ATE174036T1 - Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern - Google Patents

Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern

Info

Publication number
ATE174036T1
ATE174036T1 AT94911702T AT94911702T ATE174036T1 AT E174036 T1 ATE174036 T1 AT E174036T1 AT 94911702 T AT94911702 T AT 94911702T AT 94911702 T AT94911702 T AT 94911702T AT E174036 T1 ATE174036 T1 AT E174036T1
Authority
AT
Austria
Prior art keywords
intermediate compounds
glycoprotein iib
iiia inhibitors
producing plates
plates
Prior art date
Application number
AT94911702T
Other languages
English (en)
Inventor
Lin-Hua Zhang
Philip Ma
William Frank Degrado
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Application granted granted Critical
Publication of ATE174036T1 publication Critical patent/ATE174036T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT94911702T 1993-03-29 1994-03-28 Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern ATE174036T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US3843493A 1993-03-29 1993-03-29

Publications (1)

Publication Number Publication Date
ATE174036T1 true ATE174036T1 (de) 1998-12-15

Family

ID=21899933

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94911702T ATE174036T1 (de) 1993-03-29 1994-03-28 Prozess und zwischenverbindungen zur herstellung von blaettchen glycoprotein iib/iiia hemmern

Country Status (12)

Country Link
US (1) US5817749A (de)
EP (1) EP0691986B1 (de)
JP (1) JPH08509708A (de)
AT (1) ATE174036T1 (de)
AU (1) AU682857B2 (de)
CA (1) CA2159072A1 (de)
DE (1) DE69415001T2 (de)
DK (1) DK0691986T3 (de)
ES (1) ES2126748T3 (de)
GR (1) GR3029453T3 (de)
NZ (1) NZ263455A (de)
WO (1) WO1994022909A1 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA978758B (en) * 1996-10-02 1999-03-30 Du Pont Merck Pharma Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3505555A1 (de) * 1985-02-18 1986-09-11 Behringwerke Ag, 3550 Marburg Neue oligopeptidylargininolderivate und deren homologe, verfahren zu deren herstellung, deren verwendung und diese enthaltende mittel
FR2636066B1 (fr) * 1988-09-02 1991-10-25 Centre Nat Rech Scient Derives de cyclopeptides, utilisables comme inhibiteurs selectifs vis-a-vis de proteases a serine active
JP2945680B2 (ja) * 1988-09-09 1999-09-06 旭硝子株式会社 ペプチド誘導体およびその用途
DD289543A5 (de) * 1989-05-12 1991-05-02 Univ Halle Wittenberg Neue pharmakologisch-aktive cyclopeptide und verfahren zu ihrer herstellung
US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
NZ235564A (en) * 1989-10-13 1993-10-26 Merck & Co Inc Fibrinogen receptor antagonist and pharmaceutical compositions
CA2027936C (en) * 1989-10-23 2001-07-24 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
CA2036973A1 (en) * 1990-02-27 1991-08-28 Mark G. Bock Cyclic hexapeptide oxytocin antagonists
US5192746A (en) * 1990-07-09 1993-03-09 Tanabe Seiyaku Co., Ltd. Cyclic cell adhesion modulation compounds
WO1992001709A1 (en) * 1990-07-24 1992-02-06 Eastman Kodak Company Process for synthesizing peptides
JPH06502407A (ja) * 1990-11-02 1994-03-17 ジェネンテク，インコーポレイテッド 血小板凝集阻害剤
IL103252A (en) * 1991-09-30 1997-03-18 Du Pont Merck Pharma CYCLIC COMPOUNDS USEFUL AS INHIBITORS OF PLATELET GLYCOPROTEIN IIb/IIIa AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2153228A1 (en) * 1993-01-08 1994-07-21 Shiu-Lan Ng Chiang Peptide inhibitors of cell adhesion
AU6415894A (en) * 1993-03-29 1994-10-24 Du Pont Merck Pharmaceutical Company, The Cyclic compounds useful as inhibitors of platelet glycoprotein iib/iiia
JPH08509709A (ja) * 1993-03-29 1996-10-15 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Ｎ▲上α▼−メチルアルギニンを含有する血小板糖たんぱく▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の製造方法およびそれに用いる中間体化合物

Also Published As

Publication number Publication date
EP0691986B1 (de) 1998-12-02
WO1994022909A1 (en) 1994-10-13
NZ263455A (en) 1997-10-24
CA2159072A1 (en) 1994-10-13
AU682857B2 (en) 1997-10-23
ES2126748T3 (es) 1999-04-01
JPH08509708A (ja) 1996-10-15
EP0691986A1 (de) 1996-01-17
GR3029453T3 (en) 1999-05-28
AU6415794A (en) 1994-10-24
DK0691986T3 (da) 1999-08-16
US5817749A (en) 1998-10-06
DE69415001D1 (de) 1999-01-14
DE69415001T2 (de) 1999-05-06

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee