ATE173400T1 - Indolderivate und ihre verwendung - Google Patents

Indolderivate und ihre verwendung

Info

Publication number: ATE173400T1
Authority: AT; Austria
Prior art keywords: mammal; alkoxy; alkyl; hydrogen; independently
Prior art date: 1991-08-21

Application number

AT92610057T

Other languages

English (en)

Inventor

Soren-Peter Olesen

Leif Helth Jensen

Peter Moldt

Mikkel Thaning

Original Assignee

Neurosearch As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-21

Filing date

1992-08-14

Publication date

1998-12-15

1992-08-14 Application filed by Neurosearch As filed Critical Neurosearch As

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173400T1 publication Critical patent/ATE173400T1/de

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
229940054051 antipsychotic indole derivative Drugs 0.000 title 1
125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 2
150000002431 hydrogen Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
CJJDJQFZVLGJLB-UHFFFAOYSA-N 1-(4-methoxyphenyl)indole Chemical compound C1=CC(OC)=CC=C1N1C2=CC=CC=C2C=C1 CJJDJQFZVLGJLB-UHFFFAOYSA-N 0.000 abstract 1
208000024827 Alzheimer disease Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
102000004257 Potassium Channel Human genes 0.000 abstract 1
208000028017 Psychotic disease Diseases 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical compound [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
206010012601 diabetes mellitus Diseases 0.000 abstract 1
239000003085 diluting agent Substances 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
108020001213 potassium channel Proteins 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)

AT92610057T 1991-08-21 1992-08-14 Indolderivate und ihre verwendung ATE173400T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/748,050 US5158969A (en)	1991-08-21	1991-08-21	Indole derivatives as potassium channel blockers

Publications (1)

Publication Number	Publication Date
ATE173400T1 true ATE173400T1 (de)	1998-12-15

Family

ID=25007781

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92610057T ATE173400T1 (de)	1991-08-21	1992-08-14	Indolderivate und ihre verwendung

Country Status (6)

Country	Link
US (1)	US5158969A (de)
EP (1)	EP0528749B1 (de)
AT (1)	ATE173400T1 (de)
CA (1)	CA2076498C (de)
DE (1)	DE69227609T2 (de)
DK (1)	DK0528749T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU675484B2 (en) *	1993-03-24	1997-02-06	Neurosearch A/S	Benzimidazole compounds, their use and preparation
US5554630A (en) *	1993-03-24	1996-09-10	Neurosearch A/S	Benzimidazole compounds
US5399587A (en) *	1993-12-13	1995-03-21	Merck & Co., Inc.	Biologically active compounds
US5541208A (en) *	1994-01-24	1996-07-30	Merck & Co., Inc.	Indole diterpene alkaloid compounds
BR9608056A (pt) *	1995-04-21	1999-11-30	Neurosearch As	Compostos de benzimidazol, composições farmacêuticas contendo os compostos e sua utilização.
WO1998017651A1 (en) *	1996-10-21	1998-04-30	Neurosearch A/S	1-phenyl-benzimidazole compounds and their use as baga-a receptor modulators
GB9726630D0 (en) *	1997-12-18	1998-02-18	Glaxo Group Ltd	Kv2.1 Antagonists
AU4537600A (en)	1999-05-12	2000-12-05	Neurosearch A/S	Use of ion channel modulating agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1220628A (en) *	1968-07-20	1971-01-27	Pfizer Ltd	N-phenyl indole derivatives and pharmaceutical compositions thereof
FR2242091A1 (en) *	1973-09-04	1975-03-28	Delalande Sa	1-Phenyl-2-methyl-3-aminomethyl-5-methoxy indole derivs - with e.g. analgesic, antidepressive and anti-arrhythmic props
US4476307A (en) *	1982-09-20	1984-10-09	Pfizer Inc.	Heteroylidene indolone compounds
WO1990005721A1 (en) *	1988-11-14	1990-05-31	The Upjohn Company	Alpha-amino-indole-3-acetic acids useful as anti-diabetic, anti-obesity and anti-atherosclerotic agents
NZ239540A (en) *	1990-09-24	1993-11-25	Neurosearch As	1-phenyl benzimidazole derivatives and medicaments

1991
- 1991-08-21 US US07/748,050 patent/US5158969A/en not_active Expired - Lifetime
1992
- 1992-08-14 AT AT92610057T patent/ATE173400T1/de not_active IP Right Cessation
- 1992-08-14 EP EP92610057A patent/EP0528749B1/de not_active Expired - Lifetime
- 1992-08-14 DE DE69227609T patent/DE69227609T2/de not_active Expired - Fee Related
- 1992-08-14 DK DK92610057T patent/DK0528749T3/da active
- 1992-08-20 CA CA002076498A patent/CA2076498C/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DE69227609D1 (de)	1998-12-24
EP0528749A1 (de)	1993-02-24
DE69227609T2 (de)	1999-04-15
EP0528749B1 (de)	1998-11-18
CA2076498C (en)	2002-11-12
US5158969A (en)	1992-10-27
DK0528749T3 (da)	1999-08-02
CA2076498A1 (en)	1993-02-22

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Legal Events

Date	Code	Title	Description
1999-05-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties