ATE165350T1 - Substituierte imidazol derivate und deren herstellung und verwendung - Google Patents

Substituierte imidazol derivate und deren herstellung und verwendung

Info

Publication number: ATE165350T1
Authority: AT; Austria
Prior art keywords: compounds; pct; preparation; inden; dihydro
Prior art date: 1991-12-20

Application number

AT93900200T

Other languages

English (en)

Inventor

Arto Johannes Karjalainen

Raimo Einari Virtanen

Arja Leena Karjalainen

Maire Marjatta Eloranta

Jarmo Sakari Salonen

Hannu Tapani Sipilae

Antti Sakari Haapalinna

Original Assignee

Juvantia Pharma Ltd Oy

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-12-20

Filing date

1992-12-18

Publication date

1998-05-15

1992-12-18 Application filed by Juvantia Pharma Ltd Oy filed Critical Juvantia Pharma Ltd Oy

1998-05-15 Application granted granted Critical

1998-05-15 Publication of ATE165350T1 publication Critical patent/ATE165350T1/de

Links

RAXXELZNTBOGNW-UHFFFAOYSA-N 1H-imidazole Chemical class C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 title 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 5
150000003839 salts Chemical class 0.000 abstract 3
231100000252 nontoxic Toxicity 0.000 abstract 2
230000003000 nontoxic effect Effects 0.000 abstract 2
SBRPOGFZSCVOPD-UHFFFAOYSA-N 5-(4-chloro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole Chemical compound C1C=2C(Cl)=CC=CC=2CC1C1=CNC=N1 SBRPOGFZSCVOPD-UHFFFAOYSA-N 0.000 abstract 1
UVAHPMMTCDSQEQ-UHFFFAOYSA-N 5-(5-chloro-2,3-dihydro-1h-inden-2-yl)-1h-imidazole Chemical compound C1C2=CC(Cl)=CC=C2CC1C1=CNC=N1 UVAHPMMTCDSQEQ-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
208000010877 cognitive disease Diseases 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
230000000144 pharmacologic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Epidemiology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Epoxy Resins (AREA)

AT93900200T 1991-12-20 1992-12-18 Substituierte imidazol derivate und deren herstellung und verwendung ATE165350T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB919127050A GB9127050D0 (en)	1991-12-20	1991-12-20	Substituted imidazole derivatives and their preparation and use

Publications (1)

Publication Number	Publication Date
ATE165350T1 true ATE165350T1 (de)	1998-05-15

Family

ID=10706581

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93900200T ATE165350T1 (de)	1991-12-20	1992-12-18	Substituierte imidazol derivate und deren herstellung und verwendung

Country Status (16)

Country	Link
US (1)	US5498623A (de)
EP (1)	EP0618906B1 (de)
JP (1)	JP3276371B2 (de)
AT (1)	ATE165350T1 (de)
AU (1)	AU664584B2 (de)
CA (1)	CA2117305C (de)
DE (1)	DE69225240T2 (de)
DK (1)	DK0618906T3 (de)
ES (1)	ES2115046T3 (de)
FI (1)	FI104968B (de)
GB (1)	GB9127050D0 (de)
HU (1)	HU220043B (de)
NO (1)	NO304227B1 (de)
PL (1)	PL172532B1 (de)
RU (1)	RU2120440C1 (de)
WO (1)	WO1993013074A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9312669D0 (en) *	1993-06-18	1993-08-04	Orion Yhtymae Oy	New opticla isomers
FR2735776B1 (fr) *	1995-06-22	1997-07-18	Synthelabo	Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
GB9520150D0 (en) *	1995-10-03	1995-12-06	Orion Yhtymae Oy	New imidazole derivatives
US20020143007A1 (en) *	1996-02-02	2002-10-03	Garvey David S.	Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
US6469065B1 (en)	1996-02-02	2002-10-22	Nitromed, Inc.	Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
FI20000073A0 (fi) *	2000-01-14	2000-01-14	Orion Yhtymae Oy	Uusia imidatsolijohdannaisia
US6388090B2 (en)	2000-01-14	2002-05-14	Orion Corporation	Imidazole derivatives
US8188126B2 (en)	2002-05-16	2012-05-29	Pierre Fabre Medicament	Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
GB0226076D0 (en) *	2002-11-08	2002-12-18	Rp Scherer Technologies Inc	Improved formulations containing substituted imidazole derivatives
FI20022007A0 (fi) *	2002-11-08	2002-11-08	Juvantia Pharma Ltd Oy	Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI116292B (fi) *	2003-01-08	2005-10-31	Juvantia Pharma Ltd Oy	Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
BRPI0411841A (pt) *	2003-06-17	2006-08-08	Hoffmann La Roche	cis-2,4,5-triaril-imidazolinas
EP2456749B1 (de)	2009-07-24	2016-03-30	DSM Pharma Chemicals Regensburg GmbH	Indanderivate zur verwendung als zwischenprodukte
WO2011014613A2 (en) *	2009-07-31	2011-02-03	Dr. Reddy's Laboratories Ltd.	Preparation of fipamezole
EP2502917A1 (de)	2011-03-17	2012-09-26	Santhera Pharmaceuticals (Schweiz) AG	Im Festzustand kristalline Formen von 4-(2-Ethyl-5-fluor-2,3-dihydro-1H-inden-2-yl)-1H-imidazol
WO2017079734A1 (en) *	2015-11-05	2017-05-11	University Of Louisville Research Foundation, Inc.	Local and regional anesthesia and analgesia
LU103072B1 (en) *	2023-02-15	2024-08-19	Univ Ljubljani	N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
EP4658639A1 (de) *	2023-02-01	2025-12-10	Univerza V Ljubljani	N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazol-1-carboxamide und verwandte verbindungen zur behandlung neurodegenerativer erkrankungen
CN117186010B (zh) *	2023-08-15	2026-04-14	厦门欧瑞捷生物科技有限公司	一种盐酸阿替美唑的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1282535A (en) *	1970-03-02	1972-07-19	Pfizer	(2-IMIDAZOLIN-2-YLAMINO)SUBSTITUTED BENZO[b]THIOPHENES
US3927023A (en) *	1974-05-24	1975-12-16	Warner Lambert Co	Imidazolyl benzofurans
US3927018A (en) *	1974-12-23	1975-12-16	Sandoz Ag	3-(2-Methyl-1-imidazolyl)-3-phenyl-1-(3H)isobenzofuranones
IL66242A0 (en) *	1981-07-23	1982-11-30	Erba Farmitalia	N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene,indan and 2-substituted-1-chroman,their preparation and pharmaceutical compositions containing them
ZW13782A1 (en) *	1981-07-28	1982-10-06	Reckitt & Colmann Prod Ltd	Imidazoline derivatives
ES8503669A1 (es) *	1982-07-05	1985-03-01	Erba Farmitalia	Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
GB8409884D0 (en) *	1984-04-17	1984-05-31	Detexomat Machinery Ltd	Transporting fabric pieces
GB2167408B (en) *	1984-11-23	1988-05-25	Farmos Oy	Substituted imidazole derivatives and their preparation and use
FI81092C (fi) *	1986-05-15	1990-09-10	Farmos Oy	Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2855341B2 (ja) *	1988-06-10	1999-02-10	武田薬品工業株式会社	新規２―置換クマラン誘導体
IL91542A0 (en) *	1988-10-06	1990-04-29	Erba Carlo Spa	N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them
GB2225782A (en) *	1988-12-09	1990-06-13	Farmos Group Limited	Imidazole derivatives useful for treatment of diabetes
GB9020128D0 (en) *	1990-09-14	1990-10-24	Reckitt & Colmann Prod Ltd	Imidazoline derivatives
EP0618864A1 (de) *	1991-12-23	1994-10-12	Mobil Oil Corporation	Film mit geringer sauerstoffdurchlässigkeit
GB9127430D0 (en) *	1991-12-27	1992-02-19	Scras	Benzofuranylimidazole derivatives

1991
- 1991-12-20 GB GB919127050A patent/GB9127050D0/en active Pending
1992
- 1992-12-18 WO PCT/FI1992/000349 patent/WO1993013074A1/en not_active Ceased
- 1992-12-18 JP JP51146093A patent/JP3276371B2/ja not_active Expired - Lifetime
- 1992-12-18 DE DE69225240T patent/DE69225240T2/de not_active Expired - Lifetime
- 1992-12-18 US US08/244,932 patent/US5498623A/en not_active Expired - Lifetime
- 1992-12-18 CA CA002117305A patent/CA2117305C/en not_active Expired - Lifetime
- 1992-12-18 DK DK93900200T patent/DK0618906T3/da active
- 1992-12-18 RU RU94031215/04A patent/RU2120440C1/ru active
- 1992-12-18 ES ES93900200T patent/ES2115046T3/es not_active Expired - Lifetime
- 1992-12-18 AT AT93900200T patent/ATE165350T1/de active
- 1992-12-18 AU AU31605/93A patent/AU664584B2/en not_active Expired
- 1992-12-18 HU HU9401823A patent/HU220043B/hu unknown
- 1992-12-18 EP EP93900200A patent/EP0618906B1/de not_active Expired - Lifetime
- 1992-12-18 PL PL92304150A patent/PL172532B1/pl unknown
1994
- 1994-06-16 FI FI942882A patent/FI104968B/fi not_active IP Right Cessation
- 1994-06-17 NO NO942335A patent/NO304227B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
JP3276371B2 (ja)	2002-04-22
NO304227B1 (no)	1998-11-16
JPH07506087A (ja)	1995-07-06
FI942882A0 (fi)	1994-06-16
CA2117305C (en)	2003-11-25
CA2117305A1 (en)	1993-07-08
FI104968B (fi)	2000-05-15
HK1008962A1 (en)	1999-05-21
DE69225240D1 (de)	1998-05-28
ES2115046T3 (es)	1998-06-16
HU220043B (hu)	2001-10-28
NO942335L (no)	1994-06-20
WO1993013074A1 (en)	1993-07-08
PL172532B1 (en)	1997-10-31
GB9127050D0 (en)	1992-02-19
DE69225240T2 (de)	1998-08-27
HUT67548A (en)	1995-04-28
DK0618906T3 (da)	1999-01-25
RU2120440C1 (ru)	1998-10-20
EP0618906B1 (de)	1998-04-22
EP0618906A1 (de)	1994-10-12
HU9401823D0 (en)	1994-09-28
AU664584B2 (en)	1995-11-23
FI942882A7 (fi)	1994-06-16
AU3160593A (en)	1993-07-28
RU94031215A (ru)	1996-04-20
US5498623A (en)	1996-03-12
NO942335D0 (no)	1994-06-17

Legal Events

Date	Code	Title	Description
1998-10-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
DE69225240D1 (de)	1998-05-28	Substituierte imidazol derivate und deren herstellung und verwendung
ATE17121T1 (de)	1986-01-15	Substituierte imidazolderivate und deren herstellung und anwendung.
DE69329727D1 (de)	2001-01-11	Neue imidazol derivate, ihre herstellung und therapeutische verwendung
DE69713582D1 (de)	2002-08-01	Zimtsäurederivate und deren verwendung als integrin-antagonisten
DK0613458T3 (da)	1998-02-09	Acykliske ethylendiaminderivater som substans P receptorantagonister
DE69331190D1 (de)	2002-01-03	Überbrückte azabicyclische derivate als substanz p antagonisten
ATE250598T1 (de)	2003-10-15	5-(2-imidazolinylamino)benzimidazol derivate, deren herstellung und deren verwendung als alpha- 2-adrenoceptor agonisten
DE60140860D1 (de)	2010-02-04	2-aminonicotinamid-derivate und ihre verwendung als vegf-rezeptor tyrosin-kinase inhibitoren
DK0880517T3 (da)	2002-04-15	Quinazolin-forbindelser
JPH03118372A (ja)	1991-05-20	２―アミノピリミジン３―オキシド誘導体、及び２―アミノピリミジン３―オキシドから誘導される新規な化合物を含む、髪の損失を遅らせるためのそして髪の生長を誘発しそして刺激するための使用を意図された組成物
AU2804400A (en)	2000-08-29	Phenyl urea and phenyl thiourea derivatives as orexin receptor antagonists
FI894911A0 (fi)	1989-10-17	En terapeutiskt vaerdefull foerening.
CA2114542A1 (en)	1993-02-18	Benzimidazolone derivatives as 5-ht1a and 5-ht2 antagonists
KR920008031A (ko)	1992-05-27	퀴나졸린 유도체 및 그의 제조방법
ATE50763T1 (de)	1990-03-15	Tetralin-derivate, ihre herstellung und verwendung.
NO963706L (no)	1996-11-06	Benzenkondenserte heterosykliske derivater og deres anvendelse
FI973283A0 (fi)	1997-08-08	5-(4-substituoitu piperidinyyli-1)-3-aryyli-valeriaanahappojohdannaisia takykiniinireseptoriantagonisteina
NO872004D0 (no)	1987-05-14	Fremgangsmaate for fremstilling av terapeutisk aktive 4(5)-substituerte imidazol-derivater.
IT1256320B (it)	1995-11-30	Derivati eterociclici
TR199802552T2 (xx)	1999-02-22	5-HT-2C Resept�r kar��tlar� olarak faydal� indolin t�revleri.
ATE193705T1 (de)	2000-06-15	4-p-fluorbenzoyl-1-piperidinyl-propoxy-chromen- - on derivate, deren herstellung und deren verwendung zur behandlung von psychosen und schizophrenie
NO874211D0 (no)	1987-10-08	Fremgangsmaate til fremstilling av aralkyl-4h-1,2,4-triazolderivater.
EP0654026A1 (de)	1995-05-24	Isoserine-derivate und ihre verwendung als leukotriene antagonisten.
DE60214554D1 (de)	2006-10-19	Derivate von 3-phenyl-n-(2-(4-benzyl)piperidin-1-yl)ethyl) acrylamid mit ccr-3-rezeptor antagonistischer wirkung zur verwendung bei der behandlung von entzündungen und allergischen leiden