ATE194168T1 - Varianten in den leltin domäne von selektin - Google Patents

Varianten in den leltin domäne von selektin

Info

Publication number: ATE194168T1
Authority: AT; Austria
Prior art keywords: variants; selectin; domain; selektin; leltin
Prior art date: 1992-04-30

Application number

AT93910869T

Other languages

English (en)

Inventor

David V Erbe

Laurence A Lasky

Leonard G Presta

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-04-30

Filing date

1993-04-28

Publication date

2000-07-15

1993-04-28 Application filed by Genentech Inc filed Critical Genentech Inc

2000-07-15 Application granted granted Critical

2000-07-15 Publication of ATE194168T1 publication Critical patent/ATE194168T1/de

Links

AAEVYOVXGOFMJO-UHFFFAOYSA-N prometryn Chemical compound CSC1=NC(NC(C)C)=NC(NC(C)C)=N1 AAEVYOVXGOFMJO-UHFFFAOYSA-N 0.000 title abstract 3
102000003800 Selectins Human genes 0.000 abstract 3
108090000184 Selectins Proteins 0.000 abstract 3
108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
239000013604 expression vector Substances 0.000 abstract 2
102000004856 Lectins Human genes 0.000 abstract 1
108090001090 Lectins Proteins 0.000 abstract 1
125000003275 alpha amino acid group Chemical group 0.000 abstract 1
230000004075 alteration Effects 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
239000002523 lectin Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/7056—Lectin superfamily, e.g. CD23, CD72
- C07K14/70564—Selectins, e.g. CD62
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Cell Biology (AREA)
Rheumatology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Semiconductor Memories (AREA)
Non-Volatile Memory (AREA)

AT93910869T 1992-04-30 1993-04-28 Varianten in den leltin domäne von selektin ATE194168T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US87903692A	1992-04-30	1992-04-30
US95670192A	1992-10-01	1992-10-01
PCT/US1993/003987 WO1993022436A1 (en)	1992-04-30	1993-04-28	Lectin domain variants of selectin

Publications (1)

Publication Number	Publication Date
ATE194168T1 true ATE194168T1 (de)	2000-07-15

Family

ID=27128518

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93910869T ATE194168T1 (de)	1992-04-30	1993-04-28	Varianten in den leltin domäne von selektin

Country Status (12)

Country	Link
US (1)	US5593882A (de)
EP (1)	EP0639224B1 (de)
JP (2)	JPH07506253A (de)
AT (1)	ATE194168T1 (de)
AU (1)	AU674317B2 (de)
CA (1)	CA2134756C (de)
DE (1)	DE69328928T2 (de)
DK (1)	DK0639224T3 (de)
ES (1)	ES2152251T3 (de)
GR (1)	GR3034447T3 (de)
PT (1)	PT639224E (de)
WO (1)	WO1993022436A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU707440B2 (en)	1994-03-29	1999-07-08	Celltech Therapeutics Limited	Antibodies against E-selectin
US6127524A (en) *	1996-10-18	2000-10-03	Dade Behring Inc.	Binding molecules and computer-based methods of increasing the binding affinity thereof
EP1282425A4 (de) *	2000-05-19	2004-09-15	Inst Genetics Llc	Kristallstrukture von p-selectin, komplexe aus p- und e-selectin, und verwendung davon
EP1842551A1 (de) *	2000-05-24	2007-10-10	The Government of the United States of America as represented by The Secretary of the Department of Health and Human Services	E-selectin zur behandlung oder vorbeugung von schlaganfall
US7897575B2 (en) *	2000-05-24	2011-03-01	The United States Of America As Represented By The Department Of Health And Human Services	Treatment and prevention of vascular dementia
DE60138764D1 (de)	2000-12-13	2009-07-02	Anaphore Inc	Methode zur identifikation und isolation von peptide die andere moleküle binden aus kombinatorische proteinbibliotheken mit einer c-typ lectin-ähnlichen domäne als gerüststruktur
EP2284270A3 (de)	2000-12-13	2012-07-25	Anaphore, Inc.	Verfahren zur Identifizierung und Isolierung von bindenden Polypeptiden aus kombinatorischen Bibliotheken von Proteinen mit der Gerüststruktur von lectinähnlichen Domänen vom C-typ
ATE458045T1 (de) *	2001-02-20	2010-03-15	Summit Glycores Corp	Lectine zur analyse von zuckerketten und verfahren zu ihrer verwendung
US20040116333A1 (en) *	2001-08-03	2004-06-17	Rong-Hwa Lin	Modulators of P-selectin glycoprotein ligand 1
AU2002359815A1 (en)	2001-12-19	2003-07-09	Immunex Corporation	C-type lectin polypeptide, polynucleotide and methods of making and use thereof
US20070244043A1 (en) *	2005-03-10	2007-10-18	Novavax, Inc.	Recombinant E-selectin made in insect cells
PL2662091T3 (pl)	2006-12-01	2019-05-31	Novartis Ag	Przeciwciała skierowane przeciwko selektynie P i sposoby ich zastosowania do leczenia chorób zapalnych
US8945565B2 (en)	2006-12-01	2015-02-03	Selexys Pharmaceuticals Corporation	Methods of treating inflammatory or thrombotic conditions with anti-P-selectin antibodies
WO2009036349A1 (en) *	2007-09-12	2009-03-19	Anaphore, Inc.	Hsp70-based treatment for autoimmune diseases
US20110086806A1 (en) *	2009-10-09	2011-04-14	Anaphore, Inc.	Polypeptides that Bind IL-23R
US20110086770A1 (en) *	2009-10-09	2011-04-14	Anaphore, Inc.	Combinatorial Libraries Based on C-type Lectin-like Domain
EP3222635A1 (de) *	2010-12-21	2017-09-27	Selexys Pharmaceuticals Corporation	Anti-p-selectin-antikörper und verfahren zu ihrer verwendung und identifizierung
US9616114B1 (en)	2014-09-18	2017-04-11	David Gordon Bermudes	Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
US10676723B2 (en)	2015-05-11	2020-06-09	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en)	2016-12-07	2021-11-23	David Gordon Bermudes	Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
US11129906B1 (en)	2016-12-07	2021-09-28	David Gordon Bermudes	Chimeric protein toxins for expression by therapeutic bacteria
WO2018178991A1 (en) *	2017-03-29	2018-10-04	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd	Purification of an agent of interest
CN121108302A (zh) *	2025-09-22	2025-12-12	渼达(广州)生物科技有限公司	一种重组人Fc和P-选择素的重组蛋白、检测产品及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5081034A (en) *	1988-11-14	1992-01-14	Brigham & Women's Hospital	Cloned genes which encode elam-1
US5098833A (en) *	1989-02-23	1992-03-24	Genentech, Inc.	DNA sequence encoding a functional domain of a lymphocyte homing receptor
DK0714912T3 (da) *	1990-07-17	2003-02-03	Univ Oklahoma	Funktionelt aktive selektin-deriverede peptider og ligander for GMP-140

1993
- 1993-04-28 EP EP93910869A patent/EP0639224B1/de not_active Expired - Lifetime
- 1993-04-28 DE DE69328928T patent/DE69328928T2/de not_active Expired - Lifetime
- 1993-04-28 AT AT93910869T patent/ATE194168T1/de active
- 1993-04-28 ES ES93910869T patent/ES2152251T3/es not_active Expired - Lifetime
- 1993-04-28 AU AU42208/93A patent/AU674317B2/en not_active Expired
- 1993-04-28 JP JP5519482A patent/JPH07506253A/ja active Pending
- 1993-04-28 PT PT93910869T patent/PT639224E/pt unknown
- 1993-04-28 DK DK93910869T patent/DK0639224T3/da active
- 1993-04-28 CA CA2134756A patent/CA2134756C/en not_active Expired - Lifetime
- 1993-04-28 WO PCT/US1993/003987 patent/WO1993022436A1/en not_active Ceased
1994
- 1994-07-13 US US08/274,661 patent/US5593882A/en not_active Expired - Lifetime
2000
- 2000-09-20 GR GR20000402139T patent/GR3034447T3/el unknown
2003
- 2003-06-24 JP JP2003179641A patent/JP3749529B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0639224A1 (de)	1995-02-22
AU4220893A (en)	1993-11-29
WO1993022436A1 (en)	1993-11-11
PT639224E (pt)	2000-12-29
JPH07506253A (ja)	1995-07-13
AU674317B2 (en)	1996-12-19
DE69328928T2 (de)	2000-11-30
ES2152251T3 (es)	2001-02-01
DK0639224T3 (da)	2000-10-30
GR3034447T3 (en)	2000-12-29
JP3749529B2 (ja)	2006-03-01
CA2134756A1 (en)	1993-11-11
EP0639224B1 (de)	2000-06-28
US5593882A (en)	1997-01-14
DE69328928D1 (de)	2000-08-03
JP2004049234A (ja)	2004-02-19
CA2134756C (en)	2010-04-20

Legal Events

Date	Code	Title	Description
2000-10-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69328928D1 (de)	2000-08-03	Varianten in den leltin domäne von selektin
ATE215601T1 (de)	2002-04-15	Rezeptoren der steroid/thyroid superfamilie von rezeptoren
DK0640135T3 (da)	2001-02-05	Immunoglobulinbindende proteiner, der er afledt af protein L, og anvendelser af disse
DE69408145D1 (de)	1998-02-26	Hydrazine mit einer n3s konfiguration als radionukleide chelatoren
ATE178053T1 (de)	1999-04-15	N2s2-chelatoren des hydrazino-typs
DE69433406T2 (de)	2004-10-07	Antikörper gegen cd40
BR0011849A (pt)	2003-05-27	Anticorpos enxertados lm609 melhorados
TR199900267T2 (xx)	2000-09-21	GnRH-L�kotoksin kimeralar�.
FI20010060A7 (fi)	2001-01-11	5-metoksi-indoli-3-karboksialdehydiamino-(pentyyliamino)metyleeni-hydratsoni
DK0713495T3 (da)	2004-03-08	Fremgangsmåder til forstærkning af den biologiske aktivitet af chemokiner
EA200000144A1 (ru)	2000-08-28	Направленный цитолиз клеток-мишеней, агенты и композиции, вызывающие цитолиз, и соединения, которые можно использовать для получения этих агентов
PT726955E (pt)	2004-08-31	Proteinas quimericas compreendendo polipeptidos borrelia: suas utilizacoes
DE69434384D1 (de)	2005-06-30	Metalkomplexbildner
ES2129487T3 (es)	1999-06-16	Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
DE58903171D1 (de)	1993-02-11	Verwendung von methylpolysiloxanen mit quartaeren ammoniumgruppen als korrosionsinhibitoren fuer ueberwiegend aus wasser bestehende zubereitungen.
DE602004022390D1 (de)	2009-09-17	Verbesserte fc-fusionsproteine
ATE171212T1 (de)	1998-10-15	Corticotropin freisetzende rezeptoren des faktor 2
DK0610260T3 (da)	2000-07-24	Vacciner mod Actinobacillus pleuropneumoniae
DK1279677T3 (da)	2007-05-07	GD3-mimetiske peptider
DK1379273T3 (da)	2009-11-09	Nukleinsyreadjuvanser
ATE417112T1 (de)	2008-12-15	Steigerung der immunantwort unter verwendung von zielgerichteten molekülen
DE69619808D1 (de)	2002-04-25	Chimäre msp und daf proteine mit einem telloberflächenlokalisierendem domän
NO962827L (no)	1996-08-21	Monoklonale antistoffer mot antigener uttrykt av hematopoietider facilitatoriske celler
ATE215123T1 (de)	2002-04-15	Or-1, ein wais-rezeptor der nuklearen rezeptoren familie
DK0938555T3 (da)	2005-05-23	Konstruktioner og komplekser af cyclin E