ATE174592T1 - Sulfonamide und derivate zur modulierung der endothelin aktivitat - Google Patents

Sulfonamide und derivate zur modulierung der endothelin aktivitat

Info

Publication number: ATE174592T1
Authority: AT; Austria
Prior art keywords: sulfonamides; derivatives; endothelin activity; modulating endothelin; activity
Prior art date: 1993-05-20

Application number

AT94918081T

Other languages

English (en)

Inventor

Ming Fai Chan

Bore Gowda Raju

Adam Kois

Erik Joel Verner

Chengde Wu

Rosario Silvestre Castillo

Venkatachalapathi Yalamoori

Vitukudi Narayanaiyenga Balaji

Kalyanara-Man Ramnarayan

Original Assignee

Texas Biotechnology Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-20

Filing date

1994-05-20

Publication date

1999-01-15

1993-10-21 Priority claimed from US08/142,552 external-priority patent/US5514691A/en

1993-10-21 Priority claimed from US08/142,159 external-priority patent/US5464853A/en

1994-05-20 Application filed by Texas Biotechnology Corp filed Critical Texas Biotechnology Corp

1999-01-15 Application granted granted Critical

1999-01-15 Publication of ATE174592T1 publication Critical patent/ATE174592T1/de

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT94918081T 1993-05-20 1994-05-20 Sulfonamide und derivate zur modulierung der endothelin aktivitat ATE174592T1 (de)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US6520293A	1993-05-20	1993-05-20
US10056593A	1993-07-30	1993-07-30
US10012593A	1993-07-30	1993-07-30
US14263193A	1993-10-21	1993-10-21
US08/142,552 US5514691A (en)	1993-05-20	1993-10-21	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US08/142,159 US5464853A (en)	1993-05-20	1993-10-21	N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US08/222,287 US5591761A (en)	1993-05-20	1994-04-05	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (1)

Publication Number	Publication Date
ATE174592T1 true ATE174592T1 (de)	1999-01-15

Family

ID=27568241

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT94918081T ATE174592T1 (de)	1993-05-20	1994-05-20	Sulfonamide und derivate zur modulierung der endothelin aktivitat

Country Status (13)

Country	Link
US (1)	US5591761A (de)
EP (3)	EP1069114A3 (de)
JP (1)	JP3135922B2 (de)
AT (1)	ATE174592T1 (de)
CA (1)	CA2161346C (de)
CY (1)	CY2124B1 (de)
DE (1)	DE69415316T2 (de)
DK (1)	DK0699191T3 (de)
ES (1)	ES2127397T3 (de)
GB (1)	GB2285625B (de)
RU (1)	RU2151144C1 (de)
SG (1)	SG48742A1 (de)
WO (1)	WO1994027979A1 (de)

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1994
- 1994-04-05 US US08/222,287 patent/US5591761A/en not_active Expired - Lifetime
- 1994-05-20 RU RU95121744/04A patent/RU2151144C1/ru not_active IP Right Cessation
- 1994-05-20 AT AT94918081T patent/ATE174592T1/de not_active IP Right Cessation
- 1994-05-20 EP EP00119107A patent/EP1069114A3/de not_active Withdrawn
- 1994-05-20 GB GB9503693A patent/GB2285625B/en not_active Expired - Fee Related
- 1994-05-20 SG SG1996001101A patent/SG48742A1/en unknown
- 1994-05-20 JP JP07500856A patent/JP3135922B2/ja not_active Expired - Fee Related
- 1994-05-20 ES ES94918081T patent/ES2127397T3/es not_active Expired - Lifetime
- 1994-05-20 DE DE69415316T patent/DE69415316T2/de not_active Expired - Lifetime
- 1994-05-20 EP EP98109339A patent/EP0870764A1/de not_active Withdrawn
- 1994-05-20 EP EP94918081A patent/EP0699191B1/de not_active Expired - Lifetime
- 1994-05-20 DK DK94918081T patent/DK0699191T3/da active
- 1994-05-20 WO PCT/US1994/005755 patent/WO1994027979A1/en not_active Ceased
- 1994-05-20 CA CA002161346A patent/CA2161346C/en not_active Expired - Fee Related
1998
- 1998-12-22 CY CY9800048A patent/CY2124B1/xx unknown

Also Published As

Publication number	Publication date
AU6964694A (en)	1994-12-20
ES2127397T3 (es)	1999-04-16
AU691813B2 (en)	1998-05-28
GB9503693D0 (en)	1995-04-12
GB2285625A (en)	1995-07-19
WO1994027979A1 (en)	1994-12-08
EP0870764A1 (de)	1998-10-14
EP1069114A3 (de)	2001-01-31
RU2151144C1 (ru)	2000-06-20
DK0699191T3 (da)	1999-08-23
CA2161346C (en)	2004-11-23
DE69415316T2 (de)	1999-04-29
US5591761A (en)	1997-01-07
EP0699191A1 (de)	1996-03-06
EP1069114A2 (de)	2001-01-17
CY2124B1 (en)	2002-06-21
SG48742A1 (en)	1998-05-18
EP0699191B1 (de)	1998-12-16
GB2285625B (en)	1997-12-10
DE69415316D1 (de)	1999-01-28
JP3135922B2 (ja)	2001-02-19
JPH08510744A (ja)	1996-11-12
CA2161346A1 (en)	1994-12-08

Legal Events

Date	Code	Title	Description
2005-02-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
DE69415316D1 (de)	1999-01-28	Sulfonamide und derivate zur modulierung der endothelin aktivitat
ES2070660B1 (es)	1996-01-01	Un procedimiento para la preparacion de 2,5-damino-3-hidroxihexanos sustituidos, utiles como inhibidores de proteasas retrovirales.
ATE243203T1 (de)	2003-07-15	Thienyl-, furyl-, pyrrolyl- und biphenylsulfonamide und derivate zur modulation der endothelin-aktivität
DK0977741T3 (da)	2003-12-01	Substituerede phenylderivater, deres fremstilling og anvendelse
NO308736B1 (no)	2000-10-23	1,2-difenylpyrrolderivater, farmasøytiske preparater inneholdende disse, og deres anvendelse
GB9801690D0 (en)	1998-03-25	Therapeutic agents
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EP0976748A4 (de)	2001-08-08	Pyrrolidin-derivate die eine phospholipase-a2-hemmende wirkung haben
ATE425139T1 (de)	2009-03-15	Benzamidinderivate
FI953710A0 (fi)	1995-08-03	Uusia pyrrolokarbatsoleja
ATE124683T1 (de)	1995-07-15	Derivate von aminsäuren.
ATE192141T1 (de)	2000-05-15	Aromatische hydroxamsäure-verbindungen, ihre herstellung und verwendung
SE9704770D0 (sv)	1997-12-19	New use
ATE56967T1 (de)	1990-10-15	Amidderivate.
DK0673913T3 (da)	1999-09-20	Calcium-alkalimetalcitratforbindelser samt deres anvendelse som lægemidler
PT856511E (pt)	2004-07-30	Indometacina calcica penta-hidratada e sua preparacao
ES2045335T3 (es)	1994-01-16	Un procedimiento para la preparacion de nuevas s-difluorometilhomocisteinas.
ATE53575T1 (de)	1990-06-15	2,5-pyrrolidindion-derivate mit antiarrhythmischer wirkung.