ATE173508T1 - Befestigung von sequenzspezifischen proben - Google Patents

Befestigung von sequenzspezifischen proben

Info

Publication number
ATE173508T1
ATE173508T1 AT89906987T AT89906987T ATE173508T1 AT E173508 T1 ATE173508 T1 AT E173508T1 AT 89906987 T AT89906987 T AT 89906987T AT 89906987 T AT89906987 T AT 89906987T AT E173508 T1 ATE173508 T1 AT E173508T1
Authority
AT
Austria
Prior art keywords
nucleotides
binding
nucleic acid
target sequence
tail
Prior art date
Application number
AT89906987T
Other languages
English (en)
Inventor
Randall K Saiki
Henry A Erlich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE173508T1 publication Critical patent/ATE173508T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
AT89906987T 1988-05-20 1989-05-18 Befestigung von sequenzspezifischen proben ATE173508T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19700088A 1988-05-20 1988-05-20
US34749589A 1989-05-04 1989-05-04

Publications (1)

Publication Number Publication Date
ATE173508T1 true ATE173508T1 (de) 1998-12-15

Family

ID=26892463

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89906987T ATE173508T1 (de) 1988-05-20 1989-05-18 Befestigung von sequenzspezifischen proben

Country Status (8)

Country Link
EP (1) EP0451141B1 (de)
JP (1) JP2897959B2 (de)
AT (1) ATE173508T1 (de)
AU (1) AU632494B2 (de)
CA (1) CA1340864C (de)
DE (1) DE68928853T2 (de)
IL (1) IL90358A (de)
WO (1) WO1989011548A1 (de)

Families Citing this family (198)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5567809A (en) * 1986-03-13 1996-10-22 Hoffmann-La Roche Inc. Methods and reagents for HLA DRbeta DNA typing
US5418149A (en) * 1990-07-24 1995-05-23 Hoffmann-La Roche Inc. Reduction of non-specific amplification glycosylase using DUTP and DNA uracil
US5202231A (en) 1987-04-01 1993-04-13 Drmanac Radoje T Method of sequencing of genomes by hybridization of oligonucleotide probes
US6270961B1 (en) * 1987-04-01 2001-08-07 Hyseq, Inc. Methods and apparatus for DNA sequencing and DNA identification
GB8810400D0 (en) 1988-05-03 1988-06-08 Southern E Analysing polynucleotide sequences
US7811751B2 (en) 1988-05-03 2010-10-12 Oxford Gene Technology Limited Analysing polynucleotide sequences
US5700637A (en) * 1988-05-03 1997-12-23 Isis Innovation Limited Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays
US6054270A (en) * 1988-05-03 2000-04-25 Oxford Gene Technology Limited Analying polynucleotide sequences
US5683896A (en) 1989-06-01 1997-11-04 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5035996A (en) 1989-06-01 1991-07-30 Life Technologies, Inc. Process for controlling contamination of nucleic acid amplification reactions
US5143854A (en) 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
US5871928A (en) * 1989-06-07 1999-02-16 Fodor; Stephen P. A. Methods for nucleic acid analysis
US6040138A (en) 1995-09-15 2000-03-21 Affymetrix, Inc. Expression monitoring by hybridization to high density oligonucleotide arrays
US5744101A (en) * 1989-06-07 1998-04-28 Affymax Technologies N.V. Photolabile nucleoside protecting groups
US6919211B1 (en) 1989-06-07 2005-07-19 Affymetrix, Inc. Polypeptide arrays
US5925525A (en) * 1989-06-07 1999-07-20 Affymetrix, Inc. Method of identifying nucleotide differences
US5547839A (en) 1989-06-07 1996-08-20 Affymax Technologies N.V. Sequencing of surface immobilized polymers utilizing microflourescence detection
US6955915B2 (en) 1989-06-07 2005-10-18 Affymetrix, Inc. Apparatus comprising polymers
US5800992A (en) * 1989-06-07 1998-09-01 Fodor; Stephen P.A. Method of detecting nucleic acids
ATE131878T1 (de) * 1989-09-01 1996-01-15 Life Technologies Inc Verfahren zur überprüfung der kontamination von oligonukleotidabhängigen nukleinsäure- amplifikationsreaktionen
US5232829A (en) * 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
CA2032331A1 (en) * 1990-01-22 1991-07-23 Annie L. Wu Method and kits for detecting human leukocyte antigen dna
GB9002625D0 (en) * 1990-02-06 1990-04-04 Univ Singapore Human leukocyte antigen typing
EP0519016A1 (de) * 1990-03-07 1992-12-23 F.Hoffmann-La Roche & Co. Aktiengesellschaft Verfahren zur diagnose der lyme-krankheit
CA2037349C (en) * 1990-03-26 2008-06-17 James G. Wetmur Branch migration of nucleotides
US5650302A (en) * 1990-05-01 1997-07-22 Amgen Inc. Method for reducing carryover contamination in an amplification procedure
HU218095B (hu) * 1990-05-01 2000-05-28 Amgen Inc. Eljárás átvitt szennyeződések csökkentésére, amplifikációs eljárásokban
FR2663949A1 (fr) * 1990-06-29 1992-01-03 Genset Sa Perfectionnements a un procede d'amplification enzymatique in vitro.
US5210015A (en) † 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
AU8920191A (en) * 1990-10-31 1992-05-26 George D. Cimino Methods and compositions for minimizing inhibition of nucleic acid amplification
US5518900A (en) * 1993-01-15 1996-05-21 Molecular Tool, Inc. Method for generating single-stranded DNA molecules
EP0511559A1 (de) * 1991-04-30 1992-11-04 F.Hoffmann-La Roche & Co. Aktiengesellschaft Reagens für eine Oligonukleotidprobe
US5273883A (en) * 1991-05-07 1993-12-28 Hoffmann-La Roche Inc. Methods and reagents for γ-globin typing
US5220004A (en) * 1991-05-07 1993-06-15 Cetus Corporation Methods and reagents for G -65 -globin typing
US5437976A (en) * 1991-08-08 1995-08-01 Arizona Board Of Regents, The University Of Arizona Multi-domain DNA ligands bound to a solid matrix for protein and nucleic acid affinity chromatography and processing of solid-phase DNA
US6943034B1 (en) 1991-11-22 2005-09-13 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5412087A (en) * 1992-04-24 1995-05-02 Affymax Technologies N.V. Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
US6849462B1 (en) 1991-11-22 2005-02-01 Affymetrix, Inc. Combinatorial strategies for polymer synthesis
US5464744A (en) * 1992-09-24 1995-11-07 Norval B. Galloway Methods and compositions for reducing false positive signals in an RNA amplification system
US5554501A (en) * 1992-10-29 1996-09-10 Beckman Instruments, Inc. Biopolymer synthesis using surface activated biaxially oriented polypropylene
US5583211A (en) * 1992-10-29 1996-12-10 Beckman Instruments, Inc. Surface activated organic polymers useful for location - specific attachment of nucleic acids, peptides, proteins and oligosaccharides
US5837832A (en) * 1993-06-25 1998-11-17 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US7115364B1 (en) 1993-10-26 2006-10-03 Affymetrix, Inc. Arrays of nucleic acid probes on biological chips
US6027880A (en) * 1995-08-02 2000-02-22 Affymetrix, Inc. Arrays of nucleic acid probes and methods of using the same for detecting cystic fibrosis
US5861242A (en) * 1993-06-25 1999-01-19 Affymetrix, Inc. Array of nucleic acid probes on biological chips for diagnosis of HIV and methods of using the same
DE69431719T2 (de) 1993-06-25 2003-09-18 Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) Hybridisierung und sequenzierung von nukleinsäuren
JPH09508003A (ja) 1993-07-23 1997-08-19 ハイセック，インコーポレイション 未知の生物をスクリーニングするための方法
FR2709761B1 (fr) * 1993-09-10 1995-11-24 Pasteur Institut Procédé de détection de molécules contenant des mésappariements nucléotidiques et de localisation de ces mésappariements, et application à la détection de substitutions ou de délétions de bases .
US20060229824A1 (en) 1993-10-26 2006-10-12 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes
US6309823B1 (en) 1993-10-26 2001-10-30 Affymetrix, Inc. Arrays of nucleic acid probes for analyzing biotransformation genes and methods of using the same
US6156501A (en) * 1993-10-26 2000-12-05 Affymetrix, Inc. Arrays of modified nucleic acid probes and methods of use
US7375198B2 (en) 1993-10-26 2008-05-20 Affymetrix, Inc. Modified nucleic acid probes
US7323298B1 (en) 1994-06-17 2008-01-29 The Board Of Trustees Of The Leland Stanford Junior University Microarray for determining the relative abundances of polynuceotide sequences
US7378236B1 (en) 1994-06-17 2008-05-27 The Board Of Trustees Of The Leland Stanford Junior University Method for analyzing gene expression patterns
US6974666B1 (en) 1994-10-21 2005-12-13 Appymetric, Inc. Methods of enzymatic discrimination enhancement and surface-bound double-stranded DNA
US5556752A (en) * 1994-10-24 1996-09-17 Affymetrix, Inc. Surface-bound, unimolecular, double-stranded DNA
WO1996027680A1 (de) * 1995-03-04 1996-09-12 Boehringer Mannheim Gmbh Sequenzspezifischer nachweis von nukleinsäuren
US5968740A (en) * 1995-07-24 1999-10-19 Affymetrix, Inc. Method of Identifying a Base in a Nucleic Acid
US5569588A (en) * 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US6326140B1 (en) 1995-08-09 2001-12-04 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
US5777888A (en) * 1995-08-09 1998-07-07 Regents Of The University Of California Systems for generating and analyzing stimulus-response output signal matrices
EP0880598A4 (de) 1996-01-23 2005-02-23 Affymetrix Inc Verfahren zur analyse von nukleinsäure
US6114122A (en) 1996-03-26 2000-09-05 Affymetrix, Inc. Fluidics station with a mounting system and method of using
ATE216431T1 (de) * 1996-08-12 2002-05-15 Univ California Systemen zum erzeugen und analysieren von stimulus-reaktion ausgangssignalmatrizen
US6391550B1 (en) 1996-09-19 2002-05-21 Affymetrix, Inc. Identification of molecular sequence signatures and methods involving the same
WO1998028444A2 (en) * 1996-12-23 1998-07-02 The University Of Chicago Customized oligonucleotide microchips as multiple biosensors
US6458584B1 (en) * 1996-12-23 2002-10-01 University Of Chicago Customized oligonucleotide microchips that convert multiple genetic information to simple patterns, are portable and reusable
CA2276462C (en) 1996-12-31 2007-06-12 High Throughput Genomics, Inc. Multiplexed molecular analysis system apparatus and method
US20020042048A1 (en) 1997-01-16 2002-04-11 Radoje Drmanac Methods and compositions for detection or quantification of nucleic acid species
US6297006B1 (en) 1997-01-16 2001-10-02 Hyseq, Inc. Methods for sequencing repetitive sequences and for determining the order of sequence subfragments
US6309824B1 (en) 1997-01-16 2001-10-30 Hyseq, Inc. Methods for analyzing a target nucleic acid using immobilized heterogeneous mixtures of oligonucleotide probes
DE19708758A1 (de) * 1997-03-04 1998-09-17 Christoph Prof Dr Wagener Verfahren zum Nachweis von mutierten Allelen
US6489455B2 (en) 1997-05-21 2002-12-03 Clontech Laboratories, Inc. Methods of assaying differential expression
US5994076A (en) * 1997-05-21 1999-11-30 Clontech Laboratories, Inc. Methods of assaying differential expression
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
US6188783B1 (en) 1997-07-25 2001-02-13 Affymetrix, Inc. Method and system for providing a probe array chip design database
US6458533B1 (en) 1997-12-19 2002-10-01 High Throughput Genomics, Inc. High throughput assay system for monitoring ESTs
US6232066B1 (en) 1997-12-19 2001-05-15 Neogen, Inc. High throughput assay system
US6238869B1 (en) 1997-12-19 2001-05-29 High Throughput Genomics, Inc. High throughput assay system
US20030096232A1 (en) 1997-12-19 2003-05-22 Kris Richard M. High throughput assay system
JP2002512045A (ja) * 1998-04-20 2002-04-23 アフィメトリックス インコーポレイテッド 核酸プローブアレイに対する非特異的な結合を減少させるための方法
US6355419B1 (en) 1998-04-27 2002-03-12 Hyseq, Inc. Preparation of pools of nucleic acids based on representation in a sample
US6664045B1 (en) 1998-06-18 2003-12-16 Boston Probes, Inc. PNA probes, probe sets, methods and kits pertaining to the detection of microorganisms
US6306643B1 (en) 1998-08-24 2001-10-23 Affymetrix, Inc. Methods of using an array of pooled probes in genetic analysis
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
WO2000034457A1 (fr) * 1998-12-10 2000-06-15 Takara Shuzo Co., Ltd. Procede relatif a l'immobilisation d'un oligonucleotide sur un support
US6824866B1 (en) 1999-04-08 2004-11-30 Affymetrix, Inc. Porous silica substrates for polymer synthesis and assays
DE60000583T3 (de) 1999-05-19 2009-04-30 Eppendorf Array Technologies Verfahren zur identifizierung und/oder quantifizierung einer zielverbindung
US7144700B1 (en) 1999-07-23 2006-12-05 Affymetrix, Inc. Photolithographic solid-phase polymer synthesis
US20040023226A1 (en) * 2000-02-28 2004-02-05 Derva Ozkan Method for immobilizing nucleic acids
US6833240B2 (en) 2000-03-08 2004-12-21 Mcgill University Very low density lipoprotein receptor polymorphisms and uses therefor
US7202026B2 (en) 2000-03-24 2007-04-10 Eppendorf Array Technologies Sa (Eat) Identification of a large number of biological (micro)organisms groups at different levels by their detection on a same array
EP1136566A1 (de) * 2000-03-24 2001-09-26 Facultés Universitaires Notre-Dame de la Paix Methode und Kit zum Nachweis und/oder Quantifizierung von homologen Sequenzen mittels Arrays
US7407748B2 (en) 2000-03-24 2008-08-05 Eppendorf Array Technologies S.A. Method and kit for the determination of cellular activation profiles
US7205104B2 (en) * 2000-03-24 2007-04-17 Eppendorf Array Technologies Sa (Eat) Identification of biological (micro) organisms by detection of their homologous nucleotide sequences on arrays
EP1136567A1 (de) 2000-03-24 2001-09-26 Advanced Array Technologies S.A. Methode und Kit zum Auffinden, Nachweis und/oder Quantifizieren von Transkriptionsfaktoren
US7875442B2 (en) 2000-03-24 2011-01-25 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
US7829313B2 (en) 2000-03-24 2010-11-09 Eppendorf Array Technologies Identification and quantification of a plurality of biological (micro)organisms or their components
DE10015097A1 (de) 2000-03-28 2001-10-04 Giesecke & Devrient Gmbh Im Stichtiefdruck bedruckter Datenträger
US6511277B1 (en) 2000-07-10 2003-01-28 Affymetrix, Inc. Cartridge loader and methods
WO2002012263A1 (en) 2000-08-03 2002-02-14 Roche Diagnostics Gmbh Nucleic acid binding compounds containing pyrazolo[3,4-d]pyrimidine analogues of purin-2,6-diamine and their uses
US6422249B1 (en) 2000-08-10 2002-07-23 Affymetrix Inc. Cartridge washing system and methods
AU2001296645A1 (en) 2000-10-06 2002-04-15 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding dna and rna
US9708358B2 (en) 2000-10-06 2017-07-18 The Trustees Of Columbia University In The City Of New York Massive parallel method for decoding DNA and RNA
GB0119719D0 (en) * 2001-08-13 2001-10-03 Solexa Ltd DNA sequence analysis
DE10154291B4 (de) * 2001-11-05 2005-05-19 Hain Lifescience Gmbh Verfahren zum Nachweis von Nukleinsäuren in Form eines Trockenschnelltestes
JP2004003989A (ja) 2002-03-15 2004-01-08 Affymetrix Inc 生物学的物質の走査のためのシステム、方法、および製品
WO2003091393A2 (en) * 2002-04-23 2003-11-06 Applera Corporation Nucleic “acid molecules encoding human proteins, and uses thereof”
JP2004041109A (ja) * 2002-07-12 2004-02-12 Toshiba Corp 核酸検出方法およびそれに使用されるプライマー
WO2004011643A1 (ja) * 2002-07-26 2004-02-05 Kabushiki Kaisha Toshiba 核酸プローブ固定化基体およびそれを用いた標的核酸の存在を検出する方法
JP3917640B2 (ja) * 2002-07-26 2007-05-23 株式会社東芝 核酸プローブ固定化基体を用いた標的核酸の存在を検出する方法
WO2004058052A2 (en) 2002-12-20 2004-07-15 Applera Corporation Genetic polymorphisms associated with myocardial infarction, methods of detection and uses thereof
CA2463719A1 (en) 2003-04-05 2004-10-05 F. Hoffmann-La Roche Ag Nucleotide analogs with six membered rings
US7348420B2 (en) 2003-04-25 2008-03-25 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding cell surface protein homologues and uses therefore
EP1651750B1 (de) 2003-06-23 2011-04-06 North Carolina State University Für fructooligosaccharid-nutzende verbindungen codierende nukleinsäuren aus lactobacillus acidophilus und verwendungen davon
US7317415B2 (en) 2003-08-08 2008-01-08 Affymetrix, Inc. System, method, and product for scanning of biological materials employing dual analog integrators
WO2005056837A2 (en) 2003-11-26 2005-06-23 Applera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
GB0403039D0 (en) * 2004-02-11 2004-03-17 Health Prot Agency TB resistance assay
US7459289B2 (en) 2004-03-08 2008-12-02 North Carolina State University Lactobacillus acidophilus nucleic acid sequences encoding carbohydrate utilization-related proteins and uses therefor
US7820380B2 (en) 2004-05-07 2010-10-26 Celera Corporation Genetic polymorphisms associated with liver fibrosis
US7338763B2 (en) 2004-06-02 2008-03-04 Eppendorf Array Technologies S.A. Method and kit for the detection and/or quantification of homologous nucleotide sequences on arrays
US7858763B2 (en) 2004-06-04 2010-12-28 Council Of Scientific And Industrial Research Transforming growth factor beta 1 (TGFβ1) haplotypes and prediction of susceptibility for immunological disorders
JP2006055065A (ja) * 2004-08-19 2006-03-02 Toyo Kohan Co Ltd 非対称ｐｃｒを用いた核酸の検出方法、ポリヌクレオチドプローブ、それを固定するプローブ固定化担体およびキット
JP5341350B2 (ja) 2004-11-16 2013-11-13 トラスティーズ オブ ボストン ユニバーシティ 高血圧および血管新生におけるエンドセリン−１／アンジオテンシンｉｉ二重レセプター（ｄｅａｒ）の役割
JP2006166911A (ja) * 2004-11-19 2006-06-29 Wakunaga Pharmaceut Co Ltd 核酸検出用核酸断片および核酸検出方法
TW200626729A (en) * 2004-11-19 2006-08-01 Wakunaga Pharma Co Ltd Method for producing fermented beverage with beer taste exhibiting excellent brew flavor
GB0500996D0 (en) * 2005-01-18 2005-02-23 Delfts Diagnostic Labaratory B Detection method and materials therefor
US7495092B2 (en) 2005-01-14 2009-02-24 North Carolina State University Compositions comprising promoter sequences and methods of use
US7745389B2 (en) 2005-02-14 2010-06-29 University Of Iowa Research Foundation Methods for treatment of age-related macular degeneration
WO2006099365A2 (en) 2005-03-11 2006-09-21 Applera Corporation Genetic polymorphisms associated with coronary heart disease, methods of detection and uses thereof
WO2006104260A1 (ja) * 2005-03-31 2006-10-05 National University Corporation Nagoya University 核酸マイクロアレイ、その製造方法および核酸マイクロアレイ用基材
US9169510B2 (en) 2005-06-21 2015-10-27 The Trustees Of Columbia University In The City Of New York Pyrosequencing methods and related compositions
AU2006276813A1 (en) 2005-07-01 2007-02-15 Arbor Vita Corporation Methods and compositions for diagnosis and treatment of influenza
US7799530B2 (en) 2005-09-23 2010-09-21 Celera Corporation Genetic polymorphisms associated with cardiovascular disorders and drug response, methods of detection and uses thereof
US7695911B2 (en) 2005-10-26 2010-04-13 Celera Corporation Genetic polymorphisms associated with Alzheimer's Disease, methods of detection and uses thereof
GB2446083B (en) 2005-10-31 2011-03-02 Univ Columbia Chemically cleavable 3'-0-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods
US7982029B2 (en) 2005-10-31 2011-07-19 The Trustees Of Columbia University In The City Of New York Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods
MX2008009654A (es) * 2006-01-24 2009-01-15 Univ British Columbia Polimorfismos de vias de vasopresina como indicadores del resultado expuesto en sujetos criticamente enfermos.
EP2041304B1 (de) 2006-06-12 2011-09-07 Hadasit Medical Research Services & Development Limited Mit durch antipsychotika induzierten extrapyramidalen symptomen assoziierte rgs2-genotypen
US7642049B2 (en) 2006-06-30 2010-01-05 Bristol-Myers Squibb Company Method for identifying HIV-1 protease inhibitors with reduced metabolic affects through detection of human resistin polymorphisms
EP2479284B1 (de) 2006-07-13 2017-09-20 University of Iowa Research Foundation Verfahren und Reagenzien zur Behandlung und Diagnose von Gefäßerkrankungen und altersbedingter Makuladegeneration
EP2639317B1 (de) 2006-09-11 2015-03-04 Celera Corporation Psoriaseassoziierte genetische Polymorphien, Nachweisverfahren dafür und ihre Verwendung
US7910303B2 (en) 2006-10-20 2011-03-22 Celera Corporation Genetic polymorphisms associated with venous thrombosis, methods of detection and uses thereof
GB2457402B (en) 2006-12-01 2011-10-19 Univ Columbia Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators
US20120115131A1 (en) 2007-05-31 2012-05-10 Yale University Genetic lesion associated with cancer
EP2185726B1 (de) 2007-08-06 2014-01-08 Orion Genomics, LLC Neue einzelnukleotid-polymorphismen und kombinationen neuer und bekannter polymorphismen zur bestimmung der allelspezifischen expression des igf2-gens
WO2009029648A2 (en) 2007-08-27 2009-03-05 Applera Corporation Methods and compositions for pcr
DK2725107T3 (da) 2007-10-19 2019-01-02 Univ Columbia DNA-sekventering med ikke-fluorescerende nukleotidreversible terminatorer og ddNTP'er modificeret med spaltbart mærke og nukleinsyre omfattende inosin med reversible terminatorer
US8039212B2 (en) 2007-11-05 2011-10-18 Celera Corporation Genetic polymorphisms associated with liver fibrosis, methods of detection and uses thereof
CA2705985A1 (en) 2007-11-28 2009-06-04 Great Basin Scientific Methods and compositions for signal enhancement using multivalent interactions
EP2065474A1 (de) 2007-11-28 2009-06-03 Siemens Healthcare Diagnostics GmbH Verfahren für die Prognose der Therapiereaktion zur endokrinen Behandlung
US20090221620A1 (en) 2008-02-20 2009-09-03 Celera Corporation Gentic polymorphisms associated with stroke, methods of detection and uses thereof
EP2281069A2 (de) 2008-05-16 2011-02-09 Bristol-Myers Squibb Company Verfahren zur identifizierung von subjekten mit erhöhter wahrscheinlichkeit eines ansprechens auf dpp-iv-hemmer
EP3093351B1 (de) 2008-07-09 2018-04-18 Celera Corporation Mit kardiovaskulären krankheiten assoziierte, genetische polymorphismen, verfahren zum nachweis und verwendungen davon
US9657338B2 (en) 2008-10-01 2017-05-23 Koninklijke Philips N.V. Method for immobilizing nucleic acids on a support
EP2334808B1 (de) * 2008-10-01 2017-11-15 Koninklijke Philips N.V. Verfahren zur qualitätskontrolle von nukleinsäuren auf einem träger
CA2751758A1 (en) 2009-02-11 2010-08-19 Orion Genomics Llc Combinations of polymorphisms for determining allele-specific expression of igf2
US9767342B2 (en) 2009-05-22 2017-09-19 Affymetrix, Inc. Methods and devices for reading microarrays
CA2766210A1 (en) 2009-06-25 2010-12-29 Yale University Single nucleotide polymorphisms in brca1 and cancer risk
WO2011053774A1 (en) 2009-10-30 2011-05-05 Alcon Research, Ltd. Single nucleotide polymorphisms and genes associated with age-related macular degeneration
WO2011128096A1 (en) 2010-04-16 2011-10-20 Roche Diagnostics Gmbh Polymorphism markers for predicting response to interleukin-6 receptor-inhibiting monoclonal antibody drug treatment
US20110269735A1 (en) 2010-04-19 2011-11-03 Celera Corporation Genetic polymorphisms associated with statin response and cardiovascular diseases, methods of detection and uses thereof
US20140004510A1 (en) 2010-09-24 2014-01-02 Massachusetts Eye And Ear Infirmary Methods and compositions for prognosing and/or detecting age-related macular degeneration
US20120108651A1 (en) 2010-11-02 2012-05-03 Leiden University Medical Center (LUMC) Acting on Behalf of Academic Hospital Leiden (AZL) Genetic polymorphisms associated with venous thrombosis and statin response, methods of detection and uses thereof
US8759036B2 (en) 2011-03-21 2014-06-24 Affymetrix, Inc. Methods for synthesizing pools of probes
US9624539B2 (en) 2011-05-23 2017-04-18 The Trustees Of Columbia University In The City Of New York DNA sequencing by synthesis using Raman and infrared spectroscopy detection
AU2012300985A1 (en) 2011-08-31 2014-02-13 F. Hoffmann-La Roche Ag Responsiveness to angiogenesis inhibitors
CN103946395A (zh) 2011-08-31 2014-07-23 霍夫曼-拉罗奇有限公司 用于预测与抗血管发生疗法有关的高血压的风险的方法
WO2013059884A1 (en) 2011-10-28 2013-05-02 Itek Ventures Pty Ltd A gene and mutations thereof associated with seizure and movement disorders
CN104066852A (zh) 2011-11-23 2014-09-24 霍夫曼-拉罗奇有限公司 对血管发生抑制剂的响应性
MY154507A (en) 2012-03-19 2015-06-22 Malaysian Palm Oil Board Gene Controlling Shell Phenotype in Palm
US10633707B2 (en) 2012-04-10 2020-04-28 Vib Vzw Markers for detecting microsatellite instability in cancer and determining synthetic lethality with inhibition of the DNA base excision repair pathway
US10294529B2 (en) 2012-04-10 2019-05-21 Life Sciences Research Partners Vzw Microsatellite instability markers in detection of cancer
WO2014144883A1 (en) 2013-03-15 2014-09-18 The Trustees Of Columbia University In The City Of New York Raman cluster tagged molecules for biological imaging
GB201417499D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417497D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
GB201417500D0 (en) 2014-10-03 2014-11-19 Convergence Pharmaceuticals Novel use
JP7231326B2 (ja) 2014-11-10 2023-03-01 ジェネンテック， インコーポレイテッド Ｉｌ－３３媒介性障害のための治療及び診断方法
RU2754039C2 (ru) 2014-11-18 2021-08-25 Аква Ген Ас Способ прогнозирования резистентности
JP6858783B2 (ja) 2015-10-18 2021-04-14 アフィメトリックス インコーポレイテッド 一塩基多型及びインデルの複対立遺伝子遺伝子型決定
US11851705B2 (en) 2015-12-28 2023-12-26 PathogenDX Inc Microarray based multiplex pathogen analysis for plants, agriculture, food, and water
US11781133B2 (en) 2015-12-28 2023-10-10 Pathogendx, Inc. Microarray based multiplex pathogen analysis and uses thereof
WO2017123696A1 (en) 2016-01-12 2017-07-20 Interleukin Genetics, Inc. Methods for predicting response to treatment
WO2017182623A1 (en) 2016-04-22 2017-10-26 Aquagen As A qtl for omega-3 fatty acid content in fish
US20200308660A1 (en) 2016-06-29 2020-10-01 Tine Sa Quantitative trait loci affecting fatty acid composition in milk
US10337070B2 (en) 2017-01-12 2019-07-02 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US12577622B2 (en) 2017-06-02 2026-03-17 Myriad Genetics, Inc. Detecting cancer risk
EP3673082B1 (de) 2017-08-25 2026-01-28 Zoetis Services LLC Nukleinsäuresonde, verfahren zur immobilisierung der nukleinsäure an einem festen träger unter verwendung von uv-licht
KR20220098056A (ko) 2018-02-09 2022-07-08 제넨테크, 인크. 비만 세포 매개 염증성 질환에 대한 치료 및 진단 방법
EP3762508A4 (de) 2018-03-08 2021-12-15 Pathogendx, Inc. Auf mikroarray basierende multiplex-pathogenanalyse und deren verwendung
US20220249660A1 (en) 2019-06-06 2022-08-11 Sitokine Limited Compositions and methods for treating lung, colorectal and breast cancer
WO2021028469A1 (en) 2019-08-12 2021-02-18 Sitokine Limited Compositions and methods for treating cytokine release syndrome and neurotoxicity
PL3839066T3 (pl) 2019-12-18 2022-05-02 Aquagen As Dojrzewanie płciowe u pstrąga tęczowego
US20230110203A1 (en) 2020-03-13 2023-04-13 Medimmune Limited Therapeutic methods for the treatment of subjects with risk alelles in il33
WO2021205013A1 (en) 2020-04-09 2021-10-14 Sitokine Limited Compositions and methods for treating covid-19
WO2022020359A1 (en) 2020-07-24 2022-01-27 The Regents Of The University Of Michigan Compositions and methods for detecting and treating high grade subtypes of uterine cancer
WO2024231499A1 (en) 2023-05-10 2024-11-14 Vib Vzw Combinations of short genetic variants in the diagnosis of alzheimer disease

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713326A (en) * 1983-07-05 1987-12-15 Molecular Diagnostics, Inc. Coupling of nucleic acids to solid support by photochemical methods
JPS6091999A (ja) * 1983-10-25 1985-05-23 Fujirebio Inc ポリヌクレオチドの測定方法
IL79112A (en) * 1985-06-13 1992-01-15 Abbott Lab Method for the isolation of a nucleic acid sequence and kit for performing a hybridization assay
JPH01501339A (ja) * 1986-10-14 1989-05-11 ベックマン　インスツルメンツ　インコーポレーテッド 改良された核酸ハイブリダイゼーション方法及びそれに用いるキット

Also Published As

Publication number Publication date
CA1340864C (en) 1999-12-28
JP2897959B2 (ja) 1999-05-31
AU3754289A (en) 1989-12-12
DE68928853D1 (de) 1998-12-24
EP0451141B1 (de) 1998-11-18
DE68928853T2 (de) 1999-08-05
IL90358A0 (en) 1989-12-15
WO1989011548A1 (en) 1989-11-30
AU632494B2 (en) 1993-01-07
EP0451141A1 (de) 1991-10-16
JPH03504328A (ja) 1991-09-26
IL90358A (en) 1993-08-18

Similar Documents

Publication Publication Date Title
ATE173508T1 (de) Befestigung von sequenzspezifischen proben
ATE54028T1 (de) Hybridisierungstest fuer nukleinsaeure mittels anwendung von nachweisbaren antihybridantik¯rpern.
ATE147791T1 (de) Festphasendiagnose von medizinischen konditionen
DE68908054D1 (de) Verstaerkung und nachweis von nukleinsaeuresequenzen.
ATE321879T1 (de) Verfahren und strukturen, in welchen chemisch markierte nichtradioaktive polynukleotidesonden benutzt werden
GB2274710B (en) Detection of nucleic acid sequences in a sample using an oligonucleotide immobilised on a waveguide
DE69504094D1 (de) Verfahren zur Amplifikation von Nukleinsäuren auf einer Festphase und Reagenziensatz dafür
ATE191237T1 (de) Verfahren zur immobilisierung von nukleinsäuresonden an polystyroloberflächen
DE69231003D1 (de) Manipulation von nukleinsäuresequenzen
AU1082492A (en) Diagnostic assays using nucleic acid probes
ATE241018T1 (de) Untersuchung von nukleotiden in loesung mit hilfe von pna-sonden
ATE269161T1 (de) Kontaktierungsvorrichtung
DE69815370D1 (de) Fluoreszend-konjugaten von nukleosiden und von nukleotiden, ihrer verfahren zur herstellung und ihrer verwendungen
DE69032062D1 (de) Voraktivierte Proteine zur Markierung von Oligonukleotidsonden
AU3535389A (en) Method for diagnosis of infectious diseases and method of detecting and identifying microorganisms
JP2727625B2 (ja) 核酸の検出法
NO875058D0 (no) Oligonukleotidprober og fremgangsmaate for detektering av nukleinsyrene i bakterier og andre levende organismer ved hybridisering.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EELA Cancelled due to lapse of time