ATE174336T1 - Verfahren zur herstellung von 2'- diethylaminorifamycin p (p/dea) - Google Patents

Verfahren zur herstellung von 2'- diethylaminorifamycin p (p/dea)

Info

Publication number: ATE174336T1
Authority: AT; Austria
Prior art keywords: formula; diethylaminorifamycin; dea; producing; desacetyl derivative
Prior art date: 1991-01-28

Application number

AT92100407T

Other languages

English (en)

Inventor

Gianbattista Panzone

Anacleto Gianantonio

Original Assignee

Lepetit Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-01-28

Filing date

1992-01-13

Publication date

1998-12-15

1992-01-13 Application filed by Lepetit Spa filed Critical Lepetit Spa

1998-12-15 Application granted granted Critical

1998-12-15 Publication of ATE174336T1 publication Critical patent/ATE174336T1/de

Links

QTLQVMGAXZJADU-ZRWMMNBYSA-N Rifamexil Chemical compound S1C(N(CC)CC)=NC(C2=C(C(O)=C3C)C=4O)=C1C=4NC(=O)\C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)[C@@H](O)[C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)\C=C\O[C@@]1(C)OC3=C2C1=O QTLQVMGAXZJADU-ZRWMMNBYSA-N 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
CNLHIRFQKMVKPX-UHFFFAOYSA-N 1,1-diethylthiourea Chemical compound CCN(CC)C(N)=S CNLHIRFQKMVKPX-UHFFFAOYSA-N 0.000 abstract 1
XTPGUQSTSWYULT-ZDHWWVNNSA-N Rifamycin P Natural products COC1C=COC2(C)Oc3c(C)c(O)c4c(O)c(NC(=O)C(=C/C=C/C(C)C(O)C(C)C(O)C(C)C(OC(=O)C)C1C)C)c5scnc5c4c3C2=O XTPGUQSTSWYULT-ZDHWWVNNSA-N 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
238000002955 isolation Methods 0.000 abstract 1
238000005580 one pot reaction Methods 0.000 abstract 1
XTPGUQSTSWYULT-TXXBDZDDSA-N rifamycin p Chemical compound OC1=C(C(O)=C2C)C3=C4N=CSC4=C1NC(=O)\C(C)=C\C=C\C(C)C(O)C(C)C(O)C(C)C(OC(C)=O)C(C)C(OC)\C=C/OC1(C)OC2=C3C1=O XTPGUQSTSWYULT-TXXBDZDDSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Public Health (AREA)
Virology (AREA)
Pulmonology (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Saccharide Compounds (AREA)

AT92100407T 1991-01-28 1992-01-13 Verfahren zur herstellung von 2'- diethylaminorifamycin p (p/dea) ATE174336T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP91101037		1991-01-28

Publications (1)

Publication Number	Publication Date
ATE174336T1 true ATE174336T1 (de)	1998-12-15

Family

ID=8206332

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT92100407T ATE174336T1 (de)	1991-01-28	1992-01-13	Verfahren zur herstellung von 2'- diethylaminorifamycin p (p/dea)

Country Status (14)

Country	Link
US (1)	US5378837A (de)
EP (1)	EP0497125B1 (de)
JP (1)	JP3154783B2 (de)
KR (1)	KR920014819A (de)
AT (1)	ATE174336T1 (de)
CA (1)	CA2059999C (de)
DE (1)	DE69227790T2 (de)
DK (1)	DK0497125T3 (de)
ES (1)	ES2124708T3 (de)
GR (1)	GR3029624T3 (de)
HU (1)	HU208697B (de)
IE (1)	IE920235A1 (de)
IL (1)	IL100642A (de)
ZA (1)	ZA92537B (de)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1470426A (en) *	1974-08-30	1977-04-14	Lepetit Spa	Rifamycins
IT1053787B (it) *	1974-10-29	1981-10-10	Pastori A	Macrolidi azotati e loro preparazione
GB1523199A (en) *	1976-05-28	1978-08-31	Lepetit Spa	Rifamycin sv derivatives
GB1523198A (en) *	1976-05-28	1978-08-31	Lepetit Spa	Thiazolo-rifamycin derivatives
CH629212A5 (it) *	1976-10-18	1982-04-15	Erba Farmitalia	Procedimento per la preparazione di composti di rifamicina.
IT1090759B (it) *	1977-11-29	1985-06-26	Alfa Farmaceutici Spa	Procedimento per la preparazione di 3 iodio e 3 bromo rifamicina s
GB8531887D0 (en) *	1985-12-30	1986-02-05	Lepetit Spa	Rifamycin sv derivatives

1992
- 1992-01-13 AT AT92100407T patent/ATE174336T1/de not_active IP Right Cessation
- 1992-01-13 ES ES92100407T patent/ES2124708T3/es not_active Expired - Lifetime
- 1992-01-13 EP EP92100407A patent/EP0497125B1/de not_active Expired - Lifetime
- 1992-01-13 IL IL10064292A patent/IL100642A/en not_active IP Right Cessation
- 1992-01-13 DE DE69227790T patent/DE69227790T2/de not_active Expired - Lifetime
- 1992-01-13 DK DK92100407T patent/DK0497125T3/da active
- 1992-01-14 JP JP02333992A patent/JP3154783B2/ja not_active Expired - Lifetime
- 1992-01-27 ZA ZA92537A patent/ZA92537B/xx unknown
- 1992-01-27 IE IE023592A patent/IE920235A1/en not_active IP Right Cessation
- 1992-01-27 CA CA002059999A patent/CA2059999C/en not_active Expired - Lifetime
- 1992-01-27 HU HU9200255A patent/HU208697B/hu unknown
- 1992-01-27 KR KR1019920001122A patent/KR920014819A/ko not_active Withdrawn
1993
- 1993-10-08 US US08/134,515 patent/US5378837A/en not_active Expired - Lifetime
1999
- 1999-03-08 GR GR990400711T patent/GR3029624T3/el unknown

Also Published As

Publication number	Publication date
HU9200255D0 (en)	1992-05-28
CA2059999A1 (en)	1992-07-29
IE920235A1 (en)	1992-07-29
IL100642A (en)	1995-11-27
US5378837A (en)	1995-01-03
ZA92537B (en)	1992-12-30
HUT61315A (en)	1992-12-28
AU1033092A (en)	1992-07-30
DE69227790T2 (de)	1999-06-10
ES2124708T3 (es)	1999-02-16
GR3029624T3 (en)	1999-06-30
AU650509B2 (en)	1994-06-23
CA2059999C (en)	2001-09-25
KR920014819A (ko)	1992-08-25
DK0497125T3 (da)	1999-08-16
JPH04346990A (ja)	1992-12-02
EP0497125B1 (de)	1998-12-09
DE69227790D1 (de)	1999-01-21
JP3154783B2 (ja)	2001-04-09
HU208697B (en)	1993-12-28
EP0497125A1 (de)	1992-08-05
IL100642A0 (en)	1992-09-06

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Legal Events

Date	Code	Title
1999-07-15	UEP	Publication of translation of european patent specification
2002-09-15	EEIH	Change in the person of patent owner
2007-10-15	EEIH	Change in the person of patent owner
2012-04-15	EELA	Cancelled due to lapse of time