ATE174919T1 - 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung - Google Patents

2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung

Info

Publication number
ATE174919T1
ATE174919T1 AT90914668T AT90914668T ATE174919T1 AT E174919 T1 ATE174919 T1 AT E174919T1 AT 90914668 T AT90914668 T AT 90914668T AT 90914668 T AT90914668 T AT 90914668T AT E174919 T1 ATE174919 T1 AT E174919T1
Authority
AT
Austria
Prior art keywords
derivatives
spirocyclopropylcephalosporine
production
useful
image
Prior art date
Application number
AT90914668T
Other languages
English (en)
Inventor
Samarendra N Maiti
David Czajkowski
Paul Spevak
Kazuo Adachi
Ronald G Micetich
Original Assignee
Synphar Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synphar Lab Inc filed Critical Synphar Lab Inc
Application granted granted Critical
Publication of ATE174919T1 publication Critical patent/ATE174919T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT90914668T 1989-10-06 1990-10-05 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung ATE174919T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41807589A 1989-10-06 1989-10-06

Publications (1)

Publication Number Publication Date
ATE174919T1 true ATE174919T1 (de) 1999-01-15

Family

ID=23656604

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90914668T ATE174919T1 (de) 1989-10-06 1990-10-05 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung

Country Status (13)

Country Link
US (1) US5264430A (de)
EP (1) EP0494914B1 (de)
JP (1) JPH05503290A (de)
KR (1) KR927003605A (de)
AT (1) ATE174919T1 (de)
AU (1) AU661453B2 (de)
CA (1) CA2067803A1 (de)
DE (1) DE69032857T2 (de)
FI (1) FI921507A7 (de)
HU (2) HU213612B (de)
NZ (1) NZ235589A (de)
WO (1) WO1991004977A1 (de)
ZA (1) ZA907976B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5264429A (en) * 1989-10-06 1993-11-23 Synphar Laboratories, Inc. 2-spirocyclopropyl cephalosporin sulfone derivatives
EP0494914B1 (de) * 1989-10-06 1998-12-23 Synphar Laboratories Inc. 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung
US5258377A (en) * 1991-04-08 1993-11-02 Taiho Pharmaceutical Co., Ltd. 2-spirocyclopropyl 4-acylcephems
US5439904A (en) * 1993-12-07 1995-08-08 Synphar Laboratories, Inc. 2-spiro(2'-spirocycloalkyl)cyclopropyl cephalosporin sulfones as antiinflammatory and antigenerative agents
JPH11511463A (ja) * 1995-08-31 1999-10-05 スミスクライン・ビーチャム・コーポレイション インターロイキン変換酵素およびアポプトーシス
HRP970713A2 (en) * 1997-12-30 1999-10-31 Pliva Pharm & Chem Works 7-bromo- and 7,7 dibromo-cepham and cephem derivatives
MXPA06002125A (es) * 2003-08-25 2006-05-31 Revaax Pharmaceuticals Llc Composiciones orales de cefazolin neuroterapeutico.

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH563396A5 (de) * 1970-06-05 1975-06-30 Ciba Geigy Ag
US4547371A (en) * 1983-04-18 1985-10-15 Merck & Co., Inc. Substituted cephalosporin sulfones as anti-inflammatory and anti-degenerative agents
EP0124081A3 (de) * 1983-05-02 1986-11-26 Merck & Co. Inc. Substituierte Cephalosporinsulfone mit Antientzündungs- und Antidegenerativwirkung, sie enthaltende Zusammensetzungen und Verfahren zur Herstellung
ATE133954T1 (de) * 1986-11-12 1996-02-15 Merck & Co Inc Substituierte cephalosporinsulfone als anti- entzündliche und anti-degenerative mittel
GB8808701D0 (en) * 1988-04-13 1988-05-18 Erba Carlo Spa Beta-lactam derivatives
GB8811388D0 (en) * 1988-05-13 1988-06-15 Erba Carlo Spa 1,1-dioxo-cephem-4-carbothiolic acid derivatives
EP0494914B1 (de) * 1989-10-06 1998-12-23 Synphar Laboratories Inc. 2-spirocyclopropylcephalosporinderivate und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
FI921507A0 (fi) 1992-04-06
FI921507L (fi) 1992-04-06
HU9201149D0 (en) 1992-07-28
EP0494914A1 (de) 1992-07-22
WO1991004977A1 (en) 1991-04-18
NZ235589A (en) 1993-05-26
FI921507A7 (fi) 1992-04-06
EP0494914B1 (de) 1998-12-23
AU6513190A (en) 1991-04-28
DE69032857D1 (de) 1999-02-04
US5264430A (en) 1993-11-23
JPH05503290A (ja) 1993-06-03
HUT61769A (en) 1993-03-01
AU661453B2 (en) 1995-07-27
KR927003605A (ko) 1992-12-18
HU213612B (en) 1997-08-28
ZA907976B (en) 1991-09-25
CA2067803A1 (en) 1991-04-07
DE69032857T2 (de) 1999-08-05

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