ATE171171T1 - Alpha-aminoketon derivate - Google Patents

Alpha-aminoketon derivate

Info

Publication number: ATE171171T1
Authority: AT; Austria
Prior art keywords: cathepsin; alpha; aminoketone derivatives; therapeutic agents; cancer
Prior art date: 1992-12-25

Application number

AT93120432T

Other languages

English (en)

Inventor

Ando Ryoichi

Sakaki Toshiro

Morinaka Yasuhiro

Takahashi Chizuko

Tamao Yoshikuni

Original Assignee

Mitsubishi Chem Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-25

Filing date

1993-12-17

Publication date

1998-10-15

1993-12-17 Application filed by Mitsubishi Chem Corp filed Critical Mitsubishi Chem Corp

1998-10-15 Application granted granted Critical

1998-10-15 Publication of ATE171171T1 publication Critical patent/ATE171171T1/de

Links

239000003814 drug Substances 0.000 abstract 2
229940124597 therapeutic agent Drugs 0.000 abstract 2
208000024827 Alzheimer disease Diseases 0.000 abstract 1
206010002027 Amyotrophy Diseases 0.000 abstract 1
206010006187 Breast cancer Diseases 0.000 abstract 1
208000026310 Breast neoplasm Diseases 0.000 abstract 1
108010032088 Calpain Proteins 0.000 abstract 1
102000007590 Calpain Human genes 0.000 abstract 1
208000002177 Cataract Diseases 0.000 abstract 1
108090000712 Cathepsin B Proteins 0.000 abstract 1
102000004225 Cathepsin B Human genes 0.000 abstract 1
108090000619 Cathepsin H Proteins 0.000 abstract 1
102000004175 Cathepsin H Human genes 0.000 abstract 1
108090000624 Cathepsin L Proteins 0.000 abstract 1
102000004172 Cathepsin L Human genes 0.000 abstract 1
208000012661 Dyskinesia Diseases 0.000 abstract 1
208000037147 Hypercalcaemia Diseases 0.000 abstract 1
206010061216 Infarction Diseases 0.000 abstract 1
206010061218 Inflammation Diseases 0.000 abstract 1
208000001940 Massive Hepatic Necrosis Diseases 0.000 abstract 1
206010027476 Metastases Diseases 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
208000001132 Osteoporosis Diseases 0.000 abstract 1
108090000526 Papain Proteins 0.000 abstract 1
206010060862 Prostate cancer Diseases 0.000 abstract 1
206010051482 Prostatomegaly Diseases 0.000 abstract 1
239000004365 Protease Substances 0.000 abstract 1
208000006011 Stroke Diseases 0.000 abstract 1
101710097834 Thiol protease Proteins 0.000 abstract 1
208000030886 Traumatic Brain injury Diseases 0.000 abstract 1
238000002835 absorbance Methods 0.000 abstract 1
230000002776 aggregation Effects 0.000 abstract 1
238000004220 aggregation Methods 0.000 abstract 1
201000008275 breast carcinoma Diseases 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000005907 cancer growth Effects 0.000 abstract 1
230000000747 cardiac effect Effects 0.000 abstract 1
210000004027 cell Anatomy 0.000 abstract 1
210000000170 cell membrane Anatomy 0.000 abstract 1
230000000148 hypercalcaemia Effects 0.000 abstract 1
208000030915 hypercalcemia disease Diseases 0.000 abstract 1
230000007574 infarction Effects 0.000 abstract 1
230000004054 inflammatory process Effects 0.000 abstract 1
230000009401 metastasis Effects 0.000 abstract 1
201000006417 multiple sclerosis Diseases 0.000 abstract 1
201000006938 muscular dystrophy Diseases 0.000 abstract 1
201000001119 neuropathy Diseases 0.000 abstract 1
230000007823 neuropathy Effects 0.000 abstract 1
235000019834 papain Nutrition 0.000 abstract 1
229940055729 papain Drugs 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1
208000033808 peripheral neuropathy Diseases 0.000 abstract 1
230000035699 permeability Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/28—Radicals substituted by nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/28—Halogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Hematology (AREA)
Immunology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Gastroenterology & Hepatology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT93120432T 1992-12-25 1993-12-17 Alpha-aminoketon derivate ATE171171T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP34692792		1992-12-25

Publications (1)

Publication Number	Publication Date
ATE171171T1 true ATE171171T1 (de)	1998-10-15

Family

ID=18386761

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93120432T ATE171171T1 (de)	1992-12-25	1993-12-17	Alpha-aminoketon derivate

Country Status (8)

Country	Link
US (1)	US5422359A (de)
EP (1)	EP0603769B1 (de)
JP (1)	JPH0770058A (de)
AT (1)	ATE171171T1 (de)
CA (1)	CA2111931A1 (de)
DE (1)	DE69321087T2 (de)
DK (1)	DK0603769T3 (de)
ES (1)	ES2124281T3 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5498616A (en) *	1994-11-04	1996-03-12	Cephalon, Inc.	Cysteine protease and serine protease inhibitors
WO1996016079A2 (en) *	1994-11-24	1996-05-30	Takeda Chemical Industries, Ltd	Alpha-ketoamide derivatives as cathepsin l inhibitor
US5691368A (en) *	1995-01-11	1997-11-25	Hoechst Marion Roussel, Inc.	Substituted oxazolidine calpain and/or cathepsin B inhibitors
US5679680A (en) *	1995-02-16	1997-10-21	Warner-Lambert Company	α-substituted hydrazides having calpain inhibitory activity
EP0820464A2 (de) *	1995-03-31	1998-01-28	Takeda Chemical Industries, Ltd.	Cysteinprotease -inhibitor
CZ132798A3 (cs) *	1995-10-30	1999-02-17	Smithkline Beecham Corporation	Inhibitory proteázy
US6586466B2 (en)	1995-10-30	2003-07-01	Smithkline Beecham Corporation	Carbohydrazide-protease inhibitors
CA2209109A1 (en) *	1995-10-30	1997-05-09	Thomas Joseph . Carr	Method of inhibiting cathepsin k
US5733911A (en) *	1996-01-26	1998-03-31	Hitachi Chemical Co., Ltd.	Method for inducing death of neoplastic cells using piperazne derivatives
US5925633A (en) *	1996-03-06	1999-07-20	Synphar Laboraties, Inc.	3-Substituted-4-oxa-1-azabicyclo 3,2,0!heptan-7-one as cysteine protease inhibitors
DK0912601T4 (da) *	1996-04-22	2009-03-09	Massachusetts Inst Technology	Suppression af immunrespons ved inhibering af cathepsin S
US6303579B1 (en)	1996-10-31	2001-10-16	Alcon Laboratories, Inc.	Use of calpain inhibitors to treat ocular neural pathology
TR200101869T2 (tr) *	1998-12-23	2002-01-21	Smithkline Beecham Corporation	Proteaz İnhibitörleri.
US20030144175A1 (en) *	1998-12-23	2003-07-31	Smithkline Beecham Corporation	Protease inhibitors
US20030044399A1 (en) *	1998-12-23	2003-03-06	Smithkline Beecham Corporation	Method of treatment
UY26026A1 (es) *	1999-03-16	2000-10-31	Smithkline Beecham Corportion	Inhibidores de proteasas
US6583137B1 (en)	1999-11-10	2003-06-24	Smithkline Beecham Corporation	Protease inhibitors
EP1229914A4 (de)	1999-11-10	2004-06-23	Smithkline Beecham Corp	Proteasehemmer
US6596715B1 (en)	1999-11-10	2003-07-22	Smithkline Beecham Corporation	Protease inhibitors
AU2001228810A1 (en) *	2000-01-26	2001-08-07	Ono Pharmaceutical Co. Ltd.	Benzene-fused heterocycle derivatives and drugs containing the same as the active ingredient
AU4344101A (en) *	2000-03-21	2001-10-03	Smithkline Beecham Corp	Protease inhibitors
EP1315971A2 (de) *	2000-07-31	2003-06-04	The Regents of The University of California	Modell für alzheimer und neurodegenerative krankheiten
US20040038965A1 (en) *	2001-10-09	2004-02-26	Marquis, Jr. Robert W.	Protease inhibitors
WO2008045017A2 (en) *	2005-06-22	2008-04-17	Diamond Scott L	Sars and ebola inhibitors and use thereof, and methods for their discovery
AU2006271230A1 (en) *	2005-07-22	2007-01-25	Warner Chilcott Company, Llc	Compositions for reducing the incidence of drug induced arrhythmia
JP2020002014A (ja) *	2018-06-25	2020-01-09	日本システム企画株式会社	阻害活性物及びその精製方法
WO2024018245A1 (en)	2022-07-22	2024-01-25	INSERM (Institut National de la Santé et de la Recherche Médicale)	Use of calpain inhibitors for the treatment of the diabetic kidney disease
WO2024153744A1 (en)	2023-01-20	2024-07-25	Institut National de la Santé et de la Recherche Médicale	Autophagy activators for the treatment of rhabdomyolysis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5055451A (en) *	1986-12-22	1991-10-08	Syntex Inc.	Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
JP3190431B2 (ja) *	1991-07-01	2001-07-23	三菱化学株式会社	ケトン誘導体

1993
- 1993-12-17 AT AT93120432T patent/ATE171171T1/de not_active IP Right Cessation
- 1993-12-17 DK DK93120432T patent/DK0603769T3/da active
- 1993-12-17 EP EP93120432A patent/EP0603769B1/de not_active Expired - Lifetime
- 1993-12-17 DE DE69321087T patent/DE69321087T2/de not_active Expired - Fee Related
- 1993-12-17 ES ES93120432T patent/ES2124281T3/es not_active Expired - Lifetime
- 1993-12-20 CA CA002111931A patent/CA2111931A1/en not_active Abandoned
- 1993-12-22 US US08/171,692 patent/US5422359A/en not_active Expired - Fee Related
- 1993-12-24 JP JP5328448A patent/JPH0770058A/ja active Pending

Also Published As

Publication number	Publication date
CA2111931A1 (en)	1994-06-26
US5422359A (en)	1995-06-06
DE69321087T2 (de)	1999-05-20
EP0603769B1 (de)	1998-09-16
ES2124281T3 (es)	1999-02-01
EP0603769A1 (de)	1994-06-29
DK0603769T3 (da)	1999-06-14
DE69321087D1 (de)	1998-10-22
JPH0770058A (ja)	1995-03-14

Legal Events

Date	Code	Title	Description
1999-07-15	UEP	Publication of translation of european patent specification
2000-09-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69321087D1 (de)	1998-10-22	Alpha-aminoketon Derivate
GR3026734T3 (en)	1998-07-31	Aminoketone derivatives.
DE69706566D1 (de)	2001-10-11	Verwendung von dem chelatbildner clioquinol zur herstellung eines arzneimittelszur behandlung von alzheimerschen krankheit
ATE319447T1 (de)	2006-03-15	Pharmazeutische zubereitungen die clavulansäure oder derivate enthalten zur behandlund von neurologischen störungen
TW250435B (de)	1995-07-01
UA39158C2 (uk)	2001-06-15	Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
GEP20002300B (en)	2000-11-25	Purified Forms of Dnase, Method for Its Production, Pharmaceutical Composition and Use Thereof
SI0725779T1 (de)	2001-12-31
ATE213411T1 (de)	2002-03-15	Verwendung von phenserin zur herstellung von medikamenten zur behandlung von kognitiven störungen
DE69631478D1 (de)	2004-03-11	Verwendung von vitamin d4-derivaten zur behandlung von hauterkrankungen
DE69428325D1 (de)	2001-10-25	Verwendung von 2-phenyl-3-aroylbenzothiophen Derivaten zur Herstellung eines Medikaments zur Hemmung der Angiogenese und angiogene Krankheiten
RU94041207A (ru)	1996-06-20	Средство для лечения заболеваний, поражающих нервную систему
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