ATE166644T1 - 2-bromo- und 2-nitroxy-derivate von 3-bromo- und 3,3-dibromo-4-oxo-azetidinen, verfahren zu ihrer herstellung und deren verwendung - Google Patents

2-bromo- und 2-nitroxy-derivate von 3-bromo- und 3,3-dibromo-4-oxo-azetidinen, verfahren zu ihrer herstellung und deren verwendung

Info

Publication number: ATE166644T1
Authority: AT; Austria
Prior art keywords: bromo; dibromo; oxo; nitroxy; derivatives
Prior art date: 1993-07-09

Application number

AT94110387T

Other languages

English (en)

Inventor

Irena Lukic

Original Assignee

Pliva Pharm & Chem Works

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-07-09

Filing date

1994-07-04

Publication date

1998-06-15

1994-07-04 Application filed by Pliva Pharm & Chem Works filed Critical Pliva Pharm & Chem Works

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE166644T1 publication Critical patent/ATE166644T1/de

Links

238000000034 method Methods 0.000 title abstract 2
FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 abstract 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 abstract 3
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 abstract 2
239000002904 solvent Substances 0.000 abstract 2
BUUPQKDIAURBJP-UHFFFAOYSA-N sulfinic acid Chemical compound OS=O BUUPQKDIAURBJP-UHFFFAOYSA-N 0.000 abstract 2
FMNUBORQHLJREC-UHFFFAOYSA-N (3,3-dibromo-4-oxoazetidin-2-yl) nitrate Chemical compound [O-][N+](=O)OC1NC(=O)C1(Br)Br FMNUBORQHLJREC-UHFFFAOYSA-N 0.000 abstract 1
VVLJZVLXDNESKI-UHFFFAOYSA-N 3,3,4-tribromoazetidin-2-one Chemical compound BrC1NC(=O)C1(Br)Br VVLJZVLXDNESKI-UHFFFAOYSA-N 0.000 abstract 1
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 abstract 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000000844 anti-bacterial effect Effects 0.000 abstract 1
230000000259 anti-tumor effect Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
230000008020 evaporation Effects 0.000 abstract 1
238000001704 evaporation Methods 0.000 abstract 1
238000009472 formulation Methods 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
KPADFPAILITQBG-UHFFFAOYSA-N non-4-ene Chemical compound CCCCC=CCCC KPADFPAILITQBG-UHFFFAOYSA-N 0.000 abstract 1
RBKMMJSQKNKNEV-RITPCOANSA-N penicillanic acid Chemical compound OC(=O)[C@H]1C(C)(C)S[C@@H]2CC(=O)N21 RBKMMJSQKNKNEV-RITPCOANSA-N 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000000376 reactant Substances 0.000 abstract 1
239000011541 reaction mixture Substances 0.000 abstract 1
239000000741 silica gel Substances 0.000 abstract 1
229910002027 silica gel Inorganic materials 0.000 abstract 1
229910001961 silver nitrate Inorganic materials 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
DZLFLBLQUQXARW-UHFFFAOYSA-N tetrabutylammonium Chemical compound CCCC[N+](CCCC)(CCCC)CCCC DZLFLBLQUQXARW-UHFFFAOYSA-N 0.000 abstract 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
150000003952 β-lactams Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Cephalosporin Compounds (AREA)

AT94110387T 1993-07-09 1994-07-04 2-bromo- und 2-nitroxy-derivate von 3-bromo- und 3,3-dibromo-4-oxo-azetidinen, verfahren zu ihrer herstellung und deren verwendung ATE166644T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HR931047A HRP931047B1 (en)	1993-07-09	1993-07-09	2-bromo- and 2-nitroxy derivatives of 3-bromo- and 3,3-dibromo-4-oxo-azetidines, processes for the preparation thereof and their use

Publications (1)

Publication Number	Publication Date
ATE166644T1 true ATE166644T1 (de)	1998-06-15

Family

ID=10945991

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94110387T ATE166644T1 (de)	1993-07-09	1994-07-04	2-bromo- und 2-nitroxy-derivate von 3-bromo- und 3,3-dibromo-4-oxo-azetidinen, verfahren zu ihrer herstellung und deren verwendung

Country Status (16)

Country	Link
US (4)	US5670638A (de)
EP (1)	EP0633247B1 (de)
JP (1)	JPH07149716A (de)
CN (1)	CN1100719A (de)
AT (1)	ATE166644T1 (de)
BG (1)	BG61645B1 (de)
CA (1)	CA2127677C (de)
CZ (1)	CZ286810B6 (de)
DE (1)	DE69410539T2 (de)
ES (1)	ES2118287T3 (de)
HR (1)	HRP931047B1 (de)
HU (1)	HUT68298A (de)
PL (1)	PL178949B1 (de)
RU (1)	RU2134685C1 (de)
SI (1)	SI0633247T1 (de)
SK (1)	SK79194A3 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SK13897A3 (en)	1996-02-06	1998-05-06	Pliva Pharm & Chem Works	3-bromo- and 3,3-dibromo-4-oxo-1-azetidines, method for preparation thereof and their use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS607635B2 (ja) *	1976-04-27	1985-02-26	塩野義製薬株式会社	オキサゾリジン化合物
EP0035188B1 (de) *	1980-02-28	1985-04-17	Schering Corporation	2-Penem-Verbindungen, sie enthaltende pharmazeutische Zusammensetzungen und Verfahren zu ihrer Herstellung
WO1982001705A1 (en) *	1980-11-13	1982-05-27	Takeda Chemical Industries Ltd	4-substituted-2-oxoazetidine derivatives and process for their preparation
JPH03271297A (ja) *	1990-03-22	1991-12-03	Sankyo Co Ltd	白金複核錯体
US5075439A (en) *	1990-08-17	1991-12-24	Pfizer Inc.	Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(thiocarbonyl)thio]azetidin-2-ones and intermediates therefor
HU212573B (en) *	1991-02-12	1996-08-29	Pliva Pharm & Chem Works	Process for producing 4-oxo-azetidine-2-sulfonic acids and their salts

1993
- 1993-07-09 HR HR931047A patent/HRP931047B1/xx not_active IP Right Cessation
1994
- 1994-06-30 SK SK791-94A patent/SK79194A3/sk unknown
- 1994-07-04 SI SI9430165T patent/SI0633247T1/xx unknown
- 1994-07-04 DE DE69410539T patent/DE69410539T2/de not_active Expired - Fee Related
- 1994-07-04 ES ES94110387T patent/ES2118287T3/es not_active Expired - Lifetime
- 1994-07-04 AT AT94110387T patent/ATE166644T1/de not_active IP Right Cessation
- 1994-07-04 EP EP94110387A patent/EP0633247B1/de not_active Expired - Lifetime
- 1994-07-06 JP JP6154546A patent/JPH07149716A/ja active Pending
- 1994-07-07 CZ CZ19941647A patent/CZ286810B6/cs not_active IP Right Cessation
- 1994-07-08 BG BG98895A patent/BG61645B1/bg unknown
- 1994-07-08 CA CA002127677A patent/CA2127677C/en not_active Expired - Fee Related
- 1994-07-08 CN CN94108240A patent/CN1100719A/zh active Pending
- 1994-07-08 HU HU9402053A patent/HUT68298A/hu unknown
- 1994-07-08 US US08/272,206 patent/US5670638A/en not_active Expired - Fee Related
- 1994-07-08 RU RU94026293A patent/RU2134685C1/ru active
- 1994-07-08 PL PL94304191A patent/PL178949B1/pl unknown
1995
- 1995-07-10 US US08/500,001 patent/US5637581A/en not_active Expired - Fee Related
1996
- 1996-03-27 US US08/624,919 patent/US5847119A/en not_active Expired - Fee Related
1997
- 1997-09-10 US US08/926,449 patent/US5892036A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CA2127677A1 (en)	1995-01-10
BG61645B1 (bg)	1998-02-27
SK79194A3 (en)	1995-04-12
RU2134685C1 (ru)	1999-08-20
JPH07149716A (ja)	1995-06-13
EP0633247B1 (de)	1998-05-27
HU9402053D0 (en)	1994-09-28
HRP931047B1 (en)	2000-02-29
HUT68298A (en)	1995-06-28
DE69410539D1 (de)	1998-07-02
CA2127677C (en)	2000-02-08
US5892036A (en)	1999-04-06
PL304191A1 (en)	1995-01-23
PL178949B1 (pl)	2000-07-31
HRP931047A2 (en)	1997-04-30
CN1100719A (zh)	1995-03-29
DE69410539T2 (de)	1998-11-26
CZ164794A3 (en)	1995-07-12
US5637581A (en)	1997-06-10
BG98895A (bg)	1995-05-31
RU94026293A (ru)	1996-05-27
SI0633247T1 (en)	1998-10-31
US5670638A (en)	1997-09-23
US5847119A (en)	1998-12-08
EP0633247A1 (de)	1995-01-11
ES2118287T3 (es)	1998-09-16
CZ286810B6 (en)	2000-07-12

Legal Events

Date	Code	Title	Description
1999-01-15	UEP	Publication of translation of european patent specification
2001-04-15	REN	Ceased due to non-payment of the annual fee

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DK0568306T3 (da)	1996-12-23	Anitkonvulsive fructopyranose cycliske sulfitter og sulfater
ES8707243A1 (es)	1987-07-16	Un procedimiento para preparar derivados de tienopiridona
DE69410539D1 (de)	1998-07-02	2-Bromo- und 2-Nitroxy-Derivate von 3-Bromo- und 3,3-Dibromo-4-oxo-azetidinen, Verfahren zu ihrer Herstellung und deren Verwendung
EP0937703A4 (de)	1999-12-22	Verfahren zur reinigung von brenztraubensäureverbindungen
BR9100921A (pt)	1991-11-05	Processo para preparacao de precursor de amicacina e composto de 3,6'-di-n-acil-canamicina a potonizada
EP0024683B1 (de)	1982-10-27	Verfahren zur Herstellung von Thiochlorformiaten
DE2638555B2 (de)	1978-11-30	Verfahren zur Herstellung von Pantethin
DE2556045C2 (de)	1990-08-09
DE1951012A1 (de)	1970-04-23	Ester der 7-(alpha-Amino-alpha-phenylacctamido)-3-methyl-delta?-cephem-4-carbonsaeure
DE2828888C2 (de)	1987-10-29
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EP0362668B1 (de)	1993-01-27	Derivate der 2-Pyrrolidon-5-carbonsäure und Verfahren zu ihrer Gewinnung
CH393330A (de)	1965-06-15	Verfahren zur Herstellung von a-Aminobenzylpenicillinen
DE2558507B2 (de)	1979-03-08	Verfahren zur Racemattrennung von dJ-l-Phenyl-2-amino-2-propanol
DE2144457C3 (de)	1977-12-15	a-Aminobenzylpenicillinester, Verfahren zu deren Herstellung und sie enthaltende Arzneimittel
DE3120450A1 (de)	1982-02-25	Verfahren zur herstellung von carbonsaeureamiden
EP0658540A1 (de)	1995-06-21	Verfahren zur Herstellung von hochreinem Isobuttersäureamid
DE2344608C3 (de)	1979-07-26	Verfahren zur Herstellung von D-Lysergsäureamiden
DE1178085B (de)	1964-09-17	Verfahren zur Herstellung von 2,3,5,6-Tetra-cyan-1,4-dithiin
DE2657652C3 (de)	1982-04-08	N-Acylderivate des Cefalexins und ihre Herstellung
DE2029195A1 (de)	1970-12-17	Neues Verfahren zur Herstellung von Ampicillin
DE1047769B (de)	1958-12-31	Verfahren zur Herstellung von 2-Phenyl-1,3-propandioldicarbamat
CS238443B1 (sk)	1985-11-13	Sposob výroby l,3,5,7-tetranitro-l,3,5,7-tetraazacyklooktánu
CH643528A5 (de)	1984-06-15	Verfahren zur herstellung von beta-chloralanin.
DE4416868A1 (de)	1994-11-17	Verfahren zur Synthese von 1-Alkyl-3-hydroxy-5-halogen-1,2,4-triazolen sowie neue Hydrazinderivate