ATE172741T1 - Endothelinantagonistische peptidderivate - Google Patents

Endothelinantagonistische peptidderivate

Info

Publication number: ATE172741T1
Authority: AT; Austria
Prior art keywords: group; lower alkyl; hydrogen atom; alkyl group; formula
Prior art date: 1990-06-07

Application number

AT91109313T

Other languages

English (en)

Inventor

Kiyofumi Ishikawa

Takehiro Fukami

Takashi Hayama

Kenji Niiyama

Toshio Nagase

Toshiaki Mase

Kagari Fujita

Masaki Ihara

Fumihiko Ikemoto

Mitsuo Yano

Original Assignee

Banyu Pharma Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-06-07

Filing date

1991-06-06

Publication date

1998-11-15

1991-06-06 Application filed by Banyu Pharma Co Ltd filed Critical Banyu Pharma Co Ltd

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE172741T1 publication Critical patent/ATE172741T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
239000002308 endothelin receptor antagonist Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 32
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 27
-1 1,3-dithiol-2-ylidenemethyl group Chemical group 0.000 abstract 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 15
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 10
125000000753 cycloalkyl group Chemical group 0.000 abstract 7
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 6
125000001544 thienyl group Chemical group 0.000 abstract 6
125000004432 carbon atom Chemical group C* 0.000 abstract 4
125000002541 furyl group Chemical group 0.000 abstract 4
125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 4
125000003545 alkoxy group Chemical group 0.000 abstract 3
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
125000000623 heterocyclic group Chemical group 0.000 abstract 3
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
125000004430 oxygen atom Chemical group O* 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
229910052757 nitrogen Inorganic materials 0.000 abstract 2
125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
125000004434 sulfur atom Chemical group 0.000 abstract 2
125000003282 alkyl amino group Chemical group 0.000 abstract 1
125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 abstract 1
125000001041 indolyl group Chemical group 0.000 abstract 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000335 thiazolyl group Chemical group 0.000 abstract 1
125000004149 thio group Chemical group *S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

AT91109313T 1990-06-07 1991-06-06 Endothelinantagonistische peptidderivate ATE172741T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP14910590		1990-06-07

Publications (1)

Publication Number	Publication Date
ATE172741T1 true ATE172741T1 (de)	1998-11-15

Family

ID=15467809

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT91109313T ATE172741T1 (de)	1990-06-07	1991-06-06	Endothelinantagonistische peptidderivate

Country Status (6)

Country	Link
US (3)	US5470833A (de)
EP (1)	EP0460679B1 (de)
KR (1)	KR930008090B1 (de)
AT (1)	ATE172741T1 (de)
CA (1)	CA2043741C (de)
DE (1)	DE69130408T2 (de)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5591761A (en) *	1993-05-20	1997-01-07	Texas Biotechnology Corporation	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5594021A (en) *	1993-05-20	1997-01-14	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl sulfonamides and derivatives thereof that modulate the activity of endothelin
US5514691A (en) *	1993-05-20	1996-05-07	Immunopharmaceutics, Inc.	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5571821A (en) *	1993-05-20	1996-11-05	Texas Biotechnology Corporation	Sulfonamides and derivatives thereof that modulate the activity of endothelin
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5284828A (en) *	1990-05-14	1994-02-08	Fujisawa Pharmaceutical Co. Ltd.	Peptide compound and its preparation
US5430022A (en) *	1990-05-14	1995-07-04	Fujisawa Pharmaceutical Co., Ltd.	Peptide compound and its preparation
US5496928A (en) *	1990-06-07	1996-03-05	Banyu Pharmaceutical Co., Ltd.	Endothelin antagonistic substance
US5614498A (en) *	1990-06-07	1997-03-25	Banyu Pharmaceutical Co., Ltd.	Endothelin antagonistic substance
CA2043741C (en) *	1990-06-07	2003-04-01	Kiyofumi Ishikawa	Endothelin antagonistic peptide derivatives
US5736509A (en) *	1990-12-14	1998-04-07	Texas Biotechnology Corporation	Cyclic peptide surface feature mimics of endothelin
TW217417B (de) *	1991-12-04	1993-12-11	Manyu Seiyaku Kk
US5614497A (en) *	1991-12-27	1997-03-25	Takeda Chemical Industries, Ltd.	Peptide, production and use thereof
WO1993017701A1 (en) *	1992-03-12	1993-09-16	The Administrators Of The Tulane Educational Fund	Endothelin receptor-binding peptides
FR2689130B1 (fr) *	1992-03-30	1994-05-27	Synthelabo	Derives de 1-[2 (arylsulfonylamino)ethyl-1-oxo] piperidine, leur preparation et leur application en therapeutique.
WO1993023404A1 (en) *	1992-05-19	1993-11-25	Immunopharmaceutics, Inc.	Compounds that modulate endothelin activity
ZA939516B (en) *	1992-12-22	1994-06-06	Smithkline Beecham Corp	Endothelin receptor antagonists
GB9300048D0 (en) *	1993-01-04	1993-03-03	Wellcome Found	Endothelin converting enzyme inhibitors
US5352800A (en) *	1993-03-11	1994-10-04	Merck & Co., Inc.	Process for the production of a novel endothelin antagonist
US5374638A (en) *	1993-03-19	1994-12-20	Merck & Co., Inc.	Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5334598A (en) *	1993-03-19	1994-08-02	Merck & Co., Inc.	Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
EP0617001B1 (de) *	1993-03-19	2000-01-26	Merck & Co. Inc.	Phenoxyphenylessigsäurederivate
US5420133A (en) *	1993-03-19	1995-05-30	Merck & Co., Inc.	Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5767310A (en) *	1993-03-19	1998-06-16	Merck & Co., Inc.	Phenoxyphenylacetic acid derivatives
US5401745A (en) *	1993-03-19	1995-03-28	Merck & Co., Inc.	Quinazolinones substituted with phenoxyphenylacetic acid derivatives
FI941826A7 (fi) *	1993-04-21	1994-10-22	Takeda Chemical Industries Ltd	Menetelmät ja koostumukset elimen hypofunktion ennaltaehkäisemiseksi ja/tai terapeuttiseksi hoitamiseksi
US6342610B2 (en)	1993-05-20	2002-01-29	Texas Biotechnology Corp.	N-aryl thienyl-, furyl-, and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US6030991A (en) *	1993-05-20	2000-02-29	Texas Biotechnology Corp.	Benzenesulfonamides and the use thereof to modulate the activity of endothelin
US6613804B2 (en)	1993-05-20	2003-09-02	Encysive Pharmaceuticals, Inc.	Biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
AU673731B2 (en) *	1993-06-03	1996-11-21	Banyu Pharmaceutical Co., Ltd.	Novel endothelin antagonistic peptide
GB9313330D0 (en) *	1993-06-28	1993-08-11	Fujisawa Pharmaceutical Co	New compound and its preparation
US5686478A (en) *	1993-07-20	1997-11-11	Merck & Co. Inc.	Endothelin antagonists
WO1995008550A1 (en) *	1993-09-24	1995-03-30	Abbott Laboratories	Endothelin antagonists
WO1995012611A1 (en) *	1993-11-01	1995-05-11	Japat Ltd.	Endothelin receptor antagonists
US5686481A (en) *	1993-12-21	1997-11-11	Smithkline Beecham Corporation	Endothelin receptor antagonists
EP0753004A1 (de) *	1994-03-28	1997-01-15	Japat Ltd	Endothelin rezeptor antagoniste
US5538991A (en) *	1994-09-14	1996-07-23	Merck & Co., Inc.	Endothelin antagonists bearing 5-membered heterocyclic amides
US5559135A (en) *	1994-09-14	1996-09-24	Merck & Co., Inc.	Endothelin antagonists bearing pyridyl amides
WO1996011927A1 (en) *	1994-10-12	1996-04-25	Abbott Laboratories	Endothelin antagonists
EP0792265A1 (de) *	1994-11-14	1997-09-03	Fujisawa Pharmaceutical Co., Ltd.	Endothelin antagoniste
US6017887A (en) *	1995-01-06	2000-01-25	Sibia Neurosciences, Inc.	Peptide, peptide analog and amino acid analog protease inhibitors
US5804560A (en) *	1995-01-06	1998-09-08	Sibia Neurosciences, Inc.	Peptide and peptide analog protease inhibitors
US7001921B1 (en)	1995-01-23	2006-02-21	Biogen Idec Ma Inc.	Cell adhesion inhibitors
AU766538B2 (en) *	1995-01-23	2003-10-16	Biogen Idec Ma Inc.	Cell adhesion inhibitors
US6306840B1 (en)	1995-01-23	2001-10-23	Biogen, Inc.	Cell adhesion inhibitors
JPH11505522A (ja) *	1995-04-21	1999-05-21	ノバルティス・アクチエンゲゼルシャフト	エンドセリン阻害剤としてのｎ−アロイルアミノ酸アミド
US6248713B1 (en)	1995-07-11	2001-06-19	Biogen, Inc.	Cell adhesion inhibitors
AU7130296A (en) *	1995-09-28	1997-04-17	Ciba-Geigy Japan Limited	Antagonists of endothelin receptors
US5977117A (en)	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
FR2745570B1 (fr) *	1996-03-04	1998-06-19	Roussel Uclaf	Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
US5958905A (en)	1996-03-26	1999-09-28	Texas Biotechnology Corporation	Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
US6239108B1 (en)	1996-07-11	2001-05-29	Biogen, Inc.	Cell adhesion inhibitors
DK0914605T3 (da)	1996-07-25	2007-09-10	Biogen Idec Inc	Molekylemodel for VLA-4-inhibitorer
US6686350B1 (en)	1996-07-25	2004-02-03	Biogen, Inc.	Cell adhesion inhibitors
US5783705A (en)	1997-04-28	1998-07-21	Texas Biotechnology Corporation	Process of preparing alkali metal salys of hydrophobic sulfonamides
US6432994B1 (en)	1997-04-28	2002-08-13	Texas Biotechnology Corporation	Sulfonamides for treatment of endothelin-mediated disorders
JPH11124379A (ja) *	1997-10-17	1999-05-11	Ss Pharmaceut Co Ltd	ジチオリリデンアセトアミド誘導体
YU75500A (sh)	1998-05-28	2002-12-10	Biogen Inc.	NOVI VLA-4 INHIBITORI oMePUPA-V
EE200200070A (et)	1999-08-13	2003-04-15	Biogen, Inc.	Raku adhesiooni inhibiitorid
CN1155611C (zh) *	2000-06-21	2004-06-30	中国人民解放军军事医学科学院毒物药物研究所	内皮素拮抗剂
CA2709771A1 (en)	2000-06-23	2002-01-03	Genentech, Inc.	Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
EP2042597B1 (de)	2000-06-23	2014-05-07	Genentech, Inc.	Zusammensetzungen und Verfahren zur Diagnose und Behandlung von Erkrankungen in Verbindung mit Angiogenese
US6875743B1 (en)	2000-11-28	2005-04-05	Biogen, Inc.	Cell adhesion inhibitors
US7196112B2 (en)	2004-07-16	2007-03-27	Biogen Idec Ma Inc.	Cell adhesion inhibitors
USD978375S1 (en)	2013-03-13	2023-02-14	Abbott Laboratories	Reagent container
CN107831324B (zh)	2013-03-15	2021-11-19	雅培制药有限公司	具有后面可进入轨道系统的自动化诊断分析仪及相关方法
WO2024254218A2 (en) *	2023-06-05	2024-12-12	The Board Of Regents Of The University Of Texas System	Non-peptide small molecule fgf14:nav1.6 channel complex protein-protein interaction modulators

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE2202613C3 (de) *	1972-01-20	1974-06-20	Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt	Verfahren zur Herstellung von Peptiden
US5187156A (en) *	1988-03-16	1993-02-16	Fujisawa Pharmaceutical Co., Ltd.	Peptide compounds, processes for preparation thereof and pharmaceutical composition comprising the same
CA2032559C (en) *	1989-12-28	2001-11-06	Kiyofumi Ishikawa	Endothelin antagonistic cyclic pentapeptides
GB9104064D0 (en)	1991-02-27	1991-04-17	Fujisawa Pharmaceutical Co	Peptide compound and its preparation
US5284828A (en) *	1990-05-14	1994-02-08	Fujisawa Pharmaceutical Co. Ltd.	Peptide compound and its preparation
GB9010740D0 (en)	1990-05-14	1990-07-04	Fujisawa Pharmaceutical Co	Peptide compounds and their preparation
GB9026254D0 (en)	1990-12-03	1991-01-16	Fujisawa Pharmaceutical Co	Peptide compound and its preparation
CA2043741C (en) *	1990-06-07	2003-04-01	Kiyofumi Ishikawa	Endothelin antagonistic peptide derivatives
ES2089256T3 (es) *	1991-02-15	1996-10-01	Takeda Chemical Industries Ltd	Antagonista de la endotelina.
US5382569A (en) *	1991-05-16	1995-01-17	Warner-Lambert Company	Endotherlin antagonists
GB9123967D0 (en) *	1991-11-12	1992-01-02	Fujisawa Pharmaceutical Co	New compound and its preparation

1991
- 1991-06-03 CA CA002043741A patent/CA2043741C/en not_active Expired - Lifetime
- 1991-06-05 KR KR1019910009335A patent/KR930008090B1/ko not_active Expired - Lifetime
- 1991-06-06 EP EP91109313A patent/EP0460679B1/de not_active Expired - Lifetime
- 1991-06-06 DE DE69130408T patent/DE69130408T2/de not_active Expired - Lifetime
- 1991-06-06 AT AT91109313T patent/ATE172741T1/de not_active IP Right Cessation
1994
- 1994-03-14 US US08/213,829 patent/US5470833A/en not_active Expired - Lifetime
- 1994-03-21 US US08/214,679 patent/US5444152A/en not_active Expired - Lifetime
1995
- 1995-06-26 US US08/494,818 patent/US5691315A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0460679A3 (en)	1992-11-19
EP0460679A2 (de)	1991-12-11
AU7818291A (en)	1991-12-12
US5691315A (en)	1997-11-25
KR930008090B1 (ko)	1993-08-25
AU632695B2 (en)	1993-01-07
DE69130408T2 (de)	1999-03-18
DE69130408D1 (de)	1998-12-03
US5444152A (en)	1995-08-22
EP0460679B1 (de)	1998-10-28
CA2043741C (en)	2003-04-01
US5470833A (en)	1995-11-28
KR920000791A (ko)	1992-01-29
CA2043741A1 (en)	1991-12-08

Legal Events

Date	Code	Title	Description
1999-04-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE69130408D1 (de)	1998-12-03	Endothelinantagonistische Peptidderivate
KR100188846B1 (en)	1999-06-01	Bicyclic heterocyclic sulfonamide and sulfonic ester derivatives
ES2194986T3 (es)	2003-12-01	Compuestos de carbonil-piperazinilo y piperidinilo que inhiben la farnesil-protein-transferasa.
NZ509045A (en)	2002-09-27	Intermediates in the formation of antivirally active heterocyclic azahexane derivatives
DE69133299D1 (de)	2003-09-04	Aminosulfonylcarbamate
TW217417B (de)	1993-12-11
DE69034202D1 (de)	2005-09-22	Zwischenprodukte zur Herstellung von non-peptiden retroviralproteasehemmenden Verbindungen
EP0487502A3 (en)	1992-06-24	Pharmaceutically active aryl-substituted amine derivatives
NZ241568A (en)	1994-04-27	Amide, sulphonamide and phosphonamide derivatives and pharmaceutical compositions
EP0621270A4 (de)	1995-01-18	Collagenase inhibitoren.
MY113518A (en)	2002-03-30	Benzothiazolone derivatives
PH31172A (en)	1998-03-20	7-Fused 2-(piperazino-alkyl) indole derivatives, intermediates and compositions thereof.
DE69407709D1 (de)	1998-02-12	Carboxylatderivate mit einer die Phospholipase A2 hemmenden Aktivität
PT728748E (pt)	2002-06-28	Novos derivados da benzodiazepina
NO944577L (no)	1995-06-02	Hemming av effekten av amyloidogene proteiner
GR3007918T3 (de)	1993-08-31
ATE223907T1 (de)	2002-09-15	Arginnin analoge mit no- syntax inhibierenderwirkung
HU913892D0 (en)	1992-02-28	Method for producing new alkyl-amino-alkyl-amine and -ether derivatives and pharmaceutical preparatives containing said compounds
HRP20050617A2 (en)	2005-10-31	Imidazol derivatives having affinity for alpha 2 receptors activity
ATE119883T1 (de)	1995-04-15	Thioformamidderivate.
ATE268769T1 (de)	2004-06-15	Pyrimidinderivate mit antitumor-wirkung