ATE173726T1 - 3-hydroxypyridin-4-on-derivate als chelatbildner - Google Patents

3-hydroxypyridin-4-on-derivate als chelatbildner

Info

Publication number: ATE173726T1
Authority: AT; Austria
Prior art keywords: ethyl; pct; methylpropionyloxy; alpha; group
Prior art date: 1992-08-12

Application number

AT93910215T

Other languages

English (en)

Inventor

Robert Charles Hider

Surinder Singh

Gary Stuart Tilbrook

Cross Gerrards

Paul Samuel Dobbin

Original Assignee

Btg Int Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-08-12

Filing date

1993-05-18

Publication date

1998-12-15

1993-05-18 Application filed by Btg Int Ltd filed Critical Btg Int Ltd

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173726T1 publication Critical patent/ATE173726T1/de

Links

LQUSVSANJKHVTM-UHFFFAOYSA-N 3-hydroxy-3h-pyridin-4-one Chemical class OC1C=NC=CC1=O LQUSVSANJKHVTM-UHFFFAOYSA-N 0.000 title 1
239000002738 chelating agent Substances 0.000 title 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 4
-1 2-pivaloyloxyethyl groups Chemical group 0.000 abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 1
229910052742 iron Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
231100000816 toxic dose Toxicity 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Toxicology (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

AT93910215T 1992-08-12 1993-05-18 3-hydroxypyridin-4-on-derivate als chelatbildner ATE173726T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB929217099A GB9217099D0 (en)	1992-08-12	1992-08-12	Pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
ATE173726T1 true ATE173726T1 (de)	1998-12-15

Family

ID=10720221

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93910215T ATE173726T1 (de)	1992-08-12	1993-05-18	3-hydroxypyridin-4-on-derivate als chelatbildner

Country Status (10)

Country	Link
US (1)	US5480894A (de)
EP (1)	EP0619808B1 (de)
JP (1)	JPH07500120A (de)
AT (1)	ATE173726T1 (de)
CA (1)	CA2119020C (de)
DE (1)	DE69322250T2 (de)
ES (1)	ES2124307T3 (de)
GB (2)	GB9217099D0 (de)
WO (1)	WO1994004498A1 (de)
ZA (1)	ZA935084B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0833627B1 (de)	1995-06-10	2004-08-18	Vitra Pharmaceuticals Ltd.	Eisenverbindungen, zusammensetzungen, herstellungsverfahren und verwendungen davon
PT768302E (pt) *	1995-09-29	2005-11-30	Novartis Ag	Novas hidroxipiridinonas
US6767741B1 (en)	1999-08-27	2004-07-27	Invitrogen Corporation	Metal binding compounds and their use in cell culture medium compositions
IL135884A (en) *	2000-04-30	2005-08-31	Yissum Res Dev Co	Method for measuring non-transferrin bound iron
CA2421410C (en)	2000-09-19	2009-11-10	Vitra Pharmaceuticals Limited	Iron compositions
DE60121468T2 (de)	2000-12-22	2007-03-29	Interuniversitair Microelektronica Centrum (Imec)	Zusammensetzung mit einer oxidierenden und komplexierenden verbindung
US6426418B1 (en)	2001-11-02	2002-07-30	Apotex, Inc.	Processes for the manufacturing of 3-hydroxy-N,1,6-trialkyl-4-oxo-1,4-dihydropyridine-2-carboxamide
ATE373644T1 (de)	2002-02-05	2007-10-15	Bristol Myers Squibb Co	N-substituierte 3-hydroxy-4-pyridinone und diese enthaltende pharmazeutika
GB0211500D0 (en)	2002-05-18	2002-06-26	Vitra Pharmaceuticals Ltd	Method of forming iron hydroxypyrone compounds
WO2004040252A2 (en)	2002-10-30	2004-05-13	Yissum Research Development Company Of The Hebrew University Of Jerusalem	Molecules and methods using same for measuring non-transferrin bound iron
US7707255B2 (en)	2003-07-01	2010-04-27	Microsoft Corporation	Automatic grouping of electronic mail
NZ529657A (en) *	2003-11-20	2004-07-30	Apotex Inc	Iron chelating cycloalkyl derivatives of 3-hydroxy-4-pyridinones
CA2488034C (en) *	2004-11-19	2009-10-06	Apotex Inc.	Process for the manufacture of 3-hydroxy-n-alkyl-1-cycloalkyl-6-alkyl-4-oxo-1,4-dihydropyridine-2-carboxamide and its related analogues
US9588781B2 (en)	2008-03-31	2017-03-07	Microsoft Technology Licensing, Llc	Associating command surfaces with multiple active components
GB201007209D0 (en)	2010-04-29	2010-06-16	King S College London	Compound
WO2012137202A1 (en)	2011-04-05	2012-10-11	Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.	Composition comprising an iron indicator attached to a microparticle and uses of same for quantifying non-transferrin bound iron (ntbi) and cellular labile iron (lci)
DE102012007558A1 (de)	2012-04-14	2013-10-17	Alf Hammes	Gabe substituierter bis-aryl-harnstoffderivate zur behandlung von anämien
GB201215675D0 (en)	2012-09-03	2012-10-17	Univ Exeter	Compound

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1074038B (it) *	1976-08-05	1985-04-17	Simes	Esteri della epinina
EP0305646B1 (de) *	1983-03-24	1996-11-13	Btg International Limited	3-Hydroxypyrid-4-one und pharmazeutische Zusammensetzungen
GB8308054D0 (en) *	1983-03-24	1983-05-05	Hider R C	Pharmaceutical compositions
GB8308055D0 (en) *	1983-03-24	1983-05-05	Hider R C	Pharmaceutical compositions
US4908371A (en) *	1987-11-10	1990-03-13	Ciba-Geigy Corporation	Esterified hydroxy dihydropyridinones for treating diseases associated with trivalent metal ion overload
EP0335745A1 (de) *	1988-03-31	1989-10-04	The Royal Free Hospital School Of Medicine	Verfahren zur Herstellung von Pyridin-4-onen
GB8910521D0 (en) *	1989-05-08	1989-06-21	Nat Res Dev	The stabilization of organic compounds
GB9100465D0 (en) *	1991-01-09	1991-02-20	Hider Robert C	Pharmaceutical compositions
GB9209078D0 (en) *	1992-04-27	1992-06-10	Hider Robert C	Pharmaceutical compositions

1992
- 1992-08-12 GB GB929217099A patent/GB9217099D0/en active Pending
1993
- 1993-05-18 JP JP6505976A patent/JPH07500120A/ja active Pending
- 1993-05-18 WO PCT/GB1993/001007 patent/WO1994004498A1/en not_active Ceased
- 1993-05-18 EP EP93910215A patent/EP0619808B1/de not_active Expired - Lifetime
- 1993-05-18 ES ES93910215T patent/ES2124307T3/es not_active Expired - Lifetime
- 1993-05-18 DE DE69322250T patent/DE69322250T2/de not_active Expired - Fee Related
- 1993-05-18 AT AT93910215T patent/ATE173726T1/de not_active IP Right Cessation
- 1993-05-18 CA CA002119020A patent/CA2119020C/en not_active Expired - Fee Related
- 1993-05-18 US US08/204,202 patent/US5480894A/en not_active Expired - Fee Related
- 1993-07-01 GB GB9313557A patent/GB2269589B/en not_active Revoked
- 1993-07-14 ZA ZA935084A patent/ZA935084B/xx unknown

Also Published As

Publication number	Publication date
EP0619808A1 (de)	1994-10-19
US5480894A (en)	1996-01-02
ES2124307T3 (es)	1999-02-01
CA2119020A1 (en)	1994-03-03
GB2269589A (en)	1994-02-16
DE69322250T2 (de)	1999-05-20
GB9313557D0 (en)	1993-08-18
GB2269589B (en)	1996-06-26
DE69322250D1 (de)	1999-01-07
JPH07500120A (ja)	1995-01-05
CA2119020C (en)	2003-12-16
ZA935084B (en)	1995-01-16
GB9217099D0 (en)	1992-09-23
EP0619808B1 (de)	1998-11-25
WO1994004498A1 (en)	1994-03-03

Legal Events

Date	Code	Title	Description
2000-04-15	UEP	Publication of translation of european patent specification
2005-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69322250D1 (de)	1999-01-07	3-hydroxypyridin-4-on-derivate als chelatbildner
AU641772B2 (en)	1993-09-30	Novel anti-epileptics
DE69420394D1 (de)	1999-10-07	Pyrrolopyridinderivate als dopaminrezeptor liganden
ES2098947T3 (es)	1997-05-01	Derivados de beta,beta-dimetil-4-piperidinoetanamina como inhibidores de la biosintesis del colesterol.
GB9305641D0 (en)	1993-05-05	Therapeutic agents
DK0632805T3 (da)	1999-04-19	Melaminderivater til anvendelse i behandlingen af cancer
DE69129272D1 (de)	1998-05-20	Dextrinsulfate als anti hiv-1 wirkstoffe und diese enthaltende zubereitungen
FI934680A0 (fi)	1993-10-22	Arylmorfolin, framstaellning och anvaending
GB2115815B (en)	1985-06-19	Benzothiazoline compounds
CS9100438A2 (en)	1991-09-15	New derivative of beta-phenylisoserine, method of its preparation and its application
HUT65978A (en)	1994-08-29	Pharmaceutical compositions applicable for treatment of enteropathia and containing imidazol-1-yl-compounds
ATE141153T1 (de)	1996-08-15	Allylamino-nitroaromaten
GR3025050T3 (en)	1998-01-30	Etoposide derivatives, process for their preparation, their use as a drug and in the preparation of a drug for treating cancer.
ATE147755T1 (de)	1997-02-15	Dipeptidderivate und diese als aktive bestandteile enthaltendes prophylaktisches oder therapeutisches mittel gegen knochenkrankheiten
SE9603284D0 (sv)	1996-09-10	New compounds
GR3036908T3 (en)	2002-01-31	Streptogramine derivatives, preparation of same and pharmaceutical compositions containing same
ES2103232A1 (es)	1997-09-01	Nuevos compuestos derivados de 1h-imidazol-2-metanol.