ES2115046T3 - Derivados de imidazol sustituidos y su preparacion y uso. - Google Patents

Derivados de imidazol sustituidos y su preparacion y uso.

Info

Publication number
ES2115046T3
ES2115046T3 ES93900200T ES93900200T ES2115046T3 ES 2115046 T3 ES2115046 T3 ES 2115046T3 ES 93900200 T ES93900200 T ES 93900200T ES 93900200 T ES93900200 T ES 93900200T ES 2115046 T3 ES2115046 T3 ES 2115046T3
Authority
ES
Spain
Prior art keywords
components
preparation
salts
inden
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900200T
Other languages
English (en)
Inventor
Arto Johannes Karjalainen
Raimo Einari Virtanen
Arja Leena Karjalainen
Maire Marjatta Eloranta
Jarmo Sakari Salonen
Hannu Tapani Sipila
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Juvanita Pharma Ltd Oy
Original Assignee
Juvanita Pharma Ltd Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Juvanita Pharma Ltd Oy filed Critical Juvanita Pharma Ltd Oy
Application granted granted Critical
Publication of ES2115046T3 publication Critical patent/ES2115046T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Epoxy Resins (AREA)

Abstract

ESTE INVENTO PROVEE NUEVOS COMPONENTES DE FORMULA (I) EN DONDE Y ES -CH2R3 ES H, CH3 O CH2CH3, EXCLUYENDO 4-(5-CLORO-2,3-DIHIDRO-1H-INDEN-2-YL)-1HIMIDAZOLE Y 4-(4-CLORO-2,3-DIHIDRO-1H-INDEN-2-YL)-1H-IMIDAZOLE Y SUS SALES DE ADICION DE ACIDO NO TOXICO Y SUS MEZCLAS. SON DESCRITOS LOS PROCESOS PARA LA PREPARACION DE ESOS COMPONENTES, COMO SON NUEVAS COMPOSICIONES FARMACEUTICAS QUE COMPRENDE AL MENOS UNO DE LOS COMPONENTES O SUS SALES. LOS COMPONENTES Y SUS SALES NO TOXICAS MUESTRAN ACTIVIDAD FARMACOLOGICA VALIOSA Y SON ALTAMENTE SELECTIVOS Y ANTAGONISTAS DE ACTUACION DURADERA EN A2-ADRENOCEPTORES. SU BIODISPONIBILIDAD PERORAL ES BUENA. LOS COMPONENTES SON ESPECIALMENTE UTILES EN EL TRATAMIENTO DE DESORDENES DE CONOCIMIENTO.
ES93900200T 1991-12-20 1992-12-18 Derivados de imidazol sustituidos y su preparacion y uso. Expired - Lifetime ES2115046T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919127050A GB9127050D0 (en) 1991-12-20 1991-12-20 Substituted imidazole derivatives and their preparation and use

Publications (1)

Publication Number Publication Date
ES2115046T3 true ES2115046T3 (es) 1998-06-16

Family

ID=10706581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93900200T Expired - Lifetime ES2115046T3 (es) 1991-12-20 1992-12-18 Derivados de imidazol sustituidos y su preparacion y uso.

Country Status (17)

Country Link
US (1) US5498623A (es)
EP (1) EP0618906B1 (es)
JP (1) JP3276371B2 (es)
AT (1) ATE165350T1 (es)
AU (1) AU664584B2 (es)
CA (1) CA2117305C (es)
DE (1) DE69225240T2 (es)
DK (1) DK0618906T3 (es)
ES (1) ES2115046T3 (es)
FI (1) FI104968B (es)
GB (1) GB9127050D0 (es)
HK (1) HK1008962A1 (es)
HU (1) HU220043B (es)
NO (1) NO304227B1 (es)
PL (1) PL172532B1 (es)
RU (1) RU2120440C1 (es)
WO (1) WO1993013074A1 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9312669D0 (en) * 1993-06-18 1993-08-04 Orion Yhtymae Oy New opticla isomers
FR2735776B1 (fr) * 1995-06-22 1997-07-18 Synthelabo Derives de 2,3-dihydro-1h-indole, leur preparation et leur application en therapeutique
GB9520150D0 (en) 1995-10-03 1995-12-06 Orion Yhtymae Oy New imidazole derivatives
US6469065B1 (en) 1996-02-02 2002-10-22 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use
US20020143007A1 (en) * 1996-02-02 2002-10-03 Garvey David S. Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use
FI20000073A0 (fi) * 2000-01-14 2000-01-14 Orion Yhtymae Oy Uusia imidatsolijohdannaisia
US6388090B2 (en) 2000-01-14 2002-05-14 Orion Corporation Imidazole derivatives
US8188126B2 (en) 2002-05-16 2012-05-29 Pierre Fabre Medicament Imidazolic compounds and use thereof as alpha-2 adrenergic receptors
GB0226076D0 (en) * 2002-11-08 2002-12-18 Rp Scherer Technologies Inc Improved formulations containing substituted imidazole derivatives
FI20022007A0 (fi) * 2002-11-08 2002-11-08 Juvantia Pharma Ltd Oy Oromukosaalinen valmiste ja menetelmä sen valmistamiseksi
FI116292B (fi) * 2003-01-08 2005-10-31 Juvantia Pharma Ltd Oy Menetelmä substituoitujen imidatsolijohdannaisten valmistamiseksi ja menetelmässä käytettäviä välituotteita
CN100465163C (zh) * 2003-06-17 2009-03-04 霍夫曼-拉罗奇有限公司 顺式-2,4,5-三芳基-咪唑啉类化合物
EP2456749B1 (en) 2009-07-24 2016-03-30 DSM Pharma Chemicals Regensburg GmbH Indane derivatives for use as intermediates
WO2011014613A2 (en) * 2009-07-31 2011-02-03 Dr. Reddy's Laboratories Ltd. Preparation of fipamezole
EP2502917A1 (en) 2011-03-17 2012-09-26 Santhera Pharmaceuticals (Schweiz) AG Solid state crystalline forms of 4-(2-ethyl-5-fluoro-2,3-dihydro-1H-inden-2-yl)-1H-imidazole
US12414937B2 (en) * 2015-11-05 2025-09-16 University Of Louisville Research Foundation, Inc. Local and regional anesthesia and analgesia
EP4658639A1 (en) * 2023-02-01 2025-12-10 Univerza V Ljubljani N,n-dialkyl-4-(2-ethylindan-2-yl)-1h-imidazole-1-carboxamides and related compounds for treatment of neurodegenerative diseases
LU103072B1 (en) * 2023-02-15 2024-08-19 Univ Ljubljani N,N-DIALKYL-4-(2-ETHYLINDAN-2-YL)-lH-IMIDAZOLE-l-CARBOXAMIDES AND RELATED COMPOUNDS FOR TREATMENT OF NEURODEGENERATIVE DISEASES
CN117186010B (zh) * 2023-08-15 2026-04-14 厦门欧瑞捷生物科技有限公司 一种盐酸阿替美唑的合成方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1282535A (en) * 1970-03-02 1972-07-19 Pfizer (2-IMIDAZOLIN-2-YLAMINO)SUBSTITUTED BENZO[b]THIOPHENES
US3927023A (en) * 1974-05-24 1975-12-16 Warner Lambert Co Imidazolyl benzofurans
US3927018A (en) * 1974-12-23 1975-12-16 Sandoz Ag 3-(2-Methyl-1-imidazolyl)-3-phenyl-1-(3H)isobenzofuranones
IL66242A0 (en) * 1981-07-23 1982-11-30 Erba Farmitalia N-imidazolyl derivatives of 1,2,3,4-tetrahydro-naphthalene,indan and 2-substituted-1-chroman,their preparation and pharmaceutical compositions containing them
NZ201219A (en) * 1981-07-28 1984-10-19 Reckitt & Colmann Prod Ltd Dihydrobenzofuranyl-2-imidazolines and pharmaceutical compositions
ES8503669A1 (es) * 1982-07-05 1985-03-01 Erba Farmitalia Procedimiento para preparar derivados n-imidazolilicos de compuestos biciclicos.
GB8409884D0 (en) * 1984-04-17 1984-05-31 Detexomat Machinery Ltd Transporting fabric pieces
GB2167408B (en) * 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
FI81092C (fi) * 1986-05-15 1990-09-10 Farmos Oy Foerfarande foer framstaellning av terapeutiskt aktiva 4(5)-(2,3-dihydro-1h-inden-2-yl)-imidazolderivat.
JP2855341B2 (ja) * 1988-06-10 1999-02-10 武田薬品工業株式会社 新規２―置換クマラン誘導体
IL91542A0 (en) * 1988-10-06 1990-04-29 Erba Carlo Spa N-imidazolyl-and n-imidazolyl-methyl derivatives of substituted bicyclic compounds,their preparation and pharmaceutical compositions containing them
GB2225782A (en) * 1988-12-09 1990-06-13 Farmos Group Limited Imidazole derivatives useful for treatment of diabetes
GB9020128D0 (en) * 1990-09-14 1990-10-24 Reckitt & Colmann Prod Ltd Imidazoline derivatives
WO1993012931A1 (en) * 1991-12-23 1993-07-08 Mobil Oil Corporation Low oxygen transmissive film
GB9127430D0 (en) * 1991-12-27 1992-02-19 Scras Benzofuranylimidazole derivatives

Also Published As

Publication number Publication date
JPH07506087A (ja) 1995-07-06
AU3160593A (en) 1993-07-28
DK0618906T3 (da) 1999-01-25
FI104968B (fi) 2000-05-15
FI942882A0 (fi) 1994-06-16
HU220043B (hu) 2001-10-28
GB9127050D0 (en) 1992-02-19
NO942335D0 (no) 1994-06-17
NO304227B1 (no) 1998-11-16
HK1008962A1 (en) 1999-05-21
JP3276371B2 (ja) 2002-04-22
ATE165350T1 (de) 1998-05-15
EP0618906A1 (en) 1994-10-12
CA2117305C (en) 2003-11-25
CA2117305A1 (en) 1993-07-08
AU664584B2 (en) 1995-11-23
RU94031215A (ru) 1996-04-20
WO1993013074A1 (en) 1993-07-08
DE69225240T2 (de) 1998-08-27
PL172532B1 (en) 1997-10-31
NO942335L (no) 1994-06-20
HUT67548A (en) 1995-04-28
DE69225240D1 (de) 1998-05-28
EP0618906B1 (en) 1998-04-22
HU9401823D0 (en) 1994-09-28
RU2120440C1 (ru) 1998-10-20
US5498623A (en) 1996-03-12
FI942882A7 (fi) 1994-06-16

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