NO954151D0 - Nye piperidinforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske preparater inneholdende dem - Google Patents

Nye piperidinforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske preparater inneholdende dem

Info

Publication number: NO954151D0
Authority: NO; Norway
Prior art keywords: alkyl; substd; opt; trihalomethyl; alkoxy
Prior art date: 1994-10-21

Application number

NO954151A

Other languages

English (en)

Other versions

NO307515B1 (no

NO954151L (no

Inventor

Nanteuil Guillaume De

Georges Remond

Bernard Portevin

Jacqueline Bonnet

Emmanuel Canet

Graham Birrell

Original Assignee

Adir

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-21

Filing date

1995-10-18

Publication date

1995-10-18

1995-10-18 Application filed by Adir filed Critical Adir

1995-10-18 Publication of NO954151D0 publication Critical patent/NO954151D0/no

1996-04-22 Publication of NO954151L publication Critical patent/NO954151L/no

2000-04-17 Publication of NO307515B1 publication Critical patent/NO307515B1/no

Links

239000008194 pharmaceutical composition Substances 0.000 title 1
150000003053 piperidines Chemical class 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 9
125000003545 alkoxy group Chemical group 0.000 abstract 5
125000004953 trihalomethyl group Chemical group 0.000 abstract 5
125000001475 halogen functional group Chemical group 0.000 abstract 4
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
125000001624 naphthyl group Chemical group 0.000 abstract 2
125000004076 pyridyl group Chemical group 0.000 abstract 2
-1 1-hydroxy-2,2,2-trifluoroethyl Chemical group 0.000 abstract 1
PUAQLLVFLMYYJJ-UHFFFAOYSA-N 2-aminopropiophenone Chemical compound CC(N)C(=O)C1=CC=CC=C1 PUAQLLVFLMYYJJ-UHFFFAOYSA-N 0.000 abstract 1
JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
IUKQLMGVFMDQDP-UHFFFAOYSA-N azane;piperidine Chemical class N.C1CCNCC1 IUKQLMGVFMDQDP-UHFFFAOYSA-N 0.000 abstract 1
125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Urology & Nephrology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Plural Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)

NO954151A 1994-10-21 1995-10-18 Nye piperidinforbindelser og farmasøytiske preparater inneholdende dem NO307515B1 (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9412580A FR2725986B1 (fr)	1994-10-21	1994-10-21	Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (3)

Publication Number	Publication Date
NO954151D0 true NO954151D0 (no)	1995-10-18
NO954151L NO954151L (no)	1996-04-22
NO307515B1 NO307515B1 (no)	2000-04-17

Family

ID=9468073

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO954151A NO307515B1 (no)	1994-10-21	1995-10-18	Nye piperidinforbindelser og farmasøytiske preparater inneholdende dem

Country Status (16)

Country	Link
US (1)	US5652246A (no)
EP (1)	EP0708101B1 (no)
JP (1)	JP3004574B2 (no)
CN (1)	CN1043639C (no)
AT (1)	ATE174334T1 (no)
AU (1)	AU688120B2 (no)
CA (1)	CA2160966C (no)
DE (1)	DE69506510T2 (no)
DK (1)	DK0708101T3 (no)
ES (1)	ES2128013T3 (no)
FI (1)	FI115769B (no)
FR (1)	FR2725986B1 (no)
GR (1)	GR3029408T3 (no)
NO (1)	NO307515B1 (no)
NZ (1)	NZ280299A (no)
ZA (1)	ZA958895B (no)

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KR100821410B1 (ko)	2000-07-11	2008-04-10	에이엠알 테크놀로지, 인크.	4-페닐 치환된 테트라하이드로이소퀴놀린 및 이의치료학적 용도
NZ535764A (en) *	2002-04-18	2007-10-26	Schering Corp	1-(4-piperidinyl) benzimidazolones as histamine H3 antagonists
GB0412865D0 (en) *	2004-06-09	2004-07-14	Glaxo Group Ltd	Chemical compounds
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
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UA95454C2 (uk)	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
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AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
WO2010114780A1 (en)	2009-04-01	2010-10-07	Merck Sharp & Dohme Corp.	Inhibitors of akt activity
AU2010247763B2 (en)	2009-05-12	2015-12-24	Albany Molecular Research, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
EP2429295B1 (en)	2009-05-12	2013-12-25	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8815894B2 (en)	2009-05-12	2014-08-26	Bristol-Myers Squibb Company	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
US8859776B2 (en)	2009-10-14	2014-10-14	Merck Sharp & Dohme Corp.	Substituted piperidines that increase p53 activity and the uses thereof
CA2805265A1 (en)	2010-08-02	2012-02-09	Merck Sharp & Dohme Corp.	Rna interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (ctnnb1) gene expression using short interfering nucleic acid (sina)
WO2012024170A2 (en)	2010-08-17	2012-02-23	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
US8883801B2 (en)	2010-08-23	2014-11-11	Merck Sharp & Dohme Corp.	Substituted pyrazolo[1,5-a]pyrimidines as mTOR inhibitors
WO2012030685A2 (en)	2010-09-01	2012-03-08	Schering Corporation	Indazole derivatives useful as erk inhibitors
US9242981B2 (en)	2010-09-16	2016-01-26	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel ERK inhibitors
WO2012058210A1 (en)	2010-10-29	2012-05-03	Merck Sharp & Dohme Corp.	RNA INTERFERENCE MEDIATED INHIBITION OF GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACIDS (siNA)
EP2654748B1 (en)	2010-12-21	2016-07-27	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
WO2012143879A1 (en)	2011-04-21	2012-10-26	Piramal Healthcare Limited	A crystalline form of a salt of a morpholino sulfonyl indole derivative and a process for its preparation
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
WO2013165816A2 (en)	2012-05-02	2013-11-07	Merck Sharp & Dohme Corp.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
WO2014052563A2 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
ME02925B (me)	2012-11-28	2018-04-20	Merck Sharp & Dohme	Kompozicije i postupci za liječenje kancera
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
WO2014120748A1 (en)	2013-01-30	2014-08-07	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
US20160194368A1 (en)	2013-09-03	2016-07-07	Moderna Therapeutics, Inc.	Circular polynucleotides
WO2017136617A1 (en)	2016-02-04	2017-08-10	Cinrx Pharma, Llc	Deuterated domperidone compositions and methods for therapy of disorders
US11364226B2 (en)	2017-06-30	2022-06-21	Cinrx Pharma, Llc	Deuterated domperidone compositions, methods, and preparation
US10975084B2 (en)	2016-10-12	2021-04-13	Merck Sharp & Dohme Corp.	KDM5 inhibitors
US12478612B2 (en)	2017-06-30	2025-11-25	Cindome Pharma, Inc.	Deuterated domperidone compositions, methods, and preparation
EP3706747B1 (en)	2017-11-08	2025-09-03	Merck Sharp & Dohme LLC	Prmt5 inhibitors
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1994
- 1994-10-21 FR FR9412580A patent/FR2725986B1/fr not_active Expired - Fee Related
1995
- 1995-10-18 NO NO954151A patent/NO307515B1/no unknown
- 1995-10-19 AU AU34376/95A patent/AU688120B2/en not_active Ceased
- 1995-10-19 EP EP95402330A patent/EP0708101B1/fr not_active Expired - Lifetime
- 1995-10-19 AT AT95402330T patent/ATE174334T1/de not_active IP Right Cessation
- 1995-10-19 CA CA002160966A patent/CA2160966C/fr not_active Expired - Fee Related
- 1995-10-19 DE DE69506510T patent/DE69506510T2/de not_active Expired - Fee Related
- 1995-10-19 DK DK95402330T patent/DK0708101T3/da active
- 1995-10-19 ES ES95402330T patent/ES2128013T3/es not_active Expired - Lifetime
- 1995-10-20 NZ NZ280299A patent/NZ280299A/en unknown
- 1995-10-20 FI FI955024A patent/FI115769B/fi active IP Right Grant
- 1995-10-20 US US08/546,263 patent/US5652246A/en not_active Expired - Fee Related
- 1995-10-20 JP JP7272819A patent/JP3004574B2/ja not_active Expired - Fee Related
- 1995-10-20 CN CN95115976A patent/CN1043639C/zh not_active Expired - Fee Related
- 1995-10-25 ZA ZA958895A patent/ZA958895B/xx unknown
1999
- 1999-02-16 GR GR990400490T patent/GR3029408T3/el unknown

Also Published As

Publication number	Publication date
NZ280299A (en)	1996-10-28
AU3437695A (en)	1996-05-02
NO307515B1 (no)	2000-04-17
FI115769B (fi)	2005-07-15
DE69506510T2 (de)	1999-07-08
JPH08225570A (ja)	1996-09-03
JP3004574B2 (ja)	2000-01-31
EP0708101B1 (fr)	1998-12-09
FI955024A0 (fi)	1995-10-20
FI955024A7 (fi)	1996-04-22
AU688120B2 (en)	1998-03-05
ZA958895B (en)	1996-05-23
NO954151L (no)	1996-04-22
EP0708101A1 (fr)	1996-04-24
GR3029408T3 (en)	1999-05-28
FR2725986A1 (fr)	1996-04-26
DE69506510D1 (de)	1999-01-21
CN1128260A (zh)	1996-08-07
CN1043639C (zh)	1999-06-16
CA2160966C (fr)	2002-02-26
CA2160966A1 (fr)	1996-04-22
ATE174334T1 (de)	1998-12-15
FR2725986B1 (fr)	1996-11-29
ES2128013T3 (es)	1999-05-01
US5652246A (en)	1997-07-29
DK0708101T3 (da)	1999-08-16

Publication	Publication Date	Title
NO954151L (no)	1996-04-22	Nye piperidinforbindelser, fremgangsmåte ved deres fremstilling og farmasöytiske preparater inneholdende dem
DK0495776T3 (da)	1995-07-03	Stabiliserende nitrogenoxid/primær amin-komplekser, der er anvendelige som cardiovaskulære midler
PT96145A (pt)	1991-09-30	Processo para a preparacao de novos derivados de aminoacidos e de composicoes farmaceuticas que os contem
PT90377A (pt)	1989-11-10	Processo para a preparacao de derivados do acido piridonocarboxilico com actividade optica
MY103233A (en)	1993-05-29	Novel thiazole derivatives active on the cholinergic system, process for obtention and pharmaceutical compositions
NO180583C (no)	1997-05-14	Arylsulfonamido-substituerte hydroksamsyrer, farmasöytiske preparater inneholdende forbindelsene og anvendelse av forbindelsene for fremstilling av farmasöytiske preparater
PT94160A (pt)	1991-01-08	Processo para preparacao de derivados de alfa-aminocarboxamidas n-fenilalquil substituidas e composicoes farmaceuticas que os contem
ATE241601T1 (de)	2003-06-15	Zwischenverbindungen zur herstellung von neunen pyridoncarbonsäurederivate oder deren salzen
DK0562956T3 (da)	1996-02-05	Hidtil ukendte naphthylalkylaminer, fremgangsmåde til fremstilling heraf og farmaceutiske midler, som indeholder dem
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