ATE168986T1 - Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung - Google Patents

Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung

Info

Publication number
ATE168986T1
ATE168986T1 AT94928801T AT94928801T ATE168986T1 AT E168986 T1 ATE168986 T1 AT E168986T1 AT 94928801 T AT94928801 T AT 94928801T AT 94928801 T AT94928801 T AT 94928801T AT E168986 T1 ATE168986 T1 AT E168986T1
Authority
AT
Austria
Prior art keywords
pct
inflammatory
pain
production
acid esters
Prior art date
Application number
AT94928801T
Other languages
English (en)
Inventor
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9320599A external-priority patent/GB2283238B/en
Priority claimed from ITMI940916A external-priority patent/IT1269735B/it
Application filed by Nicox Sa filed Critical Nicox Sa
Application granted granted Critical
Publication of ATE168986T1 publication Critical patent/ATE168986T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C203/00—Esters of nitric or nitrous acid
    • C07C203/02—Esters of nitric acid
    • C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT94928801T 1993-10-06 1994-09-23 Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung ATE168986T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9320599A GB2283238B (en) 1993-10-06 1993-10-06 Nitric esters of derivatives of propionic acid and process for their preparation
ITMI940916A IT1269735B (it) 1994-05-10 1994-05-10 Prodotti provvisti di un gruppo nitroestere terminale dotati di attivita' anti-infiammatoria e/o analgesica

Publications (1)

Publication Number Publication Date
ATE168986T1 true ATE168986T1 (de) 1998-08-15

Family

ID=26303642

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94928801T ATE168986T1 (de) 1993-10-06 1994-09-23 Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung

Country Status (15)

Country Link
US (2) US5700947A (de)
EP (1) EP0722434B1 (de)
JP (1) JP3775796B2 (de)
KR (1) KR100343243B1 (de)
AT (1) ATE168986T1 (de)
AU (1) AU678063B2 (de)
BR (1) BR9407749A (de)
CA (1) CA2173582C (de)
DE (1) DE69412109T2 (de)
DK (1) DK0722434T3 (de)
ES (1) ES2120070T3 (de)
HU (1) HU218923B (de)
RU (1) RU2136653C1 (de)
SI (1) SI0722434T1 (de)
WO (1) WO1995009831A1 (de)

Families Citing this family (94)

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US5985862A (en) * 1996-05-02 1999-11-16 G.D. Searle & Co. Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
US20050137191A1 (en) * 1996-06-04 2005-06-23 Thatcher Gregory R. Nitrate esters and their use for mitigating cellular damage
US6310052B1 (en) 1996-06-04 2001-10-30 Queen's University At Kingston Nitrate esters and their use for neurological conditions
US7115661B1 (en) 1999-12-29 2006-10-03 Queen's University At Kingston Methods and compositions for mitigating pain
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Also Published As

Publication number Publication date
HUT74446A (en) 1996-12-30
KR960704834A (ko) 1996-10-09
WO1995009831A1 (en) 1995-04-13
CA2173582A1 (en) 1995-04-13
ES2120070T3 (es) 1998-10-16
CA2173582C (en) 2006-11-28
JP3775796B2 (ja) 2006-05-17
JPH09503214A (ja) 1997-03-31
DE69412109D1 (de) 1998-09-03
KR100343243B1 (ko) 2003-02-14
US5780495A (en) 1998-07-14
SI0722434T1 (en) 1998-12-31
HU9600874D0 (en) 1996-06-28
US5700947A (en) 1997-12-23
BR9407749A (pt) 1997-02-12
HU218923B (hu) 2000-12-28
RU2136653C1 (ru) 1999-09-10
DK0722434T3 (da) 1998-11-16
DE69412109T2 (de) 1999-01-21
EP0722434B1 (de) 1998-07-29
AU678063B2 (en) 1997-05-15
AU7809294A (en) 1995-05-01
EP0722434A1 (de) 1996-07-24

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