IL100336A - Methylenebisphosphonic acid derivatives their production and pharmaceutical compositions containing them - Google Patents

Methylenebisphosphonic acid derivatives their production and pharmaceutical compositions containing them

Info

Publication number
IL100336A
IL100336A IL10033691A IL10033691A IL100336A IL 100336 A IL100336 A IL 100336A IL 10033691 A IL10033691 A IL 10033691A IL 10033691 A IL10033691 A IL 10033691A IL 100336 A IL100336 A IL 100336A
Authority
IL
Israel
Prior art keywords
formula
dichloromethylene
group
ppm
ester
Prior art date
Application number
IL10033691A
Other languages
English (en)
Other versions
IL100336A0 (en
Original Assignee
Leiras Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leiras Oy filed Critical Leiras Oy
Publication of IL100336A0 publication Critical patent/IL100336A0/xx
Publication of IL100336A publication Critical patent/IL100336A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4403—Amides thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4423—Amides of poly (thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Paints Or Removers (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Luminescent Compositions (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
IL10033691A 1990-12-20 1991-12-11 Methylenebisphosphonic acid derivatives their production and pharmaceutical compositions containing them IL100336A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FI906296A FI89365C (fi) 1990-12-20 1990-12-20 Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Publications (2)

Publication Number Publication Date
IL100336A0 IL100336A0 (en) 1992-09-06
IL100336A true IL100336A (en) 1998-07-15

Family

ID=8531621

Family Applications (1)

Application Number Title Priority Date Filing Date
IL10033691A IL100336A (en) 1990-12-20 1991-12-11 Methylenebisphosphonic acid derivatives their production and pharmaceutical compositions containing them

Country Status (25)

Country Link
US (1) US5442101A (de)
EP (1) EP0570380B1 (de)
JP (1) JPH06504770A (de)
KR (1) KR930703336A (de)
CN (1) CN1028866C (de)
AT (1) ATE171182T1 (de)
AU (1) AU663268B2 (de)
CA (1) CA2098734A1 (de)
CZ (1) CZ119593A3 (de)
DE (1) DE69130231T2 (de)
DK (1) DK0570380T3 (de)
EE (1) EE02950B1 (de)
ES (1) ES2121003T3 (de)
FI (1) FI89365C (de)
HU (1) HUT64547A (de)
IE (1) IE914390A1 (de)
IL (1) IL100336A (de)
NO (1) NO303121B1 (de)
NZ (1) NZ241039A (de)
PL (1) PL169728B1 (de)
RU (1) RU2100364C1 (de)
SK (1) SK63093A3 (de)
TW (1) TW203053B (de)
WO (1) WO1992011268A1 (de)
ZA (1) ZA9110007B (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4815197A (en) 1996-10-09 1998-05-05 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
EP1469003A3 (de) * 1996-10-09 2004-11-24 Pharmasset, Ltd. Tetraphosphonat bizyklische Trisanhydride
US20040181078A1 (en) * 1997-10-10 2004-09-16 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
FI104901B (fi) * 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US5998390A (en) * 1998-09-28 1999-12-07 The Research Foundation Of State University Of New York Combination of bisphosphonate and tetracycline
RU2213959C2 (ru) * 2001-01-15 2003-10-10 Войсковая часть 61469 МО РФ Способ количественного определения о-алкиловых эфиров метилфосфоновой кислоты в водных матрицах методом реакционной газовой хроматографии с атомно-эмиссионным детектированием
WO2005090370A1 (en) * 2004-02-05 2005-09-29 The Regents Of The University Of California Pharmacologically active agents containing esterified phosphonates and methods for use thereof
JP2008538354A (ja) * 2005-04-08 2008-10-23 キメリクス，インコーポレイテッド ウイルス感染症およびその他の内科疾患を治療するための化合物、組成物および方法
WO2006110655A2 (en) 2005-04-08 2006-10-19 Chimerix, Inc. Compounds, compositions and methods for the treatment of poxvirus infections
US7862552B2 (en) 2005-05-09 2011-01-04 Boston Scientific Scimed, Inc. Medical devices for treating urological and uterine conditions
CN105055432A (zh) * 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
US8614200B2 (en) 2009-07-21 2013-12-24 Chimerix, Inc. Compounds, compositions and methods for treating ocular conditions
WO2011017253A1 (en) 2009-08-03 2011-02-10 Chimerix, Inc. Composition and methods of treating viral infections and viral induced tumors
CA2789443C (en) 2010-02-12 2016-09-13 Chimerix, Inc. Nucleoside phosphonate salts
CN102190684A (zh) * 2010-03-15 2011-09-21 南通波锐生物医药有限公司 一种具有药物应用的含磷化合物及其制备和用途
EP2563367A4 (de) 2010-04-26 2013-12-04 Chimerix Inc Verfahren zur behandlung von retroviren-infektionen und entsprechende dosierungspläne
CN102453050B (zh) 2010-11-03 2015-01-07 成都云克药业有限责任公司 一种二膦酸化合物及其制备方法
WO2018005659A1 (en) * 2016-06-28 2018-01-04 Aequor, Inc. Antimicrobial compounds and methods of use
RU2630226C1 (ru) * 2016-12-20 2017-09-06 Федеральное государственное бюджетное образовательное учреждение высшего образования "Тверской государственный университет" Новая ионная жидкость производная бис-(N,N-диметиламида) метилфосфоновой кислоты с высокими термическими свойствами

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4293505A (en) * 1967-04-06 1981-10-06 Randall David I Preparation of β-haloethylphosphonic acids and half esters thereof
US3524846A (en) * 1967-06-02 1970-08-18 Syntex Corp Process for the didealkylation of phosphonate esters
US3808265A (en) * 1971-03-26 1974-04-30 Gaf Corp Preparation of 2-haloethylphosphonic acid
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
US5212164A (en) * 1988-08-29 1993-05-18 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors
EP0356866A3 (de) * 1988-08-29 1991-03-27 E.R. SQUIBB & SONS, INC. Phosphor enthaltende Squalen-Synthetase-Inhibitoren und Verfahren
US5273969A (en) * 1988-08-29 1993-12-28 E. R. Squibb & Sons, Inc. Phosphorus-containing squalene synthetase inhibitors and method
FI89366C (fi) * 1990-12-20 1993-09-27 Leiras Oy Foerfarande foer framstaellning av nya farmakologiskt anvaendbara metylenbisfosfonsyraderivat

Also Published As

Publication number Publication date
CN1062533A (zh) 1992-07-08
CA2098734A1 (en) 1992-06-21
NO303121B1 (no) 1998-06-02
EP0570380B1 (de) 1998-09-16
HUT64547A (en) 1994-01-28
ES2121003T3 (es) 1998-11-16
FI89365C (fi) 1993-09-27
DK0570380T3 (da) 1999-02-08
JPH06504770A (ja) 1994-06-02
DE69130231T2 (de) 1999-03-25
US5442101A (en) 1995-08-15
CZ119593A3 (en) 1994-02-16
ZA9110007B (en) 1992-09-30
WO1992011268A1 (en) 1992-07-09
FI89365B (fi) 1993-06-15
ATE171182T1 (de) 1998-10-15
TW203053B (de) 1993-04-01
IL100336A0 (en) 1992-09-06
PL169728B1 (pl) 1996-08-30
EE02950B1 (et) 1996-12-16
IE914390A1 (en) 1992-07-01
RU2100364C1 (ru) 1997-12-27
FI906296A0 (fi) 1990-12-20
FI906296A7 (fi) 1992-06-21
HU9301780D0 (en) 1993-09-28
KR930703336A (ko) 1993-11-29
EP0570380A1 (de) 1993-11-24
NO932256L (no) 1993-08-20
DE69130231D1 (de) 1998-10-22
AU663268B2 (en) 1995-09-28
CN1028866C (zh) 1995-06-14
SK63093A3 (en) 1993-12-08
NO932256D0 (no) 1993-06-18
NZ241039A (en) 1993-05-26
AU9080091A (en) 1992-07-22

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Legal Events

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FF Patent granted
KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees