ATE165357T1 - Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen - Google Patents

Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen

Info

Publication number: ATE165357T1
Authority: AT; Austria
Prior art keywords: compounds; compositions; heterocyclic compounds; new use; bis
Prior art date: 1993-02-24

Application number

AT94909794T

Other languages

English (en)

Inventor

Oliver J Mcconnell

Gabriel Saucy

Robert Jacobs

Original Assignee

Harbor Branch Oceanographic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-02-24

Filing date

1994-02-24

Publication date

1998-05-15

1994-02-24 Application filed by Harbor Branch Oceanographic filed Critical Harbor Branch Oceanographic

1998-05-15 Application granted granted Critical

1998-05-15 Publication of ATE165357T1 publication Critical patent/ATE165357T1/de

Links

239000000203 mixture Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
TYGUTURXHKSOBP-UHFFFAOYSA-N 10-bromo-5,12-dihydroindolo[2,3-g]carbazole-2,3-diol Chemical class C1=C(Br)C=C2NC3=C(C4=C(C=C(C(=C4)O)O)N4)C4=CC=C3C2=C1 TYGUTURXHKSOBP-UHFFFAOYSA-N 0.000 abstract 1
AUJKXAIGSXKZBR-UHFFFAOYSA-N Dragmacidin Natural products BrC1=CC(O)=C2C(C3CN(C(CN3)C=3C4=CC=C(Br)C=C4NC=3)C)=CNC2=C1Br AUJKXAIGSXKZBR-UHFFFAOYSA-N 0.000 abstract 1
230000003110 anti-inflammatory effect Effects 0.000 abstract 1
229930186849 nortopsentin Natural products 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
ONYVJPZNVCOAFF-UHFFFAOYSA-N topsentin Natural products Oc1ccc2cc([nH]c2c1)C(=O)c3ncc([nH]3)c4c[nH]c5ccccc45 ONYVJPZNVCOAFF-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Characterised By The Charging Evacuation (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

AT94909794T 1993-02-24 1994-02-24 Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen ATE165357T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/021,929 US5290777A (en)	1993-02-24	1993-02-24	Use for topsentin compounds and pharmaceutical compositions containing same

Publications (1)

Publication Number	Publication Date
ATE165357T1 true ATE165357T1 (de)	1998-05-15

Family

ID=21806918

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94909794T ATE165357T1 (de)	1993-02-24	1994-02-24	Neue verwendung bis-heterocyclische verbindungen und dessen zusammensetzungen

Country Status (8)

Country	Link
US (3)	US5290777A (de)
EP (1)	EP0686154B1 (de)
JP (1)	JP4028888B2 (de)
AT (1)	ATE165357T1 (de)
CA (1)	CA2155323C (de)
DE (1)	DE69409796T2 (de)
ES (1)	ES2115220T3 (de)
WO (1)	WO1994019343A2 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5639468A (en) *	1995-06-07	1997-06-17	University Of Southern California	Method for reducing or preventing post-surgical adhesion formation using manoalide and analogs thereof
US5977117A (en) *	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
CA2268399C (en) *	1996-10-31	2008-08-19	Harbor Branch Oceanographic Institution, Inc.	Anti-neurogenic inflammatory compounds and compositions and methods of use thereof
WO1999042092A2 (en) *	1998-02-20	1999-08-26	Harbor Branch Oceanographic Institution, Inc.	Compounds and methods of use for treatment of neurogenic inflammation
ATE277010T1 (de) *	1998-07-08	2004-10-15	Harbor Branch Oceanographic	Bis-indolederivate und ihre verwendung als entzündungshemmende mittel
US6589975B2 (en)	1998-07-08	2003-07-08	The Regents Of The University Of California	Synthetic compounds for treatment of inflammation
US6492406B1 (en)	1999-05-21	2002-12-10	Astrazeneca Ab	Pharmaceutically active compounds
US6087363A (en) *	1999-07-16	2000-07-11	Harbor Branch Oceanographic Institution, Inc.	Use of imidazole and indole compounds as inhibitors of nitric oxide synthase
KR100404580B1 (ko) *	2000-04-20	2003-11-05	한국해양연구원	원도닌 ａ 및 그의 제조방법
CA2460345A1 (en) *	2001-09-13	2003-03-20	Synta Pharmaceuticals Corp.	2-aroylimidazole compounds for treating cancer
US7573159B1 (en)	2001-10-22	2009-08-11	Apple Inc.	Power adapters for powering and/or charging peripheral devices
WO2016023106A1 (en) *	2014-08-15	2016-02-18	The University Of British Columbia	Bis-indole alkaloids for use in the treatment of infections
CN107810961B (zh) *	2016-09-12	2021-04-02	南开大学	Topsentin类生物碱在抗植物病毒和病菌中的应用
CN107814790B (zh) *	2016-09-12	2021-03-30	南开大学	Topsentin类衍生物及其制备和在抗植物病毒和病菌中的应用
CN109422734B (zh) *	2017-08-21	2021-03-30	南开大学	Nortopsentin类生物碱衍生物及其制备和在防治病虫害中的应用
CN109418267B (zh) *	2017-08-21	2021-03-30	南开大学	Nortopsentin类生物碱及其衍生物在防治植物病虫害中的应用
CN121135694A (zh) *	2025-09-22	2025-12-16	湖南中医药大学	一种双吲哚生物碱(S)-6’’-Debromohamacanthin A的不对称制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0272810A3 (de) *	1986-11-26	1988-07-20	Harbor Branch Oceanographic Institution, Inc.	Antitumor- und Antiviral-Alkaloide
US4895844A (en) *	1987-03-25	1990-01-23	Harbor Branch Oceanographic Institution, Inc.	Indole alkaloid compositions and their methods of use
US4866084A (en) *	1987-07-17	1989-09-12	Harbor Branch Oceanographic Institution, Inc.	Topsentin compounds effective against viruses and certain tumors
NZ227850A (en) *	1988-02-10	1991-11-26	Hoffmann La Roche	Indole substituted pyrrole derivatives; preparatory process and medicaments for use against inflammatory immunological, bronchopulmonary or vascular disorders
US4970226A (en) *	1989-10-03	1990-11-13	Harbor Branch Oceanographic Institution, Inc.	Bis-indole imidazole compounds which are useful antitumor and antimicrobial agents

1993
- 1993-02-24 US US08/021,929 patent/US5290777A/en not_active Expired - Lifetime
1994
- 1994-02-24 EP EP94909794A patent/EP0686154B1/de not_active Expired - Lifetime
- 1994-02-24 CA CA002155323A patent/CA2155323C/en not_active Expired - Fee Related
- 1994-02-24 ES ES94909794T patent/ES2115220T3/es not_active Expired - Lifetime
- 1994-02-24 DE DE69409796T patent/DE69409796T2/de not_active Expired - Fee Related
- 1994-02-24 US US08/201,309 patent/US5464835A/en not_active Expired - Lifetime
- 1994-02-24 AT AT94909794T patent/ATE165357T1/de not_active IP Right Cessation
- 1994-02-24 WO PCT/US1994/002031 patent/WO1994019343A2/en not_active Ceased
- 1994-02-24 JP JP51928294A patent/JP4028888B2/ja not_active Expired - Fee Related
- 1994-10-28 US US08/330,651 patent/US5496950A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
WO1994019343A3 (en)	1994-10-27
JP4028888B2 (ja)	2007-12-26
WO1994019343A2 (en)	1994-09-01
US5464835A (en)	1995-11-07
CA2155323A1 (en)	1994-09-01
US5290777A (en)	1994-03-01
EP0686154A1 (de)	1995-12-13
DE69409796D1 (de)	1998-05-28
US5496950A (en)	1996-03-05
DE69409796T2 (de)	1998-08-13
CA2155323C (en)	2005-06-14
ES2115220T3 (es)	1998-06-16
JPH09500091A (ja)	1997-01-07
EP0686154B1 (de)	1998-04-22

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Legal Events

Date	Code	Title	Description
1998-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties