NO996453L - Nye tricykliske forbindelser med mettede ringer, samt medisinske blandinger inneholdende forbindelsene - Google Patents
Nye tricykliske forbindelser med mettede ringer, samt medisinske blandinger inneholdende forbindelseneInfo
- Publication number
- NO996453L NO996453L NO996453A NO996453A NO996453L NO 996453 L NO996453 L NO 996453L NO 996453 A NO996453 A NO 996453A NO 996453 A NO996453 A NO 996453A NO 996453 L NO996453 L NO 996453L
- Authority
- NO
- Norway
- Prior art keywords
- hydrogen atom
- compounds
- atom
- amino
- well
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000011873 medical mixture Substances 0.000 title 1
- 229920006395 saturated elastomer Polymers 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 11
- -1 hydroxy, benzyloxy, amino Chemical group 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 101100294106 Caenorhabditis elegans nhr-3 gene Proteins 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Chemical group 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/76—Dibenzothiophenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Forbindelser som representeres ved den generelle formel (I), eller salter derav: hvor R representerer et hydrogenatom eller metyl, R1 betyr et hydrogenatom, halogenatom, hydroksy, benzyloksy, amino eller hydroksymetyl, R2 betyr et hydrogenatom, hydroksy- metyl, NHR3, SO2NR4R4' eller nitro, hvor R1 er et hydrogen- atom, metyl, SO2R5, formyl eller CONHRS|, med R5 er lavere alkyl, benzyl eller NR4R4', og 4 og R4' kan være identiske eller forskjellige fra hverandre for et hydrogenatom, lavere alkyl eller benzyl, RS| representerer et hydrogen- atom eller lavere alkyl, og Rs representerer et hydrogen- atom eller lavere alkyl, n er l eller 2, og X er et sekun- dært nitrogenatom, oksygenatom eller svovelatom og, i til- felle at n er l, betyr en av R7 og R8 er et hydrogenatom og den andre er et hydrogenatom, amino, acetylamino eller hyd- roksy, eller, i tilfelle at n er 2, er R8 et hydrogenatom og R7 er et hydrogenatom, amino, acetyl amino eller hyd- roksy, og *1 betyr et usymmetrisk karbonatom og *2 og *3 viser at karbonatomet er asymmetrisk, forutsatt at R' og R8 ikke betyr et hydrogenatom. Forbindelsene er terapeutisk aktive.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17819797 | 1997-07-03 | ||
| PCT/JP1998/002680 WO1999001431A1 (en) | 1997-07-03 | 1998-06-17 | Novel tricyclic compounds having saturated rings and medicinal compositions containing the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| NO996453D0 NO996453D0 (no) | 1999-12-23 |
| NO996453L true NO996453L (no) | 2000-03-03 |
Family
ID=16044289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO996453A NO996453L (no) | 1997-07-03 | 1999-12-23 | Nye tricykliske forbindelser med mettede ringer, samt medisinske blandinger inneholdende forbindelsene |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6172099B1 (no) |
| EP (1) | EP0997458A4 (no) |
| KR (1) | KR100335169B1 (no) |
| AU (1) | AU735249B2 (no) |
| CA (1) | CA2296104A1 (no) |
| DE (1) | DE997458T1 (no) |
| ES (1) | ES2149742T1 (no) |
| NO (1) | NO996453L (no) |
| WO (1) | WO1999001431A1 (no) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1975236B1 (en) | 1998-08-04 | 2015-05-06 | Metabolix, Inc. | Polyhydroxyalkanoate production from polyols |
| TW519537B (en) * | 1999-03-26 | 2003-02-01 | Asahi Chemical Ind | Process for the preparation of tricylic amino-alcohol derivatives |
| KR20020005648A (ko) * | 1999-04-01 | 2002-01-17 | 야마모토 카즈모토 | 삼환성 아미노알콜 유도체의 아지드를 경유하는 제조법 |
| WO2001004092A1 (en) * | 1999-07-09 | 2001-01-18 | Asahi Kasei Kabushiki Kaisha | Process for the preparation of tricyclic amino alcohol derivatives |
| MXPA02002283A (es) * | 1999-09-03 | 2002-07-30 | Asahi Chemical Ind | Proceso para preparar derivados triciclicos de amino alcoholes. |
| BR0014469A (pt) * | 1999-10-04 | 2002-06-11 | Asahi Chemical Ind | Processo para melhorar a solubilidade de um derivado de amino álcool tricìclico, composição farmacêutica, processo para preparar a mesma, e, derivado de amino álcool tricìclico |
| KR20020069215A (ko) * | 1999-12-16 | 2002-08-29 | 아사히 가세이 가부시키가이샤 | 신규한 치환기를 갖는 3환성 화합물 |
| US20030018061A1 (en) * | 2000-01-28 | 2003-01-23 | Kohei Ogawa | Novel remedies with the use of beta 3 agonist |
| AU5257401A (en) * | 2000-04-28 | 2001-11-12 | Asahi Chemical Ind | Novel bicyclic compounds |
| GB0010757D0 (en) | 2000-05-05 | 2000-06-28 | Astrazeneca Ab | Chemical compounds |
| GB0029562D0 (en) * | 2000-12-04 | 2001-01-17 | Novartis Ag | Organic compounds |
| JPWO2002074306A1 (ja) * | 2001-03-19 | 2004-07-08 | 旭化成ファーマ株式会社 | 脂肪肝治療薬 |
| DK1425272T3 (da) * | 2001-08-31 | 2011-11-21 | Novartis Ag | Optiske isomerer af en iloperidon-metabolit |
| GB0121941D0 (en) | 2001-09-11 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| DE60239170D1 (de) * | 2001-10-25 | 2011-03-24 | Asahi Kasei Pharma Corp | Bicyclische Verbindungen |
| US8008506B2 (en) | 2008-10-09 | 2011-08-30 | Asahi Kasei Pharma Corporation | Indazole compounds |
| KR20110050733A (ko) | 2008-10-09 | 2011-05-16 | 아사히 가세이 파마 가부시키가이샤 | 인다졸 유도체 |
| US20100222404A1 (en) * | 2008-11-04 | 2010-09-02 | Asahi Kasei Pharma Corporation | Indazole derivative dihydrochloride |
| ES2394349B1 (es) | 2012-08-29 | 2013-11-04 | Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii | Uso de agonistas selectivos de receptores beta-3 adrenérgicos para el tratamiento de hipertensión pulmonar |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2332010A1 (fr) | 1975-11-18 | 1977-06-17 | Continental Pharma | Amino-alcool heterocyclique, son sel et son procede de preparation |
| JPS5553262A (en) | 1978-10-17 | 1980-04-18 | Yamanouchi Pharmaceut Co Ltd | Phenylethanolamine derivative |
| DE3061334D1 (en) | 1979-06-16 | 1983-01-20 | Beecham Group Plc | Ethanamine derivatives, their preparation and use in pharmaceutical compositions |
| JPS5950671B2 (ja) | 1982-08-26 | 1984-12-10 | 山之内製薬株式会社 | フェニルエタノ−ルアミン誘導体およびその製造法 |
| JPS6016980A (ja) * | 1983-07-06 | 1985-01-28 | Nippon Soda Co Ltd | ヘキサヒドロジベンゾフラン誘導体及びその製造方法 |
| GB8419797D0 (en) | 1984-08-03 | 1984-09-05 | Beecham Group Plc | Compounds |
| GB8926083D0 (en) | 1989-11-17 | 1990-01-10 | Ici Plc | Therapeutic agents |
| US5061727A (en) | 1990-05-04 | 1991-10-29 | American Cyanamid Company | Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles |
| US5100891A (en) * | 1991-01-18 | 1992-03-31 | Hoechst-Roussel Pharmaceuticals Inc. | Substituted 1,2,3,4-tetrahydrocyclopent[b]indoles, 1,2,3,3a,4,8a-hexahydrocyclopent[B]indoles and related compounds |
| BR9406823A (pt) * | 1993-06-14 | 1996-03-26 | Pfizer | Aminas secundárias e agentes anti-diabéticos e antiobesidade |
| US5776983A (en) | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5541197A (en) | 1994-04-26 | 1996-07-30 | Merck & Co., Inc. | Substituted sulfonamides as selective β3 agonists for the treatment of diabetes and obesity |
| JPH08165276A (ja) | 1994-12-14 | 1996-06-25 | Dainippon Pharmaceut Co Ltd | ２−アルキルアミノ−１−フェニルエタノール誘導体 |
| EP0828712A1 (en) * | 1995-05-10 | 1998-03-18 | Pfizer Inc. | Beta-adrenergic agonists |
| CA2242351C (en) | 1996-01-10 | 2003-03-11 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tricyclic compounds and drug compositions containing the same |
| WO1998012170A1 (en) * | 1996-09-20 | 1998-03-26 | Yamanouchi Pharmaceutical Co., Ltd. | Novel tricyclic fused ring derivatives |
-
1998
- 1998-06-17 US US09/446,515 patent/US6172099B1/en not_active Expired - Fee Related
- 1998-06-17 CA CA002296104A patent/CA2296104A1/en not_active Abandoned
- 1998-06-17 WO PCT/JP1998/002680 patent/WO1999001431A1/ja not_active Ceased
- 1998-06-17 AU AU80334/98A patent/AU735249B2/en not_active Ceased
- 1998-06-17 EP EP98928532A patent/EP0997458A4/en not_active Withdrawn
- 1998-06-17 ES ES98928532T patent/ES2149742T1/es active Pending
- 1998-06-17 KR KR1020007000008A patent/KR100335169B1/ko not_active Expired - Fee Related
- 1998-06-17 DE DE0997458T patent/DE997458T1/de active Pending
-
1999
- 1999-12-23 NO NO996453A patent/NO996453L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0997458A4 (en) | 2003-03-05 |
| ES2149742T1 (es) | 2000-11-16 |
| AU8033498A (en) | 1999-01-25 |
| KR100335169B1 (ko) | 2002-05-04 |
| NO996453D0 (no) | 1999-12-23 |
| KR20010015528A (ko) | 2001-02-26 |
| US6172099B1 (en) | 2001-01-09 |
| DE997458T1 (de) | 2001-03-01 |
| AU735249B2 (en) | 2001-07-05 |
| WO1999001431A1 (en) | 1999-01-14 |
| CA2296104A1 (en) | 1999-01-14 |
| EP0997458A1 (en) | 2000-05-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC2A | Withdrawal, rejection or dismissal of laid open patent application |