ATE174027T1 - Heterozyklische verbindungen, ihre herstellung und anwendung - Google Patents

Heterozyklische verbindungen, ihre herstellung und anwendung

Info

Publication number
ATE174027T1
ATE174027T1 AT91915629T AT91915629T ATE174027T1 AT E174027 T1 ATE174027 T1 AT E174027T1 AT 91915629 T AT91915629 T AT 91915629T AT 91915629 T AT91915629 T AT 91915629T AT E174027 T1 ATE174027 T1 AT E174027T1
Authority
AT
Austria
Prior art keywords
production
application
heterocyclic compounds
compounds
forebrain
Prior art date
Application number
AT91915629T
Other languages
English (en)
Inventor
Per Sauerberg
Preben H Olesen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE174027T1 publication Critical patent/ATE174027T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Lubricants (AREA)
  • Hydrogenated Pyridines (AREA)
AT91915629T 1990-08-21 1991-08-20 Heterozyklische verbindungen, ihre herstellung und anwendung ATE174027T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK198590A DK198590D0 (da) 1990-08-21 1990-08-21 Heterocykliske forbindelser, deres fremstilling og anvendelse

Publications (1)

Publication Number Publication Date
ATE174027T1 true ATE174027T1 (de) 1998-12-15

Family

ID=8109272

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91915629T ATE174027T1 (de) 1990-08-21 1991-08-20 Heterozyklische verbindungen, ihre herstellung und anwendung

Country Status (23)

Country Link
US (1) US5260314A (de)
EP (1) EP0544779B1 (de)
JP (1) JP3100160B2 (de)
KR (1) KR100247121B1 (de)
AT (1) ATE174027T1 (de)
AU (1) AU662105B2 (de)
CA (1) CA2089769C (de)
CZ (1) CZ282606B6 (de)
DE (1) DE69130570T2 (de)
DK (2) DK198590D0 (de)
ES (1) ES2124707T3 (de)
FI (1) FI930747A7 (de)
GR (1) GR3029289T3 (de)
HU (2) HU221433B (de)
IE (1) IE912960A1 (de)
IL (1) IL99165A (de)
NO (1) NO301883B1 (de)
NZ (1) NZ239450A (de)
PT (1) PT98736B (de)
SG (1) SG68567A1 (de)
SK (1) SK283219B6 (de)
WO (1) WO1992003433A1 (de)
ZA (1) ZA916581B (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527813A (en) * 1990-08-21 1996-06-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5418240A (en) * 1990-08-21 1995-05-23 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
WO1993014089A1 (en) * 1992-01-13 1993-07-22 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
MX9300875A (es) 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.
AU672052B2 (en) * 1992-12-23 1996-09-19 Neurosearch A/S Antidepressant and antiparkinsonian compounds
AU672644B2 (en) * 1992-12-23 1996-10-10 Neurosearch A/S Aryl substituted heterocyclic compounds
US5554626A (en) * 1992-12-23 1996-09-10 Neurosearch A/S Substituted heterocyclic compounds as dopamine-reuptake inhibitors
AU671163B2 (en) * 1992-12-23 1996-08-15 Neurosearch A/S Alkyl substituted heterocyclic compounds
US6271229B1 (en) 1993-08-19 2001-08-07 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
KR960703908A (ko) * 1993-08-19 1996-08-31 안네 세커 정신병 치료방법(Antipsychotic method)
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
US6265419B1 (en) 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
US5998404A (en) * 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5821370A (en) * 1994-10-24 1998-10-13 Eli Lilly And Company Heterocyclic compounds and their preparation and use
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5484794A (en) * 1994-11-09 1996-01-16 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5574028A (en) * 1994-10-31 1996-11-12 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
TW390883B (en) * 1994-11-21 2000-05-21 Novo Nordisk As Azacyclic or azabicyclic compounds for treating diseases in the central nervous system, their preparation and pharmaceutical composition thereof
TW304167B (de) * 1995-01-30 1997-05-01 Lilly Co Eli
PE17897A1 (es) * 1995-02-17 1997-06-12 Lilly Co Eli Formulacion transdermica en parche del 3-(4-butiltio)-1,2,5-tiadiazol-3-il)-1-azabiciclo (2,2,2) octano
EP0809494A1 (de) * 1995-02-17 1997-12-03 Novo Nordisk A/S Verwendung von heterocyclischen verbindungen
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
US5767280A (en) * 1995-06-01 1998-06-16 Eli Lilly And Company Process for making heterocyclic compounds
DE69637097T2 (de) * 1995-10-13 2007-09-20 Neurosearch A/S 8-Azabicyclo(3.2.1)Oct-2-en-Derivate, deren Herstellung und Anwendung
US5852037A (en) * 1995-11-13 1998-12-22 Eli Lilly And Company Method for treating anxiety
US5889019A (en) * 1995-11-29 1999-03-30 Eli Lilly And Company Heterocyclic compounds and their use
WO1997019669A2 (en) * 1995-11-29 1997-06-05 Eli Lilly And Company Heterocyclic compounds and their use
WO1997020819A1 (en) * 1995-12-06 1997-06-12 Eli Lilly And Company Composition for treating pain
HUP0000110A3 (en) * 1995-12-07 2000-09-28 Lilly Co Eli Pharmaceutical compositions comprising azacyclic, azabicyclic or tetrahydro-pyridine-derivatives suitable for treating pain
AU1093797A (en) * 1996-01-04 1997-08-01 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
WO1997034899A1 (en) * 1996-03-19 1997-09-25 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5914338A (en) * 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
AU2991397A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
ES2180998T3 (es) * 1996-04-23 2003-02-16 Lilly Co Eli Compuestos heterociclicos.
WO1997040043A1 (en) * 1996-04-23 1997-10-30 Eli Lilly And Company Heterocyclic compounds
AU2679497A (en) * 1996-04-23 1997-11-12 Eli Lilly And Company Heterocyclic compounds
DE69724967D1 (de) * 1996-04-24 2003-10-23 Novo Nordisk As Heterozyklische verbindungen, ihre herstellung und ihre anwendung
US5834458A (en) * 1996-10-09 1998-11-10 Eli Lilly And Company Heterocyclic compounds and their use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
GB9805557D0 (en) 1998-03-16 1998-05-13 Merck Sharp & Dohme A combination of therapeutic agents
CA2448913A1 (en) * 2001-07-06 2003-01-16 Neurosearch A/S Sulfone containing bicyclic aromatic ring compounds, their preparation and use as nicotinic acetyl-chloine receptors
EP2258359A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja) 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
EP2068872A1 (de) * 2006-09-08 2009-06-17 Braincells, Inc. Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
IL88846A0 (en) * 1988-01-08 1989-07-31 Merck Sharp & Dohme Lipophilic oxadiazoles,their preparation and pharmaceutical compositions containing them
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use

Also Published As

Publication number Publication date
NO930601L (no) 1993-04-16
CZ24493A3 (en) 1994-01-19
HU221433B (en) 2002-10-28
KR100247121B1 (ko) 2000-08-01
DK0544779T3 (da) 1999-08-16
NO301883B1 (no) 1997-12-22
NZ239450A (en) 1994-12-22
ES2124707T3 (es) 1999-02-16
GR3029289T3 (en) 1999-05-28
CA2089769C (en) 2002-10-01
SK12793A3 (en) 1993-09-08
HUT66863A (en) 1995-01-30
ZA916581B (en) 1992-05-27
CZ282606B6 (cs) 1997-08-13
IL99165A (en) 1997-11-20
JP3100160B2 (ja) 2000-10-16
CA2089769A1 (en) 1992-02-22
PT98736B (pt) 1999-01-29
FI930747L (fi) 1993-03-30
SG68567A1 (en) 1999-11-16
WO1992003433A1 (en) 1992-03-05
FI930747A0 (fi) 1993-02-19
PT98736A (pt) 1992-07-31
SK283219B6 (sk) 2003-03-04
IL99165A0 (en) 1992-07-15
HU9300464D0 (en) 1993-05-28
US5260314A (en) 1993-11-09
NO930601D0 (no) 1993-02-19
FI930747A7 (fi) 1993-03-30
EP0544779A1 (de) 1993-06-09
DE69130570T2 (de) 1999-04-29
DE69130570D1 (de) 1999-01-14
DK198590D0 (da) 1990-08-21
JPH06500542A (ja) 1994-01-20
EP0544779B1 (de) 1998-12-02
IE912960A1 (en) 1992-02-26
AU8403691A (en) 1992-03-17
HU211861A9 (en) 1995-12-28
AU662105B2 (en) 1995-08-24

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee