ATE173336T1 - Hydroxy-aryl metallchelate für bildformung zur nmr diagnose - Google Patents

Hydroxy-aryl metallchelate für bildformung zur nmr diagnose

Info

Publication number: ATE173336T1
Authority: AT; Austria
Prior art keywords: iii; nitrogens; ligand; hydroxy; nmr
Prior art date: 1989-08-28

Application number

AT90914613T

Other languages

English (en)

Inventor

Randall B Lauffer

Scott K Larsen

Original Assignee

Gen Hospital Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-08-28

Filing date

1990-08-28

Publication date

1998-11-15

1990-08-28 Application filed by Gen Hospital Corp filed Critical Gen Hospital Corp

1998-11-15 Application granted granted Critical

1998-11-15 Publication of ATE173336T1 publication Critical patent/ATE173336T1/de

Links

238000003384 imaging method Methods 0.000 title abstract 3
239000002184 metal Substances 0.000 title 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 8
239000003446 ligand Substances 0.000 abstract 6
230000002708 enhancing effect Effects 0.000 abstract 3
229910017464 nitrogen compound Inorganic materials 0.000 abstract 3
229910052693 Europium Inorganic materials 0.000 abstract 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
239000003795 chemical substances by application Substances 0.000 abstract 2
OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 abstract 2
150000002391 heterocyclic compounds Chemical class 0.000 abstract 2
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 abstract 1
229910052692 Dysprosium Inorganic materials 0.000 abstract 1
229910052691 Erbium Inorganic materials 0.000 abstract 1
229910052688 Gadolinium Inorganic materials 0.000 abstract 1
229910052689 Holmium Inorganic materials 0.000 abstract 1
WAEMQWOKJMHJLA-UHFFFAOYSA-N Manganese(2+) Chemical compound [Mn+2] WAEMQWOKJMHJLA-UHFFFAOYSA-N 0.000 abstract 1
229910052771 Terbium Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
BFGKITSFLPAWGI-UHFFFAOYSA-N chromium(3+) Chemical compound [Cr+3] BFGKITSFLPAWGI-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000002872 contrast media Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 abstract 1
UYAHIZSMUZPPFV-UHFFFAOYSA-N erbium Chemical compound [Er] UYAHIZSMUZPPFV-UHFFFAOYSA-N 0.000 abstract 1
UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 abstract 1
KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 abstract 1
150000002500 ions Chemical class 0.000 abstract 1
229910052742 iron Inorganic materials 0.000 abstract 1
MMIPFLVOWGHZQD-UHFFFAOYSA-N manganese(3+) Chemical compound [Mn+3] MMIPFLVOWGHZQD-UHFFFAOYSA-N 0.000 abstract 1
229910021645 metal ion Inorganic materials 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Radiology & Medical Imaging (AREA)
Condensed Matter Physics & Semiconductors (AREA)
Signal Processing (AREA)
High Energy & Nuclear Physics (AREA)
Engineering & Computer Science (AREA)
General Physics & Mathematics (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Magnetic Resonance Imaging Apparatus (AREA)

AT90914613T 1989-08-28 1990-08-28 Hydroxy-aryl metallchelate für bildformung zur nmr diagnose ATE173336T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US39973789A	1989-08-28	1989-08-28

Publications (1)

Publication Number	Publication Date
ATE173336T1 true ATE173336T1 (de)	1998-11-15

Family

ID=23580762

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT90914613T ATE173336T1 (de)	1989-08-28	1990-08-28	Hydroxy-aryl metallchelate für bildformung zur nmr diagnose

Country Status (6)

Country	Link
EP (1)	EP0489869B1 (de)
JP (1)	JPH05503072A (de)
AT (1)	ATE173336T1 (de)
CA (1)	CA2065290C (de)
DE (1)	DE69032761T2 (de)
WO (1)	WO1991003200A1 (de)

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US6875419B2 (en)	2000-11-20	2005-04-05	Board Of Regents The University Of Texas System	Paramagnetic metal ion-based macrocyclic magnetization transfer contrast agents and method of use
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US8722020B2 (en) *	2010-03-31	2014-05-13	General Electric Company	Hydroxylated contrast enhancement agents
US9239332B2 (en)	2011-07-11	2016-01-19	Indi Molecular, Inc.	Akt-specific capture agents, compositions, and methods of using and making
JP6297440B2 (ja) *	2013-07-31	2018-03-20	キヤノンメディカルシステムズ株式会社	造影剤
US10471163B2 (en)	2013-09-13	2019-11-12	The General Hospital Corporation	Activatable fibrin-binding probes
US20150344523A1 (en)	2014-05-05	2015-12-03	California Institute Of Technology	Mutant akt-specific capture agents, compositions, and methods of using and making
US10471162B2 (en)	2014-06-20	2019-11-12	The General Hospital Corporation	Collagen targeted imaging probes
US9913875B2 (en)	2015-03-16	2018-03-13	California Institute Of Technology	Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
CN104910030B (zh) *	2015-05-14	2018-03-23	石家庄杰克化工有限公司	一种高纯度乙醇胺类氨羧螯合剂的合成工艺
EP3101012A1 (de)	2015-06-04	2016-12-07	Bayer Pharma Aktiengesellschaft	Neue gadoliniumchelat-verbindung zur verwendung in der magnetresonanzbildgebung
IL256833B2 (en)	2015-07-15	2025-07-01	California Inst Of Techn	IL-17F-specific binding agents, compositions and methods of use and preparation
US9829474B2 (en) *	2015-10-16	2017-11-28	General Electric Company	Acetate complexes and methods for acetate quantification
WO2017176769A1 (en)	2016-04-04	2017-10-12	Indi Molecular, Inc.	Cd8-specific capture agents, compositions, and methods of using and making
EP3519425B1 (de)	2016-09-29	2024-02-28	Indi Molecular, Inc.	Zusammensetzungen zum nachweis, zur hemmung und zur bildgebung von indolamin 2,3-dioxygenase 1 (ido1) und verfahren zur herstellung und verwendung davon
US11358982B2 (en)	2016-11-01	2022-06-14	Ohio State Innovation Foundation	Methods for the iodination of biomolecules
RU2755181C2 (ru)	2016-11-28	2021-09-14	Байер Фарма Акциенгезельшафт	Новые хелатные соединения гадолиния с высокой релаксивностью для применения в магнитно-резонансной визуализации
EP3638687A1 (de)	2017-06-15	2020-04-22	Indi Molecular, Inc.	Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
WO2020093055A2 (en)	2018-11-02	2020-05-07	Indi Molecular, Inc.	Peptide libraries with non-canonical amino acids
US11638764B2 (en)	2018-11-08	2023-05-02	Indi Molecular, Inc.	Theranostic capture agents, compositions, and methods of using and making
IL321215B2 (en)	2018-11-23	2026-05-01	Bayer Ag	Contrast media formulation and process for its preparation
US20200291391A1 (en)	2019-03-12	2020-09-17	Indi Molecular, Inc.	Cross-linked epitopes and methods of use thereof
US12201679B2 (en)	2019-04-05	2025-01-21	Institute For Systems Biology	Epitope-targeted peptide immunostimulants
WO2020236952A1 (en)	2019-05-20	2020-11-26	Ohio State Innovation Foundation	Apohemoglobin-haptoglobin complexes and methods of using thereof
US12216122B2 (en)	2019-05-20	2025-02-04	Regeneron Pharmaceuticals, Inc.	Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
US11414460B2 (en)	2019-07-19	2022-08-16	Institute For Systems Biology	KRAS-specific capture agents, compositions, and methods of making and using
JP2023524464A (ja)	2020-04-30	2023-06-12	サイロパビー．ブイ．	抗ｃｄ１０３抗体
US12209142B2 (en)	2020-05-29	2025-01-28	Institute For Systems Biology	SARS-CoV-2 epitope-targeted peptide immunostimulants
WO2022098743A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
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1990
- 1990-08-28 EP EP90914613A patent/EP0489869B1/de not_active Expired - Lifetime
- 1990-08-28 CA CA002065290A patent/CA2065290C/en not_active Expired - Fee Related
- 1990-08-28 DE DE69032761T patent/DE69032761T2/de not_active Expired - Fee Related
- 1990-08-28 WO PCT/US1990/004887 patent/WO1991003200A1/en not_active Ceased
- 1990-08-28 AT AT90914613T patent/ATE173336T1/de not_active IP Right Cessation
- 1990-08-28 JP JP2513710A patent/JPH05503072A/ja active Pending

Also Published As

Publication number	Publication date
EP0489869B1 (de)	1998-11-11
JPH05503072A (ja)	1993-05-27
EP0489869A1 (de)	1992-06-17
HK1012707A1 (en)	1999-08-06
DE69032761D1 (de)	1998-12-17
EP0489869A4 (en)	1993-03-17
DE69032761T2 (de)	1999-04-22
CA2065290C (en)	2000-12-12
WO1991003200A1 (en)	1991-03-21
CA2065290A1 (en)	1991-03-01

Legal Events

Date	Code	Title	Description
2000-04-15	UEP	Publication of translation of european patent specification
2003-05-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69032761D1 (de)	1998-12-17	Hydroxy-aryl metallchelate für bildformung zur nmr diagnose
DE3566801D1 (en)	1989-01-19	Nmr contrast agents
DE68925904D1 (de)	1996-04-11	Makrocyclische chelate und verwendungsverfahren
AU1461188A (en)	1988-10-20	Nitrogen-containing cyclic ligands, metallic complexes formed by these ligands, diagnostic compositions containing these complexes and process for the preparation of the ligands
DE69527759D1 (de)	2002-09-19	Mono -und multimere verbindungen mit erhöhter relaxation
ATE215386T1 (de)	2002-04-15	Perfluoralkylhaltige metallkomplexe und ihre verwendung in der nmr-diagnostik
WO1996014878A3 (en)	1996-07-11	Calixarene conjugates useful as MRI and CT diagnostic imaging agents
DE69430730D1 (de)	2002-07-11	Hepatobillianische magnetische resonanz-kontrastmittel
ATE192778T1 (de)	2000-05-15	Perfluoro-1h-1h-neopentyl-enthaltendes kontrastmittel und verfahren zu seiner verwendung
JPS62501288A (ja)	1987-05-21	Ｍｒｉ像形成のためのジエステル−ｄｔｐａ−常磁性造影剤，装置および方法
NO950346L (no)	1995-01-30	Polyazamakrocykliske forbindelser for kompleksering av metaljoner
ES2100827T3 (es)	1998-09-16	Quelatantes macrociclicos, sus quelatos y usos de los mismos en el campo diagnostico.
GB9024208D0 (en)	1990-12-19	Compounds
ATE122665T1 (de)	1995-06-15	Zyklische, stickstoff enthaltende liganden, ihre metallkomplexe, diese enthaltende diagnostik- mittel und verfahren zur herstellung der liganden.
ATE6635T1 (de)	1984-03-15	Biologisch aktive trizyklische amine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate.
Hofer	1979	Conformational analysis by LIS. II. 2-and 3-alkyl substituted 1-indanones
Sanchez et al.	1987	2D NMR Studies of Octahydroindole Svstems
Murray	1975	Carbon-13 nuclear magnetic resonance spectra of µ-oxo-bis (disalicylideneiminatoiron) complexes
Pohl et al.	1994	13 C NMR Chemical Shift Assignments of Alkyl Chains of Histamine Analogous ω-Aminoalkylheterocycles and Bicyclic Derivatives
IT1265365B1 (it)	1996-11-22	Chelati paramagnetici per diagnosi in risonanza magnetica nucleare