ATE174334T1 - Piperidinderivate, verwendbar als neurokinin- rezeptor-antagonisten - Google Patents

Piperidinderivate, verwendbar als neurokinin- rezeptor-antagonisten

Info

Publication number: ATE174334T1
Authority: AT; Austria
Prior art keywords: alkyl; substd; opt; trihalomethyl; alkoxy
Prior art date: 1994-10-21

Application number

AT95402330T

Other languages

English (en)

Inventor

Nanteuil Guillaume De

Georges Remond

Bernard Portevin

Jacqueline Bonnet

Emmanuel Canet

Graham Birrell

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-21

Filing date

1995-10-19

Publication date

1998-12-15

1995-10-19 Application filed by Adir filed Critical Adir

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE174334T1 publication Critical patent/ATE174334T1/de

Links

NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical class C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 title abstract 3
102000009493 Neurokinin receptors Human genes 0.000 title 1
108050000302 Neurokinin receptors Proteins 0.000 title 1
239000002464 receptor antagonist Substances 0.000 title 1
229940044551 receptor antagonist Drugs 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000004953 trihalomethyl group Chemical group 0.000 abstract 5
125000001475 halogen functional group Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
-1 1-hydroxy-2,2,2-trifluoroethyl Chemical group 0.000 abstract 1
PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
IUKQLMGVFMDQDP-UHFFFAOYSA-N azane;piperidine Chemical class N.C1CCNCC1 IUKQLMGVFMDQDP-UHFFFAOYSA-N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

AT95402330T 1994-10-21 1995-10-19 Piperidinderivate, verwendbar als neurokinin- rezeptor-antagonisten ATE174334T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9412580A FR2725986B1 (fr)	1994-10-21	1994-10-21	Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number	Publication Date
ATE174334T1 true ATE174334T1 (de)	1998-12-15

Family

ID=9468073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95402330T ATE174334T1 (de)	1994-10-21	1995-10-19	Piperidinderivate, verwendbar als neurokinin- rezeptor-antagonisten

Country Status (16)

Country	Link
US (1)	US5652246A (de)
EP (1)	EP0708101B1 (de)
JP (1)	JP3004574B2 (de)
CN (1)	CN1043639C (de)
AT (1)	ATE174334T1 (de)
AU (1)	AU688120B2 (de)
CA (1)	CA2160966C (de)
DE (1)	DE69506510T2 (de)
DK (1)	DK0708101T3 (de)
ES (1)	ES2128013T3 (de)
FI (1)	FI115769B (de)
FR (1)	FR2725986B1 (de)
GR (1)	GR3029408T3 (de)
NO (1)	NO307515B1 (de)
NZ (1)	NZ280299A (de)
ZA (1)	ZA958895B (de)

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US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
CA2415532C (en)	2000-07-11	2010-05-11	Albany Molecular Research, Inc.	Novel 4-phenyl substituted tetrahydroisoquinolines therapeutic use thereof
KR20040099449A (ko) *	2002-04-18	2004-11-26	쉐링 코포레이션	히스타민 ｈ3 길항제로서의1-(4-피페리디닐)벤즈이미다졸론
GB0412865D0 (en) *	2004-06-09	2004-07-14	Glaxo Group Ltd	Chemical compounds
KR101389246B1 (ko)	2004-07-15	2014-04-24	브리스톨-마이어스스퀴브컴파니	아릴- 및 헤테로아릴-치환된 테트라히드로이소퀴놀린, 및 이것의 노르에피네프린, 도파민 및 세로토닌의 재흡수를 차단하기 위한 용도
EP1888050B1 (de)	2005-05-17	2012-03-21	Merck Sharp & Dohme Ltd.	Cis-4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropansäure zur Behandlug von Krebs
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US8389553B2 (en)	2007-06-27	2013-03-05	Merck Sharp & Dohme Corp.	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
CN102638982B (zh)	2009-05-12	2015-07-08	百时美施贵宝公司	(S)-7-([1,2,4]三唑并[1,5-a]吡啶-6-基)-4-(3,4-二氯苯基)-1,2,3,4-四氢异喹啉的晶型及其用途
KR101830447B1 (ko)	2009-05-12	2018-02-20	알바니 몰레큘라 리써치, 인크.	7-(［1,2,4］트리아졸로［1,5-α］피리딘-6-일)-4-(3,4-디클로로페닐)-1,2,3,4-테트라하이드로이소퀴놀린 및 이의 용도
EP2429295B1 (de)	2009-05-12	2013-12-25	Albany Molecular Research, Inc.	Aryl-, heteroaryl- und heterocyclen-substituierte tetrahydroisochinoline und ihre verwendung
EP2488028B1 (de)	2009-10-14	2020-08-19	Merck Sharp & Dohme Corp.	Substituierte piperidine zur erhöhung der p53-aktivität und ihre verwendung
CN107090456B (zh)	2010-08-02	2022-01-18	瑟纳治疗公司	使用短干扰核酸的RNA干扰介导的联蛋白（钙粘蛋白关联蛋白质），β1基因表达的抑制
JP2013537423A (ja)	2010-08-17	2013-10-03	メルク・シャープ・エンド・ドーム・コーポレイション	低分子干渉核酸（ｓｉＮＡ）を用いたＢ型肝炎ウイルス（ＨＢＶ）遺伝子発現のＲＮＡ干渉媒介性阻害
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en)	2010-09-01	2012-03-08	Schering Corporation	Indazole derivatives useful as erk inhibitors
EP2615916B1 (de)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Kondensierte pyrazolderivate als neue erk-hemmer
DK2632472T3 (en)	2010-10-29	2018-03-19	Sirna Therapeutics Inc	RNA INTERFERENCE-MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERRING NUCLEIC ACIDS (SINA)
WO2012087772A1 (en)	2010-12-21	2012-06-28	Schering Corporation	Indazole derivatives useful as erk inhibitors
EP2699568A1 (de)	2011-04-21	2014-02-26	Piramal Enterprises Limited	Kristalline form eines morpholinsulfonylindolderivat-salzes und verfahren zu seiner herstellung
WO2013063214A1 (en)	2011-10-27	2013-05-02	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP2844261B1 (de)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	Sina-zusammensetzungen
CN105050598B (zh)	2012-09-28	2018-04-27	默沙东公司	作为erk抑制剂的新型化合物
RS56680B1 (sr)	2012-11-28	2018-03-30	Merck Sharp & Dohme	Kompozicije i postupci za lečenje kancera
US8846657B2 (en)	2012-12-20	2014-09-30	Merck Sharp & Dohme Corp.	Substituted imidazopyridines as HDM2 inhibitors
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
EP3041938A1 (de)	2013-09-03	2016-07-13	Moderna Therapeutics, Inc.	Kreisförmige polynukleotide
US11364226B2 (en)	2017-06-30	2022-06-21	Cinrx Pharma, Llc	Deuterated domperidone compositions, methods, and preparation
CN108697700B (zh) *	2016-02-04	2021-08-17	辛多美制药有限公司	氘代多潘立酮组合物和用于治疗病症的方法
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
US12478612B2 (en)	2017-06-30	2025-11-25	Cindome Pharma, Inc.	Deuterated domperidone compositions, methods, and preparation
US11098059B2 (en)	2017-11-08	2021-08-24	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
EP3706742B1 (de)	2017-11-08	2023-03-15	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
EP3833668B1 (de)	2018-08-07	2025-03-19	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
EP3833667B1 (de)	2018-08-07	2024-03-13	Merck Sharp & Dohme LLC	Prmt5-inhibitoren
CA3108388A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors

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1994
- 1994-10-21 FR FR9412580A patent/FR2725986B1/fr not_active Expired - Fee Related
1995
- 1995-10-18 NO NO954151A patent/NO307515B1/no unknown
- 1995-10-19 DK DK95402330T patent/DK0708101T3/da active
- 1995-10-19 AT AT95402330T patent/ATE174334T1/de not_active IP Right Cessation
- 1995-10-19 AU AU34376/95A patent/AU688120B2/en not_active Ceased
- 1995-10-19 EP EP95402330A patent/EP0708101B1/de not_active Expired - Lifetime
- 1995-10-19 DE DE69506510T patent/DE69506510T2/de not_active Expired - Fee Related
- 1995-10-19 ES ES95402330T patent/ES2128013T3/es not_active Expired - Lifetime
- 1995-10-19 CA CA002160966A patent/CA2160966C/fr not_active Expired - Fee Related
- 1995-10-20 JP JP7272819A patent/JP3004574B2/ja not_active Expired - Fee Related
- 1995-10-20 CN CN95115976A patent/CN1043639C/zh not_active Expired - Fee Related
- 1995-10-20 US US08/546,263 patent/US5652246A/en not_active Expired - Fee Related
- 1995-10-20 FI FI955024A patent/FI115769B/fi active IP Right Grant
- 1995-10-20 NZ NZ280299A patent/NZ280299A/en unknown
- 1995-10-25 ZA ZA958895A patent/ZA958895B/xx unknown
1999
- 1999-02-16 GR GR990400490T patent/GR3029408T3/el unknown

Also Published As

Publication number	Publication date
NZ280299A (en)	1996-10-28
NO954151L (no)	1996-04-22
EP0708101A1 (de)	1996-04-24
CA2160966C (fr)	2002-02-26
ZA958895B (en)	1996-05-23
JP3004574B2 (ja)	2000-01-31
CN1128260A (zh)	1996-08-07
DE69506510T2 (de)	1999-07-08
AU688120B2 (en)	1998-03-05
FI955024A7 (fi)	1996-04-22
AU3437695A (en)	1996-05-02
NO954151D0 (no)	1995-10-18
EP0708101B1 (de)	1998-12-09
CA2160966A1 (fr)	1996-04-22
FI115769B (fi)	2005-07-15
ES2128013T3 (es)	1999-05-01
FI955024A0 (fi)	1995-10-20
FR2725986A1 (fr)	1996-04-26
FR2725986B1 (fr)	1996-11-29
DK0708101T3 (da)	1999-08-16
GR3029408T3 (en)	1999-05-28
CN1043639C (zh)	1999-06-16
NO307515B1 (no)	2000-04-17
JPH08225570A (ja)	1996-09-03
DE69506510D1 (de)	1999-01-21
US5652246A (en)	1997-07-29

Legal Events

Date	Code	Title	Description
1999-11-15	UEP	Publication of translation of european patent specification
2009-07-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69506510D1 (de)	1999-01-21	Piperidinderivate, verwendbar als Neurokinin-Rezeptor-Antagonisten
PT82673B (pt)	1988-08-17	Processo de preparacao de amidas derivadas da quinoleina e de medicamentos que as contem
DK0709384T3 (da)	1999-08-23	Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder
DK0992501T3 (da)	2002-10-28	Pyridoncarboxylsyre derivater som antibakterielle midler
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