ATE173918T1 - Steroide enthaltende pharmazeutische granulate - Google Patents

Steroide enthaltende pharmazeutische granulate

Info

Publication number: ATE173918T1
Authority: AT; Austria
Prior art keywords: carrier; mixture; optionally; granules; desogestrel
Prior art date: 1992-09-04

Application number

AT93203476T

Other languages

English (en)

Inventor

Jan Hendrik Dopper

Der Ven Cornelis Josephus Van

Original Assignee

Akzo Nobel Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-09-04

Filing date

1993-12-10

Publication date

1998-12-15

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27578967&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE173918(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-12-10 Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE173918T1 publication Critical patent/ATE173918T1/de

Links

239000008187 granular material Substances 0.000 title abstract 6
150000003431 steroids Chemical class 0.000 title abstract 2
239000000203 mixture Substances 0.000 abstract 3
239000011230 binding agent Substances 0.000 abstract 2
RPLCPCMSCLEKRS-BPIQYHPVSA-N desogestrel Chemical compound C1CC[C@@H]2[C@H]3C(=C)C[C@](CC)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 RPLCPCMSCLEKRS-BPIQYHPVSA-N 0.000 abstract 2
229960004976 desogestrel Drugs 0.000 abstract 2
239000003085 diluting agent Substances 0.000 abstract 2
239000000314 lubricant Substances 0.000 abstract 2
238000000034 method Methods 0.000 abstract 2
239000003960 organic solvent Substances 0.000 abstract 2
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 1
239000003963 antioxidant agent Substances 0.000 abstract 1
230000003078 antioxidant effect Effects 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229940075614 colloidal silicon dioxide Drugs 0.000 abstract 1
239000003623 enhancer Substances 0.000 abstract 1
239000007888 film coating Substances 0.000 abstract 1
238000009501 film coating Methods 0.000 abstract 1
238000002156 mixing Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/567—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in position 17 alpha, e.g. mestranol, norethandrolone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Steroid Compounds (AREA)

AT93203476T 1992-09-04 1993-12-10 Steroide enthaltende pharmazeutische granulate ATE173918T1 (de)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
US07/941,026 US5395627A (en)	1992-09-04	1992-09-04	Pharmaceutical granulate
EP93203476A EP0657161B1 (de)	1992-09-04	1993-12-10	Steroide enthaltende pharmazeutische Granulate
CA002111320A CA2111320A1 (en)	1992-09-04	1993-12-13	Pharmaceutical granulate
NO934584A NO306928B1 (no)	1992-09-04	1993-12-13	Fremgangsmåte for fremstilling av steroidholdige granuler, samt granuler og tablett
FI935584A FI111221B (fi)	1992-09-04	1993-12-13	Menetelmä farmaseuttisten rakeiden valmistamiseksi
NZ250443A NZ250443A (en)	1992-09-04	1993-12-13	Preparation of film coated, steroid-loaded granules
ZA939337A ZA939337B (en)	1992-09-04	1993-12-13	Pharmaceutical granulate
AU52391/93A AU672447B2 (en)	1992-09-04	1993-12-14	Pharmaceutical granulate
JP32229093A JP3720385B2 (ja)	1992-09-04	1993-12-21	医薬顆粒
CN93121510A CN1050043C (zh)	1992-09-04	1993-12-29	药物颗粒

Publications (1)

Publication Number	Publication Date
ATE173918T1 true ATE173918T1 (de)	1998-12-15

Family

ID=27578967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93203476T ATE173918T1 (de)	1992-09-04	1993-12-10	Steroide enthaltende pharmazeutische granulate

Country Status (15)

Country	Link
US (2)	US5395627A (de)
EP (1)	EP0657161B1 (de)
JP (1)	JP3720385B2 (de)
CN (1)	CN1050043C (de)
AT (1)	ATE173918T1 (de)
AU (1)	AU672447B2 (de)
CA (1)	CA2111320A1 (de)
DE (1)	DE69322396T2 (de)
DK (1)	DK0657161T3 (de)
ES (1)	ES2125300T3 (de)
FI (1)	FI111221B (de)
GR (1)	GR3029273T3 (de)
NO (1)	NO306928B1 (de)
NZ (1)	NZ250443A (de)
ZA (1)	ZA939337B (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5976570A (en) *	1993-12-21	1999-11-02	Applied Analytical Industries, Inc.	Method for preparing low dose pharmaceutical products
US6077533A (en) *	1994-05-25	2000-06-20	Purdue Pharma L.P.	Powder-layered oral dosage forms
IL113816A (en) *	1994-06-08	1998-12-06	Akzo Nobel Nv	Pharmaceutical compositions containing desogestrel their preparation and use
US5994348A (en) *	1995-06-07	1999-11-30	Sanofi	Pharmaceutical compositions containing irbesartan
DE69620607T2 (de) *	1995-06-22	2002-09-19	Akzo Nobel N.V., Arnheim/Arnhem	Trockengranulierte gepresste tabletten enthaltend desogestrel
WO1997004752A1 (en) *	1995-07-26	1997-02-13	Duramed Pharmaceuticals, Inc.	Pharmaceutical compositions of conjugated estrogens and methods for their use
US6348216B1 (en) *	1996-06-10	2002-02-19	Knoll Pharmaceutical Company	Ibuprofen and narcotic analgesic compositions
US6361794B1 (en)	1996-06-12	2002-03-26	Basf Corporation	Method of making ibuprofen and narcotic analgesic composition
GB9613470D0 (en) *	1996-06-27	1996-08-28	Ciba Geigy Ag	Small solid oral dosage form
DE19652196A1 (de) *	1996-12-16	1998-06-18	Jenapharm Gmbh	Homogene steroidhaltige Präformulierungen zur Herstellung niedrigdosierter fester und halbfester pharmazeutischer Zubereitungen
DE69702985T2 (de) *	1997-09-23	2001-02-15	Akzo Nobel N.V., Arnheim/Arnhem	Steroid enthaltende Dosierungsformen mit einer steroiddichten Umhüllung
EP1212345B1 (de) *	1999-04-06	2003-08-06	Akzo Nobel N.V.	Oral wirksame 7-alpha-alkyl androgene
PT1591121E (pt)	2000-12-14	2009-07-20	Ortho Mcneil Janssen Pharm	Processo para preparar produtos de hormona esteróide compreendendo um agente estabilizante na forma não cristalina
US7303763B2 (en) *	2001-02-12	2007-12-04	Watson Laboratories, Inc.	Compositions for conjugated estrogens and associated methods
US6630166B1 (en)	2001-02-12	2003-10-07	Watson Pharmaceuticals, Inc.	Compositions for conjugated estrogens and associated methods
DK1275377T3 (da) *	2001-07-11	2003-10-06	Applied Pharma Res	Granulater, der indeholder fedtopløselige stoffer, og en fremgangsmåde til fremstilling deraf
TW200403075A (en) *	2002-05-29	2004-03-01	Akzo Nobel Nv	Progestagenic dosage units
JP4756153B2 (ja) *	2004-08-27	2011-08-24	富士製薬工業株式会社	低成分含量の錠剤の製造方法
EP1853272A1 (de) *	2005-02-03	2007-11-14	Duramed Pharmaceuticals, Inc.	Zusammensetzungen aus unkonjugierten östrogenen und anwendungsverfahren dafür
US20070248665A1 (en) *	2006-04-24	2007-10-25	Sherman Bernard C	Compositions comprising co-precipitate of eplerenone and a water-soluble excipient
DK2851075T3 (da) *	2012-05-14	2022-01-31	Shionogi & Co	Præparat, der indeholder 6,7-umættet -7-carbamoylmorphinanderivat
CN113842362A (zh)	2012-11-14	2021-12-28	格雷斯公司	含有生物活性材料与无序无机氧化物的组合物
CN103271928A (zh) *	2013-05-31	2013-09-04	南通联亚药业有限公司	一种改进去氧孕烯稳定性的处方工艺
CN103271927A (zh) *	2013-05-31	2013-09-04	南通联亚药业有限公司	一种改进口服避孕药含量均匀性三级稀释法的工艺

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4180560A (en) *	1976-10-26	1979-12-25	Syntex Corporation	Inert core implant pellet
JPS59155309A (ja) *	1983-02-22	1984-09-04	Teijin Ltd	活性型ビタミンｄ↓３類組成物
US5145675A (en) *	1986-03-31	1992-09-08	Advanced Polymer Systems, Inc.	Two step method for preparation of controlled release formulations
US4786503A (en) *	1987-04-06	1988-11-22	Alza Corporation	Dosage form comprising parallel lamine
EP0300523B1 (de) *	1987-07-06	1991-08-14	Akzo N.V.	Pharmazeutische Dosierungseinheit zur Vorbeugung bzw. Behandlung von klimakterischen Beschwerden
IL92343A0 (en) *	1988-12-20	1990-07-26	Gist Brocades Nv	Granulate for multiparticulate controlled release oral compositions,their preparation and oral pharmaceutical compositions containing them
US5035897A (en) *	1989-09-05	1991-07-30	Alza Corporation	Dosage form for delivering soluble or insoluble drugs
US5284662A (en) *	1990-10-01	1994-02-08	Ciba-Geigy Corp.	Oral osmotic system for slightly soluble active agents
IE71202B1 (en) *	1990-12-17	1997-02-12	Akzo Nv	Progestagen-only contraceptive
US5200194A (en) *	1991-12-18	1993-04-06	Alza Corporation	Oral osmotic device
MX9300110A (es) *	1992-01-13	1994-07-29	Gerhard Gergely	Preparacion farmaceutica en la forma de una tableta de efervescencia o de desintegracion o de un granulado de tipo instanteneo y procedimiento para su preparacion.

1992
- 1992-09-04 US US07/941,026 patent/US5395627A/en not_active Expired - Lifetime
1993
- 1993-12-10 ES ES93203476T patent/ES2125300T3/es not_active Expired - Lifetime
- 1993-12-10 DE DE69322396T patent/DE69322396T2/de not_active Revoked
- 1993-12-10 EP EP93203476A patent/EP0657161B1/de not_active Revoked
- 1993-12-10 AT AT93203476T patent/ATE173918T1/de not_active IP Right Cessation
- 1993-12-10 DK DK93203476T patent/DK0657161T3/da active
- 1993-12-13 NZ NZ250443A patent/NZ250443A/en not_active IP Right Cessation
- 1993-12-13 ZA ZA939337A patent/ZA939337B/xx unknown
- 1993-12-13 FI FI935584A patent/FI111221B/fi not_active IP Right Cessation
- 1993-12-13 NO NO934584A patent/NO306928B1/no not_active IP Right Cessation
- 1993-12-13 CA CA002111320A patent/CA2111320A1/en not_active Abandoned
- 1993-12-14 AU AU52391/93A patent/AU672447B2/en not_active Expired
- 1993-12-21 JP JP32229093A patent/JP3720385B2/ja not_active Expired - Lifetime
- 1993-12-29 CN CN93121510A patent/CN1050043C/zh not_active Expired - Lifetime
1994
- 1994-12-29 US US08/366,348 patent/US5527543A/en not_active Expired - Lifetime
1999
- 1999-02-03 GR GR990400353T patent/GR3029273T3/el unknown

Also Published As

Publication number	Publication date
AU5239193A (en)	1995-07-13
NO934584L (no)	1995-06-14
NO306928B1 (no)	2000-01-17
EP0657161A1 (de)	1995-06-14
US5395627A (en)	1995-03-07
NO934584D0 (no)	1993-12-13
FI935584A0 (fi)	1993-12-13
CA2111320A1 (en)	1995-06-14
DE69322396D1 (de)	1999-01-14
US5527543A (en)	1996-06-18
GR3029273T3 (en)	1999-05-28
ES2125300T3 (es)	1999-03-01
CN1104487A (zh)	1995-07-05
ZA939337B (en)	1994-10-13
FI935584L (fi)	1995-06-14
CN1050043C (zh)	2000-03-08
NZ250443A (en)	1995-07-26
AU672447B2 (en)	1996-10-03
DK0657161T3 (da)	1999-08-16
FI111221B (fi)	2003-06-30
JPH07196513A (ja)	1995-08-01
DE69322396T2 (de)	1999-07-29
JP3720385B2 (ja)	2005-11-24
EP0657161B1 (de)	1998-12-02

Legal Events

Date	Code	Title	Description
1999-09-15	UEP	Publication of translation of european patent specification
2006-03-15	RZN	Patent revoked

Publication	Publication Date	Title
ATE173918T1 (de)	1998-12-15	Steroide enthaltende pharmazeutische granulate
CA1266278A (en)	1990-02-27	Therapeutic compound
KR950031056A (ko)	1995-12-18	에스트로겐 및/또는 프로게스토겐을 투여하기 위한 eva로 이루어진 경피성 매트릭스 시스템
AU2125192A (en)	1993-02-25	New naphthylethlylureas and naphthylethylthioureas, process for the preparation thereof, and pharmaceutical compositions containing them
JPS57180602A (en)	1982-11-06	Production of water-soluble chitosan derivative and film-forming agent comprising same
BE900241A (fr)	1985-01-28	Procede de preparation d'ester de a-acetoxyethyle de cefuroxime.
CA1123426A (en)	1982-05-11	1,3-DIBENZOIC ACID ESTERS OF 17.alpha.-ETHYNYL-7.alpha.- METHYL-.DELTA.1,3,5(10)-OESTRATRIENE-1,3,17.beta.-TRIOL AND THEIR MANUFACTURE AND USE
KR880001237B1 (ko)	1988-07-12	베클로메타손 17,21-디프로피오네이트의 용매화합물의 제조방법
DE60031557D1 (de)	2006-12-07	Steroide, ihre herstellung , pharmazeutische zusammensetzungen mit ihnen und verwendungen dieser verbindungen
US3133858A (en)	1964-05-19	Stable thiobarbituric acid solution
Fahrenholtz et al.	1974	Steroidal imidazole-1-carboxylic acid esters
EP0401894B1 (de)	1992-10-28	Gefriergetrocknete pulverförmige Cyclophosphamidzusammensetzung sowie Verfahren zu deren Herstellung
KR950016749A (ko)	1995-07-20	약제용 과립 및 그 제조 방법
Maulding	1978	Solid-state dispersions employing urethan
AU5971990A (en)	1991-01-31	Renin-inhibiting amino oligohydroxy derivatives
JPS57203053A (en)	1982-12-13	Preparation of cyanoacetic acid ester
GEP20002095B (en)	2000-05-10	Antracycline Disaccharides, Process for Their Preparation and Pharmaceutical Compositions
MacGee et al.	1970	O-methylation of estrogens by thermal degradation of their tetramethylammonium salts
ATE30712T1 (de)	1987-11-15	4-hydroxy-alpha-aethyl-benzhydrole, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel.
US3869481A (en)	1975-03-04	17alpha-alkanoyloxy-6alpha-methyl-3beta-trialkyl-siloxypregn-4-en-20-ones
TH14841A (th)	1994-10-28	แกรนูลยา
JPH05271017A (ja)	1993-10-19	殺虫剤組成物
JPS5655362A (en)	1981-05-15	Polyfunctional azide compound and its preparation
JPS57181012A (en)	1982-11-08	Drug composed of polyprenyl compound
JPS54125651A (en)	1979-09-29	Monocyclic beta-lactam derivative and its preparation