ATE219484T1 - 4-indolylpiperazinyl-derivate - Google Patents

4-indolylpiperazinyl-derivate

Info

Publication number: ATE219484T1
Authority: AT; Austria
Prior art keywords: indolylpiperazinyl; derivatives; alkyl; indolylpiperazine; substd
Prior art date: 1995-04-10

Application number

AT96302420T

Other languages

English (en)

Inventor

John Patrick Yardley

Horace Fletcher

Michael Gerard Kelly

Alan Chapman White

Original Assignee

American Home Prod

Wyeth John & Brother Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-10

Filing date

1996-04-04

Publication date

2002-07-15

1996-04-04 Application filed by American Home Prod, Wyeth John & Brother Ltd filed Critical American Home Prod

2002-07-15 Application granted granted Critical

2002-07-15 Publication of ATE219484T1 publication Critical patent/ATE219484T1/de

Links

-1 4-INDOLYLPIPERAZINYL Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
FBCZWQNVHNIQOD-UHFFFAOYSA-N 2-piperazin-1-yl-1h-indole Chemical compound C1CNCCN1C1=CC2=CC=CC=C2N1 FBCZWQNVHNIQOD-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Indole Compounds (AREA)

AT96302420T 1995-04-10 1996-04-04 4-indolylpiperazinyl-derivate ATE219484T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/419,342 US5486518A (en)	1995-04-10	1995-04-10	4-indolylpiperazinyl derivatives

Publications (1)

Publication Number	Publication Date
ATE219484T1 true ATE219484T1 (de)	2002-07-15

Family

ID=23661842

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96302420T ATE219484T1 (de)	1995-04-10	1996-04-04	4-indolylpiperazinyl-derivate

Country Status (12)

Country	Link
US (1)	US5486518A (de)
EP (1)	EP0737678B1 (de)
JP (1)	JPH08319274A (de)
AT (1)	ATE219484T1 (de)
CA (1)	CA2173690A1 (de)
DE (1)	DE69621877T2 (de)
DK (1)	DK0737678T3 (de)
ES (1)	ES2177727T3 (de)
HU (1)	HUP9600914A2 (de)
PT (1)	PT737678E (de)
SI (1)	SI0737678T1 (de)
TW (1)	TW454005B (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5519025A (en) *	1995-04-10	1996-05-21	American Home Products Corporation	4-indolylpiperazinyl derivatives
EP0900792B1 (de) *	1997-09-02	2003-10-29	Duphar International Research B.V	Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
DE69819266T2 (de)	1997-09-02	2004-07-29	Duphar International Research B.V.	Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
EP1087954A1 (de) *	1998-06-15	2001-04-04	American Home Products Corporation	Cycloalkyl-substituiertte aryl-piperazine, piperidine und tetrahydropyridine als serotonergische agente
US6376494B1 (en)	1998-06-15	2002-04-23	American Home Products Corporation	Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
US6306859B1 (en)	1999-03-02	2001-10-23	American Home Products Corporation	N-substituted imide derivatives with serotonergic activity
EP1157017A1 (de) *	1999-03-02	2001-11-28	American Home Products Corporation	N-substituierte imidderivate mit serotonergischer wirkung
WO2001034586A2 (en)	1999-11-12	2001-05-17	Wyeth	Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-ht1a activity
US6831084B1 (en)	1999-11-12	2004-12-14	Wyeth	Branched adamantyl and noradamantyl aryl- and aralkylpiperazines with serotonin 5-HT1A activity
WO2002085871A2 (en)	2001-04-04	2002-10-31	Wyeth	Serotonergic agents with long-acting in vivo effects
US7067518B2 (en) *	2002-09-05	2006-06-27	Wyeth	Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
US7179813B2 (en)	2003-06-11	2007-02-20	Wyeth	Bicyclic indolyl derivatives and methods for their use as serotonergic agents
EP2475643A1 (de) *	2009-09-07	2012-07-18	Vifor (International) Ag	Neue ethandiamin-hepcidin-antagonisten

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3641029A (en) *	1970-02-02	1972-02-08	American Cyanamid Co	Substituted benzoxazolecarboxamides and benzothiazolecarboxamides
US3646048A (en) *	1970-02-02	1972-02-29	American Cyanamid Co	N-(tert-aminoalkyl)-2-indenecarboxamides
IL90279A (en) *	1988-05-24	1995-03-30	American Home Prod	Piperazinyl carboxamide derivatives, their preparation and pharmaceutical com¦ositions containing them
DK611489A (da) *	1988-12-08	1990-06-09	Duphar Int Res	Anxiolytisk aktive piperazinderivater og farmaceutiske praeparater med indhold af saadanne forbindelser
GB8909209D0 (en) *	1989-04-22	1989-06-07	Wyeth John & Brother Ltd	Piperazine derivatives
US5340812A (en) *	1989-04-22	1994-08-23	John Wyeth & Brother, Limited	Piperazine derivatives
IL94151A (en) *	1989-04-22	1995-08-31	Wyeth John & Brother Ltd	History of piperazine, their preparation and pharmaceutical preparations containing them
GB9411099D0 (en) *	1994-06-03	1994-07-27	Wyeth John & Brother Ltd	Piperazine derivatives

1995
- 1995-04-10 US US08/419,342 patent/US5486518A/en not_active Expired - Lifetime
- 1995-12-09 TW TW084113142A patent/TW454005B/zh not_active IP Right Cessation
1996
- 1996-03-29 JP JP8076390A patent/JPH08319274A/ja not_active Withdrawn
- 1996-04-04 SI SI9630483T patent/SI0737678T1/xx unknown
- 1996-04-04 ES ES96302420T patent/ES2177727T3/es not_active Expired - Lifetime
- 1996-04-04 AT AT96302420T patent/ATE219484T1/de not_active IP Right Cessation
- 1996-04-04 DK DK96302420T patent/DK0737678T3/da active
- 1996-04-04 DE DE69621877T patent/DE69621877T2/de not_active Expired - Fee Related
- 1996-04-04 PT PT96302420T patent/PT737678E/pt unknown
- 1996-04-04 EP EP96302420A patent/EP0737678B1/de not_active Expired - Lifetime
- 1996-04-09 HU HU9600914A patent/HUP9600914A2/hu unknown
- 1996-04-09 CA CA002173690A patent/CA2173690A1/en not_active Abandoned

Also Published As

Publication number	Publication date
HK1010102A1 (en)	1999-06-11
EP0737678B1 (de)	2002-06-19
DE69621877D1 (de)	2002-07-25
TW454005B (en)	2001-09-11
PT737678E (pt)	2002-11-29
SI0737678T1 (en)	2002-10-31
US5486518A (en)	1996-01-23
JPH08319274A (ja)	1996-12-03
HUP9600914A2 (hu)	1998-09-28
ES2177727T3 (es)	2002-12-16
HU9600914D0 (en)	1996-05-28
CA2173690A1 (en)	1996-10-11
DE69621877T2 (de)	2002-12-19
EP0737678A1 (de)	1996-10-16
DK0737678T3 (da)	2002-10-07

Legal Events

Date	Code	Title	Description
2005-01-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE219484T1 (de)	2002-07-15	4-indolylpiperazinyl-derivate
DK705888A (da)	1989-08-13	Pyridazinonderivater
DK394189A (da)	1990-02-13	Arylalkylaminer og -amider med antikonvulsive og neurobeskyttende egenskaber
NO306296B1 (no)	1999-10-18	Substituerte kinolinderivater og deres anvendelse samt legemidler inneholdende derilvatene
NO961404L (no)	1996-10-11	4-indolylpiperazinyl-derivater
NO963374D0 (no)	1996-08-13	Substituerte 4H-pyraner
UY26568A1 (es)	2001-08-27	Nuevos derivados de amidas heterocíclicas
NO955103D0 (no)	1995-12-15	Anvendelse av 1,2-broholdige 1,4-dihydropyridiner som legemiddel
DK0713865T3 (da)	1999-09-20	Derivater af 2-aminobenzensulfonsyre og 2-aminobenzensulfonylchlorid, fremstilling og anvendelse heraf som syntesemellempro
DK0758647T3 (da)	2000-12-11	Acylsubstituerede aminopyraner med en modulerende virkning på kaliumkanaler
DE59505138D1 (de)	1999-04-01	Cyclohexadienderivate
TW349099B (en)	1999-01-01	Apovincamine derivatives and the pharmaceutical composition thereof
PT72383A (en)	1981-02-01	Novel 1-(cyclohexyl)-4-aryl-4-pipedinecarboxylic acid derivatives