ATE162946T1 - Pharmazeutische zusammensetzungen enthaltend contignasterol-verbindungen - Google Patents

Pharmazeutische zusammensetzungen enthaltend contignasterol-verbindungen

Info

Publication number: ATE162946T1
Authority: AT; Austria
Prior art keywords: compounds; pct; hydroxyl; contignasterol; compositions containing
Prior art date: 1992-12-23

Application number

AT94902581T

Other languages

English (en)

Inventor

Raymond J Andersen

Theresa M Allen

David L Burgoyne

Original Assignee

Univ British Columbia

Univ Alberta

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-23

Filing date

1993-12-21

Publication date

1998-02-15

1993-12-21 Application filed by Univ British Columbia, Univ Alberta filed Critical Univ British Columbia

1998-02-15 Application granted granted Critical

1998-02-15 Publication of ATE162946T1 publication Critical patent/ATE162946T1/de

Links

IRHVLQMEQPABHG-QUZWXNHXSA-N (3r,4r,5r,6r,7r,8r,9s,10r,13r,14r,17r)-3,4,6,7-tetrahydroxy-17-[(1s)-1-[(2r,4s)-6-hydroxy-4-propan-2-yloxan-2-yl]ethyl]-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,16,17-tetradecahydrocyclopenta[a]phenanthren-15-one Chemical class C1[C@H](C(C)C)CC(O)O[C@H]1[C@@H](C)[C@@H]1[C@@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](O)[C@H](O)[C@@H]4[C@@H](O)[C@H](O)[C@H]3[C@H]2C(=O)C1 IRHVLQMEQPABHG-QUZWXNHXSA-N 0.000 title abstract 2
239000008194 pharmaceutical composition Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
IRHVLQMEQPABHG-ZPCNDTDRSA-N Contignasterol Natural products O=C1[C@H]2[C@@](C)([C@@H]([C@H](C)[C@@H]3O[C@H](O)C[C@H](C(C)C)C3)C1)CC[C@@H]1[C@]3(C)[C@@H]([C@@H](O)[C@H](O)[C@@H]21)[C@@H](O)[C@H](O)CC3 IRHVLQMEQPABHG-ZPCNDTDRSA-N 0.000 abstract 1
206010020751 Hypersensitivity Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
230000002526 effect on cardiovascular system Effects 0.000 abstract 1
230000001435 haemodynamic effect Effects 0.000 abstract 1
230000002757 inflammatory effect Effects 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
230000002265 prevention Effects 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
-1 steroid compounds Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Immunology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT94902581T 1992-12-23 1993-12-21 Pharmazeutische zusammensetzungen enthaltend contignasterol-verbindungen ATE162946T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA002086221A CA2086221C (en)	1992-12-23	1992-12-23	Contignasterol, and related 3-alpha hydroxy-6-alpha hydroxy-7-beta hydroxy-15-keto-14-beta steroids useful as anti-inflammatory and anti-thrombosis agent

Publications (1)

Publication Number	Publication Date
ATE162946T1 true ATE162946T1 (de)	1998-02-15

Family

ID=4150905

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94902581T ATE162946T1 (de)	1992-12-23	1993-12-21	Pharmazeutische zusammensetzungen enthaltend contignasterol-verbindungen

Country Status (11)

Country	Link
US (1)	US5646138A (de)
EP (1)	EP0675721B1 (de)
JP (1)	JP3366639B2 (de)
AT (1)	ATE162946T1 (de)
AU (1)	AU673405B2 (de)
CA (2)	CA2086221C (de)
DE (1)	DE69316927T2 (de)
DK (1)	DK0675721T3 (de)
ES (1)	ES2114678T3 (de)
GR (1)	GR3026346T3 (de)
WO (1)	WO1994014451A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6046185A (en)	1996-07-11	2000-04-04	Inflazyme Pharmaceuticals Ltd.	6,7-oxygenated steroids and uses related thereto
CN100368425C (zh) *	1996-07-11	2008-02-13	茵弗莱采姆药物有限公司	6，7－氧化的甾族化合物及其用途
EP1304333A3 (de) *	1996-07-11	2005-03-09	Inflazyme Pharmaceuticals, Ltd.	6,7-oxygenierte Steroide und deren Verwendung
EP1278763B1 (de) *	2000-04-28	2007-02-14	Inflazyme Pharmaceuticals, Ltd.	3-stickstoff-6,7-dioxygenierte steroid verbindungen und verwendungen davon

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5079239A (en) *	1990-02-16	1992-01-07	Harbor Branch Oceanographic Institution, Inc.	Sterol disulfates and methods of use

1992
- 1992-12-23 CA CA002086221A patent/CA2086221C/en not_active Expired - Fee Related
1993
- 1993-12-21 CA CA002152621A patent/CA2152621C/en not_active Expired - Fee Related
- 1993-12-21 WO PCT/CA1993/000558 patent/WO1994014451A1/en not_active Ceased
- 1993-12-21 US US08/464,758 patent/US5646138A/en not_active Expired - Fee Related
- 1993-12-21 DK DK94902581.1T patent/DK0675721T3/da active
- 1993-12-21 EP EP94902581A patent/EP0675721B1/de not_active Expired - Lifetime
- 1993-12-21 JP JP51464194A patent/JP3366639B2/ja not_active Expired - Fee Related
- 1993-12-21 DE DE69316927T patent/DE69316927T2/de not_active Expired - Fee Related
- 1993-12-21 AU AU56913/94A patent/AU673405B2/en not_active Ceased
- 1993-12-21 ES ES94902581T patent/ES2114678T3/es not_active Expired - Lifetime
- 1993-12-21 AT AT94902581T patent/ATE162946T1/de not_active IP Right Cessation
1998
- 1998-03-13 GR GR980400531T patent/GR3026346T3/el unknown

Also Published As

Publication number	Publication date
US5646138A (en)	1997-07-08
AU5691394A (en)	1994-07-19
DE69316927D1 (de)	1998-03-12
DK0675721T3 (da)	1998-04-06
WO1994014451A1 (en)	1994-07-07
ES2114678T3 (es)	1998-06-01
AU673405B2 (en)	1996-11-07
DE69316927T2 (de)	1998-10-22
CA2152621A1 (en)	1994-07-07
CA2152621C (en)	2000-10-31
GR3026346T3 (en)	1998-06-30
JP3366639B2 (ja)	2003-01-14
CA2086221C (en)	2003-07-15
EP0675721A1 (de)	1995-10-11
CA2086221A1 (en)	1994-06-24
JPH08504773A (ja)	1996-05-21
EP0675721B1 (de)	1998-02-04

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Legal Events

Date	Code	Title	Description
1998-10-15	UEP	Publication of translation of european patent specification
2005-09-15	REN	Ceased due to non-payment of the annual fee