ATE174910T1 - 1h-substituierte-1,2,4-triazolverbindungen zur behandlung von herzkrankheiten - Google Patents
1h-substituierte-1,2,4-triazolverbindungen zur behandlung von herzkrankheitenInfo
- Publication number
- ATE174910T1 ATE174910T1 AT91909072T AT91909072T ATE174910T1 AT E174910 T1 ATE174910 T1 AT E174910T1 AT 91909072 T AT91909072 T AT 91909072T AT 91909072 T AT91909072 T AT 91909072T AT E174910 T1 ATE174910 T1 AT E174910T1
- Authority
- AT
- Austria
- Prior art keywords
- butyl
- treatment
- pentyl
- compounds
- substituted
- Prior art date
Links
- 208000019622 heart disease Diseases 0.000 title 1
- -1 hydroxy, methyl Chemical group 0.000 abstract 11
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 abstract 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 2
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 2
- 125000006002 1,1-difluoroethyl group Chemical group 0.000 abstract 1
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 229940123413 Angiotensin II antagonist Drugs 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 229910018828 PO3H2 Inorganic materials 0.000 abstract 1
- 229910006069 SO3H Inorganic materials 0.000 abstract 1
- 239000002333 angiotensin II receptor antagonist Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000004210 cyclohexylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000001145 hydrido group Chemical group *[H] 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- UFUASNAHBMBJIX-UHFFFAOYSA-N propan-1-one Chemical group CC[C]=O UFUASNAHBMBJIX-UHFFFAOYSA-N 0.000 abstract 1
- 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
- 125000001889 triflyl group Chemical group FC(F)(F)S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/519,380 US5098920A (en) | 1990-05-04 | 1990-05-04 | 1h-substituted-1,2,4-triazole compounds and methods of use thereof for treatment of cardiovascular disorders |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE174910T1 true ATE174910T1 (de) | 1999-01-15 |
Family
ID=24068062
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT91909072T ATE174910T1 (de) | 1990-05-04 | 1991-05-06 | 1h-substituierte-1,2,4-triazolverbindungen zur behandlung von herzkrankheiten |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5098920A (de) |
| EP (1) | EP0527851B1 (de) |
| JP (1) | JP3098772B2 (de) |
| AT (1) | ATE174910T1 (de) |
| AU (1) | AU7792491A (de) |
| CA (1) | CA2082074C (de) |
| DE (1) | DE69130671T2 (de) |
| DK (1) | DK0527851T3 (de) |
| ES (1) | ES2125868T3 (de) |
| GR (1) | GR3029772T3 (de) |
| IE (1) | IE62867B1 (de) |
| PT (1) | PT97581B (de) |
| WO (1) | WO1991017148A1 (de) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0409332A3 (en) * | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
| US5217985A (en) * | 1990-08-28 | 1993-06-08 | G. D. Searle & Co. | Renal-selective biphenylalkyl 1h-substituted-1,2,4-triazole angiotensin ii antagonists for treatment of hypertension |
| US20040121989A1 (en) * | 1990-08-28 | 2004-06-24 | G.D. Searle & Co. | Renal-selective biphenylalkyl 1H-substituted-1,2,4-triazole angiotensin II antagonists for treatment of hypertension |
| SE9501881D0 (sv) * | 1995-05-19 | 1995-05-19 | Astra Ab | New pharmacological use of AII-receptor antagonists |
| JP3890453B2 (ja) | 1996-09-18 | 2007-03-07 | リードケミカル株式会社 | 新規２，４−ジオキソピロリジンおよび２，４−ジオキソテトラヒドロフラン誘導体及び該化合物を有効成分とする医薬 |
| US6495580B1 (en) | 1998-01-29 | 2002-12-17 | Viropharma Incorporated | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| CN1289248A (zh) * | 1998-01-29 | 2001-03-28 | 维洛药品公司 | 治疗或预防肺病毒感染及有关疾病的化合物、组合物和方法 |
| EP1109552A4 (de) * | 1998-07-16 | 2007-11-07 | Res Dev Foundation | Neue krebsbehandelnde mittel die eine dna-spaltung hervorrufen |
| US6362342B1 (en) | 1999-06-29 | 2002-03-26 | Lion Bioscience Ag | Triazole compounds and methods of making same |
| SE9903028D0 (sv) | 1999-08-27 | 1999-08-27 | Astra Ab | New use |
| EP1539691A2 (de) * | 2002-08-09 | 2005-06-15 | Viropharma Incorporated | VERBINDUNGEN, ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG BZW. PRûVENTION VON PNEUMOVIRUS-INFEKTIONEN UND ASSOZIIERTEN KRANKHEITEN |
| US8202896B2 (en) * | 2002-08-09 | 2012-06-19 | Microdose Therapeutx, Inc. | Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases |
| JP4885967B2 (ja) | 2005-10-11 | 2012-02-29 | エフ．ホフマン−ラ ロシュ アーゲー | イミダゾベンゾジアゼピン誘導体 |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2627848T3 (es) | 2008-06-04 | 2017-07-31 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| US9708367B2 (en) | 2013-03-15 | 2017-07-18 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase and their uses |
| EP2968439A2 (de) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Zusammensetzungen zur behandlung von magen-darm-störungen |
| PL3004138T3 (pl) | 2013-06-05 | 2024-07-29 | Bausch Health Ireland Limited | Ultra-oczyszczeni agoniści peptydowi cyklazy guanylanowej C, sposób ich uzyskiwania i ich zastosowanie |
| MY198436A (en) | 2017-04-07 | 2023-08-29 | Shikoku Chem | Triazole Silane Compound, Method for Synthesizing Said Compound and use Thereof |
| JPWO2024247919A1 (de) | 2023-05-30 | 2024-12-05 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2461406C2 (de) * | 1974-12-24 | 1984-06-14 | Bayer Ag, 5090 Leverkusen | Azolyl-(1)-methane und deren Salze, Verfahren zu ihrer Herstellung sowie diese enthaltende Arzneimittel |
| DE2851086A1 (de) * | 1978-11-25 | 1980-06-04 | Bayer Ag | Hydroxypropyl-triazole, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
| DE2912288A1 (de) * | 1979-03-28 | 1980-10-09 | Bayer Ag | Verfahren zur herstellung von hydroxyethyl-azolen |
| US4816463A (en) * | 1986-04-01 | 1989-03-28 | Warner-Lambert Company | Substituted diimidazo [1,5-a: 4',5'-d]pyridines having antihypertensive activity |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| IL86134A (en) * | 1987-05-02 | 1993-06-10 | Basf Ag | N-substituted azoles, their manufacture and their use as pesticides and compositions containing them |
| US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
| US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
| EP0409332A3 (en) * | 1989-07-19 | 1991-08-07 | Merck & Co. Inc. | Substituted triazoles as angiotensin ii antagonists |
-
1990
- 1990-05-04 US US07/519,380 patent/US5098920A/en not_active Expired - Lifetime
-
1991
- 1991-05-06 DE DE69130671T patent/DE69130671T2/de not_active Expired - Fee Related
- 1991-05-06 WO PCT/US1991/002926 patent/WO1991017148A1/en not_active Ceased
- 1991-05-06 JP JP03508882A patent/JP3098772B2/ja not_active Expired - Fee Related
- 1991-05-06 DK DK91909072T patent/DK0527851T3/da active
- 1991-05-06 AT AT91909072T patent/ATE174910T1/de not_active IP Right Cessation
- 1991-05-06 PT PT97581A patent/PT97581B/pt not_active IP Right Cessation
- 1991-05-06 AU AU77924/91A patent/AU7792491A/en not_active Abandoned
- 1991-05-06 IE IE153391A patent/IE62867B1/en not_active IP Right Cessation
- 1991-05-06 ES ES91909072T patent/ES2125868T3/es not_active Expired - Lifetime
- 1991-05-06 CA CA002082074A patent/CA2082074C/en not_active Expired - Fee Related
- 1991-05-06 EP EP91909072A patent/EP0527851B1/de not_active Expired - Lifetime
-
1999
- 1999-03-23 GR GR990400859T patent/GR3029772T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69130671D1 (de) | 1999-02-04 |
| DE69130671T2 (de) | 1999-05-27 |
| CA2082074A1 (en) | 1991-11-05 |
| EP0527851A1 (de) | 1993-02-24 |
| GR3029772T3 (en) | 1999-06-30 |
| JPH05507079A (ja) | 1993-10-14 |
| PT97581A (pt) | 1992-01-31 |
| PT97581B (pt) | 1998-08-31 |
| US5098920A (en) | 1992-03-24 |
| CA2082074C (en) | 2002-02-05 |
| AU7792491A (en) | 1991-11-27 |
| JP3098772B2 (ja) | 2000-10-16 |
| IE911533A1 (en) | 1991-11-06 |
| DK0527851T3 (da) | 1999-08-23 |
| EP0527851B1 (de) | 1998-12-23 |
| WO1991017148A1 (en) | 1991-11-14 |
| ES2125868T3 (es) | 1999-03-16 |
| IE62867B1 (en) | 1995-03-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69130671D1 (de) | 1h-substituierte-1,2,4-triazolverbindungen zur behandlung von herzkrankheiten | |
| WO1992017469A3 (en) | N-arylheteroarylalkyl imidazol-2-one compounds for treatment of circulatory disorders | |
| DE69119089D1 (de) | N-substituierte imidazol-2-on-verbindungen zur behandlung von zirkulatorischen störungen | |
| CA2288705A1 (en) | Use of quinazoline compounds for the treatment of polycystic kidney disease | |
| NO913923D0 (no) | 17beta-substituerte-4-aza-5alfa-androstan-3-on-derivater ogfremgangsmaate ved fremstilling av disse | |
| ATE197951T1 (de) | Neue imidazol derivate, ihre herstellung und therapeutische verwendung | |
| DK0619819T3 (da) | 1-Arylheteroarylalkyl-substituerede 1H-1,2,4-triazolforbindelser til behandling af kredsløbsforstyrrelser | |
| NO970501L (no) | Substituerte kinazolinderivater | |
| PT936217E (pt) | Compostos de 1-fenilpirazole e sua utilizacao em medicina | |
| ATE185797T1 (de) | Stilben-derivate verwendbar als cyclooxygenase-2 hemmer | |
| TR200200205T2 (tr) | MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi | |
| CA2115170A1 (en) | Imidazolyl-alkenoic acids | |
| ATE103604T1 (de) | Substituierte 5-((tetrazolyl)alkenyl>-imidazole. | |
| CA2371012A1 (en) | 4-(1h-pyrrol-1-yl) imidazoles | |
| AU8844491A (en) | Renal-selective biphenylalkyl 1h-substituted-1,2,4-triazole angiotensin ii antagonists for treatment of hypertension | |
| WO2000076489A3 (en) | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits | |
| AU2001255646A1 (en) | Method of inhibiting amyloid protein aggregation and imaging amyloid deposits using aminoindane derivatives | |
| DK0825983T3 (da) | Fremgangsmåde til fremstilling af 2,2'-bipyrrolyl-pyrromethen-derivater (prodigiosiner) | |
| FI940324A7 (fi) | 1-(N-(halo-3-pyridyylimetyyli))-N-metyyliamino-1-alkyyliamino-2-nitroetyleenijohdannaiset kirppujen torjumiseksi kotieläimissä | |
| ID18951A (id) | Berbagai penggunaan sambungan tap untuk alat penghampar-angkat | |
| KR960701041A (ko) | 순환장애의 치료를 위한 1-페닐-이미다졸-2-온 비페닐 메틸 화합물(1-phenyl-imidazol-2-one biphenylmethyl compounds for treatmetnt of circulatory disorders) | |
| NO20033184L (no) | Anvendelse av forbindelsen (+)-<alfa>-(2,3-dimetoksyfenyl)-1- [2-(4-fluorfenyl)etyl]-4-piperidinmetanol | |
| DK0664802T3 (da) | N-Arylheteroarylalkyl-1-phenyl-imidazol-2-on-forbindelser til behandling af kredsløbssygdomme | |
| TR199802203A2 (xx) | 4-Siyano-4-(ikame indazol) siklohegzan-karboksilik asitleri haz�rlama y�ntemi. | |
| YU43499A (sh) | Kristalna hidratovana natrijumova so (e)-4,6-dihloro-3- (2-okso-1-fenilpirolidin-3-iliden metil)-1h-indol-2- karboksilne kiseline |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |