ATE162524T1 - Hydrazine mit einer n3s konfiguration als radionukleide chelatoren - Google Patents
Hydrazine mit einer n3s konfiguration als radionukleide chelatorenInfo
- Publication number
- ATE162524T1 ATE162524T1 AT94922812T AT94922812T ATE162524T1 AT E162524 T1 ATE162524 T1 AT E162524T1 AT 94922812 T AT94922812 T AT 94922812T AT 94922812 T AT94922812 T AT 94922812T AT E162524 T1 ATE162524 T1 AT E162524T1
- Authority
- AT
- Austria
- Prior art keywords
- radionucleate
- hydrazines
- chelators
- configuration
- targeting molecules
- Prior art date
Links
- 239000002738 chelating agent Substances 0.000 title 1
- 150000002429 hydrazines Chemical class 0.000 title 1
- 230000008685 targeting Effects 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000021615 conjugation Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Transmitters (AREA)
- Transceivers (AREA)
- Peptides Or Proteins (AREA)
- Lock And Its Accessories (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9291193A | 1993-07-19 | 1993-07-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE162524T1 true ATE162524T1 (de) | 1998-02-15 |
Family
ID=22235766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94922812T ATE162524T1 (de) | 1993-07-19 | 1994-07-18 | Hydrazine mit einer n3s konfiguration als radionukleide chelatoren |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5659041A (de) |
| EP (1) | EP0710228B1 (de) |
| JP (1) | JPH09500140A (de) |
| AT (1) | ATE162524T1 (de) |
| AU (1) | AU7261994A (de) |
| CA (1) | CA2167167A1 (de) |
| DE (1) | DE69408145T2 (de) |
| DK (1) | DK0710228T3 (de) |
| ES (1) | ES2114209T3 (de) |
| GR (1) | GR3026658T3 (de) |
| WO (1) | WO1995003280A1 (de) |
Families Citing this family (75)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849261A (en) * | 1991-02-08 | 1998-12-15 | Diatide, Inc. | Radiolabeled vasoactive intestinal peptides for diagnosis and therapy |
| US5569745A (en) * | 1994-02-25 | 1996-10-29 | Resolution Pharmaceuticals Inc. | Peptide-Chelator conjugates |
| US5662885A (en) * | 1994-07-22 | 1997-09-02 | Resolution Pharmaceuticals Inc. | Peptide derived radionuclide chelators |
| US5804158A (en) * | 1995-05-31 | 1998-09-08 | Resolution Pharmaceuticals Inc. | Sequestered imaging agents |
| US6027711A (en) * | 1995-06-07 | 2000-02-22 | Rhomed Incorporated | Structurally determined metallo-constructs and applications |
| US5891418A (en) * | 1995-06-07 | 1999-04-06 | Rhomed Incorporated | Peptide-metal ion pharmaceutical constructs and applications |
| DE19536781A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ XSNS für radioaktive Isotope |
| DE19536785A1 (de) * | 1995-09-21 | 1997-03-27 | Diagnostikforschung Inst | Bifunktionelle sulfidhaltige Sulfonamid-Chelatbildner vom Typ S¶2¶NY für radioaktive Isotope |
| AU2323197A (en) * | 1996-03-13 | 1997-10-01 | Du Pont Pharmaceuticals Company | New ternary radiopharmaceutical complexes |
| AU4753997A (en) * | 1996-10-16 | 1998-05-11 | Burnham Institute, The | Magnetic resonance imaging of thrombi |
| US7060251B1 (en) | 1997-09-08 | 2006-06-13 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
| WO1999012579A1 (en) * | 1997-09-08 | 1999-03-18 | The General Hospital Corporation | Imaging agents for early detection and monitoring of cardiovascular plaque |
| CA2320339A1 (en) * | 1998-02-11 | 1999-08-19 | Resolution Pharmaceuticals Inc. | Angiogenesis targeting molecules |
| US6548663B1 (en) | 1998-03-31 | 2003-04-15 | Bristol-Myers Squibb Pharma Company | Benzodiazepine vitronectin receptor antagonist pharmaceuticals |
| US6524553B2 (en) * | 1998-03-31 | 2003-02-25 | Bristol-Myers Squibb Pharma Company | Quinolone vitronectin receptor antagonist pharmaceuticals |
| US6537520B1 (en) | 1998-03-31 | 2003-03-25 | Bristol-Myers Squibb Pharma Company | Pharmaceuticals for the imaging of angiogenic disorders |
| EP1068224B1 (de) | 1998-03-31 | 2005-05-11 | Bristol-Myers Squibb Pharma Company | Pharmazeutika zur bildgebung der angiogenischen krankheiten |
| AU3119199A (en) | 1998-04-03 | 1999-10-25 | Du Pont Pharmaceuticals Company | Radiopharmaceuticals for imaging infection and inflammation and for imaging and treatment of cancer |
| US6511649B1 (en) * | 1998-12-18 | 2003-01-28 | Thomas D. Harris | Vitronectin receptor antagonist pharmaceuticals |
| CA2349333A1 (en) * | 1998-12-18 | 2000-06-22 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
| EP1140204A2 (de) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronektin-rezeptor antagonist arzeimittheln |
| US6794518B1 (en) * | 1998-12-18 | 2004-09-21 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| US6569402B1 (en) | 1998-12-18 | 2003-05-27 | Bristol-Myers Squibb Pharma Company | Vitronectin receptor antagonist pharmaceuticals |
| US7320784B1 (en) | 1999-02-17 | 2008-01-22 | Bracco Imaging S.P.A. | Immobilized labeling compounds and methods |
| US6409987B1 (en) | 1999-04-07 | 2002-06-25 | Intimax Corporation | Targeted agents useful for diagnostic and therapeutic applications |
| WO2001039664A1 (en) * | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Method and apparatus for measuring indices of brain activity |
| US6907280B2 (en) * | 1999-12-02 | 2005-06-14 | The General Hospital Corporation | Method and apparatus for objectively measuring pain, pain treatment and other related techniques |
| US7109167B2 (en) * | 2000-06-02 | 2006-09-19 | Bracco International B.V. | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| US8263739B2 (en) * | 2000-06-02 | 2012-09-11 | Bracco Suisse Sa | Compounds for targeting endothelial cells, compositions containing the same and methods for their use |
| US7311893B2 (en) * | 2000-07-25 | 2007-12-25 | Neurochem (International) Limited | Amyloid targeting imaging agents and uses thereof |
| JP4689803B2 (ja) * | 2000-09-11 | 2011-05-25 | 住友化学株式会社 | （２ｓ，４ｓ）−ｎ，ｎ−ジメチル−１−アリルオキシカルボニル−４−ベンゾイルチオ−２−ピロリジンカルボキサミドの製造方法 |
| GB0105224D0 (en) * | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
| US20070021345A1 (en) * | 2003-06-30 | 2007-01-25 | Ehud Gazit | Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases |
| US7781396B2 (en) * | 2002-01-31 | 2010-08-24 | Tel Aviv University Future Technology Development L.P. | Peptides directed for diagnosis and treatment of amyloid-associated disease |
| AU2003207973A1 (en) * | 2002-01-31 | 2003-09-02 | Tel Aviv University Future Technology Development L.P. | Peptides antibodies directed thereagainst and methods using same for diagnosing and treating amyloid-associated diseases |
| US20040052928A1 (en) * | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
| AU2003278807A1 (en) | 2002-03-01 | 2004-08-13 | Bracco International B.V. | Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy |
| US8623822B2 (en) | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| ES2398393T3 (es) | 2002-03-01 | 2013-03-15 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia |
| US7794693B2 (en) | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7491699B2 (en) * | 2002-12-09 | 2009-02-17 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures and methods of generating and using the same |
| ATE426575T1 (de) * | 2003-01-07 | 2009-04-15 | Univ Ramot | Peptidenanostrukturen die fremdmaterial enthalten,und verfahren zur herstellung derselben |
| ES2396368T3 (es) | 2003-03-03 | 2013-02-21 | Dyax Corporation | Péptidos que se unen específicamente al receptor del HGF (CMET) y usos de los mismos |
| EP1663199B1 (de) | 2003-09-25 | 2013-04-03 | Tel Aviv University Future Technology Development L.P. | Zusammensetzungen und diese verwendende verfahren zur behandlung von amyloid-bedingten erkrankungen |
| WO2005031362A2 (en) * | 2003-10-02 | 2005-04-07 | Ramot At Tel Aviv University Ltd. | Novel antibacterial agents and methods of identifying and utilizing same |
| US8007847B2 (en) | 2004-01-13 | 2011-08-30 | Eytan Biderman | Feeding formula appliance |
| US20090156471A1 (en) * | 2004-07-15 | 2009-06-18 | Ramot At Tel Aviv University Ltd. | Use of anti-amyloid agents for treating and typing pathogen infections |
| EP1781310B1 (de) * | 2004-08-02 | 2015-10-14 | Ramot at Tel Aviv University Ltd. | Artikel von peptidnanostrukturen und herstellungsverfahren dafür |
| US7732479B2 (en) | 2004-08-19 | 2010-06-08 | Tel Aviv University Future Technology Development L.P. | Compositions for treating amyloid associated diseases |
| WO2006027780A2 (en) * | 2004-09-08 | 2006-03-16 | Ramot At Tel Aviv University Ltd. | Peptide nanostructures containing end-capping modified peptides and methods of generating and using the same |
| PT1737889E (pt) | 2004-10-19 | 2010-12-13 | Lonza Ag | Método para síntese de péptidos em fase sólida |
| JP2008527563A (ja) * | 2005-01-16 | 2008-07-24 | ズランゴー リミテッド | アイコニック通信 |
| WO2006075335A2 (en) * | 2005-01-16 | 2006-07-20 | Zlango Ltd. | Communications network system and methods for using same |
| EP1973928A2 (de) * | 2005-10-11 | 2008-10-01 | Ramot at Tel-Aviv University Ltd. | Selbstzusammengebaute fmoc-ff-hydrogele |
| US7879212B2 (en) * | 2005-11-03 | 2011-02-01 | Ramot At Tel-Aviv University Ltd. | Peptide nanostructure-coated electrodes |
| EP1977312A2 (de) | 2006-01-16 | 2008-10-08 | Zlango Ltd. | Bildzeichenkommunikation |
| EP1982450A2 (de) * | 2006-01-16 | 2008-10-22 | Zlango Ltd. | Kommunikationsnetzsystem und verfahren zu seiner verwendung |
| CN101558081B (zh) | 2006-12-11 | 2014-08-20 | 伯拉考成像股份公司 | 用于诊断和治疗应用的纤维蛋白结合肽缀合体 |
| EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
| TW201225972A (en) | 2010-11-15 | 2012-07-01 | Univ Ramot | Dipeptide analogs for treating conditions associated with amyloid fibril formation |
| US20150344523A1 (en) | 2014-05-05 | 2015-12-03 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
| EP3322716B1 (de) | 2015-07-15 | 2025-02-12 | California Institute of Technology | Il-17f-spezifische einfänger und verfahren zur verwendung |
| WO2017137477A1 (en) | 2016-02-09 | 2017-08-17 | Bracco Suisse Sa | A recombinant chimeric protein for selectins targeting |
| EP3440101B1 (de) | 2016-04-04 | 2021-10-06 | Indi Molecular, Inc. | Cd8-spezifische einfänger, zusammensetzungen und verfahren zur verwendung und herstellung davon |
| US11884707B2 (en) | 2016-09-29 | 2024-01-30 | Regeneron Pharmaceuticals, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same |
| EP3535278A4 (de) | 2016-11-01 | 2020-06-24 | Ohio State Innovation Foundation | Verfahren zur jodierung von biomolekülen |
| WO2018232345A1 (en) | 2017-06-15 | 2018-12-20 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
| WO2019241851A1 (en) * | 2018-06-22 | 2019-12-26 | La Trobe University | Inhibitors of lysine biosynthesis via the diaminopimelate pathway |
| WO2020097531A1 (en) | 2018-11-08 | 2020-05-14 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
| US12216122B2 (en) | 2019-05-20 | 2025-02-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1) |
| US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
| WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
| CA3227425A1 (en) | 2021-07-26 | 2023-02-02 | Arvinas Operations, Inc. | Methods of manufacturing a bifunctional compound |
Family Cites Families (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732864A (en) * | 1983-10-06 | 1988-03-22 | E. I. Du Pont De Nemours And Company | Trace-labeled conjugates of metallothionein and target-seeking biologically active molecules |
| US4980147A (en) * | 1984-06-25 | 1990-12-25 | University Of Utah Research Foundation | Radiolabeled technetium chelates for use in renal function determinations |
| US4897255A (en) * | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5037630A (en) * | 1985-01-14 | 1991-08-06 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5120526A (en) * | 1985-01-14 | 1992-06-09 | Neorx Corporation | Method of producing metal radionuclide labeled proteins for diagnosis and therapy |
| US5175343A (en) * | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
| US5187264A (en) * | 1986-05-28 | 1993-02-16 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| ATE52516T1 (de) * | 1986-05-28 | 1990-05-15 | Mallinckrodt Inc | Technetiumchelate fuer die bestimmung der nierenfunktion. |
| US5082930A (en) * | 1986-05-29 | 1992-01-21 | Mallinckrodt Medical, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| US5091514A (en) * | 1987-03-26 | 1992-02-25 | Neorx Corporation | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy |
| US4965392A (en) * | 1987-03-26 | 1990-10-23 | Neorx Corporation | Chelating compounds for metal-radionuclide labeled proteins |
| DE68923274T2 (de) * | 1988-02-09 | 1995-11-09 | Mallinckrodt Inc | Verfahren zur herstellung eines mit metall-radionuklid-markierten proteins. |
| US5202451A (en) * | 1988-02-17 | 1993-04-13 | Neorx Corporation | Anchimeric radiometal chelating compounds |
| CA1340899C (en) * | 1988-03-09 | 2000-02-15 | Andre Bardy | Procede de preparation de complexes nitruro 99m tc, 186 re ou 188 re utilisables comme produits radiopharmaceutiques |
| US5089249A (en) * | 1988-06-10 | 1992-02-18 | Neorx Corporation | Conjugates for bone imaging and bone cancer therapy |
| WO1990006323A2 (en) * | 1988-11-29 | 1990-06-14 | Centocor, Inc. | Chimeric proteins incorporating a metal binding protein |
| IL93432A (en) * | 1989-02-24 | 1994-02-27 | Johnson Mathey Inc | Hydrazines and hydrazides, their conjugates with macromolecules and such conjugates labelled with metal ions |
| US5196515A (en) * | 1989-03-17 | 1993-03-23 | The Johns Hopkins University | Thiolactone bifunctional chelating agents for diagnostic and therapeutic products |
| US5095111A (en) * | 1989-03-17 | 1992-03-10 | The John Hopkins University | Thiolactone bifunctional chelating agents for diagnostic and therapeutic products |
| US5175257A (en) * | 1989-12-29 | 1992-12-29 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
| US5112953A (en) * | 1989-12-29 | 1992-05-12 | Neorx Corporation | Radiolabeled proteins for diagnostic or therapeutic use |
| WO1991016076A1 (en) * | 1990-04-17 | 1991-10-31 | Mallinckrodt Medical, Inc. | Method and kit for preparing technetium-99m complexes |
| AU9172191A (en) * | 1990-12-12 | 1992-07-08 | Mallinckrodt Medical, Inc. | Method of radioactive labelling of blood cells and kit therefor |
| US5243073A (en) * | 1990-12-14 | 1993-09-07 | Mallinckrodt Medical, Inc. | Hexadentate ligands useful in radiographic imaging agents |
| US5908931A (en) * | 1990-12-14 | 1999-06-01 | Mallinckrodt Inc. | Preorganized hexadentate ligands useful in radiographic imaging agents |
| US5112594A (en) * | 1991-04-04 | 1992-05-12 | Mallinckrodt Medical, Inc. | Kit for preparing a technetium-99m myocardial imaging agent |
| US5112595A (en) * | 1990-12-21 | 1992-05-12 | Mallinckrodt Medical, Inc. | 99MTC(III) myocardial imaging agents and method of use |
| DE69230525T2 (de) * | 1991-02-08 | 2000-06-21 | Diatide, Inc. | Technetium-99m markierte Polypeptide zur Bildformung |
| WO1992019235A2 (en) * | 1991-05-01 | 1992-11-12 | The Curators Of The University Of Missouri | Multifunctional ligand for use as a diagnostic or therapeutic pharmaceutical |
| AU1995392A (en) * | 1991-05-08 | 1992-12-21 | Mallinckrodt Medical, Inc. | Technetium chelates to be used for determining the renal function |
| WO1992021383A1 (en) * | 1991-06-03 | 1992-12-10 | Mallinckrodt Medical, Inc. | Radiolabelled somatostatin derivatives, their preparation and use |
| AU670029B2 (en) * | 1991-08-05 | 1996-07-04 | Mallinckrodt Medical, Inc. | Heavy metal clusters for use as imaging agents |
-
1994
- 1994-07-18 ES ES94922812T patent/ES2114209T3/es not_active Expired - Lifetime
- 1994-07-18 EP EP94922812A patent/EP0710228B1/de not_active Expired - Lifetime
- 1994-07-18 AU AU72619/94A patent/AU7261994A/en not_active Abandoned
- 1994-07-18 CA CA002167167A patent/CA2167167A1/en not_active Abandoned
- 1994-07-18 AT AT94922812T patent/ATE162524T1/de not_active IP Right Cessation
- 1994-07-18 WO PCT/CA1994/000395 patent/WO1995003280A1/en not_active Ceased
- 1994-07-18 JP JP7504829A patent/JPH09500140A/ja active Pending
- 1994-07-18 DE DE69408145T patent/DE69408145T2/de not_active Expired - Fee Related
- 1994-07-18 DK DK94922812T patent/DK0710228T3/da active
- 1994-09-02 US US08/299,636 patent/US5659041A/en not_active Expired - Lifetime
-
1998
- 1998-04-15 GR GR980400861T patent/GR3026658T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0710228B1 (de) | 1998-01-21 |
| US5659041A (en) | 1997-08-19 |
| DK0710228T3 (da) | 1998-09-21 |
| CA2167167A1 (en) | 1995-02-02 |
| GR3026658T3 (en) | 1998-07-31 |
| JPH09500140A (ja) | 1997-01-07 |
| DE69408145D1 (de) | 1998-02-26 |
| ES2114209T3 (es) | 1998-05-16 |
| WO1995003280A1 (en) | 1995-02-02 |
| DE69408145T2 (de) | 1998-09-03 |
| EP0710228A1 (de) | 1996-05-08 |
| AU7261994A (en) | 1995-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE162524T1 (de) | Hydrazine mit einer n3s konfiguration als radionukleide chelatoren | |
| DE69417426D1 (de) | N2s2-chelatoren des hydrazino-typs | |
| DE69434384D1 (de) | Metalkomplexbildner | |
| ATE58297T1 (de) | Kupplungsmittel zum radiomarkieren von proteinen. | |
| NO304552B1 (no) | Kompleksforbindelser, konjugater, farmas°ytiske preparater inneholdende slike og forbindelser | |
| DK0570493T3 (da) | Technetium-99m-mærkede polypeptider til billeddannelse. | |
| FI951138A7 (fi) | Puuttellisia adenovirusvektoreita ja niiden käyttö geeniterapiassa | |
| FI956019A7 (fi) | Eristettyjä peptidejä, jotka muodostavat komplekseja MHC-molekyyli HLA -C-klooni-10:n kanssa, ja niiden käyttö | |
| NO301829B1 (no) | 2-pyridylmetylenpolyazamakrocyklo-fosfonsyrer, komplekser og farmasöytiske preparater basert på disse | |
| GB9318207D0 (en) | Improvements in or relating to organic compounds | |
| EA199800946A1 (ru) | Концентрированный препарат антител | |
| EP0724456A4 (de) | Antikörper gegen cd40 | |
| ATE544776T1 (de) | Chimäre dna-bindeproteine | |
| NO983182L (no) | Nye sykloalkylsubstituertere imidazoler | |
| DE3586479D1 (de) | Markierte antikoerperfragmente. | |
| DK1017715T3 (da) | Kimært polypeptid der omfatter fragment B af shiga-toksin og peptider af terapeutisk interesse | |
| ATE476495T1 (de) | Bazillus thuringiensis und dessen insektizide proteine | |
| ATE194168T1 (de) | Varianten in den leltin domäne von selektin | |
| NO971059L (no) | Modifiserte human-C3-proteiner | |
| DK0610286T3 (da) | Rekombinante immunotoxiner | |
| ES2119161T3 (es) | Soluciones de dialisis peritoneal mejoradas que incluyen polipeptidos. | |
| TR199500854A2 (tr) | Memeli hayvanlarin karacigerinden elde edilen proteinler ve bunlarin onkolojide kullanimi. | |
| DK400786D0 (da) | Udtrykkelsesvektorer til anvendelse i e.coli | |
| FI961339A0 (fi) | Triaryylieteenijohdannaiset käytettäväksi hoidossa | |
| DK0938555T3 (da) | Konstruktioner og komplekser af cyclin E |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |