ATE166352T1 - Quinuclidinderivate als squalene synthese inhibitoren - Google Patents

Quinuclidinderivate als squalene synthese inhibitoren

Info

Publication number: ATE166352T1
Authority: AT; Austria
Prior art keywords: alkyl; derivatives; halogeno; carbamoyl; hydroxy
Prior art date: 1992-12-21

Application number

AT94902926T

Other languages

English (en)

Inventor

George Robert Brown

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-21

Filing date

1993-12-21

Publication date

1998-06-15

1993-12-21 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE166352T1 publication Critical patent/ATE166352T1/de

Links

239000003112 inhibitor Substances 0.000 title abstract 2
YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 title 1
BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 title 1
230000015572 biosynthetic process Effects 0.000 title 1
PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 title 1
SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical class C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 title 1
229940031439 squalene Drugs 0.000 title 1
TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 4
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
-1 hydroxy, amino Chemical group 0.000 abstract 2
150000002923 oximes Chemical class 0.000 abstract 2
108010022535 Farnesyl-Diphosphate Farnesyltransferase Proteins 0.000 abstract 1
102100037997 Squalene synthase Human genes 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
125000005236 alkanoylamino group Chemical group 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000005115 alkyl carbamoyl group Chemical group 0.000 abstract 1
150000005215 alkyl ethers Chemical class 0.000 abstract 1
125000004644 alkyl sulfinyl group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000004414 alkyl thio group Chemical group 0.000 abstract 1
125000005281 alkyl ureido group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
230000009286 beneficial effect Effects 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
125000001951 carbamoylamino group Chemical group C(N)(=O)N* 0.000 abstract 1
125000001589 carboacyl group Chemical class 0.000 abstract 1
235000012000 cholesterol Nutrition 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Vascular Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Urology & Nephrology (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

AT94902926T 1992-12-21 1993-12-21 Quinuclidinderivate als squalene synthese inhibitoren ATE166352T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929226577A GB9226577D0 (en)	1992-12-21	1992-12-21	Heterocyclic derivatives

Publications (1)

Publication Number	Publication Date
ATE166352T1 true ATE166352T1 (de)	1998-06-15

Family

ID=10726942

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94902926T ATE166352T1 (de)	1992-12-21	1993-12-21	Quinuclidinderivate als squalene synthese inhibitoren

Country Status (7)

Country	Link
EP (1)	EP0674636B1 (de)
JP (1)	JPH08504802A (de)
AT (1)	ATE166352T1 (de)
AU (1)	AU5708794A (de)
DE (1)	DE69318725T2 (de)
GB (1)	GB9226577D0 (de)
WO (1)	WO1994014804A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5556990A (en) *	1994-12-16	1996-09-17	Rhone-Poulenc Rorer Pharmaceuticals Inc.	Polyarylcarbamoylaza- and -carbamoylalkanedioic acids

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU1752792A (en) *	1991-03-08	1992-10-06	Rhone-Poulenc Rorer International (Holdings) Inc.	Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
GB9207961D0 (en) *	1992-04-10	1992-05-27	Ici Plc	Heterocyclic derivatives

1992
- 1992-12-21 GB GB929226577A patent/GB9226577D0/en active Pending
1993
- 1993-12-21 JP JP6514942A patent/JPH08504802A/ja active Pending
- 1993-12-21 DE DE69318725T patent/DE69318725T2/de not_active Expired - Fee Related
- 1993-12-21 AT AT94902926T patent/ATE166352T1/de not_active IP Right Cessation
- 1993-12-21 WO PCT/GB1993/002616 patent/WO1994014804A1/en not_active Ceased
- 1993-12-21 AU AU57087/94A patent/AU5708794A/en not_active Abandoned
- 1993-12-21 EP EP94902926A patent/EP0674636B1/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
AU5708794A (en)	1994-07-19
GB9226577D0 (en)	1993-02-17
EP0674636B1 (de)	1998-05-20
WO1994014804A1 (en)	1994-07-07
DE69318725T2 (de)	1998-09-17
JPH08504802A (ja)	1996-05-28
DE69318725D1 (de)	1998-06-25
EP0674636A1 (de)	1995-10-04

Legal Events

Date	Code	Title	Description
1998-11-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
ATE161843T1 (de)	1998-01-15	Chinuclidine derivate als squalen synthase inhibitoren
DE60020941D1 (de)	2005-07-28	Chinazolinderivate als angiogenesehemmer
ATE277020T1 (de)	2004-10-15	Pyrimidine verbindungen
NZ309151A (en)	2000-01-28	a 3-substituted cyano or carbamoyl pyrrole derivative and pharmaceutical composition
ATE182331T1 (de)	1999-08-15	Oxazolidone derivative als monoamine- oxidaseinhibitoren
AU6948091A (en)	1991-07-25	Thiazolidine derivatives having anti-hypertensive activity and their therapeutic use
IL116526A (en)	1999-11-30	Piperazinediones their preparation and pharmaceutical and veterinary compositions containing them
IL105882A0 (en)	1993-10-20	Heterocyclic derivatives
DE69318725D1 (de)	1998-06-25	Quinuclidinderivate als squalene synthese inhibitoren
ATE159255T1 (de)	1997-11-15	Chinuclidine derivate als squalen synthase inhibitoren
ATE170857T1 (de)	1998-09-15	Chinuclidine derivate als squalen synthase inhibitore
NO894325L (no)	1990-05-02	Fremgangsmaate for fremstilling av terapeutisk aktive pyrrolidin-derivater.
MY140507A (en)	2009-12-31	Quinazoline derivatives, pharmaceutical compositions containing them, processes for their preparation and their use in the production of an antiangiogenic and/or vascular permeability reducing effect