ATE166654T1 - Verwendung von halogenierten beta-lactamen zur herstellung von 3-hydroxycephem-derivaten - Google Patents

Verwendung von halogenierten beta-lactamen zur herstellung von 3-hydroxycephem-derivaten

Info

Publication number: ATE166654T1
Authority: AT; Austria
Prior art keywords: producing; hydroxycephem; lactams; derivatives; iii
Prior art date: 1991-03-13

Application number

AT92904403T

Other languages

English (en)

Inventor

Shigeru Torii

Hideo Tanaka

Masatoshi Taniguchi

Mitio Sasaoka

Takashi Shiroi

Yutaka Kameyama

Ryo Kikuchi

Original Assignee

Otsuka Kagaku Kk

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-03-13

Filing date

1992-02-10

Publication date

1998-06-15

1992-02-10 Application filed by Otsuka Kagaku Kk filed Critical Otsuka Kagaku Kk

1998-06-15 Application granted granted Critical

1998-06-15 Publication of ATE166654T1 publication Critical patent/ATE166654T1/de

Links

ZUBXPSDFPQTKQN-ZCFIWIBFSA-N (6r)-3-hydroxy-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class S1CC(O)=CN2C(=O)C[C@H]21 ZUBXPSDFPQTKQN-ZCFIWIBFSA-N 0.000 title abstract 2
150000003952 β-lactams Chemical class 0.000 title 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
230000000903 blocking effect Effects 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
-1 beta -lactam compound Chemical class 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
125000003107 substituted aryl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
- C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
- C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Electrolytic Production Of Non-Metals, Compounds, Apparatuses Therefor (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

AT92904403T 1991-03-13 1992-02-10 Verwendung von halogenierten beta-lactamen zur herstellung von 3-hydroxycephem-derivaten ATE166654T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP04708491A JP3195959B2 (ja)	1991-03-13	1991-03-13	３−ヒドロキシセフェム誘導体の製造法

Publications (1)

Publication Number	Publication Date
ATE166654T1 true ATE166654T1 (de)	1998-06-15

Family

ID=12765312

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92904403T ATE166654T1 (de)	1991-03-13	1992-02-10	Verwendung von halogenierten beta-lactamen zur herstellung von 3-hydroxycephem-derivaten

Country Status (5)

Country	Link
EP (1)	EP0529081B1 (de)
JP (1)	JP3195959B2 (de)
AT (1)	ATE166654T1 (de)
DE (1)	DE69225651T2 (de)
WO (1)	WO1992016532A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3775818B2 (ja)	1995-03-10	2006-05-17	大塚化学ホールディングス株式会社	ハロゲン化β−ラクタム化合物の製造法
DE69629321T2 (de) *	1995-03-10	2004-04-22	Otsuka Kagaku K.K.	Verfahren zur Herstellung von Exo-Methylenpenam-Derivaten
US5986091A (en) *	1996-03-13	1999-11-16	Otsuka Kagaku Kabushiki Kaisha	Process for preparation of β-lactam compounds
JP4953501B2 (ja) *	1999-09-30	2012-06-13	大塚化学株式会社	３−セフェム誘導体結晶の製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU498131B2 (en) *	1974-02-26	1979-02-15	Ciba-Geigy Ag	Production of cephems by cyclization
JPS51105051A (de) *	1975-02-21	1976-09-17	Shionogi Seiyaku Kk
JPS609516B2 (ja) *	1975-03-07	1985-03-11	塩野義製薬株式会社	セフエム骨格の環化製法
US4048157A (en) *	1975-10-29	1977-09-13	Eli Lilly And Company	4(Formylthio)-azetidin-2-ones and ozonization process therefor
US4048162A (en) *	1975-10-29	1977-09-13	Eli Lilly And Company	Process for preparing 3-hydroxy cephalosporins
JP3007986B2 (ja) *	1990-03-02	2000-02-14	大塚化学株式会社	β―ラクタム誘導体の製法

1991
- 1991-03-13 JP JP04708491A patent/JP3195959B2/ja not_active Expired - Fee Related
1992
- 1992-02-10 EP EP92904403A patent/EP0529081B1/de not_active Expired - Lifetime
- 1992-02-10 AT AT92904403T patent/ATE166654T1/de not_active IP Right Cessation
- 1992-02-10 WO PCT/JP1992/000126 patent/WO1992016532A1/ja not_active Ceased
- 1992-02-10 DE DE69225651T patent/DE69225651T2/de not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0529081B1 (de)	1998-05-27
DE69225651D1 (de)	1998-07-02
EP0529081A1 (de)	1993-03-03
EP0529081A4 (en)	1993-06-02
JP3195959B2 (ja)	2001-08-06
WO1992016532A1 (fr)	1992-10-01
DE69225651T2 (de)	1998-11-12
JPH04283584A (ja)	1992-10-08

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Legal Events

Date	Code	Title	Description
1999-02-15	UEP	Publication of translation of european patent specification
2003-11-15	REN	Ceased due to non-payment of the annual fee