, process for their preparation and their use in medicines
EP0529410A3 (en) Antibiotic ge 2270 factor c2a
ATE240350T1 (de) Hydroxypropionitril-cyclohexapeptide
ES2094757T3 (es) Un factor megacariocitopoyetico.
DK0675900T3 (da) Antibiotika GE 37468 A, B og C
FR2703048B1 (fr) Nouveaux composes n-benzylpiperazine, leur procede de preparation et les compositions pharmaceutiques les renfermant.
GR3004095T3 (de)
NO911798D0 (no) 3'-deamino-4'-deoksy-4'-amino-8-fluorantracykliner og deres fremstilling.
DK0580644T3 (da) 1,3,4-trisubstituerede piperidin-derivater, fremstilling og anvendelse heraf
DK627188A (da) Farmaceutisk komposition
BR1100204A (pt) Composição farmacêutica para tratar esquizofrenia

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee