ATE163934T1 - Indol-derivate als 5-ht1-like agonisten - Google Patents
Indol-derivate als 5-ht1-like agonistenInfo
- Publication number
- ATE163934T1 ATE163934T1 AT95934124T AT95934124T ATE163934T1 AT E163934 T1 ATE163934 T1 AT E163934T1 AT 95934124 T AT95934124 T AT 95934124T AT 95934124 T AT95934124 T AT 95934124T AT E163934 T1 ATE163934 T1 AT E163934T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- date apr
- sec
- alkyl
- pharmaceutically acceptable
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000001845 4 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 206010009094 Chronic paroxysmal hemicrania Diseases 0.000 abstract 1
- 208000006561 Cluster Headache Diseases 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 208000018912 cluster headache syndrome Diseases 0.000 abstract 1
- 231100000869 headache Toxicity 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 208000007777 paroxysmal Hemicrania Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 208000019553 vascular disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Child & Adolescent Psychology (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9420503A GB9420503D0 (en) | 1994-10-11 | 1994-10-11 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE163934T1 true ATE163934T1 (de) | 1998-03-15 |
Family
ID=10762688
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95934124T ATE163934T1 (de) | 1994-10-11 | 1995-09-29 | Indol-derivate als 5-ht1-like agonisten |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5770611A (de) |
| EP (1) | EP0785933B1 (de) |
| JP (1) | JP2902484B2 (de) |
| AT (1) | ATE163934T1 (de) |
| DE (1) | DE69501791T2 (de) |
| DK (1) | DK0785933T3 (de) |
| ES (1) | ES2113213T3 (de) |
| FI (1) | FI113863B (de) |
| GB (1) | GB9420503D0 (de) |
| GR (1) | GR3026532T3 (de) |
| WO (1) | WO1996011195A1 (de) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| WO1999024432A1 (fr) | 1997-11-12 | 1999-05-20 | Mitsubishi Chemical Corporation | Derives de purine et medicament les renfermant en tant qu'ingredient actif |
| CN1295561A (zh) | 1998-06-03 | 2001-05-16 | Gpinil控股公司 | N－杂环羧酸或羧酸等排物的n－结合氨磺酰 |
| ES2206227T3 (es) | 1999-05-11 | 2004-05-16 | Mitsubishi Chemical Corporation | Dihidrato de un derivado de purina, farmacos que lo contienen como ingrediente activo, e intermedio en su preparacion. |
| WO2011158149A1 (en) | 2010-06-18 | 2011-12-22 | Pfizer Inc. | 2-(3,5-disubstitutedphenyl)pyrimidin-4(3h)-one derivatives |
| WO2025104491A1 (en) * | 2023-11-14 | 2025-05-22 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5559129A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc | Indole derivatives |
| US5559246A (en) * | 1990-10-15 | 1996-09-24 | Pfizer Inc. | Indole derivatives |
| US5545644A (en) * | 1990-10-15 | 1996-08-13 | Pfizer Inc. | Indole derivatives |
| US5607951A (en) * | 1990-10-15 | 1997-03-04 | Pfizer Inc | Indole derivatives |
| US5578612A (en) * | 1990-10-15 | 1996-11-26 | Pfizer Inc. | Indole derivatives |
| BR9206810A (pt) * | 1991-11-25 | 1995-10-31 | Pfizer | Derivados de indol |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (de) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| US5498626A (en) * | 1992-04-10 | 1996-03-12 | Pfizer Inc. | Acylaminoindole derivatives as 5-ht1 agonists |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| GB9208161D0 (en) * | 1992-04-14 | 1992-05-27 | Pfizer Ltd | Indoles |
| ATE144773T1 (de) * | 1993-04-22 | 1996-11-15 | Pfizer Res & Dev | Indol-derivate als 5-ht1-ähnliche antagonisten zur behandlung von migräne |
| GB9424471D0 (en) * | 1994-12-03 | 1995-01-18 | Pfizer Ltd | Treatment of emesis |
-
1994
- 1994-10-11 GB GB9420503A patent/GB9420503D0/en active Pending
-
1995
- 1995-09-29 US US08/809,600 patent/US5770611A/en not_active Expired - Fee Related
- 1995-09-29 WO PCT/EP1995/003884 patent/WO1996011195A1/en not_active Ceased
- 1995-09-29 JP JP8512312A patent/JP2902484B2/ja not_active Expired - Fee Related
- 1995-09-29 AT AT95934124T patent/ATE163934T1/de not_active IP Right Cessation
- 1995-09-29 EP EP95934124A patent/EP0785933B1/de not_active Expired - Lifetime
- 1995-09-29 ES ES95934124T patent/ES2113213T3/es not_active Expired - Lifetime
- 1995-09-29 DK DK95934124.9T patent/DK0785933T3/da active
- 1995-09-29 DE DE69501791T patent/DE69501791T2/de not_active Expired - Fee Related
-
1997
- 1997-04-10 FI FI971492A patent/FI113863B/fi active
-
1998
- 1998-04-03 GR GR980400716T patent/GR3026532T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2902484B2 (ja) | 1999-06-07 |
| FI971492L (fi) | 1997-04-10 |
| FI113863B (fi) | 2004-06-30 |
| EP0785933B1 (de) | 1998-03-11 |
| EP0785933A1 (de) | 1997-07-30 |
| GB9420503D0 (en) | 1994-11-23 |
| DE69501791T2 (de) | 1998-07-02 |
| ES2113213T3 (es) | 1998-04-16 |
| FI971492A0 (fi) | 1997-04-10 |
| WO1996011195A1 (en) | 1996-04-18 |
| DK0785933T3 (da) | 1998-05-11 |
| MX9702643A (es) | 1997-07-31 |
| US5770611A (en) | 1998-06-23 |
| JPH09512034A (ja) | 1997-12-02 |
| GR3026532T3 (en) | 1998-07-31 |
| DE69501791D1 (de) | 1998-04-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0695301A1 (de) | Indol-derivate als 5-h1-ähnliche antagonisten zur behandlung von migräne | |
| EP0354777A3 (de) | 3-(4-Piperidin)-5-(2-sulphonylaminoethyl)-indol-Derivate | |
| ATE92057T1 (de) | Indol-derivate. | |
| NO20023995D0 (no) | 2-okso-1-pyrrolidinderivater, fremgangsmåte for fremstilling og anvendelse av disse | |
| PT729455E (pt) | Arilpiperazinas derivadas de indol como ligados para os receptores 5ht1-like, 5ht1b e 5ht1d | |
| CA2340999A1 (en) | 5-arylindole derivatives | |
| PT87183A (pt) | Procede de preparation de derives d:aryl-heteroaryl carbinol avec activite analgesique | |
| ATE17249T1 (de) | 9-(2-(3-indolyl)aethyl)-1-oxa-4,9diazaspiro(5.5)undecan-3-one. | |
| ES8406440A1 (es) | Procedimiento para preparar derivados de 2-amino-3-acilamino-6-bencilamino-piridina | |
| NO893480L (no) | Fremgangsmaate for fremstilling av disubstituerte benzylaminer. | |
| ATE133169T1 (de) | Indol derivate als ''5-ht1-like'' agonisten | |
| NO996453L (no) | Nye tricykliske forbindelser med mettede ringer, samt medisinske blandinger inneholdende forbindelsene | |
| ATE163934T1 (de) | Indol-derivate als 5-ht1-like agonisten | |
| DK0871626T3 (da) | Triazoloner som apolipoprotein-B syntheseinhibitorer | |
| DE69231466D1 (de) | Enantiomere von cyclopenten-derivaten | |
| GB8320005D0 (en) | Benzothiazoline derivatives | |
| NO985685L (no) | Dibenzo-oksazepin- og -dioksazepin-derivater og deres anvendelse som anti-tumormidler | |
| ES2128572T3 (es) | Utilizacion de los derivados de cefem como agentes antimetastaticos. | |
| ES2099963T3 (es) | Sintesis de indoles mediante deshidrogenacion de indolinas. | |
| CA2202348A1 (en) | Indole derivatives as 5ht1-like agonists | |
| ES8507539A1 (es) | Proceso para producir indolcarboxilato de benzoil | |
| ES2070087A1 (es) | Derivados de indol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |