ATE165096T1 - Verfahren für die synthese von 9-(2- hydroxyethoxymethyl)guanin - Google Patents

Verfahren für die synthese von 9-(2- hydroxyethoxymethyl)guanin

Info

Publication number: ATE165096T1
Authority: AT; Austria
Prior art keywords: guanine; synthesis; hydroxyethoxymethyl; acyclovir; subject
Prior art date: 1993-06-14

Application number

AT94108426T

Other languages

English (en)

Inventor

Tiberio Bruzzese

Giuseppe Guazzi

Marco Rognoni

Giuliano Marcon

Original Assignee

Solar Chem Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-06-14

Filing date

1994-06-01

Publication date

1998-05-15

1994-06-01 Application filed by Solar Chem Sa filed Critical Solar Chem Sa

1998-05-15 Application granted granted Critical

1998-05-15 Publication of ATE165096T1 publication Critical patent/ATE165096T1/de

Links

MKUXAQIIEYXACX-UHFFFAOYSA-N aciclovir Chemical compound N1C(N)=NC(=O)C2=C1N(COCCO)C=N2 MKUXAQIIEYXACX-UHFFFAOYSA-N 0.000 title abstract 3
230000015572 biosynthetic process Effects 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
238000003786 synthesis reaction Methods 0.000 title abstract 2
UYTPUPDQBNUYGX-UHFFFAOYSA-N guanine Chemical compound O=C1NC(N)=NC2=C1N=CN2 UYTPUPDQBNUYGX-UHFFFAOYSA-N 0.000 abstract 2
229960004150 aciclovir Drugs 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT94108426T 1993-06-14 1994-06-01 Verfahren für die synthese von 9-(2- hydroxyethoxymethyl)guanin ATE165096T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT93MI001264A IT1264599B1 (it)	1993-06-14	1993-06-14	Processo per la sintesi della 9-(2-idrossietossimetil)- guanina

Publications (1)

Publication Number	Publication Date
ATE165096T1 true ATE165096T1 (de)	1998-05-15

Family

ID=11366388

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94108426T ATE165096T1 (de)	1993-06-14	1994-06-01	Verfahren für die synthese von 9-(2- hydroxyethoxymethyl)guanin

Country Status (7)

Country	Link
US (1)	US5496945A (de)
EP (1)	EP0628558B1 (de)
AT (1)	ATE165096T1 (de)
DE (1)	DE69409578T2 (de)
DK (1)	DK0628558T3 (de)
ES (1)	ES2117172T3 (de)
IT (1)	IT1264599B1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1276126B1 (it) *	1995-11-14	1997-10-27	Archimica Spa	Procedimento per la preparazine di 9-((2-idrossietossi)metil) guanina
CN103601768B (zh) *	2013-11-13	2015-09-30	齐鲁天和惠世制药有限公司	一种阿米卡星的制备方法
CN107903268A (zh) *	2017-11-16	2018-04-13	湖北省宏源药业科技股份有限公司	一种阿昔洛韦的提纯方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1523865A (en) *	1974-09-02	1978-09-06	Wellcome Found	Purine compunds and salts thereof
US4146715A (en) *	1975-08-27	1979-03-27	Burroughs Wellcome Co.	2-amido-9-(2-acyloxyethoxymethyl)hypoxanthines
DK135489D0 (da) *	1989-03-20	1989-03-20	Gea Farmaceutisk Fabrik As	Fremgangsmaade til fremstilling af 9-substituerede guaninderivater og mellemprodukter til brug ved fremgangsmaaden
JP3225545B2 (ja) *	1991-09-18	2001-11-05	味の素株式会社	非環状ヌクレオシド類の製造法

1993
- 1993-06-14 IT IT93MI001264A patent/IT1264599B1/it active IP Right Grant
1994
- 1994-06-01 DK DK94108426T patent/DK0628558T3/da active
- 1994-06-01 EP EP94108426A patent/EP0628558B1/de not_active Expired - Lifetime
- 1994-06-01 AT AT94108426T patent/ATE165096T1/de not_active IP Right Cessation
- 1994-06-01 DE DE69409578T patent/DE69409578T2/de not_active Expired - Fee Related
- 1994-06-01 ES ES94108426T patent/ES2117172T3/es not_active Expired - Lifetime
- 1994-06-13 US US08/261,053 patent/US5496945A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0628558B1 (de)	1998-04-15
ITMI931264A1 (it)	1994-12-14
ITMI931264A0 (it)	1993-06-14
DE69409578D1 (de)	1998-05-20
ES2117172T3 (es)	1998-08-01
US5496945A (en)	1996-03-05
IT1264599B1 (it)	1996-10-04
DE69409578T2 (de)	1998-11-19
DK0628558T3 (da)	1999-02-08
EP0628558A1 (de)	1994-12-14

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Legal Events

Date	Code	Title
1998-12-15	UEP	Publication of translation of european patent specification
2000-11-15	EEIH	Change in the person of patent owner
2004-03-15	REN	Ceased due to non-payment of the annual fee