ATE167230T1 - Wundheilmittel enthaltend heparanase - Google Patents
Wundheilmittel enthaltend heparanaseInfo
- Publication number
- ATE167230T1 ATE167230T1 AT90913352T AT90913352T ATE167230T1 AT E167230 T1 ATE167230 T1 AT E167230T1 AT 90913352 T AT90913352 T AT 90913352T AT 90913352 T AT90913352 T AT 90913352T AT E167230 T1 ATE167230 T1 AT E167230T1
- Authority
- AT
- Austria
- Prior art keywords
- pct
- heparanase
- hep
- wound healant
- sec
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01166—Heparanase (3.2.1.166)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/924—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
- G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum
- G01N2400/40—Glycosaminoglycans, i.e. GAG or mucopolysaccharides, e.g. chondroitin sulfate, dermatan sulfate, hyaluronic acid, heparin, heparan sulfate, and related sulfated polysaccharides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Dermatology (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Primary Cells (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US39755489A | 1989-08-23 | 1989-08-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE167230T1 true ATE167230T1 (de) | 1998-06-15 |
Family
ID=23571661
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90913352T ATE167230T1 (de) | 1989-08-23 | 1990-08-22 | Wundheilmittel enthaltend heparanase |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5362641A (de) |
| EP (1) | EP0487627B1 (de) |
| JP (1) | JP3188691B2 (de) |
| KR (1) | KR927003090A (de) |
| AT (1) | ATE167230T1 (de) |
| AU (1) | AU654804B2 (de) |
| CA (1) | CA2065744A1 (de) |
| DE (1) | DE69032406T2 (de) |
| WO (1) | WO1991002977A1 (de) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH05509403A (ja) * | 1990-05-31 | 1993-12-22 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | マウスおよびヒトメラノーマ(黒色腫)中のヘパラナーゼの免疫化学的方法による位置確定 |
| FR2708198B1 (fr) * | 1993-07-28 | 1995-10-20 | Dior Christian Parfums | Composition cosmétique ou pharmaceutique, notamment dermatologique contenant un extrait de Tephrosia, en particulier Tephrosia purpurea. |
| AU7368994A (en) * | 1993-07-29 | 1995-02-28 | Upjohn Company, The | Use of heparanase to identify and isolate anti-heparanase compound |
| CA2176934A1 (en) * | 1993-11-17 | 1995-05-26 | Ramnath Sasisekharan | Method for inhibiting angiogenesis using heparinase |
| US5783568A (en) * | 1994-06-10 | 1998-07-21 | Sugen, Inc. | Methods for treating cancer and other cell proliferative diseases |
| US5997863A (en) * | 1994-07-08 | 1999-12-07 | Ibex Technologies R And D, Inc. | Attenuation of wound healing processes |
| US5876728A (en) * | 1995-02-15 | 1999-03-02 | Howard David Kass | Natural composition extracted from plants used in the treatment of cancer |
| DE69633127T2 (de) * | 1995-09-29 | 2005-08-04 | BioMarin Pharmaceutical, Inc., Novato | Verwendung von heparinasen zur verminderung von entzündungsreaktionen |
| TW565614B (en) * | 1996-07-18 | 2003-12-11 | Univ Australian | Detection of mammalian heparanase activity and purification of mammalian heparanase |
| AU772311B2 (en) * | 1997-09-02 | 2004-04-22 | Hadasit Medical Research Services & Development Company Ltd | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
| US20040213789A1 (en) * | 1997-09-02 | 2004-10-28 | Oron Yacoby-Zeevi | Heparanase activity neutralizing anti-heparanase monoclonal antibody and other anti-heparanase antibodies |
| US6153187A (en) * | 1997-09-02 | 2000-11-28 | Insight Strategy & Marketing Ltd. | Use of glycosaminoglycans degrading enzymes for management of airway associated diseases |
| US6348344B1 (en) * | 1997-09-02 | 2002-02-19 | Insight Strategy & Marketing Ltd. | Genetically modified cells and methods for expressing recombinant heparanase and methods of purifying same |
| US5968822A (en) * | 1997-09-02 | 1999-10-19 | Pecker; Iris | Polynucleotide encoding a polypeptide having heparanase activity and expression of same in transduced cells |
| US20030161823A1 (en) * | 1998-08-31 | 2003-08-28 | Neta Ilan | Therapeutic and cosmetic uses of heparanases |
| US20020088019A1 (en) * | 1997-09-02 | 2002-07-04 | Oron Yacoby-Zeevi | Methods of and pharmaceutical compositions for improving implantation of embryos |
| US6190875B1 (en) * | 1997-09-02 | 2001-02-20 | Insight Strategy & Marketing Ltd. | Method of screening for potential anti-metastatic and anti-inflammatory agents using mammalian heparanase as a probe |
| US6562950B2 (en) * | 1997-09-02 | 2003-05-13 | Insight Strategy & Marketing Ltd. | Heparanase activity neutralizing anti-heparanase monoclonal antibody |
| US20010006630A1 (en) * | 1997-09-02 | 2001-07-05 | Oron Yacoby-Zeevi | Introducing a biological material into a patient |
| US6699672B1 (en) | 1997-09-02 | 2004-03-02 | Insight Biopharmaceuticals Ltd. | Heparanase specific molecular probes and their use research and medical applications |
| US6177545B1 (en) | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
| GB9802725D0 (en) * | 1998-02-09 | 1998-04-08 | Ciba Geigy Ag | Organic compounds |
| WO1999043830A2 (en) * | 1998-02-24 | 1999-09-02 | Pharmacia & Upjohn Company | Human platelet heparanase polypeptides, polynucleotide molecules that encode them, and methods for the identification of compounds that alter heparanase activity |
| DK2316475T3 (da) | 1998-08-06 | 2017-11-20 | Mountain View Pharmaceuticals Inc | Isoleret tetramer urikase |
| US20020068054A1 (en) * | 2000-09-11 | 2002-06-06 | Insight Strategy & Marketing Ltd. And Hadasit Medical Research Services And Development Ltd. | Therapeutic and cosmetic uses of heparanases |
| US20030217375A1 (en) * | 1998-08-31 | 2003-11-20 | Eyal Zcharia | Transgenic animals expressing heparanase and uses thereof |
| EP1157118A4 (de) * | 1999-03-01 | 2002-07-17 | Insight Strategy & Marketing | POLYNUKLEOTID, DAS FüR EIN POLYPEPTID MIT HEPARANASE-AKTIVäT KODIERT, UND DESSEN EXPRESSION IN GENETISCH VERäNDERTEN ZELLEN |
| US20040171535A1 (en) * | 2000-04-20 | 2004-09-02 | Heinrikson Robert Leroy | Heparanase II, a novel human heparanase paralog |
| US6677137B2 (en) * | 2000-09-20 | 2004-01-13 | Insight Strategy & Marketing Ltd. | Avian and reptile derived polynucleotide encoding a polypeptide having heparanase activity |
| WO2002032283A2 (en) * | 2000-10-17 | 2002-04-25 | Insight Strategy And Marketing Ltd. | Methods of and pharmaceutical compositions for improving implantation of embryos |
| FR2818131B1 (fr) * | 2000-12-14 | 2005-02-11 | Oreal | Composition cosmetique comprenant de l'heparanase |
| WO2003011119A2 (en) * | 2001-07-31 | 2003-02-13 | Reddy Us Therapeutics, Inc. | Methods and compositions for diagnosis and treatment of vascular conditions |
| US6671189B2 (en) * | 2001-11-09 | 2003-12-30 | Minebea Co., Ltd. | Power converter having primary and secondary side switches |
| CH696701A5 (de) * | 2001-12-18 | 2007-10-15 | Hoffmann La Roche | Verfahren zum Testen eines Mittels auf dessen Fähigkeit, die Heparanaseaktivität zu hemmen. |
| IL150829A0 (en) * | 2002-07-21 | 2003-02-12 | Yissum Res Dev Co | Method and compositions for treatment of bone disorders |
| WO2004043989A2 (en) * | 2002-11-07 | 2004-05-27 | Medarex, Inc. | Human monoclonal antibodies to heparanase |
| IL153059A0 (en) * | 2002-11-24 | 2003-06-24 | Hadasit Med Res Service | Heparanase mediated cell adhesion and uses thereof |
| WO2004108065A2 (en) * | 2003-06-09 | 2004-12-16 | Insight Biopharmaceuticals Ltd. | Heparanase activity neutralizing anti- heparanase monoclonal antibody and other anti-heparanase antibodies |
| US20070009989A1 (en) * | 2003-09-26 | 2007-01-11 | Christian Steinkuhler | Synthetic heparanase molecules and uses thereof |
| US7772185B2 (en) * | 2004-01-30 | 2010-08-10 | Emory University | Method for promoting axonal outgrowth in damaged nerves |
| WO2006023487A2 (en) * | 2004-08-16 | 2006-03-02 | Massachusetts Institute Of Technology | Rapid two-step synthesis of anti-coagulants |
| WO2006035445A2 (en) * | 2004-09-29 | 2006-04-06 | Insight Biopharmaceuticals Ltd. | Methods of treating pathologies associated with oxidative stress |
| HU229068B1 (hu) | 2005-04-11 | 2013-07-29 | Savient Pharmaceuticals | Urát oxidáz változatok és alkalmazásuk |
| US20080159976A1 (en) * | 2005-04-11 | 2008-07-03 | Jacob Hartman | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| NZ562291A (en) | 2005-04-11 | 2010-02-26 | Savient Pharmaceuticals Inc | A variant form of urate oxidase and use thereof |
| US8148123B2 (en) | 2005-04-11 | 2012-04-03 | Savient Pharmaceuticals, Inc. | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase |
| US20090081122A1 (en) * | 2005-05-23 | 2009-03-26 | Universite De Geneve | Injectable superparamagnetic nanoparticles for treatment by hyperthermia and use for forming an hyperthermic implant |
| CN101622270B (zh) * | 2006-04-12 | 2014-01-01 | 萨文特医药公司 | 用阳离子表面活性剂纯化蛋白质的方法 |
| HUP1200205A3 (en) | 2009-06-25 | 2012-09-28 | Savient Pharmaceuticals | Method and kits for perdicting infusion reaction risk and antibody-mediated low of response by monitoring serum uric acid during pegylated uricare therapy |
| BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
| US20200237881A1 (en) | 2019-01-30 | 2020-07-30 | Horizon Pharma Rheumatology Llc | Reducing immunogenicity to pegloticase |
| WO2018089808A1 (en) | 2016-11-11 | 2018-05-17 | Horizon Pharma Rheumatology Llc | Combination therapies of prednisone and uricase molecules and uses thereof |
| WO2020160322A1 (en) | 2019-01-30 | 2020-08-06 | Horizon Pharma Rheumatology Llc | Tolerization reduces intolerance to pegloticase and prolongs the urate lowering effect (triple) |
| US12269875B2 (en) | 2023-08-03 | 2025-04-08 | Jeff R. Peterson | Gout flare prevention methods using IL-1BETA blockers |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4481195A (en) * | 1978-10-13 | 1984-11-06 | Adolf Schwimmer | Method for the treatment of tumors with β-glucuronidase activity dependent pharmaceuticals |
| US4584368A (en) * | 1978-10-13 | 1986-04-22 | Adolf W. Schwimmer | β-Glucuronidase activity and/or pH-dependent pharmaceuticals and thier methods of production |
| IL61201A (en) * | 1979-10-05 | 1984-09-30 | Choay Sa | Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them |
| JPS58209980A (ja) * | 1982-04-27 | 1983-12-07 | Kyowa Hakko Kogyo Co Ltd | 酵素の精製法 |
| IL71683A0 (en) * | 1984-04-27 | 1984-09-30 | Yeda Res & Dev | Pharmaceutical compositions for treating arthritis type diseases comprising fractions obtained from mycobacteria |
| JPS61282076A (ja) * | 1985-06-08 | 1986-12-12 | Teruhiko Beppu | 耐熱性トリプトファナーゼおよびその製法 |
| US4859581A (en) * | 1986-03-10 | 1989-08-22 | Board Of Regents, The University Of Texas System | Endoglycosidase assay |
| IL79255A0 (en) * | 1986-06-26 | 1986-09-30 | Hadassah Med Org | Composition for metastasis prevention |
| US5279824A (en) * | 1988-04-14 | 1994-01-18 | Merck Patent Gmbh | Pharmaceutical formulation containing heparin and endo-beta-glucuronidase, useful for the treatment of thrombosis |
-
1990
- 1990-08-22 AT AT90913352T patent/ATE167230T1/de not_active IP Right Cessation
- 1990-08-22 DE DE69032406T patent/DE69032406T2/de not_active Expired - Fee Related
- 1990-08-22 CA CA002065744A patent/CA2065744A1/en not_active Abandoned
- 1990-08-22 KR KR1019920700417A patent/KR927003090A/ko not_active Withdrawn
- 1990-08-22 JP JP51253290A patent/JP3188691B2/ja not_active Expired - Fee Related
- 1990-08-22 EP EP90913352A patent/EP0487627B1/de not_active Expired - Lifetime
- 1990-08-22 US US07/768,900 patent/US5362641A/en not_active Expired - Fee Related
- 1990-08-22 AU AU63364/90A patent/AU654804B2/en not_active Ceased
- 1990-08-22 WO PCT/US1990/004772 patent/WO1991002977A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP0487627A1 (de) | 1992-06-03 |
| WO1991002977A1 (en) | 1991-03-07 |
| CA2065744A1 (en) | 1991-02-24 |
| EP0487627B1 (de) | 1998-06-10 |
| EP0487627A4 (en) | 1993-03-03 |
| DE69032406D1 (de) | 1998-07-16 |
| US5362641A (en) | 1994-11-08 |
| AU654804B2 (en) | 1994-11-24 |
| KR927003090A (ko) | 1992-12-17 |
| AU6336490A (en) | 1991-04-03 |
| JPH05504047A (ja) | 1993-07-01 |
| DE69032406T2 (de) | 1998-10-29 |
| JP3188691B2 (ja) | 2001-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |